CN107714845A - A kind of pharmaceutical composition and its preparation and purposes - Google Patents
A kind of pharmaceutical composition and its preparation and purposes Download PDFInfo
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- CN107714845A CN107714845A CN201711240662.6A CN201711240662A CN107714845A CN 107714845 A CN107714845 A CN 107714845A CN 201711240662 A CN201711240662 A CN 201711240662A CN 107714845 A CN107714845 A CN 107714845A
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention belongs to biomedicine technical field, and in particular to a kind of pharmaceutical composition and its preparation and purposes, pharmaceutical composition of the present invention are prepared by following raw materials：Cloves, kuh-seng, saussurea involucrata, Chinese violet；Using cloves and kuh-seng as monarch drug in a prescription in the pharmaceutical composition, using saussurea involucrata, Chinese violet as ministerial drug, help with safflower, peppermint, borneol, for treating the treatment of the infectious diseases such as gynaecology bacterium, virus, trichomonad；The present invention is on the basis of clinical research for many years, is obtained with reference to screening test, and pharmaceutical research shows, the present invention has good pharmacological action.
Description
Technical field
The invention belongs to biomedicine technical field, and in particular to a kind of pharmaceutical composition and its preparation and purposes.
Background technology
The disease of female reproductive system is gynecological disease, including vulva disease, vaginal disease, uterine disease, fallopian tubal
Disease, disease of ovary etc..Gynecological disease is women common disease, frequently-occurring disease.But because many people are due to gynecological disease shortage
Understanding, lacks the health care to body, various bad life habits etc., make physiological health go from bad to worse in addition, cause some women
It is eaten up with illness, and obstinate, bring great inconvenience to normal life, work.Common gynecological disease has：Dysmenorrhoea, the moon
Through uncomfortable, urethritis, cervicitis, mastitis, vesicular mole, uterine cancer, cervical carcinoma, vaginitis, fibroid etc..
Cassia leguminous plant kuh-seng has been widely used in East Asia Region as Chinese tradition Chinese medicine and feature food materials
The history kuh-seng histories for having thousands of years are loaded in《Sheng Nong's herbal classic》, also known as foxtail-like sophora root, matrine, sweetclover-like milkvetch herb, matrine, matrine etc.,
Shanxi, Shaanxi, Hubei and Henan kuh-seng heat-clearing and damp-drying drugs are distributed mainly on, desinsection, diuresis, for hot dysentery, is had blood in stool, jaundice renal shutdown,
Leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, mange leprosy；Control trichomonas vaginitis outside.Containing abundant in kuh-seng
Physiological activator, such as matrine, oxymatrine, flavanone, kuh-seng saponin(e, amino acid, aliphatic acid, and have
Diversified pharmacological activity numerous studies show：Main active alkaloid and flavone compound are present anti-in kuh-seng
Bacterium, anti-inflammatory, it is antitumor, antiviral, suppress the extensive physiologically actives such as nervous centralis, regulation be immune, and there is low side effect
And the features such as efficient, cause the extensive concern and interest of domestic and international researcher；Kuh-seng and its active ingredient Banlangen are because of it
Feature and effect, clinically it is mainly used in treating various vaginitis in the treatment of gynecological disease, such as trichomonas vaginitis and mould
Bacterium property vagina infection etc.；And the inferior female chronic inflammation of cervical erosion, red leukorrhea.Its other pharmacological activity, such as antifertility
All very significants such as activity, anti HIV-1 virus effect, antitumor action and regulation immunity of organism effect.
Therefore, it is necessary to more adding system, deep clinical research are carried out to it, and to more effectively utilize kuh-seng, developing
New advantage of the Chinese medicine in gynecopathy therapeutic.
The content of the invention
For these reasons, applicant passes through clinical research for many years, is studied with reference to modern medicine, obtains a kind of new medicine
Composition, using cloves and kuh-seng as monarch drug in a prescription in the pharmaceutical composition, using saussurea involucrata, Chinese violet as ministerial drug, help with safflower, thin
Lotus, borneol, for treating the treatment of the infectious diseases such as gynaecology bacterium, virus, trichomonad；The present invention is the base in clinical research for many years
On plinth, with reference to screening test, acquisition, pharmaceutical research shows, the present invention has good pharmacological action.
This product using saussurea involucrata, Chinese violet as ministerial drug, then is helped with safflower, peppermint, borneol using cloves and kuh-seng as monarch drug in a prescription.
Cloves resuscitation with aromatics, modern pharmacology prove that the Main Ingredients and Appearance caryophyllus oil contained by it is to staphylococcus, streptococcus, colibacillus etc.
