CN107789441A - 一种治疗小面积烫伤中药膏的制备方法 - Google Patents

一种治疗小面积烫伤中药膏的制备方法 Download PDF

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CN107789441A
CN107789441A CN201711213378.XA CN201711213378A CN107789441A CN 107789441 A CN107789441 A CN 107789441A CN 201711213378 A CN201711213378 A CN 201711213378A CN 107789441 A CN107789441 A CN 107789441A
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齐芳
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Abstract

本发明公开了一种治疗小面积烫伤中药贴的制备方法，包括以下方面：（1）提取物，将石梓花和星叶草分别粉碎，进行低温保存、超声波振荡和回流提取；（2）发酵液，将平车前、鸡骨草、柴胡、舒筋草、大活血、紫珠叶粉碎后混合得混合粉，加入水进行沸煮和发酵；（3）药粉，将百草王、五香血藤等粉化进行烘制、密封浸泡和回流提取；（4）参芝粉，将人参和灵芝粉化后碾磨和密闭发酵；（5）制膏，向发酵液加入提取药粉、石梓花提取物和星叶草提取物，升温后加入参芝粉、银杏果油和蜂王浆混合，再加入凹凸棒石粉搅拌至胶状，制得中药膏；（6）使用方法，将中药膏敷在烫伤部位用膏药纸外部包裹，使用红外线对膏药纸照射。

