CN107812168A - A kind of composition, preparation method and applications for being used to alleviate senile plaque expelling - Google Patents
A kind of composition, preparation method and applications for being used to alleviate senile plaque expelling Download PDFInfo
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- CN107812168A CN107812168A CN201710966832.2A CN201710966832A CN107812168A CN 107812168 A CN107812168 A CN 107812168A CN 201710966832 A CN201710966832 A CN 201710966832A CN 107812168 A CN107812168 A CN 107812168A
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- 208000037259 Amyloid Plaque Diseases 0.000 title claims abstract description 59
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- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 40
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 40
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 40
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 40
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 40
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 40
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 40
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 40
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 34
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 26
- 235000000346 sugar Nutrition 0.000 claims abstract description 26
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- 244000241838 Lycium barbarum Species 0.000 claims abstract description 24
- 235000015459 Lycium barbarum Nutrition 0.000 claims abstract description 24
- 235000018417 cysteine Nutrition 0.000 claims abstract description 24
- 229920001817 Agar Polymers 0.000 claims abstract description 23
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- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims abstract description 23
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- 229940070765 laurate Drugs 0.000 claims abstract description 23
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 18
- 239000011709 vitamin E Substances 0.000 claims abstract description 18
- 239000009636 Huang Qi Substances 0.000 claims abstract description 17
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 17
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 17
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 17
- 239000011719 vitamin A Substances 0.000 claims abstract description 17
- 229940046009 vitamin E Drugs 0.000 claims abstract description 17
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 16
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract description 16
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 16
- 229940045997 vitamin a Drugs 0.000 claims abstract description 16
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 13
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims abstract description 13
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- 150000003722 vitamin derivatives Chemical class 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000000706 filtrate Substances 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 9
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 8
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The present invention relates to a kind of composition, preparation method and applications for being used to alleviate senile plaque expelling, using ginger, sugar, honey, vitamin A, vitamin C, vitamin E, cysteine, the Radix Astragali, ganoderma lucidum, hawthorn, matrimony vine, laurate, sorbierite, agar is extracted as raw material, compatibility forms, the extracting process of Jiang Caiyong low-pressure supercriticals carries out effective component extracting, extraction time is short, temperature is low, extraction system is closed, effectively reduces the oxidation of chemical substance.The composition for being used to alleviate senile plaque expelling prepared by the present invention, good effect is quick, has no toxic side effect, and prepares simply, convenient to take.
Description
Technical field
The present invention relates to the field of health care products for alleviating senile plaque expelling, is used to alleviate senile plaque expelling more particularly to a kind of
Composition, preparation method and applications.
Background technology
Senile plaque expelling is in brown-black, and diameter between 1 millimeter to 10 millimeters, differs in size mostly, and big spot diameter is reachable
2-3 centimetres, majority is not higher by skin, and the big spot (mole) having can also be higher by skin, and in flat, it is by lipofuscin pigment structure
Into being apt to occur in face, the back of the hand, shank, instep, trunk etc. of the elderly usually on exposed skin, people's custom is referred to as the " longevity
Spot ", medically then it is referred to as senile pigmented spots (mole).Senile plaque expelling is not only present in skin, and may occur in which in heart, blood vessel,
Liver and interior point must gland etc., affect each internal organs normal function.Therefore, for senile plaque expelling, can't adopt a casual attitude.
Mainly there is following viewpoint in the present science of the origin cause of formation of senile plaque expelling：
The first is thought, into after old age, cell metabolism hypofunction, body fat easily aoxidizes, and produces old
Year pigment, this pigment can not excrete, in being deposited on cell body, so as to form senile plaque expelling.
Think for second, to after old, internal metabolism starts to go down hill people, the decline of cell function year by year plus
Speed, blood circulation also tend to slow, and plus change of the elderly in dietary structure and dynamic, the ratio of plant fat intake is lost
The reasons such as tune, have promoted a kind of atomic small brown particle for being called lipofuscin to be deposited in the basal layer cell of skin, this
Brown particle is the product during peroxidatic reaction of lipid, and the histocyte of aging loses due decomposition and foreign substance removing function,
The brown particle of excess is caused to be deposited in local cells basalis, so as to form senile plaque expelling in human body surface.
