CN104324244A - Compound dendrobium candidum blood-glucose-reducing capsule - Google Patents

Compound dendrobium candidum blood-glucose-reducing capsule Download PDF

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Publication number
CN104324244A
CN104324244A CN201410508301.5A CN201410508301A CN104324244A CN 104324244 A CN104324244 A CN 104324244A CN 201410508301 A CN201410508301 A CN 201410508301A CN 104324244 A CN104324244 A CN 104324244A
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capsule
extraction
radix
powder
blood
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刘方旭
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/428—Trichosanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8984—Dendrobium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses a compound dendrobium candidum blood-glucose-reducing capsule. The capsule is prepared from the dendrobium candidum with other seven traditional Chinese medicines, including astragalus, kudzu roots, dried radix rehmanniae, root of Chinese trichosanthes, polygonatum kingianum, fructus lycii and red peony roots, and is prepared through following steps: crushing, extraction, mixing, granulation and packaging. The components influent on each other and work synergistically. The capsule can promote pancreatic [beta] cells to secrete insulin and inhibit pancreatic [alpha] cells to secrete glucagon, and meanwhile can inhibit decomposition of hepatic glycogen due to epinephrine and promote synthesis of the hepatic glycogen, thereby reducing sources of blood glucose, increasing outlet of the blood glucose and reducing a blood glucose value. The capsule is free of toxic and side effect and untoward reactions, and can effectively control and eliminate symptoms, including polyphagia, polydipsia, polyuria and emaciation, in diabetes and diabetic complications.