Various bacteria has inhibitory action.Kuh-seng heat-clearing bath is wet, and desinsection is antipruritic, is that TCM Gynecology often uses externally applied drug.Saussurea involucrata energy dispelling cold and removing dampness,
Promote human body discharge endotoxin effect.Chinese violet assists kuh-seng dampness removing desinsection.Along with safflower is invigorated blood circulation, strengthen skin toxin expelling
Function, book lotus, borneol are refrigerant to have one's ideas straightened out, fungi-proofing sterilization, and a few taste medicine phases need to mutually make, and preparation is made, can effectively treat gynaecology because bacterium,
The disease that the infection such as virus, trichomonad trigger.
What the present invention was achieved through the following technical solutions.
A kind of pharmaceutical composition, pharmaceutical composition contain：Cloves, kuh-seng, saussurea involucrata, Chinese violet.Wherein cloves and kuh-seng
For monarch drug in a prescription, saussurea involucrata, Chinese violet are ministerial drug.
Further, described pharmaceutical composition contains：Cloves, kuh-seng, saussurea involucrata, Chinese violet, safflower, peppermint, borneol.Its
Middle cloves and kuh-seng are monarch drug in a prescription, and saussurea involucrata, Chinese violet are ministerial drug, and safflower, peppermint, borneol are adjutant.
Preferable pharmaceutical composition, wherein cloves 3-6 parts by weight, kuh-seng 85-105 parts by weight, saussurea involucrata 3.0-5.5 weight
Part, Chinese violet 3.0-5.5 parts by weight.Wherein cloves and kuh-seng are monarch drug in a prescription, and saussurea involucrata, Chinese violet are ministerial drug.
Preferable pharmaceutical composition contains：Cloves 3-6 parts by weight, kuh-seng 85-105 parts by weight, saussurea involucrata 3.0-5.5 weight
Part, Chinese violet 3.0-5.5 parts by weight, safflower 3.0-6.0 parts by weight, peppermint 3.5-5.5 parts by weight, borneol 3.5-5.5 weights
Measure part.Wherein cloves and kuh-seng are monarch drug in a prescription, and saussurea involucrata, Chinese violet are ministerial drug, and safflower, peppermint, borneol are adjutant.
It is one or more of that pharmaceutical composition described above contains following raw materials：Tea oil, Seabuckthorm Seed Oil, rare earth, vitamin,
The bletilla striata, frutus cnidii, Asian puccoon, honeysuckle, the bark of ash, Radix Isatidis, golden cypress, purslane, the coptis, Golden Larch Bark, pericarpium zanthoxyli, folium isatidis, giant knotweed,
Commeline communis, Chinese prickly ash, dark plum, pearl, folium artemisiae argyi, motherwort, dandelion, sweet wormwood.Above-mentioned flavour of a drug are to make medicine.
It is one or more of that pharmaceutical composition described above contains following raw materials：Tea oil 4-6 parts by weight, Seabuckthorm Seed Oil 3-
5.5 parts by weight, rare earth 3-5.2 parts by weight, vitamin 3-5.2 parts by weight, bletilla striata 4.5-5.5 parts by weight, frutus cnidii 4.5-5.5 weights
Measure part, Asian puccoon 3.0-5.2 parts by weight, honeysuckle 3.0-5.2 parts by weight, bark of ash 3.0-5.2 parts by weight, Radix Isatidis 3.0-5.2 weights
Measure part, golden cypress 3.0-5.2 parts by weight, purslane 3.0-5.2 parts by weight, coptis 3.0-5.2 parts by weight, Golden Larch Bark 3.0-5.2 weights
Measure part, pericarpium zanthoxyli 3.0-5.2 parts by weight, folium isatidis 3.0-5.2 parts by weight, giant knotweed 3.0-5.2 parts by weight, Commeline communis 3.0-5.2 weights
Measure part, Chinese prickly ash 3.0-5.2 parts by weight, dark plum 3.0-5.2 parts by weight, pearl 5.0-8.0 parts by weight, folium artemisiae argyi 3.8-5.5 parts by weight,
Motherwort 3.5-6.5 parts by weight, dandelion 5.6-7.3 parts by weight, sweet wormwood 3.0-6.0 parts by weight.Above-mentioned flavour of a drug are to make medicine.
