CN107743961A - A kind of complex composition and preparation of the lactams of ketoxime containing isolonglifolene and chlorobromide isocyanuric acid - Google Patents
A kind of complex composition and preparation of the lactams of ketoxime containing isolonglifolene and chlorobromide isocyanuric acid Download PDFInfo
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- CN107743961A CN107743961A CN201711218760.XA CN201711218760A CN107743961A CN 107743961 A CN107743961 A CN 107743961A CN 201711218760 A CN201711218760 A CN 201711218760A CN 107743961 A CN107743961 A CN 107743961A
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- isocyanuric acid
- lactams
- bactericide
- isolonglifolene
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/46—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom rings with more than six members
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
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Abstract
The present invention discloses a kind of complex composition and its bactericide being made up of isolonglifolene ketoxime lactams and chlorobromide isocyanuric acid, and said composition is made up of isolonglifolene ketoxime lactams and chlorobromide isocyanuric acid；The weight of isolonglifolene ketoxime lactams and chlorobromide isocyanuric acid ratio is (40~1)：(1~40), it is preferably (10~1):(1~10).Bactericide provided by the invention includes acceptable adjuvant on described complex composition and agricultural chemicals, wherein the weight percentage that described bactericidal composition accounts for the bactericide is 0.1%~90%.The complex composition and its bactericide of the present invention, obvious synergistic function is shown for controlling disease, improves prevention effect, reduces the dosage of active ingredient, reduces cost accounting, the resistance to the action of a drug for slowing down pathogen produces.
Description
Technical field
The present invention relates to technical field of pesticide, more particularly to a kind of lactams of ketoxime containing isolonglifolene and chlorobromide isocyanuric acid
Complex composition and preparation.
Background technology
The resistance problem of agricultural pests is a global problem.With the continuity of disease chemical prevention, Pesticide use
The increase of amount and not scientifical use agricultural chemicals, the resistance getting worse of germ, the germ species for producing resistance are on the increase.Especially
It is bacterial disease, resistance level is high, and resistance development speed is fast.
As people constantly strengthen the consciousness of environmental protection and social sustainable development, especially 21 century, from plant
New natural drug is found and excavated in resource applied to medical science or agriculturally, has become countries in the world important subject.
It is increasingly difficult to using traditional bactericide of the synthetic method synthesis with excellent activity, and this bactericide that is synthesized is past
It is past that there is certain toxicity, the resistance to the action of a drug and pollution environment etc., for example the agricultural chemicals such as DDT, BHC organochlorine is due to environmental disruption
Property it is relatively strong and be gradually backed out market or be eliminated.Therefore, researching and developing and formulate the newtype drug with autonomous property right turns into medicine
Learn the focus with Pesticide Science research.Oximido ether compound tool has been widely used, for example as bactericide, antifungal agent, weeding
Agent etc., and there is hypotoxicity, low-residual, high activity, widely attract the research interest of research-on-research.Recently, people
Find 1,2,3,4,5,6- hexahydros -1,1,5,5- tetramethyl -7H-2,4 α-methanonaphthalene -7- ketone (Isolongifolenone) is to suppressing
Junket ammonia enzyme and anti-breast cancer have preferably activity, and Isolongifolenone is highly effective to prevention tick and bite by mosquitos, effect
Fruit is better than traditional Metadelphene.
Chlorobromide isocyanuric acid has efficient, wide spectrum, safer bactericidal action, has to bacterium, fungi etc. and preferably kills
Bacterium acts on.But because its long-time uses, alone its prevents and treats crop disease, and prevention effect is undesirable, and disease also generates to it
Certain resistance to the action of a drug.Therefore, it is necessary to develop a kind of pesticide complex composition efficiently, less toxic, environmentally friendly.
Isolonglifolene ketoxime lactam structure formula is as follows:
The step of preparation process of the compound：Using Isolongifolenone as raw material, different come into leaves is synthesized by addition elimination reaction
Ketenes oxime, then acyl in described isolonglifolene ketoxime should be prepared by the progress Beckmann rearrangement reactions of isolonglifolene ketoxime
Amine.