Description

A kind of compound dendrobium officinale Jiangtang capsule
Technical field
The present invention relates to the technical field of Chinese medicinal capsule, espespecially a kind of compound dendrobium officinale Jiangtang capsule.
Background technology
Diabetes are metabolic diseases of a kind of multi-pathogenesis, and feature is chronic hyperglycemia, with because of insulin secretion Ji ∕ or effect the defect sugar, fat and the protein metabolism disorder that cause.This functional disorder causes concentration of glucose in blood to increase, and can jeopardize a lot of system of whole body, particularly to vascular system and nervous system effect maximum, thus bring out many mortality complication.Data shows, and diabetes cause lower extremity amputation and the blind primary cause of disease of being grown up.Meanwhile, diabetics generation coronary heart disease, apoplexy, uremic danger also exceed ordinary people's several times.
At present, the conventional Western medicine for the treatment of diabetes comprises sulphanylureas (diamicron), biguanides (glucophage), glycosidase inhibitor (acarbose), and its main mechanism of action is the synthesis strengthening the sensitivity of insulin, the secretion promoting insulin, suppression glucosidase.The targeting of Western medicine, can reduce blood glucose really, but does not have definite curative effect to " three-many-one-little " of diabetes and complication, once blood glucose of stopping using also can rise, and long-term taking Western medicine patent diabetes have certain side effect; If utilize doctor trained in Western medicine to control blood glucose target, the recycling traditional Chinese medical science is improved function, so both can make blood glucose fluctuation, and can stop and delay again the generation of complication, and allow the quality of life of diabetics further improve.
But treatment by Chinese herbs needs to add water decoction when taking decocts and could extract medicinal ingredient, not only the amount of drinking is greatly also very loaded down with trivial details, causes many inconvenience to patient; And adopt the carrying out of traditional method to extract, then can not extract Effective Component of Chinese Medicine completely, the effective ingredient manufactured in Chinese medicine runs off.
Summary of the invention
A kind of compound dendrobium officinale Jiangtang capsule of the present invention, the deficiency of above-mentioned technology can be solved, be aided with the Radix Astragali, Radix Puerariae, the Radix Rehmanniae, Radix Trichosanthis, Rhizoma Polygonati, Fructus Lycii, Radix Paeoniae Rubra 7 taste Chinese medicine with Herba Dendrobii, pulverizing, extraction, mixing, granulation, packaging is adopted to prepare Jiangtang capsule, the object of the auxiliary steady blood sugar lowering of realization.
To achieve these goals, technical solution of the present invention is: a kind of Chinese medicinal components of compound dendrobium officinale Jiangtang capsule: Herba Dendrobii 28% ~ 30%, the Radix Astragali 12% ~ 14%, Radix Puerariae 10% ~ 12%, the Radix Rehmanniae 10% ~ 12%, Radix Trichosanthis 8% ~ 10%, Rhizoma Polygonati 8% ~ 10%, Fructus Lycii 8% ~ 10%, Radix Paeoniae Rubra 8% ~ 10%.
Technique preparation process is as follows:
(1) pulverize: by raw material components remove impurity, pulverize, cross 60 mesh sieves, extracting screen underflow, obtains mixed powder;
(2) extract: adopt supercritical extracting equipment device, mixed powder is put into supercritical CO 2in the extraction kettle of extraction equipment, with supercritical CO 2for extractant, extraction temperature 30 DEG C ~ 50 DEG C, extracting pressure 15Mpa ~ 30Mpa, extraction time is 4h ~ 6h, is then separated through separating still intensification, blood pressure lowering, collects caking product in separating still, pulverizes 100 mesh sieves, and obtained extraction powder in drying;
(3) mix: extraction powder is inserted in the efficient asymmetric mixer of V-type, and speed of agitator 12 turns/min, incorporation time 30min ~ 60min, obtain mixing loose powder;
(4) granulate: mixing loose powder is added in capsule loading machine and makes the capsule that every quality is 0.5g;
(5) sterilization packaging: pack in time after irradiating 20min under capsule being inserted ultraviolet.
The present invention is monarch drug with Herba Dendrobii, plays nourishing the stomach of promoting the production of body fluid, nourishing YIN and clearing away heat, reduction blood glucose, lung moistening kidney tonifying; The effect of the strong waist of improving eyesight, is equipped with the Radix Astragali, Radix Puerariae, the Radix Rehmanniae, Radix Trichosanthis, Rhizoma Polygonati, Fructus Lycii, Radix Paeoniae Rubra 7 taste Chinese medicine, plays and influence each other, the collaborative effect done altogether; Islet β cell insulin can be promoted, suppress alpha Cell of islet secretion glucagon, the hepatic glycogenolytic that simultaneously epinephrine can be suppressed to cause and the synthesis of promotion hepatic glycogen, thus reduce blood glucose source, increase blood glucose outlet, reduce blood glucose value, have no side effect and untoward reaction, " three-many-one-little " symptom of diabetes and diabetic complication can be made to be effectively controlled and to eliminate.
The present invention is through clinical research, and take every day three times, each 2 ~ 3, blood glucose can effectively be alleviated and alleviate, and 4 ~ 6 weeks evident in efficacy, can alleviate kidney microangiopathies, prevention type Ⅱdiabetes mellitus vascular lesion; Also can strengthen patient's body constitution simultaneously, improve sugar, protein and fat metabolic disturbance, blood viscosity and blood fat etc. can also be reduced by benefiting QI for activating blood circulation, thus prevent and treat complication.Long-term taking not only effectively can reduce blood glucose, can also eliminate comprehensively and alleviate the puzzlement of complication.
Detailed description of the invention
Embodiment 1
(1) raw material components: Herba Dendrobii 30%, the Radix Astragali 12%, Radix Puerariae 12%, the Radix Rehmanniae 10%, Radix Trichosanthis 8%, Rhizoma Polygonati 8%, Fructus Lycii 10%, Radix Paeoniae Rubra 10%.
(2) technique preparation process is as follows:
1. pulverize: by raw material components remove impurity, pulverize, cross 60 mesh sieves, extracting screen underflow, obtains mixed powder;
2. extract: adopt supercritical extracting equipment device, mixed powder is put into supercritical CO 2in the extraction kettle of extraction equipment, with supercritical CO 2for extractant, extraction temperature 30 DEG C ~ 50 DEG C, extracting pressure 15Mpa ~ 30Mpa, extraction time is 4h ~ 6h, is then separated through separating still intensification, blood pressure lowering, collects caking product in separating still, pulverizes 100 mesh sieves, and obtained extraction powder in drying;
3. mix: extraction powder is inserted in the efficient asymmetric mixer of V-type, and speed of agitator 12 turns/min, incorporation time 30min ~ 60min, obtain mixing loose powder;
4. granulate: mixing loose powder is added in capsule loading machine and makes the capsule that every quality is 0.5g;
5. sterilization packaging: pack in time after irradiating 20min under capsule being inserted ultraviolet.
Embodiment 2
(1) raw material components: Herba Dendrobii 28%, the Radix Astragali 14%, Radix Puerariae 10%, the Radix Rehmanniae 12%, Radix Trichosanthis 10%, Rhizoma Polygonati 10%, Fructus Lycii 8%, Radix Paeoniae Rubra 8%.
(2) technique preparation process is as follows:
1. pulverize: by raw material components remove impurity, pulverize, cross 60 mesh sieves, extracting screen underflow, obtains mixed powder;
2. extract: adopt supercritical extracting equipment device, mixed powder is put into supercritical CO 2in the extraction kettle of extraction equipment, with supercritical CO 2for extractant, extraction temperature 30 DEG C ~ 50 DEG C, extracting pressure 15Mpa ~ 30Mpa, extraction time is 4h ~ 6h, is then separated through separating still intensification, blood pressure lowering, collects caking product in separating still, pulverizes 100 mesh sieves, and obtained extraction powder in drying;
3. mix: extraction powder is inserted in the efficient asymmetric mixer of V-type, and speed of agitator 12 turns/min, incorporation time 30min ~ 60min, obtain mixing loose powder;
4. granulate: mixing loose powder is added in capsule loading machine and makes the capsule that every quality is 0.5g;
5. sterilization packaging: pack in time after irradiating 20min under capsule being inserted ultraviolet.
Embodiment 3
(1) raw material components: Herba Dendrobii 29%, the Radix Astragali 13%, Radix Puerariae 11%, the Radix Rehmanniae 11%, Radix Trichosanthis 9%, Rhizoma Polygonati 9%, Fructus Lycii 9%, Radix Paeoniae Rubra 9%.
(2) technique preparation process is as follows:
1. pulverize: by raw material components remove impurity, pulverize, cross 60 mesh sieves, extracting screen underflow, obtains mixed powder;
2. extract: adopt supercritical extracting equipment device, mixed powder is put into supercritical CO 2in the extraction kettle of extraction equipment, with supercritical CO 2for extractant, extraction temperature 30 DEG C ~ 50 DEG C, extracting pressure 15Mpa ~ 30Mpa, extraction time is 4h ~ 6h, is then separated through separating still intensification, blood pressure lowering, collects caking product in separating still, pulverizes 100 mesh sieves, and obtained extraction powder in drying;
3. mix: extraction powder is inserted in the efficient asymmetric mixer of V-type, and speed of agitator 12 turns/min, incorporation time 30min ~ 60min, obtain mixing loose powder;
4. granulate: mixing loose powder is added in capsule loading machine and makes the capsule that every quality is 0.5g;
5. sterilization packaging: pack in time after irradiating 20min under capsule being inserted ultraviolet.
Application result:
Group Number of cases Effective Effectively Total effective rate
Embodiment one 50 47 3 100%
Embodiment two 50 43 7 100%
Embodiment three 50 45 5 100%
Apply this product clinical treatment through 150 routine patients, after medication, symptom can well be alleviated, and have no obvious toxic and side effects in application patient, do not find untoward reaction, total effective rate reaches 100%.
The above; embodiment is only be described the preferred embodiment of the present invention; not scope of the present invention is limited; under the prerequisite of spirit not departing from the technology of the present invention; the various distortion that this area engineers and technicians make technical scheme of the present invention and improvement, all should fall in protection domain that claims of the present invention determine.