Pharmaceutical composition of the present invention, it can be prepared by following raw materials：Cloves 3-6 parts by weight, kuh-seng 85-105 weights
Measure part, saussurea involucrata 3.0-5.5 parts by weight, Chinese violet 3.0-5.5 parts by weight, safflower 3.0-6.0 parts by weight, peppermint 3.5-5.5
Parts by weight, borneol 3.5-5.5 parts by weight, tea oil 4-6 parts by weight, Seabuckthorm Seed Oil 3-5.5 parts by weight, rare earth 3-5.2 parts by weight,
Vitamin 3-5.2 parts by weight, bletilla striata 4.5-5.5 parts by weight, frutus cnidii 4.5-5.5 parts by weight, Asian puccoon 3.0-5.2 parts by weight, gold
Honeysuckle flower 3.0-5.2 parts by weight, bark of ash 3.0-5.2 parts by weight, Radix Isatidis 3.0-5.2 parts by weight, golden cypress 3.0-5.2 parts by weight, horse
Bitterroot 3.0-5.2 parts by weight, coptis 3.0-5.2 parts by weight, Golden Larch Bark 3.0-5.2 parts by weight, pericarpium zanthoxyli 3.0-5.2 parts by weight, greatly
Leafiness 3.0-5.2 parts by weight, giant knotweed 3.0-5.2 parts by weight, Commeline communis 3.0-5.2 parts by weight, Chinese prickly ash 3.0-5.2 parts by weight, crow
Plum 3.0-5.2 parts by weight, pearl 5.0-8.0 parts by weight, folium artemisiae argyi 3.8-5.5 parts by weight, motherwort 3.5-6.5 parts by weight, Pu Gong
English 5.6-7.3 parts by weight, sweet wormwood 3.0-6.0 parts by weight.The prescription is 32 taste Chinese medicines, for gynecological lotion.Wherein cloves and hardship
It is ministerial drug to join as monarch drug in a prescription, saussurea involucrata, Chinese violet, and safflower, peppermint, borneol are adjutant, and remaining flavour of a drug is to make medicine.
Application of the described pharmaceutical composition in antibacterial, anti-trichomonal, antiviral drugs is prepared.
Described pharmaceutical composition is preparing the application in suppressing tumour (cancer) medicine.
The pharmaceutical preparation that described pharmaceutical composition is prepared into.
Vitamin of the present invention is：Vitamin also known as vitamin, for popular, that is, the material that sustains life, it is dimension
The necessary a kind of organic substance of human life activity is held, is also to maintain the important active substances of health.It is of the present invention
Vitamin includes vitamin A, B, C, D, E etc..
In pharmaceutical composition described above, using cloves and kuh-seng as side in monarch drug in a prescription, using saussurea involucrata, Chinese violet as ministerial drug, with
Safflower, peppermint, borneol adjutant, for the disease such as gynaecology's bacterium infection, viral infection, trichomonas infection, antitumor.According to clinic
Symptom, it can select to add following one or more of flavour of a drug, to use medicine：It is tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, white
Splendid achnatherum, frutus cnidii, Asian puccoon, honeysuckle, the bark of ash, Radix Isatidis, golden cypress, purslane, the coptis, Golden Larch Bark, pericarpium zanthoxyli, folium isatidis, giant knotweed, duck
Open up grass, Chinese prickly ash, dark plum, pearl, folium artemisiae argyi, motherwort, dandelion, sweet wormwood.
Embodiment
Technical scheme, but protection scope of the present invention not limited to this are illustrated with specific embodiment below.
Content described in this specification embodiment is only enumerating to the way of realization of inventive concept, protection of the invention
Scope is not construed as being only limitted to the concrete form that embodiment is stated, protection scope of the present invention is also and in art technology
Personnel according to present inventive concept it is conceivable that equivalent technologies mean.Although embodiment of the invention below is retouched
State, but the invention is not limited in above-mentioned specific embodiments and applications field, following specific embodiments are only to show
It is meaning property, guiding rather than restricted.One of ordinary skill in the art is under the enlightenment of this specification and is not taking off
In the case of the scope protected from the claims in the present invention, the form of many kinds can also be made, these belong to the present invention
The row of protection.
The following experiments of the present invention, it is on the basis of multiple creative experiment, with the claimed technical scheme of the present invention
Based on, the conclusive experiment of the research staff of summary.
Test 1 screening test I
Test 1 group：Kuh-seng 95g；
Preparation method：Kuh-seng is taken, is crushed, it is 60% ethanol solution 1000ml to add concentration, is decocted 2.5 hours, filtering, filtrate
Standby, it is 55% ethanol solution 800ml to take residue to add concentration, is decocted 1.5 hours, and filtering, filtrate is standby, and merging is filtered twice
Liquid, stand, filtering, filtrate, concentrate, dry, obtain extract sample；
Test 2 groups：Cloves 4.5g, kuh-seng 95g；
Preparation method：Cloves, kuh-seng is taken to crush, it is 60% ethanol solution 1000ml to add concentration, is decocted 3 hours, is filtered, filter
