CN107812077A - A kind of Chinese and Western compound medicine for treating superficial gastritis and preparation method thereof - Google Patents

A kind of Chinese and Western compound medicine for treating superficial gastritis and preparation method thereof Download PDF

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CN107812077A
CN107812077A CN201711082722.6A CN201711082722A CN107812077A CN 107812077 A CN107812077 A CN 107812077A CN 201711082722 A CN201711082722 A CN 201711082722A CN 107812077 A CN107812077 A CN 107812077A
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parts
chinese
superficial gastritis
fine powder
compound medicine
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黄建文
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/245—Bismuth; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/808—Scrophularia (figwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

Abstract

The present invention relates to a kind of Chinese and Western compound medicine for treating superficial gastritis and preparation method thereof, the Chinese and Western compound medicine includes the bulk drug of following parts by weight：12 15 parts of rheum officinale, 12 15 parts of pinellia, 15 22 parts of rhizoma atractylodis macrocephalae, 15 22 parts of corydalis tuber, 13 17 parts of dandelion, 13 18 parts of borneol, 15 20 parts of radix scrophulariae, 14 parts of CBS, 14 parts of CLA.The Chinese and Western compound medicine of the treatment superficial gastritis of the present invention is collectively constituted by Chinese herbal medicine and Western medicine, has the advantages of evident in efficacy, rapid-action, Small side effects for treating superficial gastritis.

