CN107714846A - 一种含生物活性玻璃的口腔溃疡贴及制备方法 - Google Patents

一种含生物活性玻璃的口腔溃疡贴及制备方法 Download PDF

Info

Publication number
CN107714846A
CN107714846A CN201710968190.XA CN201710968190A CN107714846A CN 107714846 A CN107714846 A CN 107714846A CN 201710968190 A CN201710968190 A CN 201710968190A CN 107714846 A CN107714846 A CN 107714846A
Authority
CN
China
Prior art keywords
bioactivity glass
canker sore
sodium
paeonol
matched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710968190.XA
Other languages
English (en)
Inventor
张劲松
朱礼飞
李保芝
张宇辰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhangjiagang Blue Zhi Biological Technology Co Ltd
Original Assignee
Zhangjiagang Blue Zhi Biological Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhangjiagang Blue Zhi Biological Technology Co Ltd filed Critical Zhangjiagang Blue Zhi Biological Technology Co Ltd
Priority to CN201710968190.XA priority Critical patent/CN107714846A/zh
Publication of CN107714846A publication Critical patent/CN107714846A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Insects & Arthropods (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及一种含生物活性玻璃的口腔溃疡贴及制备方法，由下述重量份的原料制成的：羧甲基淀粉钠1‑12g、生物活性玻璃10‑30g、薁磺酸钠0.5‑2 g、丹皮酚0.05‑2 g、聚乙烯醇68‑90g；制备时，先将配比好的羧甲基淀粉钠和聚乙烯醇混合好后投入加热的蒸馏水中，并加热溶解，趁热过滤；冷却后再在溶液中加入配比好的薁磺酸钠和丹皮酚，搅拌均匀后再投入配比好的生物活性玻璃，混匀，脱气泡，干燥。本发明有效隔绝水分、尘垢及细菌，保护伤口免受感染，且抗菌并加速伤口愈合。

