CN107736618A - A kind of pill with anti-fatigue effect and its preparation method and application - Google Patents
A kind of pill with anti-fatigue effect and its preparation method and application Download PDFInfo
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- CN107736618A CN107736618A CN201710877972.2A CN201710877972A CN107736618A CN 107736618 A CN107736618 A CN 107736618A CN 201710877972 A CN201710877972 A CN 201710877972A CN 107736618 A CN107736618 A CN 107736618A
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- fatigue effect
- wrinkled giant
- giant hyssop
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- 230000002929 anti-fatigue Effects 0.000 title claims abstract description 20
- 230000000694 effects Effects 0.000 title claims abstract description 20
- 239000006187 pill Substances 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 240000004510 Agastache rugosa Species 0.000 claims abstract description 19
- 244000111489 Gardenia augusta Species 0.000 claims abstract description 9
- 235000018958 Gardenia augusta Nutrition 0.000 claims abstract description 9
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims abstract description 9
- 240000002853 Nelumbo nucifera Species 0.000 claims abstract description 9
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims abstract description 9
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims abstract description 9
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims abstract description 9
- 240000003582 Platycodon grandiflorus Species 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 239000000341 volatile oil Substances 0.000 claims description 19
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 15
- 238000000605 extraction Methods 0.000 claims description 11
- 229920000858 Cyclodextrin Polymers 0.000 claims description 9
- 239000001116 FEMA 4028 Substances 0.000 claims description 9
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 9
- 229960004853 betadex Drugs 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 6
- 229940126678 chinese medicines Drugs 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 238000001256 steam distillation Methods 0.000 claims description 5
- 238000000108 ultra-filtration Methods 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 2
- 235000013402 health food Nutrition 0.000 claims description 2
- 239000012982 microporous membrane Substances 0.000 claims description 2
- 235000014676 Phragmites communis Nutrition 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 15
- 229940079593 drug Drugs 0.000 description 11
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 230000009182 swimming Effects 0.000 description 5
- 241001529821 Agastache Species 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000005374 membrane filtration Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010048232 Yawning Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 238000005899 aromatization reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000037080 exercise endurance Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 210000001034 respiratory center Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of pill with anti-fatigue effect, and it is prepared by the raw material of following parts by weight：10 20 parts of 15 35 parts of fresh Rhizoma Phragmitis, 10 30 parts of wrinkled giant hyssop, 15 25 parts of lotus leaf, 10 20 parts of malt, 10 20 parts of cape jasmine and balloonflower root, also disclose preparation method and its application in preparing with anti-fatigue effect medicine.
Description
Technical field
The present invention relates to technical field of health care food, and in particular to a kind of pill and its preparation side with anti-fatigue effect
Method and application.
Background technology
Fatigue is a kind of subjective uncomfortable sensation, but objectively under equal conditions can lose what its completion was engaged in originally
Normal activity or ability to work.Main cause is change physiologically：Due to the accumulation of lactic acid and other metabolites, muscle
Power declines, and exercise endurance reduces；Due to the accumulation of carbon dioxide, respiratory center is stimulated, also results in and yawns.Every disease
Develop into certain phase and all may occur in which tired, therefore tired disease can be caused a lot.So far, people are look for one kind
Make antifatigue Chinese medicine simple, convenient to take.
The content of the invention
Goal of the invention：In order to solve the above problems, it is an object of the invention to provide a kind of ball with anti-fatigue effect
Agent and its preparation method and application.
Technical scheme：The purpose of the present invention is realized by following scheme：
A kind of pill with anti-fatigue effect, it is prepared by the raw material of following parts by weight：Fresh Rhizoma Phragmitis 15-35
Part, wrinkled giant hyssop 10-30 parts, lotus leaf 15-25 parts, malt 10-20 parts, cape jasmine 10-20 parts and balloonflower root 10-20 parts.
The pill with anti-fatigue effect, it is prepared by the raw material of following parts by weight：25 parts of fresh Rhizoma Phragmitis, the leaves of pulse plants
15 parts of fragrant 20 parts, 20 parts of lotus leaf, 15 parts of malt, 15 parts of cape jasmine and balloonflower root.