Liquid is standby, and it is 55% ethanol solution 800ml to take residue to add concentration, decocts 1.5 hours, filtering, merges filtrate twice, stands,
Filtering, filtrate are concentrated and dried, and obtain extract sample；
Test 3 groups：Cloves 4.5g, kuh-seng 95g, saussurea involucrata 4.5g, Chinese violet 4g；
Preparation method：Cloves, kuh-seng, saussurea involucrata, Chinese violet is taken to crush, it is 60% ethanol solution 1000ml to add concentration, is decocted
Boil 3 hours, filter, filtrate is standby, and it is 55% ethanol solution 800ml to take residue to add concentration, decocts 1.5 hours, filters, merges
Filtrate twice, stand, filtering, filtrate is concentrated and dried, and obtains extract sample；
Test 4 groups：Cloves 4.5g, kuh-seng 95g, saussurea involucrata 4.5g, Chinese violet 4g, safflower 5g, peppermint 4.2g, borneol
4.2g。
Preparation method：Cloves, kuh-seng, saussurea involucrata, Chinese violet, safflower is taken to crush, addition concentration is 60% ethanol solution
1000ml, decoct 3 hours, filtering, filtrate is standby, and it is 55% ethanol solution 800ml to take residue to add concentration, adds peppermint, decocts
Boil 1.5 hours, filter, merge filtrate twice, add borneol, dissolving is complete, stands, and filtering, filtrate is concentrated and dried, and is extracted
Thing, closed preservation, obtains sample；
Test 5 groups：Cloves 4.5g, kuh-seng 95g, saussurea involucrata 4.5g, Chinese violet 4g, safflower 5g, peppermint 4.2g, borneol
4.2g, tea oil 4g；
Preparation method：Cloves, kuh-seng, saussurea involucrata, Chinese violet, safflower is taken to crush, it is 60% ethanol solution to add concentration
1000ml, decoct 3 hours, filtering, filtrate is standby, and it is 55% ethanol solution 800ml to take residue to add concentration, adds peppermint, decocts
Boil 1.5 hours, filter, merge filtrate twice, add borneol, dissolving is complete, stands, and filtering, filtrate is concentrated and dried, and is extracted
Thing, tea oil is added, mixing is complete, closed preservation, obtains sample；
Bacteriostatic test：Medical Colleges of the Inner Mongol's pharmacological evaluation room is entrusted, in the case of dosage identical, is tested, is tried
Test and the results are shown in Table 1：
Antibacterial circle diameter (x ± s, n=6) of the different tests group of table 1 to experimental bacteria
Note：Compared with 1 group of experiment, * * P<0.01, * P<0.05.
Conclusion (of pressure testing)：(1) Chinese medicine flavour of a drug are not to be simply superimposed, by above-mentioned experiment prove monarch drug in a prescription cloves of the present invention and
Kuh-seng composition, with good bacteriostasis (compared with kuh-seng group P<0.05)；(2) kuh-seng and cloves be as monarch drug in a prescription,
It is aided with ministerial drug, or after being aided with ministerial drug, adjutant, making medicine, fungistatic effect is significantly improved (with pole significance difference compared with kuh-seng group
It is different)；(3) there is science by pharmacological testing, preliminary proof Chinese traditional medicine composition of the present invention.
Test the influence of 2 pairs of herpesvirals
Test 1 group：Cloves 4.5g, kuh-seng 95g, saussurea involucrata 4.5g, Chinese violet 4g, safflower 5g, peppermint 4.2g, borneol
4.2g, tea oil 4g；
Preparation method：Cloves, kuh-seng, saussurea involucrata, Chinese violet, safflower is taken to crush, it is 60% ethanol solution to add concentration
1000ml, decoct 3 hours, filtering, filtrate is standby, and it is 55% ethanol solution 800ml to take residue to add concentration, adds peppermint, decocts
Boil 1.5 hours, filter, merge filtrate twice, add borneol, dissolving is complete, stands, and filtering, filtrate is concentrated and dried, and is extracted
Thing, oil is added, mixing is complete, closed preservation, obtains sample；
Test 2 groups：Cloves 4.5g, kuh-seng 95g, saussurea involucrata 4.5g, Chinese violet 4g, safflower 5g, peppermint 4.2g, borneol
4.2g, tea oil 4g, bletilla striata 5g；
Preparation method：Take cloves, kuh-seng, saussurea involucrata, Chinese violet, safflower, the bletilla striata to crush, add concentration molten for 60% ethanol
Liquid 1000ml, decocting 3 hours, filtering, filtrate is standby, and it is 55% ethanol solution 800ml to take residue to add concentration, adds peppermint,
Decoct 1.5 hours, filtering, merge filtrate twice, add borneol, dissolving is complete, stands, and filtering, filtrate is concentrated and dried, and is carried
Thing is taken, adds tea oil, mixing is complete, closed preservation, obtains sample；
Test 3 groups：Cloves 4.5g, kuh-seng 95g, saussurea involucrata 4.5g, Chinese violet 4g, safflower 5g, peppermint 4.2g, borneol
4.2g, tea oil 4g, bletilla striata 5g, Seabuckthorm Seed Oil 4g, rare earth 4.2g, vitamin 4.2g, frutus cnidii 5g, Asian puccoon 4.2g, honeysuckle
It is 4.2g, bark of ash 4.2g, Radix Isatidis 4.2g, golden cypress 4.2g, purslane 4.2g, coptis 4.2g, Golden Larch Bark 4.2g, pericarpium zanthoxyli 4.2g, big
Leafiness 4.2g, giant knotweed 4.2g, Commeline communis 4.2g, Chinese prickly ash 4.2g, dark plum 4.2g, pearl 6.5g, folium artemisiae argyi 4.4g, motherwort 5g, Pu
Public English 6.2g, sweet wormwood 4.5g.