The third thinks, is that the vigor of the old superoxide dismutase with Hardy dwarfing in vivo reduces, from
By base also with regard to relative increase, the peroxidization of free radical and its induction poisons the result of organism for a long time.
4th kind is thought, the formation of senile plaque expelling and number, is influenceed by many factors, and some has with congenital heredity factor
Close, some is relevant with certain trophic factor shortage, and what is also had is relevant with some physical factors, such as ultraviolet irradiation, can promote old
Year spot appearance.
Aging of the formation all with body of senile plaque expelling, weak relevant for alleviating the ability of senile plaque expelling as a whole, therefore, adds
The ability for being used to alleviate senile plaque expelling of strong body is imperative.
The medicine of the treatment senile plaque expelling of present commercial type is mostly based on external application, is cured the symptoms, not the disease, it is impossible to from root
Solve the problems, such as that body is used to alleviate senile plaque expelling in sheet.
The disclosure of background above technology contents is only used for inventive concept and the technical scheme that auxiliary understands the present invention, and it is not
The prior art of present patent application is necessarily belonged to, shows the applying date of the above in present patent application in no tangible proof
In the case of disclosed, above-mentioned background technology should not be taken to evaluate the novelty and creativeness of the application.
The content of the invention
Present invention aims at propose it is a kind of be used to alleviate composition, the preparation method and applications of senile plaque expelling, with
Solve above-mentioned prior art and ginger extraction process time length, temperature height be present, enhancing body is used for the ability for alleviating senile plaque expelling
The technical problems such as medicine is cured the symptoms, not the disease, slowly effect, side effect is big, preparation method is cumbersome.
A kind of composition for being used to alleviate senile plaque expelling, the composition include following component：Ginger, sugar, honey, vitamin A,
Vitamin C, vitamin E, cysteine, the Radix Astragali, ganoderma lucidum, hawthorn, matrimony vine, laurate, sorbierite, agar；The composition
Preparation method is：Ginger is extracted by the method for supercritical extract, obtains the filter residue that ginger extract again extracted ginger
Decocted with the Radix Astragali, ganoderma lucidum, matrimony vine and medicinal extract is made；Hawthorn powder and ginger extract, medicinal extract and sugar, honey, vitamin is made in hawthorn
A, vitamin C, vitamin E, cysteine, laurate, sorbierite, agar mixing, pelletize, dry, prepare composition.
Preferably, the described composition for being used to alleviate senile plaque expelling, the composition include the component of following parts by weight：
10-50 parts ginger, 2-8 parts sugar, 4-10 parts honey, 5-10 parts Radix Astragali, 3-9 parts ganoderma lucidum, 6-12 parts hawthorn, 6-12 parts matrimony vine, 2-10
Part vitamin A, 2-10 parts vitamin C, 2-10 parts vitamin E, 1-7 parts cysteine, 1-5 parts laurate, 1-5 parts sorbierite,
1-5 part agar.
It is further preferred that the described composition for being used to alleviate senile plaque expelling, the composition include following parts by weight
Component：20-40 parts ginger, 4-6 parts sugar, 6-8 parts honey, 6-9 parts Radix Astragali, 5-7 parts ganoderma lucidum, 8-10 parts hawthorn, 8-10 parts matrimony vine,
4-8 parts vitamin A, 4-8 parts vitamin C, 4-8 parts vitamin E, 3-5 parts cysteine, 2-4 parts laurate, 2-4 parts sorbierite,
2-4 part agar.
It is highly preferred that the described composition for being used to alleviate senile plaque expelling, the composition include the group of following parts by weight
Part：30 portions of ginger, 5 portions of sugar, 7 parts of honey, 7.5 parts of Radixs Astragali, 6 portions of ganoderma lucidums, 9 portions of hawthorn, 9 portions of matrimony vines, 6 parts of vitamin As, 6 parts of dimension lifes
Plain C, 6 parts of vitamin Es, 4 parts of cysteines, 3 parts of laurate, 3 parts of sorbierites, 3 parts of agar.