Claims (2)

1. a compound dendrobium officinale Jiangtang capsule, is characterized in that: Chinese medicinal components: Herba Dendrobii 28% ~ 30%, the Radix Astragali 12% ~ 14%, Radix Puerariae 10% ~ 12%, the Radix Rehmanniae 10% ~ 12%, Radix Trichosanthis 8% ~ 10%, Rhizoma Polygonati 8% ~ 10%, Fructus Lycii 8% ~ 10%, Radix Paeoniae Rubra 8% ~ 10%.
2. a kind of compound dendrobium officinale Jiangtang capsule according to claim 1, is characterized in that: preparation process is as follows:
(1) pulverize: by raw material components remove impurity, pulverize, cross 60 mesh sieves, extracting screen underflow, obtains mixed powder;
(2) extract: adopt supercritical extracting equipment device, mixed powder is put into supercritical CO 2in the extraction kettle of extraction equipment, with supercritical CO 2for extractant, extraction temperature 30 DEG C ~ 50 DEG C, extracting pressure 15Mpa ~ 30Mpa, extraction time is 4h ~ 6h, is then separated through separating still intensification, blood pressure lowering, collects caking product in separating still, pulverizes 100 mesh sieves, and obtained extraction powder in drying;
(3) mix: extraction powder is inserted in the efficient asymmetric mixer of V-type, and speed of agitator 12 turns/min, incorporation time 30min ~ 60min, obtain mixing loose powder;
(4) granulate: mixing loose powder is added in capsule loading machine and makes the capsule that every quality is 0.5g;
(5) sterilization packaging: pack in time after irradiating 20min under capsule being inserted ultraviolet.
CN201410508301.5A 2014-09-29 2014-09-29 Compound dendrobium candidum blood-glucose-reducing capsule Pending CN104324244A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105687771A (en) * 2016-02-18 2016-06-22 云南久丽康源石斛开发有限公司 Herba dendrobii capsule with auxiliary blood glucose lowering function and method for preparing herba dendrobii capsule
CN106560200A (en) * 2015-10-04 2017-04-12 浙江佳诚生物工程有限公司 Novel product formula and manufacturing technique of dendrobium officinale which lowers blood glucose
CN109692277A (en) * 2019-01-25 2019-04-30 龙步明 A kind of Chinese herbal and crude drugs preparations for treating diabetes
CN115501301A (en) * 2022-11-03 2022-12-23 安徽牧龙山铁皮石斛生物科技开发有限公司 Dendrobium officinale composition with auxiliary blood sugar reducing function

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106560200A (en) * 2015-10-04 2017-04-12 浙江佳诚生物工程有限公司 Novel product formula and manufacturing technique of dendrobium officinale which lowers blood glucose
CN105687771A (en) * 2016-02-18 2016-06-22 云南久丽康源石斛开发有限公司 Herba dendrobii capsule with auxiliary blood glucose lowering function and method for preparing herba dendrobii capsule
CN109692277A (en) * 2019-01-25 2019-04-30 龙步明 A kind of Chinese herbal and crude drugs preparations for treating diabetes
CN115501301A (en) * 2022-11-03 2022-12-23 安徽牧龙山铁皮石斛生物科技开发有限公司 Dendrobium officinale composition with auxiliary blood sugar reducing function

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