Preparation method：Except peppermint, borneol, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, pearl, remaining Chinese medicine flavour of a drug is taken
Crush, it is 60% ethanol solution 2000ml to add concentration, is decocted 3 hours, and filtering, filtrate is standby, and it is 55% to take residue to add concentration
Ethanol solution 1500ml, peppermint being added, decocted 1.5 hours, filtering, merge filtrate twice, add borneol, dissolving is complete, stands,
Filtering, filtrate are concentrated and dried, and obtain extract, add tea oil, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, the treasure crushed
Pearl powder, mixing is complete, closed preservation, obtains sample；
Test method：Medical Colleges of the Inner Mongol's pharmacological evaluation room is entrusted, in the case of dosage identical, is tested, with
Mtt assay detects viral suppression, and result of the test is shown in Table 2：
The inhibitory action that table 2 is bred to herpesviral
Conclusion (of pressure testing)：Above-mentioned experiment shows, the present invention is using cloves and kuh-seng as monarch drug in a prescription, after being aided with ministerial drug, adjutant, making medicine,
There is good anti-herpesvirus.
Test the effect of 3 anti-verruca acuminatas
Test 1 group：Cloves 4.5g, kuh-seng 95g, saussurea involucrata 4.5g, Chinese violet 4g, safflower 5g, peppermint 4.2g, borneol
4.2g, tea oil 4g；
Preparation method：Cloves, kuh-seng, saussurea involucrata, Chinese violet, safflower is taken to crush, it is 60% ethanol solution to add concentration
1000ml, decoct 3 hours, filtering, filtrate is standby, and it is 55% ethanol solution 800ml to take residue to add concentration, adds peppermint, decocts
Boil 1.5 hours, filter, merge filtrate twice, add borneol, dissolving is complete, stands, and filtering, filtrate is concentrated and dried, and is extracted
Thing, oil is added, mixing is complete, closed preservation, obtains sample；
Test 2 groups：Cloves 4.5g, kuh-seng 95g, saussurea involucrata 4.5g, Chinese violet 4g, safflower 5g, peppermint 4.2g, borneol
4.2g, tea oil 4g, bletilla striata 5g；
Preparation method：Take cloves, kuh-seng, saussurea involucrata, Chinese violet, safflower, the bletilla striata to crush, add concentration molten for 60% ethanol
Liquid 1000ml, decocting 3 hours, filtering, filtrate is standby, and it is 1.5% ethanol solution 800ml to take residue to add concentration, adds peppermint,
Decoct 1.5 hours, filtering, merge filtrate twice, add borneol, dissolving is complete, stands, and filtering, filtrate is concentrated and dried, and is carried
Thing is taken, adds tea oil, mixing is complete, closed preservation, obtains sample；
Test 3 groups：Cloves 4.5g, kuh-seng 95g, saussurea involucrata 4.5g, Chinese violet 4g, safflower 5g, peppermint 4.2g, borneol
4.2g, tea oil 4g, bletilla striata 5g, Seabuckthorm Seed Oil 4g, rare earth 4.2g, vitamin 4.2g, frutus cnidii 5g, Asian puccoon 4.2g, honeysuckle
It is 4.2g, bark of ash 4.2g, Radix Isatidis 4.2g, golden cypress 4.2g, purslane 4.2g, coptis 4.2g, Golden Larch Bark 4.2g, pericarpium zanthoxyli 4.2g, big
Leafiness 4.2g, giant knotweed 4.2g, Commeline communis 4.2g, Chinese prickly ash 4.2g, dark plum 4.2g, pearl 6.5g, folium artemisiae argyi 4.4g, motherwort 5g, Pu
Public English 6.2g, sweet wormwood 4.5g.
Preparation method：Except peppermint, borneol, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, pearl, remaining Chinese medicine flavour of a drug is taken
Crush, it is 60% ethanol solution 2000ml to add concentration, is decocted 3 hours, and filtering, filtrate is standby, and it is 55% to take residue to add concentration
Ethanol solution 1500ml, peppermint being added, decocted 1.5 hours, filtering, merge filtrate twice, add borneol, dissolving is complete, stands,
Filtering, filtrate are concentrated and dried, and obtain extract, add tea oil, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, the treasure crushed
Pearl powder, mixing is complete, closed preservation, obtains sample；
Test method：Medical Colleges of the Inner Mongol's pharmacological evaluation room is entrusted, in the case of dosage identical, is tested, adopted
With content viral in every group of each sample of FQ-PCR technology for detection, result of the test is shown in Table 3：
Table 3 is to wart body function influence
| Group | Group number | Viral level average value |
| Physiological saline group | 20 | 504.33±5.94 |
| Test 1 group | 20 | 6.74±0.77*** |
| Test 2 groups | 20 | 5.42±1.03*** |
| Test 3 groups | 20 | 2.71±0.44*** |
Note：The * * * P compared with physiological saline group<0.001.
