CN107802729A - 一种可有效治疗耳鸣的内服药物及制备方法 - Google Patents
一种可有效治疗耳鸣的内服药物及制备方法 Download PDFInfo
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Abstract
本发明属于中药制剂领域,目的是根据中医治疗耳鸣的认识机理而提供一种可有效治疗耳鸣的内服药物,所述药物的各个组分及其质量份比如下:车前子9~16g、芦荟6~15g、丹参5~16g、女贞子6~16g、知母6~16g、茯苓10~16g、竹叶兰15~36g、黄芪9~36g、豨签草9~16g、陈皮3~16g、金银花10~25g、楮实10~16g、龙骨15~30g、蔓荆子5~12g、桑白皮9~16g、葛根9~16g、鬼针草15~36g、酸枣仁10~26g、红花5~16g、生地黄9~16g、夏枯草9~16g、大血藤9~16g、桂枝2~8g、菟丝子15~30g、川芎3~12g、五味子3~8g、徐长卿3~15g、薄荷3~8g、韭菜50~120g、麦冬6~16g、甘草3~15g、桑枝9~16g,本发明提供的药物是一个很好的中药组方。
Description
技术领域
本发明属于中药制剂领域,具体涉及一种可有效治疗耳鸣的内服药物,特别是供耳鸣患者使用的内服药物及制备方法的领域。
背景技术
祖国医学认为:耳鸣是累及听觉系统的许多疾病不同病理变化的结果,病因复杂,机制不清,主要表现为无相应的外界声源或电刺激,而主观上在耳内或颅内有声音感觉。在临床上它既是许多疾病的伴发症状,也是一些严重疾病的首发症状(如听神经瘤)。
临床表现:总体说呈多样性,可单侧或双侧,也可为头鸣,可持续性存在也可间歇性出现,声音可以为各种各样,音调高低不等。
A.耳鸣与听力的关系
有些耳鸣病人伴有听力下降,有些听力正常,但是耳鸣不会引起或加重听力下降。
B.耳鸣与心理因素的关系
长期耳鸣会引起患者产生烦躁、焦虑、紧张、害怕或者抑郁的情绪,而不良的情绪状态可加重耳鸣,造成耳鸣与不良情绪之间的恶性循环,心理因素在耳鸣发病的过程中起重要作用。
那么,就如何找到一种可有效治疗耳鸣的中药组合物,是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗耳鸣上,人们逐渐意识到了中医治疗耳鸣的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西医治疗耳鸣的现状,本发明的目的是在于提供一种可有效治疗耳鸣的内服药物,以解决耳鸣患者早日恢复健康的问题。该药物是以常见的中药为原料,通过选择合理的药物及质量份比,可有效治疗上述耳鸣。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种可有效治疗耳鸣的内服药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
车前子9~16g、芦荟6~15g、丹参5~16g、女贞子6~16g、知母6~16g、茯苓10~16g、竹叶兰15~36g、黄芪9~36g、豨签草9~16g、陈皮3~16g、金银花10~25g、楮实10~16g、龙骨15~30g、蔓荆子5~12g、桑白皮9~16g、葛根9~16g、鬼针草15~36g、酸枣仁10~26g、红花5~16g、生地黄9~16g、夏枯草9~16g、大血藤9~16g、桂枝2~8g、菟丝子15~30g、川芎3~12g、五味子3~8g、徐长卿3~15g、薄荷3~8g、韭菜50~120g、麦冬6~16g、甘草3~15g、桑枝9~16g。
一种可有效治疗耳鸣的内服药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
车前子10~14g、芦荟8~13g、丹参6~14g、女贞子8~14g、知母8~14g、茯苓11~14g、竹叶兰18~32g、黄芪10~32g、豨签草10~14g、陈皮6~14g、金银花11~22g、楮实11~14g、龙骨16~26g、蔓荆子6~11g、桑白皮10~14g、葛根10~14g、鬼针草18~32g、 酸枣仁11~23g、红花8~14g、生地黄10~14g、夏枯草10~14g、大血藤10~14g、桂枝3~7g、菟丝子18~26g、川芎5~11g、五味子5~7g、徐长卿5~13g、薄荷4~7g、韭菜58~105g、麦冬8~14g、甘草5~13g、桑枝10~14g。