A kind of described preparation method for being used to alleviate the composition of senile plaque expelling, comprises the following steps：
S1：Take ginger to clean, be crushed to 20-80 mesh sieves, ginger powder is made；
S2：Ginger powder supercritical fluid extraction 0.5-5h under conditions of 30-80 DEG C, 10-50MPa, be made ginger extract and
Filter residue, it is standby；
S3：The Radix Astragali, ganoderma lucidum, matrimony vine are cleaned respectively, are ground into powder, crosses 10-60 mesh sieves；
S4：Filter residue in powder and S2 made from step S3 is mixed, the decocting for adding 2-5 times of parts by weight boils 1 time, mistake
Filter, filter residue are boiled 1-2 times with 2-5 times of decocting again, merging filtrate, decompression dehydration, and 75% ethanol, closed refrigeration are added after cooling
22-30h, filtering, filtrate concentration, obtain medicinal extract；
S5：Hawthorn is cleaned, fruit stone, rotten pulp are removed after crushing, crushes, cross 20-60 mesh sieves, be dried to moisture
Less than 12%, obtain hawthorn powder；
S6：By step S2, S4, S5, the ginger extract prepared, medicinal extract, hawthorn powder and sugar, honey, vitamin A, vitamin
C, vitamin E, cysteine, laurate, sorbierite, agar mixing, pelletize, dry, the moisture of control composition 8% with
Under, produce.
Preferably, the described preparation method for being used to alleviate the composition of senile plaque expelling, the ginger described in step S1 include fresh
Ginger, rhizoma zingiberis.
Preferably, the described preparation method for being used to alleviate the composition of senile plaque expelling, the sugar described in step S6 is brown sugar, sugarcane
One or more in sugar, white sugar, brown sugar.
Preferably, the described preparation method for being used to alleviate the composition of senile plaque expelling, medicinal extract described in step S4 it is relative
Density 1.20-1.35.
A kind of described application for being used to alleviate the composition of senile plaque expelling, being used for of the composition strengthen being used for for body
Alleviate senile plaque expelling.
The present invention compared with prior art, there is following beneficial effect：
(1) extracting process of Jiang Caiyong low-pressure supercriticals carries out effective component extracting, and extraction time is short, temperature is low, extraction
System is closed, effectively reduces the oxidation of chemical substance.
(2) composition for being used to alleviate senile plaque expelling prepared by the present invention, good effect is quick, has no toxic side effect, and prepares letter
It is single, it is convenient to take.
(3) composition of the alleviation senile plaque expelling used in the present invention contains the Chinese medicines such as the Radix Astragali, ganoderma lucidum, hawthorn, matrimony vine, coordinates
Ginger, the use of vitamin A, vitamin C, vitamin E, cysteine, can strengthen the oxidability of body, effectively alleviate and control
Treat senile plaque expelling.
Embodiment
It is foregoing broadly to have elaborated the feature and technical advantage of the present invention, so as to more fully understand the present invention's
It is described in detail.The further feature and advantage of the present invention will be described below.It should be appreciated by those skilled in the art that the concept disclosed
It is used for changing or designing other structures based on being easily used as with specific embodiment to complete the phase of the present invention
Same purpose.Those skilled in the art are not it should also be appreciated that this equivalent construction offsets the spirit and scope of the present invention.
It is considered as the novel features of feature of the present invention, its structure and operation method.However, it should profoundly recognize, there is provided
Each feature is merely to description and explanation, the definition without being intended to the limitation present invention.
The present invention is described in further detail with reference to embodiment.It is emphasized that the description below is only
Only it is exemplary, the scope being not intended to be limiting of the invention and its application.