Conclusion (of pressure testing)：Above-mentioned experiment shows, the present invention is using cloves and kuh-seng as monarch drug in a prescription, after being aided with ministerial drug, adjutant, making medicine,
Have the function that antiviral well.
Experiment 4
Anti- Trichomonas vaginalis effect
Test group：Cloves 4.5g, kuh-seng 95g, saussurea involucrata 4.5g, Chinese violet 4g, safflower 5g, peppermint 4.2g, borneol
4.2g, tea oil 4g, bletilla striata 5g, Seabuckthorm Seed Oil 4g, rare earth 4.2g, vitamin 4.2g, frutus cnidii 5g, Asian puccoon 4.2g, honeysuckle
It is 4.2g, bark of ash 4.2g, Radix Isatidis 4.2g, golden cypress 4.2g, purslane 4.2g, coptis 4.2g, Golden Larch Bark 4.2g, pericarpium zanthoxyli 4.2g, big
Leafiness 4.2g, giant knotweed 4.2g, Commeline communis 4.2g, Chinese prickly ash 4.2g, dark plum 4.2g, pearl 6.5g, folium artemisiae argyi 4.4g, motherwort 5g, Pu
Public English 6.2g, sweet wormwood 4.5g.
Preparation method：Except peppermint, borneol, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, pearl, remaining Chinese medicine flavour of a drug is taken
Crush, it is 60% ethanol solution 2000ml to add concentration, is decocted 3 hours, and filtering, filtrate is standby, and it is 55% to take residue to add concentration
Ethanol solution 1500ml, peppermint being added, decocted 1.5 hours, filtering, merge filtrate twice, add borneol, dissolving is complete, stands,
Filtering, filtrate are concentrated and dried, and obtain extract, add tea oil, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, the treasure crushed
Pearl powder, mixing is complete, closed preservation, obtains sample；
Result of the test：Medical Colleges of the Inner Mongol's pharmacological evaluation room is entrusted, the minimum suppression worm concentration to Trichomonas vaginalis is 0.06mg/
Ml, without significant difference compared with metronidazole (2.5mg/ml) effect.
Experiment 5
Anti-AIDS toxic action
Test group：Cloves 4.5g, kuh-seng 95g, saussurea involucrata 4.5g, Chinese violet 4g, safflower 5g, peppermint 4.2g, borneol
4.2g, tea oil 4g, bletilla striata 5g, Seabuckthorm Seed Oil 4g, rare earth 4.2g, vitamin 4.2g, frutus cnidii 5g, Asian puccoon 4.2g, honeysuckle
It is 4.2g, bark of ash 4.2g, Radix Isatidis 4.2g, golden cypress 4.2g, purslane 4.2g, coptis 4.2g, Golden Larch Bark 4.2g, pericarpium zanthoxyli 4.2g, big
Leafiness 4.2g, giant knotweed 4.2g, Commeline communis 4.2g, Chinese prickly ash 4.2g, dark plum 4.2g, pearl 6.5g, folium artemisiae argyi 4.4g, motherwort 5g, Pu
Public English 6.2g, sweet wormwood 4.5g.
Preparation method：Except peppermint, borneol, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, pearl, remaining Chinese medicine flavour of a drug is taken
Crush, it is 60% ethanol solution 2000ml to add concentration, is decocted 3 hours, and filtering, filtrate is standby, and it is 55% to take residue to add concentration
Ethanol solution 1500ml, peppermint being added, decocted 1.5 hours, filtering, merge filtrate twice, add borneol, dissolving is complete, stands,
Filtering, filtrate are concentrated and dried, and obtain extract, add tea oil, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, the treasure crushed
Pearl powder, mixing is complete, closed preservation, obtains sample；
Result of the test：Medical Colleges of the Inner Mongol's pharmacological evaluation room is entrusted, with 0.06mg/ml test groups to the type (2* of AIDS I
105TCID50/ml) make external inactivation test, show virus all inactivations.
Experiment 6
Antitumor experiment
Test group：Cloves 4.5g, kuh-seng 95g, saussurea involucrata 4.5g, Chinese violet 4g, safflower 5g, peppermint 4.2g, borneol
4.2g, tea oil 4g, bletilla striata 5g, Seabuckthorm Seed Oil 4g, rare earth 4.2g, vitamin 4.2g, frutus cnidii 5g, Asian puccoon 4.2g, honeysuckle
It is 4.2g, bark of ash 4.2g, Radix Isatidis 4.2g, golden cypress 4.2g, purslane 4.2g, coptis 4.2g, Golden Larch Bark 4.2g, pericarpium zanthoxyli 4.2g, big
Leafiness 4.2g, giant knotweed 4.2g, Commeline communis 4.2g, Chinese prickly ash 4.2g, dark plum 4.2g, pearl 6.5g, folium artemisiae argyi 4.4g, motherwort 5g, Pu
Public English 6.2g, sweet wormwood 4.5g.