The content of the invention
Applicant further study show that, show that isolonglifolene ketoxime lactams bacterial disease is equal by substantial amounts of experiment
With preferable prevention effect and inhibitory action.Bacterium such as staphylococcus aureus, ETEC, kerekou pneumonia can be suppressed
Primary Salmonella, proteus vulgaris and pseudomonas aeruginosa and fungi Ru Aspergillus, Exserohilum turcicum, corn line be withered, banana
Lotus lattice bacterium, banana anthrax etc.；Superior insecticidal action is shown to insect pests such as aphid and planthoppers.The compound have efficiently,
Wide spectrum, it is safe to use the characteristics of, be with exploitation for large tonnage product potential quality bactericide.Acute toxicity and environmental toxicity examination
Test and show that isolonglifolene ketoxime lactams belongs to low toxicity compounds, there are good market prospects.
However, a kind of appearance of new drug, if long-term single use, is all inevitably generated resistance, Isolongifolenone
This new type bactericide of oxime lactams is no exception, and single dose uses, and its preventing and treating to pest and disease damage is also difficult to obtain its optimum efficiency.
Therefore, it is to improve preventing and treating crop disease by isolonglifolene ketoxime lactams and chlorobromide isocyanuric acid compounding by compounding channel
Effect, and the effective way of delaying drug resistance development.
In view of this, the purpose of the present invention solves above-mentioned technical problem, there is provided a kind of lactams of ketoxime containing isolonglifolene with
The complex composition of chlorobromide isocyanuric acid, the complex composition have obvious synergistic function relative to single dose, reduce agriculture
The dosage of medicine, while delay the resistance to the action of a drug of the pathogen to isolonglifolene ketoxime lactams and chlorobromide isocyanuric acid.
To realize above-mentioned purpose, use following technical scheme of the invention：
The present invention provides a kind of complex composition of the lactams of ketoxime containing isolonglifolene and chlorobromide isocyanuric acid, the compounding group
Compound is made up of isolonglifolene ketoxime lactams and chlorobromide isocyanuric acid；Wherein, the chemical name of isolonglifolene ketoxime lactams
For 2- (p-fluorophenyl) -5- isolonglifolene ketoxime lactams acyl group -1,3,4- oxadiazoles.
The complex composition of the lactams of ketoxime containing isolonglifolene and chlorobromide isocyanuric acid described above, in order to ensure have more
Good prevention effect and synergistic effect, preferably, above-described isolonglifolene ketoxime lactams and chlorobromide isocyanuric acid
Weight ratio is (40：1)~(1：40).
The complex composition of the lactams of ketoxime containing isolonglifolene and chlorobromide isocyanuric acid described above, it is furthermore preferred that more than
Described isolonglifolene ketoxime lactams and the weight ratio of chlorobromide isocyanuric acid are (10：1)~(1：10).
The present invention also provides a kind of bactericide of the lactams of ketoxime containing isolonglifolene and chlorobromide isocyanuric acid, the bactericide bag
Include acceptable adjuvant on the above-described complex composition of the present invention and agricultural chemicals.
Preferably, the bactericide of the above-described lactams of ketoxime containing isolonglifolene and chlorobromide isocyanuric acid, described answers
The weight percentage that the bactericide is accounted for composition is 0.1%~90%.
It is highly preferred that the bactericide of the above-described lactams of ketoxime containing isolonglifolene and chlorobromide isocyanuric acid, described
The weight percentage that complex composition accounts for the bactericide is 1%~80%.
Acceptable adjuvant is a kind of and mixture of auxiliary agent in solvent and filler on agricultural chemicals of the present invention.It is logical
Often any solvent, filler and the auxiliary agent for preparing agricultural chemicals can be used for use, the present invention does not limit herein.
The one kind of filler in white carbon, kaolin, clay, bentonite, diatomite, soil powder, potassium sulfate or urea
It is or several.
Solvent is selected from dimethylbenzene, trimethylbenzene, dimethylformamide, ethanol, methanol, solvent naphtha, methyl naphthalene or N- methyl pyrroles
It is one or more of in pyrrolidone.
Auxiliary agent of the present invention can include surfactant, defoamer, thickener, disintegrant and antifreezing agent as needed
In one or more, can also as needed include the industry commonly use other auxiliary agents.