Description

一种治疗小面积烫伤中药膏的制备方法
技术领域
本发明属于烫伤治疗技术领域，具体涉及一种治疗小面积烫伤中药膏的制备方法。
背景技术
烫伤是由于接触非火焰性温度相对较高的液体、固体等对组织皮肤造成的损伤，以高温烫伤和低温烫伤最为常见，其中高温烫伤会导致皮肤组织坏死，愈合速度慢会留下长久伤疤，而低温烫伤所造成的创伤程度较低，表面出现水泡、红肿等现象，严重者会造成深度组织坏死，发生溃烂而无法愈合。烫伤过后的皮肤组织经伤口愈合后，残留疤痕的机率相对较高，并且烫伤部位皮肤颜色也异于其他部位，影响烫伤者的形象，同时也在烫伤者心理留下了永远的伤痛；而传统对烫伤部位使用抗生素类西药或更换皮肤组织的方式进行治疗，只能起到对伤口修复作用，对修复后的疤痕和颜色色差等不能起到很好的治疗作用。
发明内容
本发明针对现有的问题：烫伤过后的皮肤组织经伤口愈合后，残留疤痕的机率相对较高，并且烫伤部位皮肤颜色也异于其他部位，影响烫伤者的形象，同时也在烫伤者心理留下了永远的伤痛；而传统对烫伤部位使用抗生素类西药或更换皮肤组织的方式进行治疗，只能起到对伤口修复作用，对修复后的疤痕和颜色色差等不能起到很好的治疗作用。为解决上述问题，本发明提供了一种治疗小面积烫伤中药膏的制备方法。
本发明是通过以下技术方案实现的：
一种治疗小面积烫伤中药膏的制备方法，包括以下步骤：
（1）提取物：将石梓花和星叶草分别粉碎，先放入-14--11℃低温保存5-6h，取出后分别加入其质量4-6倍的无水乙醇超声波振荡30-40min，然后回流提取1-2h，对提取液浓缩烘干后制得石梓花提取物和星叶草提取物，含有丰富的植物活性物质，可对促进烫伤部位组织修复和恢复；
（2）发酵液：将平车前、鸡骨草、柴胡、舒筋草、大活血、紫珠叶粉碎后混合得混合粉，向混合粉中加入其质量5-7倍的水沸煮24-28min，然后向其中加入菌剂发酵40-43h，过滤后浓缩至原体积的1/6，制得发酵液，所提取成分具有抗菌消炎、止痛等功效，可避免伤口愈合过程中感染；
（3）药粉：将百草王、五香血藤、救心菜、接骨草和菟丝子粉化后置于65-70℃烘箱内烘制17-20min，再浸入无水乙醇中密封浸泡26-30天，然后倒入提取器中回流提取2-3h，将提取液浓缩烘干制得提取药粉，所提取成分具有活血祛瘀、消肿止痛等功效，可提高皮肤组织修复；
（4）参芝粉：将人参和灵芝粉化后碾磨两次，加入菌剂后密闭发酵2-3天，灭菌烘干后制得参芝粉，含有多糖、三萜类、香豆精甙等成分可提供伤口愈合所需营养，并且提高伤口愈合速度；
（5）制膏：向发酵液中加入提取药粉、石梓花提取物和星叶草提取物搅拌混合，然后升温至43-46℃加入参芝粉、银杏果油和蜂王浆混合，再加入凹凸棒石粉搅拌15-20min至胶状，制得中药膏；
（6）使用方法：先使用酒精对烫伤部位喷洒杀菌，再将中药膏敷在烫伤部位用膏药纸外部包裹，使用红外线对膏药纸照射8-10min即可，可促进中药膏中药活性成分发挥功效。
所述的治疗小面积烫伤中药膏的制备方法，其各配制成分质量计份为：
平车前11-14份、鸡骨草9-11份、柴胡7-10份、舒筋草5-7份、大活血4-6份、紫珠叶3-5份、百草王2-4份、五香血藤1-3份、救心菜7-9份、接骨草6-8份、菟丝子5-7份、石梓花提取物7-9份、星叶草提取物6-8份、凹凸棒石粉7-10份份、人参4-6份、灵芝3-5份、银杏果油2-4份、蜂王浆2-5份。
步骤（1）所述的回流提取，其温度为60-65℃。
步骤（2）所述的菌剂，其中包括酵母菌、根霉菌、枯草杆菌和乳酸菌中的两种或两种以上；其加入量为混合粉质量的1%-2%。
步骤（6）所述的红外线，其温度为35-38℃。
本发明相比现有技术具有以下优点：提取物，以石梓花和星叶草为原料进行提取，所提取成分含有丰富的植物活性物质，可促进烫伤部位组织修复和恢复，并且可降低疤痕残留率和颜色色差；而采用低温保存、超声波振荡和回流提取方法，可提高对原料中有效成分提取率，并且保持提取成分相对较高活性。发酵液，以平车前、鸡骨草等为原料所提取成分具有抗菌消炎、止痛等功效，可避免伤口愈合过程中感染，提高伤口愈合速度。药粉，以百草王、五香血藤、救心菜等为提取原料，所提取成分具有活血祛瘀、消肿止痛等功效，可提高皮肤组织修复，降低烫伤疤痕残留率和颜色色差。参芝粉，通过碾磨和固态发酵方法将人参、灵芝制成粉，最大程度的保留其中活性成分，其中含有多糖、三萜类、香豆精甙等成分可提供伤口愈合所需营养，并且提高伤口愈合速度。使用方法，将所制中药膏敷在伤口后使用红外线低温照射，可促进中药膏中药活性成分发挥功效，提高中药膏的功能作用。
具体实施方式
实施例1：
一种治疗小面积烫伤中药膏的制备方法，包括以下步骤：
（1）提取物：将石梓花和星叶草分别粉碎，先放入-12℃低温保存5.5h，取出后分别加入其质量4.5倍的无水乙醇超声波振荡32min，然后回流提取1.5h，对提取液浓缩烘干后制得石梓花提取物和星叶草提取物，含有丰富的植物活性物质，可对促进烫伤部位组织修复和恢复；
（2）发酵液：将平车前、鸡骨草、柴胡、舒筋草、大活血、紫珠叶粉碎后混合得混合粉，向混合粉中加入其质量5.5倍的水沸煮25min，然后向其中加入菌剂发酵41h，过滤后浓缩至原体积的1/6，制得发酵液，所提取成分具有抗菌消炎、止痛等功效，可避免伤口愈合过程中感染；