Preparation method：Except peppermint, borneol, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, pearl, remaining Chinese medicine flavour of a drug is taken
Crush, it is 60% ethanol solution 2000ml to add concentration, is decocted 3 hours, and filtering, filtrate is standby, and it is 55% to take residue to add concentration
Ethanol solution 1500ml, peppermint being added, decocted 1.5 hours, filtering, merge filtrate twice, add borneol, dissolving is complete, stands,
Filtering, filtrate are concentrated and dried, and obtain extract, add tea oil, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, the treasure crushed
Pearl powder, mixing is complete, closed preservation, obtains sample；
Result of the test：Medical Colleges of the Inner Mongol's pharmacological evaluation room is entrusted, 1.24mg/ml concentration tests group medicines have been carried out in vitro
Antitumor experiment, there is inhibitory action to ehrlich ascites cell, show that the present invention also has certain preventing and treating function of tumor.
Test 7 toxicity tests
Test group：Cloves 4.5g, kuh-seng 95g, saussurea involucrata 4.5g, Chinese violet 4g, safflower 5g, peppermint 4.2g, borneol
4.2g, tea oil 4g, bletilla striata 5g, Seabuckthorm Seed Oil 4g, rare earth 4.2g, vitamin 4.2g, frutus cnidii 5g, Asian puccoon 4.2g, honeysuckle
It is 4.2g, bark of ash 4.2g, Radix Isatidis 4.2g, golden cypress 4.2g, purslane 4.2g, coptis 4.2g, Golden Larch Bark 4.2g, pericarpium zanthoxyli 4.2g, big
Leafiness 4.2g, giant knotweed 4.2g, Commeline communis 4.2g, Chinese prickly ash 4.2g, dark plum 4.2g, pearl 6.5g, folium artemisiae argyi 4.4g, motherwort 5g, Pu
Public English 6.2g, sweet wormwood 4.5g.
Preparation method：Except peppermint, borneol, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, pearl, remaining Chinese medicine flavour of a drug is taken
Crush, it is 60% ethanol solution 2000ml to add concentration, is decocted 3 hours, and filtering, filtrate is standby, takes residue to add slag concentration and is
55% ethanol solution 1500ml, peppermint being added, decocted 1.5 hours, filtering, merge filtrate twice, add borneol, dissolving is complete,
Stand, filtering, filtrate is concentrated and dried, and obtains extract, adds tea oil, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, crushing
Pearl powder, mixing is complete, closed preservation, obtains sample；
Result of the test：Medical Colleges of the Inner Mongol's pharmacological evaluation room is entrusted, mouse mouth is given with the trial drug of 9.33mg/ml concentration
Clothes, mouse part skin and rabbit vagina mucous membrane are smeared with 18.66mg/ml concentration, carry out acute toxicity test, excitant and mistake
Quick property Germicidal efficacy, mouse and rabbit behavior, food is as usual, does not find any toxicity, excitant and allergic reaction.
Prepare embodiment
Embodiment 1
Cloves 4.5kg, kuh-seng 95kg, saussurea involucrata 4.5kg, Chinese violet 4kg, safflower 5kg, peppermint 4.2kg, borneol
4.2kg, tea oil 4kg, bletilla striata 5kg, Seabuckthorm Seed Oil 4kg, rare earth 4.2kg, vitamin 4.2kg, frutus cnidii 5kg, Asian puccoon
4.2kg, honeysuckle 4.2kg, bark of ash 4.2kg, Radix Isatidis 4.2kg, golden cypress 4.2kg, purslane 4.2kg, coptis 4.2kg, native chaste tree
Skin 4.2kg, pericarpium zanthoxyli 4.2kg, folium isatidis 4.2kg, giant knotweed 4.2kg, Commeline communis 4.2kg, Chinese prickly ash 4.2kg, dark plum 4.2kg, pearl
6.5kg, folium artemisiae argyi 4.4kg, motherwort 5kg, dandelion 6.2kg, sweet wormwood 4.5kg.
Preparation method：Except peppermint, borneol, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, pearl, remaining Chinese medicine flavour of a drug is taken
Crush, it is 60% ethanol solution 2000L to add concentration, is decocted 3 hours, and filtering, filtrate is standby, and it is 55% second to take residue to add concentration
Alcoholic solution 1500L, peppermint is added, decocted 1.5 hours, filtering, merge filtrate twice, add borneol, dissolving is complete, stands, mistake
Filter, filtrate are concentrated and dried, and obtain extract, add tea oil, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, the pearl crushed
Powder, mixing is complete, closed preservation, obtains raw material, adds raw materials into pharmaceutic adjuvant, is prepared into pharmaceutical preparation, including lotion.