Surfactant, which includes polyoxyethylene sorbitan fatty acid ester series, includes AEO series
Including AEO-9, polyoxyethylene nonylphenol ether series is condensation compound of alkyl phenol and epoxy ethane, and OP series includes OP-10, OP-18, and nonyl phenol gathers
Oxygen vinethene series include NP-10, NP-15, nonionic surfactant series include 37#, three phenethyl phenol polyethenoxy ethers
Series includes 602#, and double phenethyl phenol polyethenoxy ether series include 606#, and calcium dodecyl benzene sulfonate (500#), polycarboxylic acids spreads out
In the sodium lignin sulfonate (abbreviation M-9) of biological (abbreviation CF), acrylic acid and propionamide copolymer (abbreviation DA), desugar and classification
One or more.
Wetting dispersing agent includes K12, diisobutyl sodium naphthalene sulfonate (abbreviation pull open powder), di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate (referred to as
NNO), acrylic acid and propionamide copolymer (abbreviation DA), dispersing agent MF (abbreviation MF), Sodium Polyacrylate (letter
Claim DC), desugar and be classified sodium lignin sulfonate (abbreviation M-9), desugar condensation and modification sodium lignin sulfonate (abbreviation M-10),
Lignosulfonates (abbreviation M-11), poly carboxylic acid derivative (abbreviation CF), one kind in sodium lignin sulfonate (abbreviation M-14) or
It is several.
Thickener includes xanthans, aluminium-magnesium silicate, Arabic gum, pectin etc..
Disintegrant includes sodium chloride, ammonium chloride, sodium carbonate, ammonium carbonate, sodium sulphate, potassium sulfate, sodium phosphate.
Antifreezing agent includes isopropanol, propane diols, glycerine, ethylene glycol, urea.
Bactericidal composition of the present invention can be configured to wettable powder, micro emulsion according to method generally in the art
Agent, aqueous emulsion, water dispersible granules, suspending agent, missible oil, kind clothing suspending agent or granule.
Bactericidal composition of the present invention is applied to preventing and treating crop bacterium venereal disease evil, or prevents and treats crop bacterium simultaneously
Disease and fungoid, Disease, such as bacterial leaf streak of rice, tobacco bacterial wilt, Cucumber wilt, c itrus canker
The soft corruption of disease, bacterial wilt of tomato, Muskmelon Fusarium wilt, bacterial blight of rice, cucumber bacterial angular leaf spot, bacterial wilt of peanut, Chinese cabbage
Disease, tomato late blight, leaf spot of peanut, downy mildew of crucifers, gray mold of cucumber, tomato virus disease, tobacco virus,
Virus Diseases of Rice etc..
The present composition can be applied by commonsense method, such as plus water spray cauline leaf process, can also root apply, can be with
Seed dressing or seed pelleting use.Be mainly used in the crops such as rice, tobacco, cucumber, tomato, peanut, capsicum, citrus, prevention and
Control bacterial disease and some fungi and Disease, it is ensured that yield.
Complex composition of the present invention has following advantage compared with prior art：
1st, shown by the indoor virulence for Different Crop disease and field control effectiveness test result, in isolonglifolene ketoxime
Acid amides compounds with chlorobromide isocyanuric acid in the range of certain proportion, has obvious synergistic function, and co-toxicity coefficient is more than
120.Meanwhile active ingredient dosage is fewer than single dose after both compoundings, but prevention effect is far above single dose, both reduces active ingredient
Dosage, cost accounting is reduced again.
2nd, preventing and treating spectrum is expanded.Complex composition provided by the invention is mainly used in preventing and treating bacterial disease, moreover it is possible to simultaneous to cure the disease
Viral disease and fungal disease, preventing and treating spectrum are wide.
3rd, complex composition of the invention is grown to the lasting period of crop disease, while delays the resistance to the action of a drug of pathogen.Different length
Leaf ketenes oxime lactams and chlorobromide isocyanuric acid are broad-spectrum germicide, there is bigger difference in the mechanism of action, and both compound
Complementary synergistic effect can be played, increases the action site to action target each other, so as to ensure crop to the full extent
Yield.