(1) preparation of composition
Embodiment 1
A kind of composition for being used to alleviate senile plaque expelling, include the component of following parts by weight：10 parts of fresh gingers, 2 parts it is red
Sugar, 4 parts of honey, 5 parts of Radixs Astragali, 3 portions of ganoderma lucidums, 6 portions of hawthorn, 6 portions of matrimony vines, 2 parts of vitamin As, 2 parts of vitamin Cs, 2 parts of vitamin Es, 1
Part cysteine, 1 part of laurate, 1 part of sorbierite, 1 part of agar；
The described preparation method for being used to alleviate the composition of senile plaque expelling, comprises the following steps：
S1：Take fresh ginger to clean, be crushed to 20 mesh sieves, ginger powder is made；
S2：Ginger extract and filter residue is made at 30 DEG C, supercritical fluid extraction 0.5h under conditions of 10MPa in ginger powder, standby
With；
S3：The Radix Astragali, ganoderma lucidum, matrimony vine are cleaned respectively, are ground into powder, crosses 10 mesh sieves；
S4：Filter residue in powder and S2 made from step S3 is mixed, the decocting for adding 2 times of parts by weight is boiled 1 time, is filtered,
Filter residue is boiled 1 time with 2 times of decoctings again, merging filtrate, decompression dehydration, and 75% ethanol is added after cooling, closed refrigeration 22h, is filtered,
Filtrate concentrates, and obtains the medicinal extract of relative density 1.20；
S5：Hawthorn is cleaned, fruit stone, rotten pulp are removed after crushing, crushes, cross 20-60 mesh sieves, be dried to moisture
Less than 12%, obtain hawthorn powder；
S6：By step S2, S4, S5, the ginger extract, medicinal extract, hawthorn powder and the brown sugar that prepare, honey, vitamin A, dimension life
Plain C, vitamin E, cysteine, laurate, sorbierite, agar mixing, pelletize, dry, the moisture of control composition 8% with
Under, produce.
Embodiment 2
A kind of composition for being used to alleviate senile plaque expelling, include the component of following parts by weight：50 portions of rhizoma zingiberis, 8 parts of sucrose, 10
Part honey, 10 parts of Radixs Astragali, 9 portions of ganoderma lucidums, 12 portions of hawthorn, 12 portions of matrimony vines, 10 parts of vitamin As, 10 parts of vitamin Cs, 10 parts of vitamins
E, 7 parts of cysteines, 5 parts of laurate, 5 parts of sorbierites, 5 parts of agar；
The described preparation method for being used to alleviate the composition of senile plaque expelling, comprises the following steps：
S1：Take ginger to clean, be crushed to 80 mesh sieves, ginger powder is made；
S2：Ginger extract and filter residue is made at 80 DEG C, supercritical fluid extraction 5h under conditions of 50MPa in ginger powder, standby；
S3：The Radix Astragali, ganoderma lucidum, matrimony vine are cleaned respectively, are ground into powder, crosses 60 mesh sieves；
S4：Filter residue in powder and S2 made from step S3 is mixed, the decocting for adding 5 times of parts by weight is boiled 1 time, is filtered,
Filter residue is boiled 2 times with 5 times of decoctings again, merging filtrate, decompression dehydration, and 75% ethanol is added after cooling, closed refrigeration 30h, is filtered,
Filtrate concentrates, and obtains the medicinal extract of relative density 1.35；
S5：Hawthorn is cleaned, fruit stone, rotten pulp are removed after crushing, crushes, cross 60 mesh sieves, be dried to moisture 12%
Hereinafter, hawthorn powder is obtained；
S6：By step S2, S4, S5, the ginger extract, medicinal extract, hawthorn powder and the sucrose that prepare, honey, vitamin A, dimension life
Plain C, vitamin E, cysteine, laurate, sorbierite, agar mixing, pelletize, dry, the moisture of control composition 8% with
Under, produce.
Embodiment 3
A kind of composition for being used to alleviate senile plaque expelling, include the component of following parts by weight：20 parts of fresh gingers, 4 parts it is white
Sugar, 6 parts of honey, 6 parts of Radixs Astragali, 5 portions of ganoderma lucidums, 8 portions of hawthorn, 8 portions of matrimony vines, 4 parts of vitamin As, 4 parts of vitamin Cs, 4 parts of vitamin Es, 3
Part cysteine, 2 parts of laurate, 2 parts of sorbierites, 2 parts of agar；
The described preparation method for being used to alleviate the composition of senile plaque expelling, comprises the following steps：
S1：Take fresh ginger to clean, be crushed to 20 mesh sieves, ginger powder is made；
S2：Ginger extract and filter residue is made at 30 DEG C, supercritical fluid extraction 0.5h under conditions of 10MPa in ginger powder, standby
With；
S3：The Radix Astragali, ganoderma lucidum, matrimony vine are cleaned respectively, are ground into powder, crosses 10 mesh sieves；
S4：Filter residue in powder and S2 made from step S3 is mixed, the decocting for adding 2 times of parts by weight is boiled 1 time, is filtered,
Filter residue is boiled 1 time with 2 times of decoctings again, merging filtrate, decompression dehydration, and 75% ethanol is added after cooling, closed refrigeration 22h, is filtered,
Filtrate concentrates, and obtains the medicinal extract of relative density 1.25；
S5：Hawthorn is cleaned, fruit stone, rotten pulp are removed after crushing, crushes, cross 20 mesh sieves, be dried to moisture 12%
Hereinafter, hawthorn powder is obtained；
S6：By step S2, S4, S5, the ginger extract, medicinal extract, hawthorn powder and the white sugar that prepare, honey, vitamin A, dimension life
Plain C, vitamin E, cysteine, laurate, sorbierite, agar mixing, pelletize, dry, the moisture of control composition 8% with
Under, produce.