The pill with anti-fatigue effect, preparation method comprise the following steps：The wrinkled giant hyssop crushed is taken to be steamed using water
Steam distillation method is extracted 3 hours, obtains total volatile oil, according to weight than 1: 10, with beta-cyclodextrin inclusion compound, and 100KDa milipore filter ultrafiltration,
Volatile oil beta cyclodextrin solution is obtained, takes other Chinese medicines to be mixed with the dregs of a decoction after wrinkled giant hyssop extraction volatile oil, adds 10 times of amount water refluxing extractions
2 times, 1 hour every time, merging extract solution, 0.45 μm of filtering with microporous membrane, filtrate merges with Herba Agastaches Rugosae volatile oil beta-schardinger dextrin solution,
Concentrated using 300~500Da of molecular cut off NF membranes, concentrate is dried under reduced pressure, and is crushed, and addition auxiliary material is prepared into pill.
The pill with anti-fatigue effect is being prepared with the application in anti-fatigue effect health food..
Beneficial effect：Theory of traditional Chinese medical science thinks, fresh Rhizoma Phragmitis clearing heat and promoting fluid, relieving restlessness, preventing or arresting vomiting, diuresis in we, wrinkled giant hyssop aromatization
Turbid, and middle preventing or arresting vomiting, it is monarch drug in a prescription to deliver relieving summer-heat, lotus leaf clear away heart-fire relieving summer-heat, dissipate stasis of blood hemostasis, disappear wind clearing damp, malt promoting the circulation of qi helps digestion, invigorating the spleen is opened
Stomach, delaactation dissipate-swelling are ministerial drug, and cape jasmine heat-clearing, purging intense heat, cool blood, balloonflower root facilitaing lung, relieving sore-throat, eliminating the phlegm, apocenosis is adjuvant, all medicine phases
Close, for alleviating physical fatigue.Present invention composition is Chinese medicine, is had no toxic side effect, cheap.
Embodiment
Form by the following examples, the above of the present invention is described in further detail again, but should not be by this
The scope for being interpreted as the above-mentioned theme of the present invention is only limitted to following example, and all technologies for being realized based on the above of the present invention are equal
Belong to the scope of the present invention.
Embodiment 1：20 parts of 15 parts of fresh Rhizoma Phragmitis, 30 parts of wrinkled giant hyssop, 15 parts of lotus leaf, 20 parts of malt, 10 parts of cape jasmine and balloonflower root are taken, is made
Preparation Method comprises the following steps：Take the wrinkled giant hyssop crushed to use extraction by steam distillation 3 hours, obtain total volatile oil, according to weight
Ratio 1: 10 is measured, with beta-cyclodextrin inclusion compound, 100KDa milipore filter ultrafiltration, volatile oil beta cyclodextrin solution is obtained, takes other Chinese medicines and wrinkled giant hyssop
The dregs of a decoction mixing after volatile oil is extracted, adds 10 times to measure water refluxing extraction 2 times, 1 hour every time, merges extract solution, 0.45 μm of micropore
Membrane filtration, filtrate merge with Herba Agastaches Rugosae volatile oil beta-schardinger dextrin solution, are concentrated using 300~500Da of molecular cut off NF membranes,
Concentrate is dried under reduced pressure, and is crushed, and addition auxiliary material is prepared into pill.
Embodiment 2：10 parts of 35 parts of fresh Rhizoma Phragmitis, 10 parts of wrinkled giant hyssop, 25 parts of lotus leaf, 10 parts of malt, 20 parts of cape jasmine and balloonflower root are taken, is made
Preparation Method comprises the following steps：Take the wrinkled giant hyssop crushed to use extraction by steam distillation 3 hours, obtain total volatile oil, according to weight
Ratio 1: 10 is measured, with beta-cyclodextrin inclusion compound, 100KDa milipore filter ultrafiltration, volatile oil beta cyclodextrin solution is obtained, takes other Chinese medicines and wrinkled giant hyssop
The dregs of a decoction mixing after volatile oil is extracted, adds 10 times to measure water refluxing extraction 2 times, 1 hour every time, merges extract solution, 0.45 μm of micropore
Membrane filtration, filtrate merge with Herba Agastaches Rugosae volatile oil beta-schardinger dextrin solution, are concentrated using 300~500Da of molecular cut off NF membranes,
Concentrate is dried under reduced pressure, and is crushed, and addition auxiliary material is prepared into pill.