Embodiment
The present invention is illustrated with the following example, but is not limited the scope of the invention.It is used in the present invention different to come into leaves
For ketenes oxime lactams active compound by being provided by Guangxi National Univ., other active compounds used and preparation are purchased in market.Wherein activearm
It is isolonglifolene ketoxime lactams to divide (A)；Active component (B) is chlorobromide isocyanuric acid.
Preparation prepares embodiment：
For unification, it is adjuvant used all using abbreviation or commercial disignation that embodiment is prepared below.
First, the preparation of microemulsion
Isolonglifolene ketoxime lactams and chlorobromide isocyanuric acid are added in solvent, transparent mixing is obtained after stirring
Liquid；Surfactant is added into above-mentioned mixed liquor, stirs to emulsifying agent and is completely dissolved；, will under 50r/min mixing speed
The water of surplus is added in the above-mentioned mixed liquor dissolved with surfactant, at ambient temperature, is stirred 30min, is obtained uniformly
Transparent liquid；Antifreezing agent is eventually adding, is stirred, obtains the microemulsion of bactericide of the present invention.Formula composition：
2nd, the preparation of wettable powder
Isolonglifolene ketoxime lactams, chlorobromide isocyanuric acid, wetting dispersing agent, filler are well mixed, through air-flow crushing
After machine crushes, 30min is stirred, obtains the wettable powder of bactericide of the present invention.
3rd, the preparation of suspending agent
Antifreezing agent, thickener, auxiliary agent, moisture content are mixed, is well mixed through high speed shear, sequentially adds isolonglifolene ketoxime
Lactams, chlorobromide isocyanuric acid, abrading-ball 2~3 hours in ball crusher, the suspending agent of obtained bactericide of the present invention.
4th, the preparation of aqueous emulsion
Isolonglifolene ketoxime lactams, chlorobromide isocyanuric acid, surfactant and solvent are mixed, are dissolved into uniform oil
Phase；Part water, antifreezing agent are mixed into uniform aqueous phase；Oil phase is added into water while high-speed stirred in a kettle
Phase, open cutter and carry out high speed shear, and add thickener and remaining water, shearing about half an hour, form aqueous emulsion, that is, make
Obtain the aqueous emulsion of bactericide of the present invention.
5th, the preparation of water dispersible granules
Isolonglifolene ketoxime lactams, chlorobromide isocyanuric acid, wetting dispersing agent, white carbon, filler are well mixed, through gas
After flowing pulverizer crushing, 30min is stirred, through mediating, rear add in fluidized-bed granulation dryer is granulated, dried, obtained originally
The water dispersible granules of invention bactericide.
6th, the preparation of missible oil
Isolonglifolene ketoxime lactams and chlorobromide isocyanuric acid are added in solvent, add surfactant, stirring is equal
Transparent mixed liquor is obtained after even, that is, the missible oil of bactericide of the present invention is made.
7th, suspension seed-coating agent
Isolonglifolene ketoxime lactams and chlorobromide isocyanuric acid are passed through into air-flow crushing, adding assistant (including surfactant
And dispersant), film forming agent, thickener, antifreezing agent and water be thoroughly mixed after after, put into sand mill in proportion and grind 2 times, until outstanding
The grain fineness of supernatant liquid reaches D50 for 2-3 μm, 8 μm of D90 ＜, that is, the suspension seed-coating agent of bactericide of the present invention is made.
8th, granule
Isolonglifolene ketoxime lactams, chlorobromide isocyanuric acid, wetting dispersing agent, disintegrant, filler are well mixed, powder
It is broken, add water to be stirred after soaking, then be granulated with screw extruder pelletizer, sieved after drying, that is, present invention sterilization is made
The granule of agent.
Micro-capsule suspension, injection drying agent, super-low capacity can also be made in addition to it can be made into above formulation in the present composition
A variety of formulations such as amount.
Toxicity Determination
Following indoor biometricses experiment calculates co-toxicity coefficient (CTC) to evaluate mixed effect using the abundant methods of Sun Yun.