Description

A kind of Chinese and Western compound medicine for treating superficial gastritis and preparation method thereof
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of Chinese and Western compound medicine for treating superficial gastritis and its system Preparation Method.
Background technology
Chronic superficial gastritis is the chronic inflammation lesion of gastric mucosa caused by many reasons, and this disease is very common, its The incidence of disease increases with the growth at age, complete being the gastritis based on antrum in China's majority, its course of disease is delayed, and symptom can show For different degrees of indigestion, including upper abdomen is glutted (especially postprandial), the epigastric pain of no evident regularity, belch, anti- Acid, burn feeling, poor appetite, nausea and vomiting etc., small number of patients can have UGB performance (generally a small amount of bleeding) can With anaemia.Acute attack is often because violent spontaneous stomachache influences feed and sleep.Clinically it is used for shallow stomach at present Scorching medicine therapeutic effect is unsatisfactory, often treats, attends to one thing and lose sight of another just for some symptoms, curative effect can not still make us It is satisfied.
Therefore the medicine of people's treatment superficial gastritis more preferable to curative effect still suffers from demand.
The content of the invention
It is an object of the invention to provide a kind of Chinese and Western compound medicine for treating superficial gastritis and preparation method thereof, the Chinese and Western Compound medicine is collectively constituted by Chinese herbal medicine and Western medicine, has evident in efficacy, rapid-action, Small side effects for treating superficial gastritis The advantages of.
Technical scheme is as follows：
A kind of Chinese and Western compound medicine for treating superficial gastritis, include the bulk drug of following parts by weight：Rheum officinale 12-15 Part, pinellia 12-15 parts, rhizoma atractylodis macrocephalae 15-22 parts, corydalis tuber 15-22 parts, dandelion 13-17 parts, borneol 13-18 parts, radix scrophulariae 15-20 parts, CBS 1-4 parts, CLA 1-4 parts.
Further, the bulk drug of following parts by weight is included：14 parts of rheum officinale, 14 parts of pinellia, 18 parts of rhizoma atractylodis macrocephalae, prolong recklessly 18 parts of rope, 15 parts of dandelion, 15 parts of borneol, 18 parts of radix scrophulariae, 2 parts of CBS, clamycin 2 part.
A kind of preparation method for the Chinese and Western compound medicine for treating superficial gastritis, comprises the following steps：
S1：Rheum officinale, pinellia, rhizoma atractylodis macrocephalae, corydalis tuber, dandelion, borneol, radix scrophulariae are weighed by said ratio respectively, is cleaned Afterwards, add water to cook twice, for the first time plus 8 times are measured water, are decocted 3h, second plus 6 times of amount water, decoction 2h, are merged decoction liquor, filter Cross, it is 1.2 (85 DEG C) that filtrate, which is concentrated into relative density, after cooling, adds 90% ethanol of 4 times of amounts, stirring, stands 24h, take supernatant Liquid is concentrated into relative density 1.2-1.3 (85 DEG C), is dried in vacuo, and grinding, obtains fine powder I；
S2：CBS and CLA are weighed by said ratio, grinds, obtains fine powder II；
S3：After fine powder I and fine powder II are well mixed, load capsule, capsule is made.
The present invention selected rheum officinale, pinellia, rhizoma atractylodis macrocephalae, corydalis tuber, dandelion, borneol, radix scrophulariae and CBS and gram Draw mycin to be combined, overcome that pure Chinese medicine composition curative effect is slow, curative effect is low, pure western medicine composition side effect is big, easily produces dependence The defects of.Each efficacy of drugs is caused to produce synergy these drug regimens, so as to effectively treat superficial gastritis.
Embodiment
Embodiments of the present invention are described in detail below with reference to embodiment, and illustrated embodiment is served only for explaining this hair It is bright, it is not intended to limit the scope of the present invention.
Embodiment 1
A kind of preparation method for the Chinese and Western compound medicine for treating superficial gastritis comprises the following steps：
S1：Weigh 12 parts of rheum officinale, 12 parts of pinellia, 15 parts of rhizoma atractylodis macrocephalae, 15 parts of corydalis tuber, 13 parts of dandelion, 13 parts of borneol, 15 parts of radix scrophulariae, after cleaning, add water to cook twice, for the first time plus 8 times are measured water, are decocted 3h, second plus 6 times of amount water, decoction 2h, are closed And decoction liquor, filtration, it is 1.2 (85 DEG C) that filtrate, which is concentrated into relative density, after cooling, adds 90% ethanol of 4 times of amounts, stirs, quiet 24h is put, takes supernatant concentration to be dried in vacuo to relative density 1.2-1.3 (85 DEG C), grinding, obtain fine powder I；
S2：1 part of CBS, clamycin 2 part are weighed, grinds, obtains fine powder II；
S3：After fine powder I and fine powder II are well mixed, load capsule, capsule is made.
Embodiment 2
A kind of preparation method for the Chinese and Western compound medicine for treating superficial gastritis comprises the following steps：
S1：Weigh 14 parts of rheum officinale, 14 parts of pinellia, 18 parts of rhizoma atractylodis macrocephalae, 18 parts of corydalis tuber, 15 parts of dandelion, 15 parts of borneol, 18 parts of radix scrophulariae, after cleaning, add water to cook twice, for the first time plus 8 times are measured water, are decocted 3h, second plus 6 times of amount water, decoction 2h, are closed And decoction liquor, filtration, it is 1.3 (85 DEG C) that filtrate, which is concentrated into relative density, after cooling, adds 90% ethanol of 4 times of amounts, stirs, quiet 24h is put, takes supernatant concentration to be dried in vacuo to relative density 1.2-1.3 (85 DEG C), grinding, obtain fine powder I；
S2：2 parts of CBS, clamycin 2 part are weighed, grinds, obtains fine powder II；
S3：After fine powder I and fine powder II are well mixed, load capsule, capsule is made.
Embodiment 3
A kind of preparation method for the Chinese and Western compound medicine for treating superficial gastritis comprises the following steps：
S1：Weigh 15 parts of rheum officinale, 15 parts of pinellia, 22 parts of rhizoma atractylodis macrocephalae, 22 parts of corydalis tuber, 17 parts of dandelion, 18 parts of borneol, 20 parts of radix scrophulariae, after cleaning, add water to cook twice, for the first time plus 8 times are measured water, are decocted 3h, second plus 6 times of amount water, decoction 2h, are closed And decoction liquor, filtration, it is 1.2 (85 DEG C) that filtrate, which is concentrated into relative density, after cooling, adds 90% ethanol of 4 times of amounts, stirs, quiet 24h is put, takes supernatant concentration to be dried in vacuo to relative density 1.2-1.3 (85 DEG C), grinding, obtain fine powder I；
S2：4 parts of CBS, 4 parts of CLA are weighed, grinds, obtains fine powder II；
S3：After fine powder I and fine powder II are well mixed, load capsule, capsule is made.
Comparative example 1
A kind of preparation method for the Chinese medicine for treating superficial gastritis comprises the following steps：
Weigh 15 parts of rheum officinale, 15 parts of pinellia, 22 parts of rhizoma atractylodis macrocephalae, 22 parts of corydalis tuber, 17 parts of dandelion, 18 parts of borneol, profound 20 parts of ginseng, after cleaning, add water to cook twice, for the first time plus 8 times are measured water, are decocted 3h, second plus 6 times of amount water, decoction 2h, are merged Decoction liquor, filtration, it is 1.2 (85 DEG C) that filtrate, which is concentrated into relative density, after cooling, adds 90% ethanol of 4 times of amounts, stirs, stands 24h, supernatant concentration is taken to be dried in vacuo, grinding, obtained fine powder loads capsule, is made to relative density 1.2-1.3 (85 DEG C) Capsule.
Comparative example 2
The preparation method of CBS clarithromycin capsule agent is as follows：4 parts of CBS, 4 parts of CLA are weighed, Grinding, obtained fine powder load capsule, CBS clarithromycin capsule agent are made.
Clinical observation on the therapeutic effect is tested
1st, general information
Accept out-patient totally 100, wherein male 50 for medical treatment, women 50, age 30-60 year, be equally divided into 5 groups, often 20 people of group.
2nd, diagnostic criteria
Superficial gastritis, clinical symptoms are：Gastral cavity pain, abdominal distension receive difference, and inhibited defecation, tongue is red, and yellow and greasy fur, deficiency of food is received It is slow-witted；Meet angry or nervous (emotional factors influence) recurrence or aggravate, sour regurgitation belch, nausea, mouth is sticky.
3rd, treatment method
The 1st group of Chinese and Western compound medicine taken prepared by embodiment 1, the 2nd group of Chinese and Western compound taken prepared by embodiment 2 Medicine, the 3rd group of Chinese and Western compound medicine taken prepared by embodiment 3, the 4th group of Chinese medicine taken prepared by comparative example 1, the 5th group Take the CBS clarithromycin capsule agent prepared by comparative example 2,2 tablets/time, 3 times/day, warm boiled water, two weeks is One course for the treatment of, 2 courses for the treatment of are used in conjunction.
4th, efficacy assessment standard
It is effective：Indigestion symptom, the intermittent phases such as upper abdomen pain and glutted disappearance, nausea and vomiting, upper abdomen burn feeling prolong It is long, 3 months are observed without recurrence.
Take a turn for the better：Epigastric pain and glutted obvious mitigation, nausea and vomiting and upper abdomen burn feeling are clearly better, and the intermittent phase extends, More than 1 month is observed without recurrence.
It is invalid：Above standard person is not reached.
Effective percentage=(effective number+improvement number)/each group total number of persons
5th, treatment results (see the table below)
Table 1
Group Effective number Improvement number Invalid number Efficient %
Embodiment 1 14 3 3 85
Embodiment 2 15 4 1 95
Embodiment 3 16 4 0 100
Comparative example 1 6 5 9 55
Comparative example 2 5 4 11 45
As it can be seen from table 1 after taking 1-3 of the embodiment of the present invention Chinese and Western compound medicine for the treatment of superficial gastritis, show Effect number, it is efficient be far above comparative example, illustrate the present invention will after Chinese herbal medicine and Western medicine compounding, with it is extraordinary treat it is shallow The effect of table gastritis.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.