一种可有效治疗耳鸣的内服药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
车前子12g、芦荟12g、丹参12g、女贞子12g、知母12g、茯苓12g、竹叶兰26g、黄芪26g、豨签草12g、陈皮12g、金银花20g、楮实12g、龙骨23g、蔓荆子10g、桑白皮12g、葛根12g、鬼针草26g、 酸枣仁20g、红花12g、生地黄12g、夏枯草12g、大血藤12g、桂枝6g、菟丝子23g、川芎10g、五味子6g、徐长卿12g、薄荷6g、韭菜95g、麦冬12g、甘草12g、桑枝12g。
一种可有效治疗耳鸣的内服药物及制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、将上述原料中药拣去杂质和粉尘后,按照质量份比分别粉碎成粗粒状包煎;
B、①将包好的原料中药放入冷开水中浸泡60min,然后再将浸泡好的药物和浸泡药物的澄清液一并放入砂锅内,注入过药65mm的冷开水进行第一次武火煎煮,待煎煮到15min时,转文火熬制35 min,滤取药液;②药渣中再次注入过药60mm的微温开水进行第二次武火煎煮,待煎煮到10min时,转文火熬制30 min,滤取药液;③将两次药液混合浓缩成50%的中药液420ml(毫升)即可。
一种可有效治疗耳鸣的内服药物及制备方法,其特征在于,所述服用方法为:将制备好的中药液以一天服用,每日一剂,早晚分服,给药量210ml(毫升)/次,饭前半小时服(治疗期间忌:生冷、辛辣刺激性食物)。5天为一个疗程,服药2~6个疗程,症状消失,病获痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
车前子,性味:甘、微寒,具有清热利尿、渗湿通淋、明目、祛痰之功效,用于治疗水肿胀满、热淋涩痛、暑湿泄泻、目赤肿痛、痰热咳嗽;
芦荟,性味:味苦、性寒,具有泻下、清肝、杀虫之功效,用于治疗热结便秘、肝火头痛、目赤惊风、虫积腹痛、疥癣、痔瘘等症;
丹参,性味:味苦、性微寒,具有活血祛瘀、调经止痛、养血安神、凉血消痈之功效 ,用于治疗妇女月经不调、痛经、经闭、产后瘀滞腹痛、心腹疼痛、癥瘕积聚、热痹肿痛、跌打损伤、热入营血、烦躁不安、心烦失眠、痈疮肿毒;
女贞子,性味:甘、苦、性凉,具有补益肝肾、清虚热、明目之功效,用于治疗头昏目眩、腰膝酸软、遗精、耳鸣、须发早白、骨蒸潮热、目暗不明;
知母,性味:味苦、性寒,具有清热泻火、滋阴润燥、止渴除烦之功效,用于治疗温热病、高热烦渴、咳嗽气喘、燥咳、便秘、骨蒸潮热、虚烦不眠、消渴淋浊;
茯苓,性味:甘、淡、平,具有渗湿利水、健脾和胃、宁心安神之功效,用于治疗小便不利、水肿胀满、痰饮咳逆、呕吐、脾虚食少、泄泻、心悸不安、失眠健忘、遗精白浊;
竹叶兰,性味:味甘、微苦、性平,具有清肺止咳、补肺益肾、调经止血之功效,用于治疗肺热咳嗽、气虚喘咳、头晕耳鸣、骨折、吐血等症;
黄芪,性味:甘、温,具有补气固表、利尿消肿、托毒排脓、敛疮生肌、生肌之功效,用于治疗气虚乏力、食少便溏、中气下陷、久泻脱肛、便血崩漏、表虚自汗、气虚水肿、痈疽难溃、久溃不敛、血虚痿黄、内热消渴,慢性肾炎蛋白尿、糖尿病;
豨签草,性味:味苦、辛、性寒,具有祛风湿、利关节、解毒之功效,用于治疗风湿痹痛、筋骨无力、腰膝酸软、四肢麻痹、半身不遂、风疹湿疮;
陈皮,性味:味辛、苦、性温,具有理气和中,燥湿化痰,利水通便之功效,用于治疗脾胃不和、脘腹胀痛、不思饮食、呕吐哕逆、痰湿阻肺、咳嗽痰多、胸膈满闷、头目眩晕、水肿、小便不利、大便秘结、乳痈疥癣、中鱼蟹毒、酒毒等症;
金银花,性味:性甘、寒,具有清热解毒、消炎退肿外感风热或温病发热、中暑、热毒血痢、痈肿疔疮、喉痹、多种感染性疾病;
楮实,性味:甘、寒,具有滋肾、清肝、明目之功效,用于治疗虚劳、目昏、目翳、水气浮肿;
龙骨,性味:甘涩、平,无毒,具有镇惊安神、平肝潜阳、固涩、收敛之功效,用于治疗惊痫癫狂、心悸怔忡、失眠健忘、头晕目眩、自汗盗汗、遗精遗尿、崩漏带下、久泻久痢、溃疡久不收口及湿疮等症;