Toxicity index TI (B)=(standard agent A EC50The EC of ÷ B agent50)×100
Actual toxicity index ATI (AB)=(A EC50÷ AB EC50)×100
Percentage+TI (B) × B percentages in mixture of theoretical toxicity index TTI (AB)=TI (the A) × A in mixture
Number
Survey toxicity index (ATI)=(standard agent EC50÷ reagent agents EC50)×100
A percentage composition+B medicament toxicity index in theoretical toxicity index (TTI)=A medicament toxicity index × mixture × mixed
B percentage composition in agent
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI) ÷ mixtures theoretical toxicity index (TTI)] × 100
Evaluation criterion is：Co-toxicity coefficient >=120 show as synergistic effect；Co-toxicity coefficient≤80 show as antagonism；80<
Co-toxicity coefficient<120 show as summation action.
Prevent and treat the Toxicity Determination of bacterial leaf streak of rice：
Test method：Toxicity Determination is carried out using in vitro nephelometry, it is target to select bacterial leaf streak of rice
Mark, is repeated 4 times, 24 hours inspection results after investigating.It is corresponding with it using drug concentration (mg/l) logarithm value as independent variable x
The probit value of corrected mortality be dependent variable y, establish virulence regression equation respectively, obtain the common poison system of two single dose different ratios
Number, the results are shown in Table 1.Experimental method calculates co-toxicity coefficient (CTC) to evaluate mixed effect using the abundant methods of Sun Yun.
Specific method：Using in vitro Nephelometric Determination, the design concentration on the basis of pilot study, each medicament is added respectively
Enter into NA fluid nutrient mediums, pastille culture medium is made in gradient dilution, and 28 DEG C are placed in after Inoculated Rice Xanthomonas campestris PV.oryzicola and is shaken
Culture 24h or so is swung, its turbidity (turbidity and bacterium amount be changing into positive correlation) is determined with transmissometer, according to the turbidity of blank control
The inhibiting rate bred with each chemicals treatment of turbidity calculating of processing to bacterial growth, probit value and serial medicament by inhibiting rate
Linear regression analysis between the logarithm value of concentration, obtain the EC of each medicament50Value, CTC values.
The indoor virulence of the isolonglifolene ketoxime lactams of table 1 and chlorobromide isocyanuric acid compounding preventing and treating bacterial leaf streak of rice
Measurement result
| Composition | EC50(μg/ml) | ATI | TTI | CTC |
| Isolonglifolene ketoxime lactams (A) | 5.75 | 100.00 | / | / |
| Chlorobromide isocyanuric acid (B) | 75.77 | 7.59 | / | / |
| A:B=40:1 | 4.83 | 119.05 | 97.75 | 121.79 |
| A:B=30:1 | 4.42 | 130.09 | 97.02 | 134.09 |
| A:B=25:1 | 4.31 | 133.41 | 96.45 | 138.33 |
| A:B=20:1 | 4.12 | 139.56 | 95.60 | 145.99 |
| A:B=14:1 | 4.07 | 141.28 | 93.84 | 150.55 |
| A:B=10:1 | 3.98 | 144.47 | 91.60 | 157.72 |
| A:B=5:1 | 3.67 | 156.68 | 84.60 | 185.20 |
| A:B=2:1 | 3.54 | 162.43 | 69.20 | 234.74 |
| A:B=1:1 | 4.29 | 85.55 | 53.79 | 159.03 |
| A:B=1:2 | 6.15 | 93.50 | 38.39 | 243.53 |
| A:B=1:5 | 10.52 | 54.66 | 22.99 | 237.74 |
| A:B=1:10 | 20.68 | 27.80 | 15.99 | 173.89 |
| A:B=1:14 | 26.19 | 21.95 | 13.75 | 159.68 |
| A:B=1:20 | 31.3 | 18.37 | 11.99 | 153.23 |
| A:B=1:25 | 36.6 | 15.71 | 11.14 | 140.99 |
| A:B=1:30 | 42.05 | 13.67 | 10.57 | 129.37 |
| A:B=1:40 | 45.3 | 12.69 | 9.84 | 128.96 |
| A:B=1:50 | 55.79 | 10.31 | 9.40 | 109.64 |
From table 1, isolonglifolene ketoxime lactams is (40 by weight with chlorobromide isocyanuric acid：1)~(1：40) model
The co-toxicity coefficient for enclosing interior compounding preventing and treating bacterial leaf streak of rice is all higher than 120, has notable synergistic effect；When weight ratio is
(10：1)~(1：10) in the range of, the co-toxicity coefficient respectively handled is all higher than 150, and synergy is especially pronounced.