Embodiment 4
A kind of composition for being used to alleviate senile plaque expelling, include the component of following parts by weight：40 portions of rhizoma zingiberis, 6 parts of brown sugar, 8
Part honey, 9 parts of Radixs Astragali, 7 portions of ganoderma lucidums, 10 portions of hawthorn, 10 portions of matrimony vines, 8 parts of vitamin As, 8 parts of vitamin Cs, 8 parts of vitamin Es, 5 parts
Cysteine, 4 parts of laurate, 4 parts of sorbierites, 4 parts of agar；
The described preparation method for being used to alleviate the composition of senile plaque expelling, comprises the following steps：
S1：Take rhizoma zingiberis to clean, be crushed to 40 mesh sieves, ginger powder is made；
S2：Ginger extract and filter residue is made at 50 DEG C, supercritical fluid extraction 3h under conditions of 20MPa in ginger powder, standby；
S3：The Radix Astragali, ganoderma lucidum, matrimony vine are cleaned respectively, are ground into powder, crosses 20 mesh sieves；
S4：Filter residue in powder and S2 made from step S3 is mixed, the decocting for adding 3 times of parts by weight is boiled 1 time, is filtered,
Filter residue is boiled 1 time with 5 times of decoctings again, merging filtrate, decompression dehydration, and 75% ethanol is added after cooling, closed refrigeration 24h, is filtered,
Filtrate concentrates, and obtains the medicinal extract of relative density 1.30；
S5：Hawthorn is cleaned, fruit stone, rotten pulp are removed after crushing, crushes, cross 20 mesh sieves, be dried to moisture 12%
Hereinafter, hawthorn powder is obtained；
S6：By step S2, S4, S5, the ginger extract, medicinal extract, hawthorn powder and the brown sugar that prepare, honey, vitamin A, dimension life
Plain C, vitamin E, cysteine, laurate, sorbierite, agar mixing, pelletize, dry, the moisture of control composition 8% with
Under, produce.
Embodiment 5
A kind of composition for being used to alleviate senile plaque expelling, include the component of following parts by weight：30 parts of fresh gingers, 3 parts it is red
Sugar, 2 parts of white sugar, 7 parts of honey, 7.5 parts of Radixs Astragali, 6 portions of ganoderma lucidums, 9 portions of hawthorn, 9 portions of matrimony vines, 6 parts of vitamin As, 6 parts of vitamin Cs, 6
Part vitamin E, 4 parts of cysteines, 3 parts of laurate, 3 parts of sorbierites, 3 parts of agar；
The described preparation method for being used to alleviate the composition of senile plaque expelling, comprises the following steps：
S1：Take fresh ginger to clean, be crushed to 60 mesh sieves, ginger powder is made；
S2：Ginger extract and filter residue is made at 60 DEG C, supercritical fluid extraction 3.5h under conditions of 30MPa in ginger powder, standby
With；
S3：The Radix Astragali, ganoderma lucidum, matrimony vine are cleaned respectively, are ground into powder, crosses 40 mesh sieves；
S4：Filter residue in powder and S2 made from step S3 is mixed, the decocting for adding 4 times of parts by weight is boiled 1 time, is filtered,
Filter residue is boiled 1 time with 4 times of decoctings again, merging filtrate, decompression dehydration, and 75% ethanol is added after cooling, closed refrigeration 26h, is filtered,
Filtrate concentrates, and obtains the medicinal extract of relative density 1.28；
S5：Hawthorn is cleaned, fruit stone, rotten pulp are removed after crushing, crushes, cross 50 mesh sieves, be dried to moisture 12%
Hereinafter, hawthorn powder is obtained；
S6：By step S2, S4, S5, the ginger extract prepared, medicinal extract, hawthorn powder and sugar, honey, vitamin A, vitamin
C, vitamin E, cysteine, laurate, sorbierite, agar mixing, pelletize, dry, the moisture of control composition 8% with
Under, produce.
