CN107714865A - 一种抗痛风的复方药物及其制备方法 - Google Patents
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Abstract
本发明涉及一种抗痛风的复方药物及其制备方法，包括如下重量份数的原料药：秦皮4‑6份、附子5‑10份、枸杞10‑15份、石菖蒲8‑14份、穿山甲9‑18份、当归7‑14份、九香虫3‑8份、海风藤8‑12份、秋水仙碱5‑8份、丙磺舒3‑8份。本发明的复方药物对痛风和高尿酸血症有很好的疗效，能够快速减轻症状，对预防痛风复发有很好的作用。本发明的复方药物由中药和西药复合制成，毒副作用小，对患者的损伤小，治愈后不易复发，适合广大痛风患者和高尿酸血症患者长期服用。
Description
技术领域
本发明属于医药技术领域，具体涉及一种抗痛风的复方药物及其制备方法。
背景技术
痛风是一种由于嘌呤代谢紊乱所导致的疾病，临床表现为高尿酸血症和尿酸盐结晶沉积所致的特征性急性关节炎、痛风石形成、痛风石性慢性关节炎，并可发生尿酸盐肾病、尿酸性尿路结石等，严重者可出现关节致残、肾功能不全。
治疗痛风的西药主要有秋水仙碱、丙磺舒、阿司匹林等，这些西药虽然对痛风的治疗有一定的疗效，但会产生胃肠道反应，影响肝肾功能，减少白细胞等副作用，对人体伤害较大。鉴于中药的副作用较西药小，中药治疗痛风也成为当前的常用手段，但中药起效慢，疗效较差，因此，纯中药对痛风的治疗，并未取得较大进展。
发明内容
为了解决上述问题，本发明提供了一种抗痛风的复方药物及其制备方法，该复方药物为中西结合药物，对痛风和高尿酸血症有非常好的疗效，且毒副作用小。
本发明的技术方案如下：
本发明一方面提供了一种抗痛风的复方药物，包括如下重量份数的原料药：秦皮4-6份、附子5-10份、枸杞10-15份、石菖蒲8-14份、穿山甲9-18份、当归7-14份、九香虫3-8份、海风藤8-12份、秋水仙碱5-8份、丙磺舒3-8份。
进一步的，包括如下重量份数的原料药：秦皮5份、附子8份、枸杞12份、石菖蒲11份、穿山甲13份、当归10份、九香虫6份、海风藤10份、秋水仙碱6份、丙磺舒6份。
本发明另一方面提供了如上所述的复方药物的制备方法，步骤如下：
S1：分别按上述配比称取秦皮、附子、枸杞、石菖份、穿山甲、当归、九香虫、海风藤，加水浸泡12h，煎煮两次，第一次加8倍量水，煎煮2h，第二次加6倍量水，煎煮1h，合并煎煮液，滤过，滤液浓缩至相对密度为1.1(80℃)，冷却后，加4倍量的90％乙醇，搅拌，静置24h，取上清液浓缩至相对密度1.1-1.2(80℃)，真空干燥，粉碎，得到细粉I；
S2：按上述配比称取秋水仙碱和丙磺舒，分别干燥、粉碎，得到细粉Ⅱ；
S3：将细粉|和细粉Ⅱ混合，加入药学可接受的辅料按药学常规制药方法制备成复方药物。
进一步的，所述复方药物为口服制剂。
进一步的，所述口服制剂的剂型为丸剂、胶囊剂、片剂或颗粒剂。
进一步的，所述口服制剂的剂型为丸剂。
本发明的复方药物对痛风和高尿酸血症有很好的疗效，能够快速减轻症状，对预防痛风复发有很好的作用。本发明的复方药物由中药和西药复合制成，毒副作用小，对患者的损伤小，治愈后不易复发，适合广大痛风患者和高尿酸血症患者长期服用。
具体实施方式
以下将结合实施例来详细说明本发明的实施方式，所举实施例只用于解释本发明，并非用于限定本发明的范围。
实施例1
一种抗痛风的复方药物丸剂的制备方法如下：
S1：分别称取秦皮4份、附子5份、枸杞10份、石菖蒲8份、穿山甲9份、当归7份、九香虫3份和海风藤8份，加水浸泡12h，煎煮两次，第一次加8倍量水，煎煮2h，第二次加6倍量水，煎煮1h，合并煎煮液，滤过，滤液浓缩至相对密度为1.1(80℃)，冷却后，加4倍量的90％乙醇，搅拌，静置24h，取上清液浓缩至相对密度1.1-1.2(80℃)，真空干燥，粉碎，得到细粉|；
S2：称取秋水仙碱5份和丙磺舒3份，分别干燥、粉碎，得到细粉Ⅱ；
S3：将细粉|和细粉Ⅱ混合，加入炼蜜适量，混匀、干燥，制成丸剂。
实施例2
一种抗痛风的复方药物丸剂的制备方法如下：