Prevent and treat the Toxicity Determination of tobacco virus：
Test method indoor pot tobacco susceptible variety plant is mixed to the 4-5 leaf phases with the decoction of different ratio various concentrations
Isometric viral juice frictional inoculation is closed, 3 plants is often handled, 3 leaves of often selecting good strains in the field for seed, is repeated 4 times, withered spot number is investigated after 3-4 days, is counted
Inhibiting rate is calculated, uses EC50Value calculates co-toxicity coefficient by the abundant methods of Sun Yun, and measurement result is shown in Table 2.
The Toxicity Determination knot of the isolonglifolene ketoxime lactams of table 2 and chlorobromide isocyanuric acid compounding preventing and treating tobacco virus
Fruit
| Composition | EC50(μg/ml) | ATI | TTI | CTC |
| Isolonglifolene ketoxime lactams (A) | 94.88 | 100.00 | / | / |
| Chlorobromide isocyanuric acid (B) | 65.76 | 144.28 | / | / |
| A:B=40:1 | 75.37 | 125.89 | 101.08 | 124.54 |
| A:B=30:1 | 71.54 | 132.63 | 101.43 | 130.76 |
| A:B=20:1 | 64.5 | 147.10 | 102.11 | 144.06 |
| A:B=10:1 | 57.84 | 164.04 | 104.03 | 157.69 |
| A:B=4:1 | 49.97 | 189.87 | 108.86 | 174.43 |
| A:B=2:1 | 39.96 | 237.44 | 114.76 | 206.90 |
| A:B=1:1 | 30.64 | 309.66 | 122.14 | 253.53 |
| A:B=1:2 | 35.98 | 263.70 | 129.52 | 203.60 |
| A:B=1:4 | 40.53 | 234.10 | 135.43 | 172.86 |
| A:B=1:10 | 44.97 | 210.99 | 140.26 | 150.43 |
| A:B=1:20 | 48.5 | 195.63 | 142.17 | 137.60 |
| A:B=1:30 | 51.78 | 183.24 | 142.85 | 128.27 |
| A:B=1:40 | 53.03 | 178.92 | 143.20 | 124.94 |
| A:B=1:50 | 56.75 | 167.19 | 143.41 | 116.58 |
From table 2, isolonglifolene ketoxime lactams is (40 by weight with chlorobromide isocyanuric acid：1)~(1：40) model
The co-toxicity coefficient for enclosing interior compounding preventing and treating tobacco virus is all higher than 120, has notable synergistic effect；When weight ratio is (10：1)~
(1：10) in the range of, the co-toxicity coefficient respectively handled is more than 150, and synergy is especially pronounced.
Prevent and treat the Toxicity Determination of tomato late blight：
Test method：Cultured tomato late blight disease fungus spore deionized water is eluted from culture medium, mistake
Filter, it is prepared into every milliliter and contains 1 × 10~1 × 107The spore suspension of individual spore, it is standby.Medicament mother liquor is prepared, with 0.1%
The Tween 80 aqueous solution is diluted to corresponding concentration.With the decoction and spore suspension of liquid-transfering gun draws equal amounts (each 0.5ml) in small
In test tube, it is well mixed.Above-mentioned mixed liquor is drawn with micro sample adding appliance to drip on concave slide, then frame is put in shallow seated groundwater
In culture dish, it is capped after moisturizing culture in 26 DEG C of insulating boxs.4 repetitions are often handled, and sets the processing without medicament and makees blank
Control.When blank control spore germination rate reaches more than 90%, each processing spore germination number is investigated, and records investigation sum,
Spore germination rate and relative inhibition are calculated, according to the several of each drug concentration logarithm value and corresponding spore germination relative inhibition
Rate value makees regression analysis, calculates the EC of each medicament50, and according to the co-toxicity coefficient of the abundant method calculating mixtures of Sun Yun.
