CN106668506A - Poria cocos and ginkgo biloba buccal tablets - Google Patents

Poria cocos and ginkgo biloba buccal tablets Download PDF

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CN106668506A
CN106668506A CN201611184568.9A CN201611184568A CN106668506A CN 106668506 A CN106668506 A CN 106668506A CN 201611184568 A CN201611184568 A CN 201611184568A CN 106668506 A CN106668506 A CN 106668506A
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poria cocos
ginkgo
ginkgo biloba
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刘杰
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

Poria cocos and ginkgo biloba buccal tablets comprise raw materials in parts by mass as follows: 100-160 parts of poria cocos, 60-80 parts of dry ginkgo biloba fruit, 30-40 parts of dry ginkgo biloba leaf, 20-30 parts of folium mori, 20-25 parts of fragrant solomonseal rhizome, 15-20 parts of persimmon leaf, 8-12 parts of glossy ganoderma, 8-15 parts of lactose and 30-80 parts of refined honey. During preparation, the dry ginkgo biloba fruit, the dry ginkgo biloba leaf and the glossy ganoderma are smashed, 50% ethanol is added, the mixture is left to stand and subjected to reflux extraction, and a filtrate is concentrated into an extract; the poria cocos is diced and combined with the folium mori, the fragrant solomonseal rhizome and the persimmon leaf, the mixture is decocted twice, two times of decoctions are combined after respective solid-liquid separation, the combined decoction is filtered, a filtrate is concentrated into clear paste, the clear paste and the extract are combined, the lactose and the refined honey are added, the water content is regulated, granulation is performed by a granulator, and the finished buccal tablets are obtained after drying, shaping and tableting. The poria cocos and ginkgo biloba buccal tablets have the effects of building body, strengthening the brain, enhancing intelligence, resisting fatigue and aging and enhancing body immunity.