Embodiment 3：15 parts of 25 parts of fresh Rhizoma Phragmitis, 20 parts of wrinkled giant hyssop, 20 parts of lotus leaf, 15 parts of malt, 15 parts of cape jasmine and balloonflower root are taken, is made
Preparation Method comprises the following steps：Take the wrinkled giant hyssop crushed to use extraction by steam distillation 3 hours, obtain total volatile oil, according to weight
Ratio 1: 10 is measured, with beta-cyclodextrin inclusion compound, 100KDa milipore filter ultrafiltration, volatile oil beta cyclodextrin solution is obtained, takes other Chinese medicines and wrinkled giant hyssop
The dregs of a decoction mixing after volatile oil is extracted, adds 10 times to measure water refluxing extraction 2 times, 1 hour every time, merges extract solution, 0.45 μm of micropore
Membrane filtration, filtrate merge with Herba Agastaches Rugosae volatile oil beta-schardinger dextrin solution, are concentrated using 300~500Da of molecular cut off NF membranes,
Concentrate is dried under reduced pressure, and is crushed, and addition auxiliary material is prepared into pill.
Embodiment 4：The antifatigue pharmacodynamic study of the present invention
Experimental animal：Kunming mouse, male, body weight 18-22g, Shanghai Slac Experimental Animal Co., Ltd. provide, raw
Produce licensing：SCXK (Shanghai) 2007-0005.
Experimental agents：Pill is prepared by the preparation method of above-described embodiment 3.
Dosage：The oral liquid of daily every 20g mouse stomach is respectively 0.4g, 0.8g, 1.2g containing crude drug amount, then presses
Mice Body restatement, low dosage, middle dosage and high dose be respectively 20g crude drug amounts/kg, 40g crude drug amount/kg and 80g crude drug amounts/
kg。
Positive drug essence side hall board is supported and capsule, upper Nereid Fang Tang bio tech ltd, the strong word G20050641 of state's food,
Lot number：20160523.Specification：Every dress 0.5g.Patient uses typically 2 tablets each time, 2 times a day, i.e. people's consumption per day 2g, equivalent to
Every 20g mouse dosage is 2*0.0026=0.0052g, by per kilogram mouse calculate, i.e., positive drug group give essence side hall board support with
Capsule 0.26g/kg.
Experimentation：Healthy mice 50 is selected, 10 is separated at random and is only used as normal group, remaining 40 mouse, is randomly divided into 4
Group：High dose group, middle dose group, low dose group, positive drug essence side hall board support and Capsules group, wherein 3 dosage groups, essence side's hall board
Support and Capsules group presses above-mentioned dosage gastric infusion, water of the normal group to 0.2ml, every morning 1 time, continuous 30d, carry out mouse and bear
Weight swimming test, mouse tail bear the sheet lead of mouse weight 5%, and it is 25 DEG C to be put into water temperature, in depth of water 35cm swimming trunk, with the second
Token record exhausts the time of death from swimming to power, and each group of data is represented with means standard deviation, and t tests are carried out between group.As a result see
Table.
Influence (n=10) of the present invention to mice burden swimming test
Note:The * p compared with normal group<0.05**<0.01
Conclusion：The present invention is compared with normal group, hence it is evident that extends the mice burden swimming time, it is antifatigue to illustrate that the present invention has
Effect, compared with positive drug, time lengthening, illustrate that the antifatigue effect of the present invention is better than positive drug.