（3）药粉：将百草王、五香血藤、救心菜、接骨草和菟丝子粉化后置于66℃烘箱内烘制18min，再浸入无水乙醇中密封浸泡27天，然后倒入提取器中回流提取2.5h，将提取液浓缩烘干制得提取药粉，所提取成分具有活血祛瘀、消肿止痛等功效，可提高皮肤组织修复；
（4）参芝粉：将人参和灵芝粉化后碾磨两次，加入菌剂后密闭发酵2天，灭菌烘干后制得参芝粉，含有多糖、三萜类、香豆精甙等成分可提供伤口愈合所需营养，并且提高伤口愈合速度；
（5）制膏：向发酵液中加入提取药粉、石梓花提取物和星叶草提取物搅拌混合，然后升温至44℃加入参芝粉、银杏果油和蜂王浆混合，再加入凹凸棒石粉搅拌16min至胶状，制得中药膏；
（6）使用方法：先使用酒精对烫伤部位喷洒杀菌，再将中药膏敷在烫伤部位用膏药纸外部包裹，使用红外线对膏药纸照射9min即可，可促进中药膏中药活性成分发挥功效。
所述的治疗小面积烫伤中药膏的制备方法，其各配制成分质量计份为：
平车前12份、鸡骨草9.5份、柴胡8份、舒筋草5.2份、大活血4.7份、紫珠叶3.6份、百草王2.1份、五香血藤1.3份、救心菜7.2份、接骨草6.4份、菟丝子5.3份、石梓花提取物7.2份、星叶草提取物6.5份、凹凸棒石粉8份份、人参4.3份、灵芝3.4份、银杏果油2.1份、蜂王浆3份。
步骤（1）所述的回流提取，其温度为62℃。
步骤（2）所述的菌剂，其中包括酵母菌、根霉菌、枯草杆菌和乳酸菌中的两种或两种以上；其加入量为混合粉质量的1.2%。
步骤（6）所述的红外线，其温度为36℃。
实施例2：
（1）提取物：将石梓花和星叶草分别粉碎，先放入-13℃低温保存6h，取出后分别加入其质量5.5倍的无水乙醇超声波振荡37min，然后回流提取2h，对提取液浓缩烘干后制得石梓花提取物和星叶草提取物，含有丰富的植物活性物质，可对促进烫伤部位组织修复和恢复；
（2）发酵液：将平车前、鸡骨草、柴胡、舒筋草、大活血、紫珠叶粉碎后混合得混合粉，向混合粉中加入其质量6.5倍的水沸煮27min，然后向其中加入菌剂发酵42h，过滤后浓缩至原体积的1/6，制得发酵液，所提取成分具有抗菌消炎、止痛等功效，可避免伤口愈合过程中感染；
（3）药粉：将百草王、五香血藤、救心菜、接骨草和菟丝子粉化后置于69℃烘箱内烘制19min，再浸入无水乙醇中密封浸泡29天，然后倒入提取器中回流提取3h，将提取液浓缩烘干制得提取药粉，所提取成分具有活血祛瘀、消肿止痛等功效，可提高皮肤组织修复；
（4）参芝粉：将人参和灵芝粉化后碾磨两次，加入菌剂后密闭发酵3天，灭菌烘干后制得参芝粉，含有多糖、三萜类、香豆精甙等成分可提供伤口愈合所需营养，并且提高伤口愈合速度；
（5）制膏：向发酵液中加入提取药粉、石梓花提取物和星叶草提取物搅拌混合，然后升温至45℃加入参芝粉、银杏果油和蜂王浆混合，再加入凹凸棒石粉搅拌19min至胶状，制得中药膏；
（6）使用方法：先使用酒精对烫伤部位喷洒杀菌，再将中药膏敷在烫伤部位用膏药纸外部包裹，使用红外线对膏药纸照射10min即可，可促进中药膏中药活性成分发挥功效。
所述的治疗小面积烫伤中药膏的制备方法，其各配制成分质量计份为：
平车前13份、鸡骨草10.7份、柴胡9份、舒筋草6.7份、大活血5.8份、紫珠叶4.2份、百草王3.6份、五香血藤2.7份、救心菜8.5份、接骨草7.2份、菟丝子6.1份、石梓花提取物8.4份、星叶草提取物7.6份、凹凸棒石粉9份份、人参5.7份、灵芝4.6份、银杏果油3.7份、蜂王浆4份。
步骤（1）所述的回流提取，其温度为64℃。
步骤（2）所述的菌剂，其中包括酵母菌、根霉菌、枯草杆菌和乳酸菌中的两种或两种以上；其加入量为混合粉质量的1.7%。
步骤（6）所述的红外线，其温度为37℃。
对比1：
本对比1与实施例1比较，中药膏中未使用石梓花和星叶草提取物，其他步骤与实施例1相同。
对比2：
本对比2与实施例1比较，中药膏中未使用发酵液，其他步骤与实施例1相同。
对比3：
本对比3与实施例1比较，中药膏中未使用提取药粉，其他步骤与实施例1相同。
对比4：
本对比4与实施例2比较，中药膏中未使用参芝粉，其他步骤与实施例2相同。
对比5：
本对比5与实施例2比较，未进行步骤（6）中红外线使用，其他步骤与实施例2相同。
对照组：
对照组采用莫匹罗星软膏对烫伤进行治疗，未使用石梓花和星叶草提取物、发酵液、提取药粉、参芝粉、红外线。
对实施例1、实施例2、对比1、对比2、对比3、对比4、对比5及对照组所制药物对烫伤患者使用，统计烫伤治愈率、疤痕残留率和皮肤色差比例。
实验数据：
项目 烫伤治愈率% 疤痕残留率% 皮肤色差比例%
实施例1 98.1 3.42 21.5
实施例2 97.4 3.27 20.7
对比1 92.5 8.28 33.0
对比2 95.8 3.37 21.9
对比3 94.7 6.15 27.9
对比4 94.6 5.05 24.9
对比5 95.5 3.19 20.3
对照组 81.7 12.78 43.6
综合结果：本发明所制中药膏，与对照组比较，烫伤治愈率提高16.4%，疤痕残留率降低9.36%，皮肤色差比例降低22.1%。采用石梓花和星叶草提取物、提取药粉、参芝粉方法，可提高烫伤治愈率为5.6%、3.4%、2.8%，疤痕残留率降低4.86%、2.73%、1.78%，皮肤色差比例降低11.5%、6.4%、4.2%；而使用发酵液和红外线方法，可提高烫伤治愈率为2.3%、1.9%。