The isolonglifolene ketoxime lactams of table 3 and the Toxicity Determination knot of chlorobromide isocyanuric acid compounding preventing and treating leaf spot of peanut
Fruit
From table 3, isolonglifolene ketoxime lactams is (40 by weight with chlorobromide isocyanuric acid：1)~(1：40) model
The co-toxicity coefficient for enclosing interior compounding preventing and treating leaf spot of peanut is all higher than 120, has notable synergistic effect；When weight ratio is (10：1)~
(1：10) in the range of, the co-toxicity coefficient respectively handled is more than 151, and synergy is especially pronounced.
Prevent and treat the field control effectiveness test of bacterial leaf streak of rice：
Test method：With reference to the part of G B/T 17980.105-2004 pesticide field efficacy medicine tests criterion (two) the 105th：Kill
Microbial inoculum prevents and treats bacterial leaf streak of rice；
Controlling object：Bacterial leaf streak of rice
Test site：Nanning doube bridge
Experimental plot：36 cell is chosen, random alignment, 9 groups is divided into, every group of 4 repetitions, totally 9 corresponds to 9 processing.
Test method：Using directed spraying method, first time dispenser is away from second of spraying time at intervals of 7 days.
Investigation method：Sampled using diagonal, take altogether at 5 points, 25 clumps every (100 plants), before medicine, 7 days and 14 natural gift after medicine
Do not investigate.
Comparison medicament 2：1.8% chlorobromide isocyanuric acid aqua, it is purchased in market.
Table 4 prevents and treats the field control effectiveness test result of bacterial leaf streak of rice
From result of the test table 4, when preventing and treating bacterial leaf streak of rice, the identical (active ingredient of active ingredient dosage
Dosage 20g/667m2) or even it is less in the case of, 7d after isolonglifolene ketoxime lactams+second of chlorobromide isocyanuric acid medicine
Prevention effect be respectively higher than single dose, be higher by isolonglifolene ketoxime lactams, the prevention effect of chlorobromide isocyanuric acid single dose is
More than more than 25%；And 14d remains to the preventive effect up to more than 79%, lasting period length after second of medicine.
Prevent and treat the field control effectiveness test of tobacco virus：
Test method and drug effect computational methods：With reference to NY/T1464.8-2007 pesticide field efficacy medicine test criterions：Bactericide
Prevent and treat tomato virus disease；
Controlling object：Tobacco virus；
Test site：Nanning Wuming.
Experimental plot：36 cells are chosen in field, are divided into 9 groups, every group of 4 repetitions, random number；
Test method：Directed spraying method is used with test medicine processing different districts respectively, first time dispenser is away from second
Spraying time was at intervals of 7 days.
Investigation method：Per 5 points of samplings of cell, every is investigated 6 plants, before medicine, investigates each cell respectively within 7 days and 14 days after medicine
The total strain number and diseased plant number of interior tobacco.
Comparison medicament 2：1.8% chlorobromide isocyanuric acid aqua, it is purchased in market.
Table 5 prevents and treats the field control effectiveness test result of tobacco virus
From result of the test table 5, when preventing and treating tobacco virus, identical (the active ingredient dosage of active ingredient dosage
15g/667m2) or even it is less in the case of, 7d preventing and treating after isolonglifolene ketoxime lactams+second of chlorobromide isocyanuric acid medicine
Effect is respectively higher than single dose, be higher by isolonglifolene ketoxime lactams, chlorobromide isocyanuric acid single dose prevention effect for 29% with
On；And 14d remains to the preventive effect up to more than 80%, lasting period length after second of medicine.
Prevent and treat the field control effectiveness test of tomato late blight：
Test method：With reference to the part of GB/T17980.31-2000 field control effectiveness tests criterion (one) the 31st：Bactericidal agent for preventing and treating
Tomato late blight.
Controlling object：Tomato late blight
Test site：Nanning Shi Bu
Experimental plot：36 cells are chosen, random alignment, each ㎡ of cell 20, each handle 4 repetitions, at totally 9
Reason；
Test method：Using directed spraying method, first time dispenser is away from second of spraying time at intervals of 7 days.