S1：分别称取秦皮5份、附子8份、枸杞12份、石菖蒲11份、穿山甲13份、当归10份、九香虫6份和海风藤10份，加水浸泡12h，煎煮两次，第一次加8倍量水，煎煮2h，第二次加6倍量水，煎煮1h，合并煎煮液，滤过，滤液浓缩至相对密度为1.1(80℃)，冷却后，加4倍量的90％乙醇，搅拌，静置24h，取上清液浓缩至相对密度1.1-1.2(80℃)，真空干燥，粉碎，得到细粉I；
S2：称取秋水仙碱6份和丙磺舒6份，分别干燥、粉碎，得到细粉Ⅱ；
S3：将细粉I和细粉Ⅱ混合，加入炼蜜适量，混匀、干燥，制成丸剂。
实施例3
一种抗痛风的复方药物丸剂的制备方法如下：
S1：分别称取秦皮4-6份、附子5-10份、枸杞10-15份、石菖蒲8-14份、穿山甲9-18份、当归7-14份、九香虫3-8份、海风藤8-12份、秋水仙碱5-8份、丙磺舒3-8份，加水浸泡12h，煎煮两次，第一次加8倍量水，煎煮2h，第二次加6倍量水，煎煮1h，合并煎煮液，滤过，滤液浓缩至相对密度为1.1(80℃)，冷却后，加4倍量的90％乙醇，搅拌，静置24h，取上清液浓缩至相对密度1.1-1.2(80℃)，真空干燥，粉碎，得到细粉I；
S2：称取秋水仙碱和丙磺舒，分别干燥、粉碎，得到细粉Ⅱ；
S3：将细粉I和细粉Ⅱ混合，加入炼蜜适量，混匀、干燥，制成丸剂。
效果测试：
一、治疗对象
痛风患者120例，年龄35-65周岁；患者中包括轻度、中度和重度痛风性关节炎患者。将上述病例随机平分为4组，每组30人，每组均有不同程度的痛风性关节炎急性发作患者。第1组服用实施例1的药物组合物，第2组服用实施例2的药物组合物，第3组服用实施例3的药物组合物，第4组为对照组，服用秋水仙碱。
二、服用方法
第1-3组，每日三次，1丸/次，以开水冲泡后饮用。连服30天。服用过程无需严格忌口。
第4组，每日一次，1片/次，连服30天，治疗过程需严格忌口。
三、疗效判定标准
以症状、体征等改善程度为疗效判定标准，分为：
显效：症状有明显改善；
有效：症状有一定改善。
无效：和用药前相比较，各方面无变化。
四、结果
第一组显效人数21例，有效人数5例，无效人数4例；
第二组显效人数22例，有效人数5例，无效人数3例；
第二组显效人数24例，有效人数4例，无效人数2例；
第四组显效人数14例，有效人数6例，无效人数10例。
可以看出，本发明的药物组合物显效率、有效率均比对照组高，服用本发明的药物组合物的患者，无明显不良反应，而服用对照组的患者，超过80％的患者都有腹痛、腹泻、呕吐及食欲不振的不良反应，30％严重者造成脱水及电解质紊乱等表现。长期反复使用者出现严重的出血性胃肠炎或吸收不良综合征。
以上所述仅为本发明的较佳实施例，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (6)
1.一种抗痛风的复方药物，其特征在于，包括如下重量份数的原料药：秦皮4-6份、附子5-10份、枸杞10-15份、石菖蒲8-14份、穿山甲9-18份、当归7-14份、九香虫3-8份、海风藤8-12份、秋水仙碱5-8份、丙磺舒3-8份。
2.根据权利要求1所述的抗痛风的复方药物，其特征在于，包括如下重量份数的原料药：秦皮5份、附子8份、枸杞12份、石菖蒲11份、穿山甲13份、当归10份、九香虫6份、海风藤10份、秋水仙碱6份、丙磺舒6份。
3.如权利要求1或2任一项所述的复方药物的制备方法，步骤如下：
S1：分别按权利要求1或2的配比称取秦皮、附子、枸杞、石菖份、穿山甲、当归、九香虫、海风藤，加水浸泡12h，煎煮两次，第一次加8倍量水，煎煮2h，第二次加6倍量水，煎煮1h，合并煎煮液，滤过，滤液浓缩至相对密度为1.1(80℃)，冷却后，加4倍量的90％乙醇，搅拌，静置24h，取上清液浓缩至相对密度1.1-1.2(80℃)，真空干燥，粉碎，得到细粉I；
S2：按权利要求1或2的配比称取秋水仙碱和丙磺舒，分别干燥、粉碎，得到细粉Ⅱ；
S3：将细粉I和细粉Ⅱ混合，加入药学可接受的辅料按药学常规制药方法制备成复方药物。
4.根据权利要求3所述的制备方法，其特征在于，所述复方药物为口服制剂。
5.根据权利要求4所述的制备方法，其特征在于，所述口服制剂的剂型为丸剂、胶囊剂、片剂或颗粒剂。
6.根据权利要求5所述的制备方法，其特征在于，所述口服制剂的剂型为丸剂。
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