(2) clinical verification
(1) general information
The composition that Application Example 6 is made carries out clinical treatments to 50 patients, age of patient in over-65s,
There is senile plaque expelling on skin.
(2) treatment method
The long-term use of present composition, it even served 1 month, it is seen that senile plaque expelling color slowly shoals, and continuously takes 3 months
Afterwards, senile plaque expelling disappears substantially, unhealed, continues to take this product.
(3) the standard of curative effect evaluation
Cure：Clinical symptom disappearance, functional activity is normal, and senile plaque expelling disappears.
Take a turn for the better：Clinical symptoms partial disappearance is clearly better.
It is invalid：Clinical symptom and sign is without improvement.
(4) therapeutic effect
Most of patients is taken 3~4 months and can cured, the course of disease is longer, the state of an illness than more severe case, need to take 6~8 months,
It is specific as follows：
After treating three courses for the treatment of：35 are cured, is taken a turn for the better 13, invalid 2.
After treating five courses for the treatment of：43 are cured, is taken a turn for the better 7, invalid 0.
(5) model case 1
Field, female, 69 years old, because the age is slowly big, there is senile plaque expelling (embodiment 6) occur on skin and treated, controlled
After treating 2 courses for the treatment of, symptom mitigation, 4 courses for the treatment of are taken, symptom disappears, and continues to strengthen 2 courses for the treatment of, recurrence that so far there are no.
(6) model case 2
Cai, man, 75 years old, due to being had no result on skin, internal organ with senile plaque expelling, many places treatment.After take preparation of the present invention
Composition (embodiment 6) treated, treat 3 courses for the treatment of after, symptom substantially mitigates, and continues to take 2 courses for the treatment of, cure.Follow-up
Recurrence that so far there are no.
Above content is to combine specific/preferred embodiment further description made for the present invention, it is impossible to
Assert that the specific implementation of the present invention is confined to these explanations.Come for general technical staff of the technical field of the invention
Say, without departing from the inventive concept of the premise, it can also make some replacements or modification to the embodiment that these have been described,
And these are substituted or variant should all be considered as belonging to protection scope of the present invention.
Claims (9)
1. a kind of composition for being used to alleviate senile plaque expelling, it is characterised in that the composition includes following component：Ginger, sugar, honeybee
Honey, vitamin A, vitamin C, vitamin E, cysteine, the Radix Astragali, ganoderma lucidum, hawthorn, matrimony vine, laurate, sorbierite, agar；Institute
The preparation method for stating composition is：Ginger is extracted by the method for supercritical extract, ginger extract is obtained and again carries ginger
The filter residue taken decocts with the Radix Astragali, ganoderma lucidum, matrimony vine and medicinal extract is made；By hawthorn be made hawthorn powder and ginger extract, medicinal extract, with sugar,
Honey, vitamin A, vitamin C, vitamin E, cysteine, laurate, sorbierite, agar mixing, pelletize, dry, preparation group
Compound.
2. the composition as claimed in claim 1 for being used to alleviate senile plaque expelling, it is characterised in that the composition includes following heavy
Measure the component of number：10-50 parts ginger, 2-8 parts sugar, 4-10 parts honey, 5-10 parts Radix Astragali, 3-9 parts ganoderma lucidum, 6-12 parts hawthorn, 6-
12 portions of matrimony vines, 2-10 parts vitamin A, 2-10 parts vitamin C, 2-10 parts vitamin E, 1-7 parts cysteine, 1-5 parts laurate,
1-5 parts sorbierite, 1-5 part agar.