蔓荆子,性味:味辛、苦、性微寒,具有疏散风热、清利头目、除湿处关节之功效,用于治疗外感头痛、偏正头风、昏晕目暗、赤眼多泪、目睛内痛、齿龈肿痛、湿痹拘挛;
桑白皮,性味:味甘、辛,性寒,具有泻肺平喘、利水消肿之功效,用于治疗肺热喘咳痰、水饮停肺、胀满喘急、水肿、脚气、小便不利;
葛根,性味:味甘、辛、性凉,具有解肌退热、透疹、生津止渴、升阳止泻之功效,用于治疗表证发热、项背强痛、麻疹不透、热病口渴、阴虚消渴、热泻热痢、脾虚泄泻;
鬼针草,性味:味苦、性微寒,具有清热解毒、祛风除湿、活血消肿之功效,用于治疗咽喉、肿痛、泄泻、痢疾、黄疸、肠痈、疔疮肿毒、蛇早咬伤、风湿痹痛、跌打损伤;
酸枣仁,性味:味甘、酸、性平,具有养心补肝、宁心安神、敛汗、生津之功效,用于治疗虚烦不眠、惊悸多梦、体虚多汗、盗汗、津伤口渴,酸枣仁的养心安神作用很好,多用于心阴不足和肝肾亏损的惊悸、健忘、眩晕、虚烦不眠;
红花,性味:味辛、性温,具有活血能经、祛瘀止痛之功效,用于治疗经闭、痛经、产后瘀阻腹痛、胞痹心痛症瘕积聚、跌打损伤、关节疼痛、中风偏竣、斑疹等症;
生地黄:性味:甘、寒,具有清热凉血、养阴、生津之功效,用于治疗热病舌绛烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发斑发疹;
夏枯草,性味:辛、苦、寒,具有清肝火、散郁结之功效,用于治疗目赤肿痛、头痛眩晕、凛痈瘤瘤;
大血藤,性味:味苦、性平,具有清热解毒、活血,祛风止痛之功效,用于治疗肠痈腹痛、热毒疮疡、经闭、痛经、跌扑肿痛、风湿痹痛;
桂枝,性味:辛、甘、性温,具有散寒解表、温通经脉、通阳化气之功效,用于治疗风寒表证、寒湿痹痛、四肢厥冷、经闭痛经、癥瘕结块、胸痹、心悸、痰饮、小便不利;
菟丝子,性味:甘、温,具有补肝肾、益精髓、明目之功效,用于治疗腰膝酸痛、遗精、消渴、尿有余沥、目暗等症;
川芎,性味:辛,温,具有活血行气、祛风止痛之功效,用于治疗胸痹心痛、胸胁刺痛、跌扑肿痛、月经不调、经闭痛经、癥瘕腹痛、头痛、风湿痹痛;
五味子,性味:味酸、性温,具有收敛固涩、益气生津、宁心安神之功效,用于治疗咳嗽虚喘、梦遗滑精、尿颇遗尿、久泻不止、自汗盗汗、津伤口渴、心悸失眠;
徐长卿,性味:性温、味辛,具有祛风化湿、行气通络,属祛风湿药下分类的祛风湿强筋骨药,用于治疗风湿痹痛、胃痛胀满、牙痛、痛经、跌打肿痛等;
薄荷,性味:味辛、性凉,具有散风热、清头目、利咽喉、透疹、解郁之功效,用于治疗风热表证、头痛目赤、咽喉肿痛、麻疹不透、陷疹瘙痒、肝郁胁痛;
韭菜,性味:辛、甘、温,具有温中、行气、散血、解毒之功效,用于治疗胸痹、噎膈、反胃、吐血、衄血、尿血、痢疾、消渴、痔漏、脱肛、跌扑损伤、虫、蝎螫伤;
麦冬,性味:甘、微苦、微寒,具有养阴润肺、益胃生津、清心除烦之功效,用于治疗肺阴不足、而有燥热的干咳痰粘、劳嗽咳血、胃阴虚或热伤胃阴、口渴咽干、大便燥结、心阴虚及温病热邪扰及心营、心烦不眠、舌绛而干等;
甘草,性味:甘、平,具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药之功效,用于治疗倦怠食少、肌瘦面黄、心悸气短、腹痛便溏、四肢挛急疼痛、脏躁、咳嗽气喘、咽喉肿痛、痈疮肿痛、小儿胎毒及药物、食物中毒;
桑枝,性味:味微苦、性平,具有有祛风湿、利关节的之功效,用于治疗风湿痹病、肩臂、关节酸痛麻木。
本发明药物是基于中医治疗耳鸣的原则,从依据耳鸣的病理机制及药理作用认为:就耳鸣,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的效果。
具体实施方式
本发明就是针对上述耳鸣的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个很好的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种可有效治疗耳鸣的内服药物,其特征在于,所述药物的各个组分及质量份比如下所示:
车前子12g、芦荟12g、丹参12g、女贞子12g、知母12g、茯苓12g、竹叶兰26g、黄芪26g、豨签草12g、陈皮12g、金银花20g、楮实12g、龙骨23g、蔓荆子10g、桑白皮12g、葛根12g、鬼针草26g、 酸枣仁20g、红花12g、生地黄12g、夏枯草12g、大血藤12g、桂枝6g、菟丝子23g、川芎10g、五味子6g、徐长卿12g、薄荷6g、韭菜95g、麦冬12g、甘草12g、桑枝12g。
实施例2:
一种可有效治疗耳鸣的内服药物,其特征在于,所述药物的各个组分及质量份比如下所示:
车前子14g、芦荟13g、丹参14g、女贞子14g、知母14g、茯苓14g、竹叶兰32g、黄芪32g、豨签草14g、陈皮14g、金银花22g、楮实14g、龙骨26g、蔓荆子11g、桑白皮14g、葛根14g、鬼针草32g、 酸枣仁23g、红花14g、生地黄14g、夏枯草14g、大血藤14g、桂枝7g、菟丝子26g、川芎11g、五味子7g、徐长卿13g、薄荷7g、韭菜105g、麦冬14g、甘草13g、桑枝14g。
实施例3:
一种可有效治疗耳鸣的内服药物,其特征在于,所述药物的各个组分及质量份比如下所示:
车前子16g、芦荟15g、丹参16g、女贞子16g、知母16g、茯苓16g、竹叶兰36g、黄芪36g、豨签草16g、陈皮16g、金银花25g、楮实16g、龙骨30g、蔓荆子12g、桑白皮16g、葛根16g、鬼针草36g、 酸枣仁26g、红花16g、生地黄16g、夏枯草16g、大血藤16g、桂枝8g、菟丝子30g、川芎12g、五味子8g、徐长卿15g、薄荷8g、韭菜120g、麦冬16g、甘草15g、桑枝16g。
典型病例
经临床诊断治疗耳鸣患者共1450例,年龄为59岁以上的850例,只有600例为59岁以下。1450例患者中痊愈的865例,有效的512例,无效的73例。总有效率达95%。
Claims (3)
1.一种可有效治疗耳鸣的内服药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
车前子9~16g、芦荟6~15g、丹参5~16g、女贞子6~16g、知母6~16g、茯苓10~16g、竹叶兰15~36g、黄芪9~36g、豨签草9~16g、陈皮3~16g、金银花10~25g、楮实10~16g、龙骨15~30g、蔓荆子5~12g、桑白皮9~16g、葛根9~16g、鬼针草15~36g、酸枣仁10~26g、红花5~16g、生地黄9~16g、夏枯草9~16g、大血藤9~16g、桂枝2~8g、菟丝子15~30g、川芎3~12g、五味子3~8g、徐长卿3~15g、薄荷3~8g、韭菜50~120g、麦冬6~16g、甘草3~15g、桑枝9~16g。
2.根据权利要求1所述的可有效治疗耳鸣的内服药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
车前子10~14g、芦荟8~13g、丹参6~14g、女贞子8~14g、知母8~14g、茯苓11~14g、竹叶兰18~32g、黄芪10~32g、豨签草10~14g、陈皮6~14g、金银花11~22g、楮实11~14g、龙骨16~26g、蔓荆子6~11g、桑白皮10~14g、葛根10~14g、鬼针草18~32g、 酸枣仁11~23g、红花8~14g、生地黄10~14g、夏枯草10~14g、大血藤10~14g、桂枝3~7g、菟丝子18~26g、川芎5~11g、五味子5~7g、徐长卿5~13g、薄荷4~7g、韭菜58~105g、麦冬8~14g、甘草5~13g、桑枝10~14g。
3.根据权利要求1至2所述的可有效治疗耳鸣的内服药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
车前子12g、芦荟12g、丹参12g、女贞子12g、知母12g、茯苓12g、竹叶兰26g、黄芪26g、豨签草12g、陈皮12g、金银花20g、楮实12g、龙骨23g、蔓荆子10g、桑白皮12g、葛根12g、鬼针草26g、 酸枣仁20g、红花12g、生地黄12g、夏枯草12g、大血藤12g、桂枝6g、菟丝子23g、川芎10g、五味子6g、徐长卿12g、薄荷6g、韭菜95g、麦冬12g、甘草12g、桑枝12g。
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