Claims (4)
1. a kind of pill with anti-fatigue effect, it is characterised in that it is prepared by the raw material of following parts by weight：Fresh reed
Root 15-35 parts, wrinkled giant hyssop 10-30 parts, lotus leaf 15-25 parts, malt 10-20 parts, cape jasmine 10-20 parts and balloonflower root 10-20 parts.
A kind of 2. pill with anti-fatigue effect as claimed in claim 1, it is characterised in that it by following parts by weight original
Material is prepared：15 parts of 25 parts of fresh Rhizoma Phragmitis, 20 parts of wrinkled giant hyssop, 20 parts of lotus leaf, 15 parts of malt, 15 parts of cape jasmine and balloonflower root.
3. there is the pill of anti-fatigue effect as claimed in claim 1, it is characterised in that preparation method comprises the following steps：Take
The wrinkled giant hyssop crushed uses extraction by steam distillation 3 hours, total volatile oil is obtained, according to weight than 1: 10, with beta-schardinger dextrin bag
Close, 100KDa milipore filter ultrafiltration, obtain volatile oil beta cyclodextrin solution, take other Chinese medicines to be mixed with the dregs of a decoction after wrinkled giant hyssop extraction volatile oil
Close, add 10 times to measure water refluxing extraction 2 times, 1 hour every time, merge extract solution, 0.45 μm of filtering with microporous membrane, filtrate is waved with wrinkled giant hyssop
Hair oil beta-schardinger dextrin solution merges, and is concentrated using 300~500Da of molecular cut off NF membranes, and concentrate is dried under reduced pressure, and crushes,
Addition auxiliary material is prepared into pill.
4. the pill as claimed in claim 1 or 2 with anti-fatigue effect is being prepared with anti-fatigue effect health food
Using.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710877972.2A CN107736618A (en) | 2017-09-26 | 2017-09-26 | A kind of pill with anti-fatigue effect and its preparation method and application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710877972.2A CN107736618A (en) | 2017-09-26 | 2017-09-26 | A kind of pill with anti-fatigue effect and its preparation method and application |
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| Publication Number | Publication Date |
|---|---|
| CN107736618A true CN107736618A (en) | 2018-02-27 |
Family
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| CN201710877972.2A Withdrawn CN107736618A (en) | 2017-09-26 | 2017-09-26 | A kind of pill with anti-fatigue effect and its preparation method and application |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1475229A (en) * | 2002-08-14 | 2004-02-18 | 卫永生 | Antifatigue compound Chinese medicine prescription and its preparation method |
| CN1526433A (en) * | 2003-09-25 | 2004-09-08 | 威海健方医药研究所 | Compound American ginseng prepn and its prepn process |
| CN102824446A (en) * | 2012-09-21 | 2012-12-19 | 云南云药科技股份有限公司 | Medicinal composition with anti-fatigue effect as well as preparation method and application thereof |
| CN102908498A (en) * | 2012-11-12 | 2013-02-06 | 江苏正大清江制药有限公司 | Pharmaceutical composition for clearing away heat and toxic materials and method for preparing the same |
| CN103284266A (en) * | 2013-05-31 | 2013-09-11 | 周明刚 | Mulberry leaf and chrysanthemum beverage functional beverage and preparation method thereof |
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2017
- 2017-09-26 CN CN201710877972.2A patent/CN107736618A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1475229A (en) * | 2002-08-14 | 2004-02-18 | 卫永生 | Antifatigue compound Chinese medicine prescription and its preparation method |
| CN1526433A (en) * | 2003-09-25 | 2004-09-08 | 威海健方医药研究所 | Compound American ginseng prepn and its prepn process |
| CN102824446A (en) * | 2012-09-21 | 2012-12-19 | 云南云药科技股份有限公司 | Medicinal composition with anti-fatigue effect as well as preparation method and application thereof |
| CN102908498A (en) * | 2012-11-12 | 2013-02-06 | 江苏正大清江制药有限公司 | Pharmaceutical composition for clearing away heat and toxic materials and method for preparing the same |
| CN103284266A (en) * | 2013-05-31 | 2013-09-11 | 周明刚 | Mulberry leaf and chrysanthemum beverage functional beverage and preparation method thereof |
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