Description

一种含生物活性玻璃的口腔溃疡贴及制备方法
技术领域
本发明属于医用材料技术利用领域，尤其涉及一种含生物活性玻璃的口腔溃疡贴及制备方法。
背景技术
口腔溃疡又称口疮，多发于舌、唇、齿龈部位，可成圆形、椭圆形的浅溃疡，是一种常见多发病。该病影响饮水，进食，说话，痛苦非常。口腔溃疡在中医学中属心火范畴，引起该病的原因主要是心火过重。心火炽盛型口腔溃疡的症状表现为：除有口腔溃疡外，伴见舌体糜烂疼痛，心烦失眠，口渴，尿黄便秘，舌尖赤，苔黄，脉数。轻到中度的口腔溃疡给人们日常生活带来不适，严重的口腔溃疡会影响人们的进食，同时口腔溃疡具有发病率高，治愈后易于复发的特点，严重影响着人们的正常生活。
目前治疗口腔溃疡的药物主要有：免疫促进剂和激素类药物。这类药物在国外应用较广，可以有效的治疗某些深大、久治不愈的溃疡，并能有效抑制溃疡复发长达3-6个月。但是，激素类药物长期应用会产生某些严重不良副作用；免疫促进剂例如转移因子、胸腺肽等药物，虽然能降低溃疡的复发率，但长期使用上述药物容易产生药物耐药性，降低治疗效果。至今为止，对于口腔溃疡疾病尚未有安全有效的治疗药物，因此开发新型、疗效高的治疗口腔溃疡药物是目前亟需解决的难题。
其中，薁磺酸钠的化学名称为1,4-二甲基-7-异丙基甘菊环-3-磺酸钠，化学通式为C15H17NAO3S.1/2H2O。它具有抗菌、抗过敏及组织再生功能（促进肉芽生长）等作用，而且安全性高，特别是对皮肤及口腔疾病的治疗和预防，效果显著。加入薁磺酸钠的口腔溃疡贴主要用于治疗咽炎、扁桃体炎、口腔创伤等症的治疗，对常见的牙龈红肿出血、牙龈炎、牙菌斑、口腔溃疡等都有很好的预防和治疗效果。
丹皮酚具有镇痛、抗炎、解热和抑制变态反应的作用。对压尾、醋酸等物理或化学因素 所致的疼痛具有明显的镇痛作用。对由角叉菜胶、蛋清、甲醛、组胺、5-羟色胺、缓激肽、二甲苯及内毒素等所致的炎症反应，具有明显的抑制作用。对伤寒菌苗、三联疫苗等引起的体温升高，具有明显的解热作用。对II、III、IV型变态反应均具有抑制作用。
中国发明专利ZL201310099318.5公开了一种治疗口腔溃疡的缓释贴膜,它主要公开了该缓释贴膜的的结构,它具有三层结构，上层为与口腔溃疡面接触的缓释涂层；下层为具有保护作用的聚丙烯酸薄膜；中层为载药层由细菌纤维素/载药物质复合膜组成。该发明仅仅公开了相关的结构特征,对于药物本身并没有较多的公开,难以对溃疡面形成好的治疗效果。
发明内容
本发明针对以上不足，提供了一种含生物活性玻璃的口腔溃疡贴及制备方法，该口腔溃疡贴粘覆于溃疡面，功能性核心材料与溃疡创面产生一系列反应，迅速止疼，长效抑菌，促进口腔溃疡愈合。
本发明所采用的技术方案是：
一种含生物活性玻璃的的口腔溃疡贴，由下述重量份的原料制成的：羧甲基淀粉钠1-12g、生物活性玻璃10-30g、薁磺酸钠0.1-2g、丹皮酚0.01-2g、中草药提取物，聚乙烯醇68-90g。
作为优选的，所述的聚乙烯醇和羧甲基淀粉钠作为成膜材料，生物活性玻璃和薁磺酸钠、丹皮酚、中草药提取物为必须成分。且其中生物活性玻璃：薁磺酸钠：丹皮酚的克重比例为20:10:1或15:5:1为最优选择。
中草药提取物主要是其中一种或是二种以上的组合物，包括：五倍子，异叶花椒根，白屈菜，银杏白果，银杏叶，桑叶，芍药，厚朴，全柿果实，葡萄籽，毛冬青，唇香草。具体的抗菌性能可以参考提供的论文。
作为优选的，所述的生物玻璃陶瓷中含氧化钙≥3%、60%≥二氧化硅≥10%。这个部分还需要具体的细化到粒径（≤10-90um）和透光性参数（透光率45-99%）。
一种含生物活性玻璃的口腔溃疡贴制备方法：先将配比好的羧甲基淀粉钠和聚乙烯醇混合好后投入加热的蒸馏水中，并加热溶解，趁热过滤；冷却后再在溶液中加入配比好的薁磺酸钠和丹皮酚，搅拌均匀后再投入配比好的生物活性玻璃，混匀，脱气泡，干燥。
本发明的有益效果是：
1、将口腔溃疡的消炎和愈合同步达到，快速达到消肿、止疼的作用；
2、含植物性的消炎成分，降低对口腔黏膜刺激；
3、贴服时间长，溶解彻底，全面解决口腔溃疡的并发症；
4、含人体所需矿物质，减少口腔溃疡的发生次数。
具体实施方式：
实施例一，一种含生物活性玻璃的的口腔溃疡贴，由下述重量份的原料制成的：羧甲基淀粉钠1-12g、生物活性玻璃10-30g、薁磺酸钠0.5-2 g、丹皮酚0.05-2 g、聚乙烯醇68-90g；聚乙烯醇和羧甲基淀粉钠作为成膜材料，生物活性玻璃和薁磺酸钠、丹皮酚为主要功能成分。生物玻璃陶瓷中含氧化钙≥3%、60%≥二氧化硅≥10%。
一种含生物活性玻璃的口腔溃疡贴制备方法：先将配比好的羧甲基淀粉钠和聚乙烯醇混合好后投入加热的蒸馏水中，并加热溶解，趁热过滤；冷却后再在溶液中加入配比好的薁磺酸钠和丹皮酚，搅拌均匀后再投入配比好的生物活性玻璃，混匀，脱气泡，干燥。
以上所述，仅为本发明的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本领域的技术人员在本发明所揭露的技术范围内，可轻易想到的变化或替换，都应涵盖在本发明的保护范围之内。因此，本发明的保护范围应该以权利要求书所限定的保护范围为准。

Claims (4)

1.一种含生物活性玻璃的的口腔溃疡贴，其特征在于：由下述重量份的原料制成的：羧甲基淀粉钠1-12g、生物活性玻璃10-30g、薁磺酸钠0.5-2g、丹皮酚0.05-2g、聚乙烯醇68-90g。
2.根据权利要求1所述的一种含生物活性玻璃的的口腔溃疡贴，其特征在于：聚乙烯醇和羧甲基淀粉钠作为成膜材料，生物活性玻璃和薁磺酸钠、丹皮酚为主要功能成分。
3.根据权利要求1所述的一种含生物活性玻璃的的口腔溃疡贴，其特征在于：生物玻璃陶瓷中含氧化钙≥3%、60%≥二氧化硅≥10%。
4.一种含生物活性玻璃的的口腔溃疡贴制备方法，其特征在于：先将配比好的羧甲基淀粉钠和聚乙烯醇混合好后投入加热的蒸馏水中，并加热溶解，趁热过滤；冷却后再在溶液中加入配比好的薁磺酸钠和丹皮酚，搅拌均匀后再投入配比好的生物活性玻璃，混匀，脱气泡，干燥。
CN201710968190.XA 2017-10-18 2017-10-18 一种含生物活性玻璃的口腔溃疡贴及制备方法 Pending CN107714846A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710968190.XA CN107714846A (zh) 2017-10-18 2017-10-18 一种含生物活性玻璃的口腔溃疡贴及制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710968190.XA CN107714846A (zh) 2017-10-18 2017-10-18 一种含生物活性玻璃的口腔溃疡贴及制备方法