3. the composition as claimed in claim 2 for being used to alleviate senile plaque expelling, it is characterised in that the composition includes following heavy
Measure the component of number：20-40 parts ginger, 4-6 parts sugar, 6-8 parts honey, 6-9 parts Radix Astragali, 5-7 parts ganoderma lucidum, 8-10 parts hawthorn, 8-10
Part matrimony vine, 4-8 parts vitamin A, 4-8 parts vitamin C, 4-8 parts vitamin E, 3-5 parts cysteine, 2-4 parts laurate, 2-4 parts
Sorbierite, 2-4 part agar.
4. the composition as claimed in claim 3 for being used to alleviate senile plaque expelling, it is characterised in that the composition includes following heavy
Measure the component of number：30 portions of ginger, 5 portions of sugar, 7 parts of honey, 7.5 parts of Radixs Astragali, 6 portions of ganoderma lucidums, 9 portions of hawthorn, 9 portions of matrimony vines, 6 parts of vitamins
A, 6 parts of vitamin Cs, 6 parts of vitamin Es, 4 parts of cysteines, 3 parts of laurate, 3 parts of sorbierites, 3 parts of agar.
5. a kind of preparation method for being used to alleviate the composition of senile plaque expelling as described in claim 1-4 any one, its feature
It is, comprises the following steps：
S1：Take ginger to clean, be crushed to 20-80 mesh sieves, ginger powder is made；
S2：Ginger powder supercritical fluid extraction 0.5-5h under conditions of 30-80 DEG C, 10-50MPa, ginger extract and filter residue is made,
It is standby；
S3：The Radix Astragali, ganoderma lucidum, matrimony vine are cleaned respectively, are ground into powder, crosses 10-60 mesh sieves；
S4：Filter residue in powder and S2 made from step S3 is mixed, the decocting for adding 2-5 times of parts by weight is boiled 1 time, is filtered, filter
Slag is boiled 1-2 times with 2-5 times of decocting again, merging filtrate, decompression dehydration, the ethanol of addition 75% after cooling, closed refrigeration 22-30h,
Filtering, filtrate concentration, obtains medicinal extract；
S5：By hawthorn clean, crush after remove fruit stone, rotten pulp, crush, cross 20-60 mesh sieves, be dried to moisture 12% with
Under, obtain hawthorn powder；
S6：By step S2, S4, S5, the ginger extract prepared, medicinal extract, hawthorn powder and sugar, honey, vitamin A, vitamin C, dimension
Raw plain E, cysteine, laurate, sorbierite, agar mixing, pelletize, dry, the moisture of control composition is below 8%, i.e.,
.
6. the preparation method as claimed in claim 5 for being used to alleviate the composition of senile plaque expelling, it is characterised in that：Described in step S1
Ginger include fresh ginger, rhizoma zingiberis.
7. the preparation method as claimed in claim 5 for being used to alleviate the composition of senile plaque expelling, it is characterised in that：Described in step S6
Sugar be brown sugar, sucrose, white sugar, the one or more in brown sugar.
8. the preparation method as claimed in claim 5 for being used to alleviate the composition of senile plaque expelling, it is characterised in that：Described in step S4
Medicinal extract relative density 1.20-1.35.
A kind of 9. application as claimed in claim 1 for being used to alleviate the composition of senile plaque expelling, it is characterised in that：The composition
Be used for strengthen body be used for alleviate senile plaque expelling.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1544036A (en) * | 2003-11-14 | 2004-11-10 | 刘贤英 | Speckle removing and whitening traditional medicinal healthy product and its preparation |
| CN101194737A (en) * | 2006-12-08 | 2008-06-11 | 陈光福 | Health care beverage for fast eliminating senile plaque and producing method thereof |
| CN106166194A (en) * | 2016-08-10 | 2016-11-30 | 武夷山元生泰生物科技有限公司 | A kind of Ganoderma tuckahoe teat for treating senile plaque |
-
2017
- 2017-10-17 CN CN201710966832.2A patent/CN107812168A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1544036A (en) * | 2003-11-14 | 2004-11-10 | 刘贤英 | Speckle removing and whitening traditional medicinal healthy product and its preparation |
| CN101194737A (en) * | 2006-12-08 | 2008-06-11 | 陈光福 | Health care beverage for fast eliminating senile plaque and producing method thereof |
| CN106166194A (en) * | 2016-08-10 | 2016-11-30 | 武夷山元生泰生物科技有限公司 | A kind of Ganoderma tuckahoe teat for treating senile plaque |
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