Description

Poria cocos ginkgo lozenge
Technical field
The present invention relates to oral traditional Chinese medicine preparation field, and in particular to a kind of brain tonic, anti-blooming, the Poria cocos ginkgo lozenge allayed excitement.
Background technology
Poria cocos, another name cloud Siberian cocklebur, Fu spirits, loose Poria cocos, pine potato etc., are the Polyporaceae plants for colonizing in pine tree root, are one Precious medicine-food two-purpose bacterium is planted, is exactly since ancient times the health food of integration of drinking and medicinal herbs, the concern of people is constantly subjected to, rich in Poria cocos The multiple efficacies composition such as polysaccharide, with strengthening the spleen and stomach, inducing diuresis for removing edema, reducing blood lipid, adjusts immunity of organism, anti-aging, antitumor, anti-prominent The functions such as change；Ancients' Poria cocos is called " god's medicine when four ", because its effect is widely, regardless of the four seasons, it is matched somebody with somebody with various medicines 5, no matter cold, temperature, wind, wet all diseases, can play its unique effects.
Ginkgo also known as gingko, its value be mainly reflected in it is edible and medicinal, in Ancient Times in China just with ginkgo as curing the disease Good medicine and the delicacies for entering food, food method mainly has roasting, cooks, stir-fries and eats and garnish food, and it is rich in flavonoids, terpene, phenols, biology Alkali, polyisoamylene, quininic acid, linoleic acid, boa oxalic acid, ascorbic acid, a- hexenoic aldehydes, gingko alcohol, bilobanone etc. are conducive to human body Material, relieving asthma with astringing the lung, reduce amount of expectoration, inducing astrigency stop-band, eliminating phlegm relieving asthma, convergence dehumidifying effect, while institute in its epidermis The ginkgoic acid for containing has stronger inhibitory action for tubercle bacillus, dermatophyte etc., therefore, it can also be used to treat pulmonary tuberculosis and Skin disease, in addition, ginkgo is preventing and treating hypertension, heart disease conveniently, also all it is highly important dosage component.
At present, for the application of the medicine of said components is mainly based on simple powder, need through human body body Digestion after can be absorbed so that the bioavailability of its these preparation is relatively low, meanwhile, exist in-convenience in use, Work slow defect, is even directly milled into pulvis orally, also poor taste, it is difficult to the defect of hypopharynx, it is difficult to adapt to fast pace The modern life requirement.
The content of the invention
Technical problem solved by the invention is to provide a kind of Poria cocos ginkgo lozenge, to solve above-mentioned technical background in Defect.
Technical problem solved by the invention employs the following technical solutions to realize：
Poria cocos ginkgo lozenge, including the raw material of following mass parts：
Poria cocos：100 ~ 160 parts, ginkgo dry fruit：60 ~ 80 parts, dry Folium Ginkgo：30 ~ 40 parts, mulberry leaf：20 ~ 30 parts, solomon's seal：20~25 Part, Folium Kaki：15 ~ 20 parts, glossy ganoderma：8 ~ 12 parts, lactose：8 ~ 15 parts, refining honey：30 ~ 80 parts.
Its preferred mass part is：Poria cocos：130 parts, ginkgo dry fruit：65 parts, dry Folium Ginkgo：35 parts, mulberry leaf：25 parts, solomon's seal： 22 parts, Folium Kaki：18 parts, glossy ganoderma：10 parts, lactose：13 parts, refining honey：60 parts.
Its concrete preparation method is as follows：
1）Take ginkgo dry fruit, dry Folium Ginkgo and glossy ganoderma together carries out ultramicro grinding by colloid mill, crosses 200 ~ 300 mesh sieves, then Plus 50% ethanol, stand and carry out after 1 ~ 2h refluxing extraction, extract and reclaim ethanol and simultaneously filtrate is condensed into into medicinal extract.
2）Poria cocos is cut into into the fritter of 8 ~ 10mm square, is together added in container with mulberry leaf, solomon's seal, Folium Kaki, while pressing Add the ratio of 50 ~ 60ml to add water per 5g medicines gross mass, small fire is turned after being boiled by fire and decocts 2 ~ 3h, carry out separation of solid and liquid, then Add the ratio of 30 ~ 50ml to add water in every 5g medicines gross mass, small fire is turned after being boiled by fire and decocts 1 ~ 2h, after carrying out separation of solid and liquid Merge decocting liquid twice, filter, filtrate is concentrated into the clear cream that density is 1.05~1.25.
3）Obtained medicinal extract in step 1 is added in clear cream, while lactose and refining honey are added, and to refine honey Make excipient, mixture moisture content is controlled within 10%, to make softwood, above-mentioned softwood particle wobbler is sieved and is made Wet granular；
4）By above-mentioned wet granular insulating box heated-air drying, by water content control below 3%, then dried particle is led to again 40 mesh ~ 60 mesh particle wobbler whole grains are crossed, add 0.3 by mass parts material parts per hundred parts ~ 0.5 part of amount adds magnesium stearate to carry out mix After be dried compression molding and get product.
As the further restriction of the present invention：
The step 2）Middle decocting liquid is filtered when filtering with 180~200 mesh filter clothes.