Publications (1)

Publication Number Publication Date
CN107714846A true CN107714846A (zh) 2018-02-23

Family

ID=61211618

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710968190.XA Pending CN107714846A (zh) 2017-10-18 2017-10-18 一种含生物活性玻璃的口腔溃疡贴及制备方法

Country Status (1)

Country Link
CN (1) CN107714846A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112807153A (zh) * 2021-01-08 2021-05-18 温州医科大学慈溪生物医药研究院 一种促进创面愈合的生物活性玻璃水胶体敷料

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104644460A (zh) * 2015-03-06 2015-05-27 北京华素制药股份有限公司 一种药物牙膏组合物及其制备方法和用途
CN105213353A (zh) * 2015-10-16 2016-01-06 天津市顶硕科贸有限公司 含有薁磺酸钠的复方口腔膜剂及制备方法
CN106138096A (zh) * 2016-07-28 2016-11-23 山东赛克赛斯药业科技有限公司 一种口腔溃疡贴膜及其制备方法与应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104644460A (zh) * 2015-03-06 2015-05-27 北京华素制药股份有限公司 一种药物牙膏组合物及其制备方法和用途
CN105213353A (zh) * 2015-10-16 2016-01-06 天津市顶硕科贸有限公司 含有薁磺酸钠的复方口腔膜剂及制备方法
CN106138096A (zh) * 2016-07-28 2016-11-23 山东赛克赛斯药业科技有限公司 一种口腔溃疡贴膜及其制备方法与应用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112807153A (zh) * 2021-01-08 2021-05-18 温州医科大学慈溪生物医药研究院 一种促进创面愈合的生物活性玻璃水胶体敷料

Similar Documents

Publication Publication Date Title
CN105816908B (zh) 一种防水型液体创口保护膜及其制备方法
CN1927160A (zh) 漱口液及制备方法
CN100536881C (zh) 治疗痔类肛肠疾病的凝胶剂及制备方法
CN107714846A (zh) 一种含生物活性玻璃的口腔溃疡贴及制备方法
CN103169768B (zh) 治疗鼻息肉的中药粉剂
CN105168500B (zh) 一种用于治疗小儿口腔溃疡的药物组合物及其制备方法
CN105616679A (zh) 一种养血安神中药制剂及其制备方法
CN101461832A (zh) 治疗口腔溃疡的生物粘附贴片
CN110151786A (zh) 纳米碳颗粒在制备治疗口腔溃疡的药物中的应用及该药物
CN105169290A (zh) 一种治疗原发性三叉神经痛的中药组合物及其用途
CN101744871B (zh) 一种治疗牙疼的蜂胶中药制剂及其制备方法
CN100596280C (zh) 口腔溃疡贴膜及其制备方法
CN102440912A (zh) 一种具有消炎止血功能的口腔清洁泡腾片及其制备方法
CN100355437C (zh) 一种治疗烧烫伤的药物及其制备方法
CN101564418B (zh) 一种治疗口腔溃疡的药物组合物
CN104306764B (zh) 一种用于治鼻炎的中药复方喷剂
CN106551979A (zh) 一种口腔溃疡贴膜及其制备方法
CN108421018A (zh) 一种祛疮中药组合物、祛疮膏及其制备方法
CN101862392B (zh) 鱼腥草防治血栓的新制药用途
CN111437343B (zh) 一种消炎止痛组合物和花红消炎止痛液及其制备方法
CN100591335C (zh) 预防和快速解救心绞痛的人工麝香口崩片制剂及制备方法
CN115300554B (zh) 一种活血通络的中药制剂及其制备方法
CN106798916A (zh) 一种治疗hpv感染的组合物及其应用
CN105250774A (zh) 一种治疗慢性流行性感冒的中药组合物
CN111329881A (zh) 一种口腔溃疡贴膜及其制备方法和应用

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20180223

RJ01 Rejection of invention patent application after publication