Claims (3)

1. a kind of Chinese and Western compound medicine for treating superficial gastritis, it is characterised in that include the bulk drug of following parts by weight：Greatly Yellow 12-15 parts, pinellia 12-15 parts, rhizoma atractylodis macrocephalae 15-22 parts, corydalis tuber 15-22 parts, dandelion 13-17 parts, borneol 13-18 Part, radix scrophulariae 15-20 parts, CBS 1-4 parts, CLA 1-4 parts.
2. the Chinese and Western compound medicine for the treatment of superficial gastritis according to claim 1, it is characterised in that including following weight The bulk drug of number：It is 14 parts of rheum officinale, 14 parts of pinellia, 18 parts of rhizoma atractylodis macrocephalae, 18 parts of corydalis tuber, 15 parts of dandelion, 15 parts of borneol, profound 18 parts of ginseng, 2 parts of CBS, clamycin 2 part.
3. a kind of preparation method for the Chinese and Western compound medicine for treating superficial gastritis, it is characterised in that comprise the following steps：
S1：Respectively rheum officinale, pinellia, rhizoma atractylodis macrocephalae, corydalis tuber, dandelion, borneol, profound is weighed by the proportioning of claim 1 or 2 Ginseng, after cleaning, add water to cook twice, for the first time plus 8 times are measured water, are decocted 3h, second plus 6 times of amount water, decoction 2h, are merged and decoct Liquid, filtration, it is 1.2 (85 DEG C) that filtrate, which is concentrated into relative density, after cooling, adds 90% ethanol of 4 times of amounts, stirring, stands 24h, Supernatant concentration is taken to be dried in vacuo to relative density 1.2-1.3 (85 DEG C), grinding, obtain fine powder I；
S2：CBS and CLA are weighed by the proportioning of claim 1 or 2, grinds, obtains fine powder II；
S3：After fine powder I and fine powder II are well mixed, load capsule, capsule is made.
CN201711082722.6A 2017-11-07 2017-11-07 A kind of Chinese and Western compound medicine for treating superficial gastritis and preparation method thereof Withdrawn CN107812077A (en)

Priority Applications (1)

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CN201711082722.6A CN107812077A (en) 2017-11-07 2017-11-07 A kind of Chinese and Western compound medicine for treating superficial gastritis and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711082722.6A CN107812077A (en) 2017-11-07 2017-11-07 A kind of Chinese and Western compound medicine for treating superficial gastritis and preparation method thereof

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