The step 3）In carry out particle wobbler sieve granulation when, its grain diameter is controlled in 2mm.
The step 4）In when being dried operation, Thermostat Temperature Control between 50 DEG C ~ 60 DEG C, drying time control For 6 ~ 8 hours.
Beneficial effect：Poria cocos ginkgo lozenge of the present invention, by adding ginkgo in Poria cocos mediation supplement is carried out, and coordinates glossy ganoderma In various active principles can effectively improve body immunity, with salubrity, brain tonic, increase intelligence, antifatigue, anti-aging and enhancing machine Effect of body immunity, while hypertension, heart disease can also be prevented and treated effectively.
Specific embodiment
In order that technological means, creation characteristic, reached purpose and effect that the present invention is realized are easy to understand, tie below Specific embodiment is closed, the present invention is expanded on further.
Embodiment one：
In this embodiment including the raw material of following components：
Poria cocos：140 parts, ginkgo dry fruit：65 parts, dry Folium Ginkgo：32 parts, mulberry leaf：24 parts, solomon's seal：22 parts, Folium Kaki：16 parts, spirit Sesame：8 parts, lactose：8 parts, refining honey：40 parts.
During preparation, take ginkgo dry fruit, dry Folium Ginkgo and glossy ganoderma together carries out ultramicro grinding by colloid mill, crosses 200 mesh Sieve, then add 50% ethanol, stand and carry out after 120min refluxing extraction, extract and reclaim ethanol and filtrate is condensed into into medicinal extract.Then will Poria cocos is cut into the fritter of 8 ~ 10mm square, and by these fritters and mulberry leaf, solomon's seal, Folium Kaki and 2200ml water, is boiled by fire After turn small fire decoct 150min, filtered with 200 mesh filter clothes after separation of solid and liquid, in filter residue add 1800ml water, after being boiled by fire Turn small fire and decoct 90min, then filtered with 180 mesh filter clothes after separation of solid and liquid, merge decocting liquid twice, filter, filtrate is dense It is reduced to the clear cream that density is 1.18.
Clear cream is merged with medicinal extract, while add lactose and refining honey to stir, water content in adjustment compound, And controlled, 8%, to make softwood, above-mentioned softwood particle wobbler is sieved granulation, bulky grain particle diameter≤2mm is made wet Insulating box heated-air drying is used after particle, at 58 DEG C, 6 hours time, after being dried, detection comprehensive moisture content is 2.6% to temperature control, 0.4 part of amount is added to add by mass parts material parts per hundred parts stearic again by 60 mesh particle wobbler whole grains dried particle again Sour magnesium is carried out being dried compression molding after mix and got product.
Embodiment two：
In this embodiment including the raw material of following components：
Poria cocos：130 parts, ginkgo dry fruit：65 parts, dry Folium Ginkgo：35 parts, mulberry leaf：25 parts, solomon's seal：22 parts, Folium Kaki：18 parts, spirit Sesame：10 parts, lactose：13 parts, refining honey：60 parts.
During preparation, take ginkgo dry fruit, dry Folium Ginkgo and glossy ganoderma together carries out ultramicro grinding by colloid mill, crosses 200 mesh Sieve, then add 50% ethanol, stand and carry out after 80min refluxing extraction, extract and reclaim ethanol and filtrate is condensed into into medicinal extract.Then will Poria cocos is cut into the fritter of 8 ~ 10mm square, and by these fritters and mulberry leaf, solomon's seal, Folium Kaki and 2100ml water, is boiled by fire After turn small fire decoct 150min, filtered with 200 mesh filter clothes after separation of solid and liquid, in filter residue add 1680ml water, after being boiled by fire Turn small fire and decoct 90min, then filtered with 180 mesh filter clothes after separation of solid and liquid, merge decocting liquid twice, filter, filtrate is dense It is reduced to the clear cream that density is 1.15.
Clear cream is merged with medicinal extract, while add lactose and refining honey to stir, water content in adjustment compound, And controlled, 7%, to make softwood, above-mentioned softwood particle wobbler is sieved granulation, bulky grain particle diameter≤2mm is made wet Insulating box heated-air drying is used after particle, at 60 DEG C, 7 hours time, after being dried, detection comprehensive moisture content is 2.5% to temperature control, 0.4 part of amount is added to add by mass parts material parts per hundred parts stearic again by 50 mesh particle wobbler whole grains dried particle again Sour magnesium is carried out being dried compression molding after mix and got product.
General principle, principal character and the advantages of the present invention of the present invention has been shown and described above.The technology of the industry Personnel it should be appreciated that the present invention is not restricted to the described embodiments, the simply explanation described in above-described embodiment and specification this The principle of invention, without departing from the spirit and scope of the present invention, the present invention also has various changes and modifications, these changes Change and improvement is both fallen within scope of the claimed invention.The claimed scope of the invention by appending claims and its Equivalent thereof.