Investigation method：Per cell, random 5 points of samplings, often click two plants, and every plant is divided upper, middle and lower to investigate 10 leaves, with every
Lesion area on a piece of leaf accounts for the percentage of whole leaf area to be classified, and disease fruit number is investigated while blade is investigated to be included falling
Ground fruit, show prevention effect so that diseased fruit rate is embedding.Investigate once, investigate respectively once before dispenser within 7 days and 14 days after dispenser.
Comparison medicament 2：1.8% chlorobromide isocyanuric acid aqua, it is purchased in market.
Table 6 prevents and treats the field control effectiveness test result of tomato late blight
From result of the test table 6, when preventing and treating tomato late blight, identical (the active ingredient dosage of active ingredient dosage
20g/667m2) or even it is less in the case of, 7d preventing and treating after isolonglifolene ketoxime lactams+second of chlorobromide isocyanuric acid medicine
Effect is respectively higher than single dose, be higher by isolonglifolene ketoxime lactams, chlorobromide isocyanuric acid single dose prevention effect for 31% with
On；And 14d remains to the preventive effect up to more than 81%, lasting period length after second of medicine.
Claims (9)
- A kind of 1. complex composition of lactams of ketoxime containing isolonglifolene and chlorobromide isocyanuric acid, it is characterised in that：Described answers It is made up of with composition isolonglifolene ketoxime lactams and chlorobromide isocyanuric acid；Described isolonglifolene ketoxime lactams and chlorine bromine The weight ratio of isocyanuric acid is (40：1)~(1：40).
- 2. the complex composition of a kind of lactams of ketoxime containing isolonglifolene according to claim 1 and chlorobromide isocyanuric acid, Characterized in that, described isolonglifolene ketoxime lactams and the weight ratio of chlorobromide isocyanuric acid are (10：1)~(1：10).
- 3. the bactericide of a kind of lactams of ketoxime containing isolonglifolene and chlorobromide isocyanuric acid, it is characterised in that including claim Acceptable adjuvant on 1-2 any described complex composition and agricultural chemicals, then it is prepared into the bactericide of agricultural.
- 4. the bactericide of the lactams of ketoxime containing isolonglifolene and chlorobromide isocyanuric acid according to claim 3, it is characterised in that The weight percentage that described complex composition accounts for the bactericide is 0.1%~90%.
- 5. the bactericide of the lactams of ketoxime containing isolonglifolene and chlorobromide isocyanuric acid according to claim 4, it is characterised in that The weight percentage that described complex composition accounts for the bactericide is 1%~80%.
- 6. according to any described lactams of ketoxime containing isolonglifolene of claim 3-5 and the bactericide of chlorobromide isocyanuric acid, its It is characterised by, the bactericide is configured to wettable powder, microemulsion, aqueous emulsion, water dispersible granules, suspending agent, missible oil, kind clothing Suspending agent or granule.
- 7. the bactericide of the lactams of ketoxime containing isolonglifolene and chlorobromide isocyanuric acid according to claim 3, it is characterised in that： Acceptable adjuvant is a kind of and mixture of auxiliary agent in solvent and filler on the agricultural chemicals.
- 8. application of the complex composition in preventing and treating crop bacterium venereal disease evil as described in claim 1-2 is any.
- 9. the answering in preventing and treating crop fungal disease and Disease of the complex composition as described in claim 1-2 is any With.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108477184A (en) * | 2018-04-03 | 2018-09-04 | 孙利嫚 | A kind of bactericidal composition containing isolonglifolene ketoxime lactams |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102823603A (en) * | 2012-09-13 | 2012-12-19 | 王学权 | Sterilization compound containing chloroisobromine cyanuric acid |
| CN106588772A (en) * | 2016-12-19 | 2017-04-26 | 广西中医药大学 | Heavy turpentine longifolene derivative, preparation thereof and application |
-
2017
- 2017-11-28 CN CN201711218760.XA patent/CN107743961A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102823603A (en) * | 2012-09-13 | 2012-12-19 | 王学权 | Sterilization compound containing chloroisobromine cyanuric acid |
| CN106588772A (en) * | 2016-12-19 | 2017-04-26 | 广西中医药大学 | Heavy turpentine longifolene derivative, preparation thereof and application |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108477184A (en) * | 2018-04-03 | 2018-09-04 | 孙利嫚 | A kind of bactericidal composition containing isolonglifolene ketoxime lactams |
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