Claims (5)

1.一种治疗小面积烫伤中药膏的制备方法，其特征在于，包括以下步骤：
（1）提取物：将石梓花和星叶草分别粉碎，先放入-14--11℃低温保存5-6h，取出后分别加入其质量4-6倍的无水乙醇超声波振荡30-40min，然后回流提取1-2h，对提取液浓缩烘干后制得石梓花提取物和星叶草提取物；
（2）发酵液：将平车前、鸡骨草、柴胡、舒筋草、大活血、紫珠叶粉碎后混合得混合粉，向混合粉中加入其质量5-7倍的水沸煮24-28min，然后向其中加入菌剂发酵40-43h，过滤后浓缩至原体积的1/6，制得发酵液；
（3）药粉：将百草王、五香血藤、救心菜、接骨草和菟丝子粉化后置于65-70℃烘箱内烘制17-20min，再浸入无水乙醇中密封浸泡26-30天，然后倒入提取器中回流提取2-3h，将提取液浓缩烘干制得提取药粉；
（4）参芝粉：将人参和灵芝粉化后碾磨两次，加入菌剂后密闭发酵2-3天，灭菌烘干后制得参芝粉；
（5）制膏：向发酵液中加入提取药粉、石梓花提取物和星叶草提取物搅拌混合，然后升温至43-46℃加入参芝粉、银杏果油和蜂王浆混合，再加入凹凸棒石粉搅拌15-20min至胶状，制得中药膏；
（6）使用方法：先使用酒精对烫伤部位喷洒杀菌，再将中药膏敷在烫伤部位用膏药纸外部包裹，使用红外线对膏药纸照射8-10min即可。
2.如权利要求1所述的治疗小面积烫伤中药膏的制备方法，其特征在于，其各配制成分质量计份为：
平车前11-14份、鸡骨草9-11份、柴胡7-10份、舒筋草5-7份、大活血4-6份、紫珠叶3-5份、百草王2-4份、五香血藤1-3份、救心菜7-9份、接骨草6-8份、菟丝子5-7份、石梓花提取物7-9份、星叶草提取物6-8份、凹凸棒石粉7-10份份、人参4-6份、灵芝3-5份、银杏果油2-4份、蜂王浆2-5份。
3.如权利要求1所述的治疗小面积烫伤中药膏的制备方法，其特征在于，步骤（1）所述的回流提取，其温度为60-65℃。
4.如权利要求1所述的治疗小面积烫伤中药膏的制备方法，其特征在于，步骤（2）所述的菌剂，其中包括酵母菌、根霉菌、枯草杆菌和乳酸菌中的两种或两种以上；其加入量为混合粉质量的1%-2%。
5.如权利要求1所述的治疗小面积烫伤中药膏的制备方法，其特征在于，步骤（6）所述的红外线，其温度为35-38℃。
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102416090A (zh) * 2011-12-19 2012-04-18 大连创达技术交易市场有限公司 治疗烫伤外用药膏
CN106606619A (zh) * 2016-12-23 2017-05-03 陈鹏 一种治疗烧伤、烫伤的中药膏

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102416090A (zh) * 2011-12-19 2012-04-18 大连创达技术交易市场有限公司 治疗烫伤外用药膏
CN106606619A (zh) * 2016-12-23 2017-05-03 陈鹏 一种治疗烧伤、烫伤的中药膏

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