Claims (6)

1. Poria cocos ginkgo lozenge, it is characterised in that including the raw material of following mass parts：Poria cocos：100 ~ 160 parts, ginkgo dry fruit：60 ~ 80 parts, dry Folium Ginkgo：30 ~ 40 parts, mulberry leaf：20 ~ 30 parts, solomon's seal：20 ~ 25 parts, Folium Kaki：15 ~ 20 parts, glossy ganoderma：8 ~ 12 parts, Lactose：8 ~ 15 parts, refining honey：30 ~ 80 parts.
2. Poria cocos ginkgo lozenge according to claim 1, it is characterised in that including the raw material of following mass parts：Poria cocos： 130 parts, ginkgo dry fruit：65 parts, dry Folium Ginkgo：35 parts, mulberry leaf：25 parts, solomon's seal：22 parts, Folium Kaki：18 parts, glossy ganoderma：10 parts, Lactose：13 parts, refining honey：60 parts.
3. a kind of preparation method of Poria cocos ginkgo lozenge, it is characterised in that using each component described in claim 1 or 2 Raw material prepares Poria cocos ginkgo lozenge, and its concrete preparation method is as follows：
1）Take ginkgo dry fruit, dry Folium Ginkgo and glossy ganoderma together carries out ultramicro grinding by colloid mill, crosses 200 ~ 300 mesh sieves, then Plus 50% ethanol, stand and carry out after 1 ~ 2h refluxing extraction, extract and reclaim ethanol and simultaneously filtrate is condensed into into medicinal extract；
2）Poria cocos is cut into into the fritter of 8 ~ 10mm square, is together added in container with mulberry leaf, solomon's seal, Folium Kaki, while by per 5g Medicine gross mass adds the ratio of 50 ~ 60ml to add water, and small fire is turned after being boiled by fire and decocts 2 ~ 3h, carries out separation of solid and liquid, then by every 5g medicines gross mass adds the ratio of 30 ~ 50ml to add water, and small fire is turned after being boiled by fire and decocts 1 ~ 2h, carries out merging after separation of solid and liquid Decocting liquid twice, filters, and filtrate is concentrated into the clear cream that density is 1.05~1.25；
3）Obtained medicinal extract in step 1 is added in clear cream, while adding lactose and refining honey, and is assigned with refining honey Shape agent, mixture moisture content is controlled within 10%, to make softwood, above-mentioned softwood particle wobbler is sieved and makes wet Grain；
4）By above-mentioned wet granular insulating box heated-air drying, by water content control below 3%, then dried particle is led to again 40 mesh ~ 60 mesh particle wobbler whole grains are crossed, add 0.3 by mass parts material parts per hundred parts ~ 0.5 part of amount adds magnesium stearate to carry out mix After be dried compression molding and get product.
4. preparation method according to claim 3, it is characterised in that the step 2）With 180~200 when middle decocting liquid is filtered Mesh filter cloth is filtered.
5. preparation method according to claim 3, it is characterised in that the step 3）In carry out particle wobbler and cross sieve series During grain, its grain diameter is controlled in 2mm.
6. preparation method according to claim 3, it is characterised in that the step 4）In when being dried operation, constant temperature Between 50 DEG C ~ 60 DEG C, drying time is controlled to 6 ~ 8 hours to case temperature control.
CN201611184568.9A 2016-12-20 2016-12-20 Poria cocos and ginkgo biloba buccal tablets Withdrawn CN106668506A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109662980A (en) * 2018-11-29 2019-04-23 青川县农村产业技术服务中心 The preparation method of ginkgo oral buccal tablet

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109662980A (en) * 2018-11-29 2019-04-23 青川县农村产业技术服务中心 The preparation method of ginkgo oral buccal tablet

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Application publication date: 20170517