Embodiment 2
Cloves 3kg, kuh-seng 85kg, saussurea involucrata 3.0kg, Chinese violet 3.0kg, safflower 3.0kg, peppermint 3.5kg, borneol
3.5kg, tea oil 4kg, Seabuckthorm Seed Oil 3kg, rare earth 3kg, vitamin 3kg, bletilla striata 4.5kg, frutus cnidii 4.5kg, Asian puccoon
3.0kg, honeysuckle 3.0kg, bark of ash 3.0kg, Radix Isatidis 3.0kg, golden cypress 3.0kg, purslane 3.0kg, coptis 3.0kg, native chaste tree
Skin 3.0kg, pericarpium zanthoxyli 3.0kg, folium isatidis 3.0kg, giant knotweed 3.0kg, Commeline communis 3.0kg, Chinese prickly ash 3.0kg, dark plum 3.0kg, pearl
5.0kg, folium artemisiae argyi 3.8kg, motherwort 3.5kg, dandelion 5.6kg, sweet wormwood 3.0kg.
Preparation method：Except peppermint, borneol, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, pearl, remaining Chinese medicine flavour of a drug is taken
Crush, it is 60% ethanol solution 1850L to add concentration, is decocted 3 hours, and filtering, filtrate is standby, and it is 55% second to take residue to add concentration
Alcoholic solution 1300L, peppermint is added, decocted 1.5 hours, filtering, merge filtrate twice, add borneol, dissolving is complete, stands, mistake
Filter, filtrate are concentrated and dried, and obtain extract, add tea oil, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, the pearl crushed
Powder, mixing is complete, closed preservation, obtains raw material, adds raw materials into pharmaceutic adjuvant, is prepared into pharmaceutical preparation, including lotion.
Embodiment 3
Cloves 6kg, kuh-seng 105kg, saussurea involucrata 5.5kg, Chinese violet 5.5kg, safflower 6kg, peppermint 5.5kg, borneol
5.5kg, tea oil 6kg, Seabuckthorm Seed Oil 5.5kg, rare earth 5.2kg, vitamin 5.2kg, bletilla striata 5.5kg, frutus cnidii 5.5kg are purple
Careless 5.2kg, honeysuckle 5.2kg, bark of ash 5.2kg, Radix Isatidis 5.2kg, golden cypress 5.2kg, purslane 5.2kg, coptis 5.2kg, soil
Chaste tree skin 5.2kg, pericarpium zanthoxyli 5.2kg, folium isatidis 5.2kg, giant knotweed 5.2kg, Commeline communis 5.2kg, Chinese prickly ash 5.2kg, dark plum 5.2kg, it is precious
Pearl 5.2kg, folium artemisiae argyi 5.5kg, motherwort 6.5kg, dandelion 7.3kg, sweet wormwood 6kg.
Preparation method：Except peppermint, borneol, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, pearl, remaining Chinese medicine flavour of a drug is taken
Crush, it is 60% ethanol solution 3200L to add concentration, is decocted 3 hours, and filtering, filtrate is standby, and it is 55% second to take residue to add concentration
Alcoholic solution 2100L, peppermint is added, decocted 1.5 hours, filtering, merge filtrate twice, add borneol, dissolving is complete, stands, mistake
Filter, filtrate are concentrated and dried, and obtain extract, add tea oil, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, the pearl crushed
Powder, mixing is complete, closed preservation, obtains raw material, adds raw materials into pharmaceutic adjuvant, is prepared into pharmaceutical preparation, including lotion.
Embodiment 4
Cloves 3.1kg, kuh-seng 90kg, saussurea involucrata 3.1kg, Chinese violet 3.1kg, safflower 3.1kg, peppermint 3.7kg, borneol
3.6kg, tea oil 4.2kg, Seabuckthorm Seed Oil 3.2kg, rare earth 3.2kg, vitamin 3.1kg, bletilla striata 4.6kg, frutus cnidii 4.6kg,
Asian puccoon 3.1kg, honeysuckle 3.1kg, bark of ash 3.1kg, Radix Isatidis 3.1kg, golden cypress 3.1kg, purslane 3.1kg, coptis 3.1kg,
Golden Larch Bark 3.1kg, pericarpium zanthoxyli 3.1kg, folium isatidis 3.1kg, giant knotweed 3.1kg, Commeline communis 3.2kg, Chinese prickly ash 3.2kg, dark plum 3.2kg,
Pearl 5.1kg, folium artemisiae argyi 3.9kg, motherwort 3.6kg, dandelion 5.8kg, sweet wormwood 3.3kg.
Preparation method：Except peppermint, borneol, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, pearl, remaining Chinese medicine flavour of a drug is taken
Crush, it is 60% ethanol solution 1850L to add concentration, is decocted 3 hours, and filtering, filtrate is standby, and it is 55% second to take residue to add concentration
Alcoholic solution 1400L, peppermint is added, decocted 1.5 hours, filtering, merge filtrate twice, add borneol, dissolving is complete, stands, mistake
Filter, filtrate are concentrated and dried, and obtain extract, add tea oil, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, the pearl crushed
Powder, mixing is complete, closed preservation, obtains raw material, adds raw materials into pharmaceutic adjuvant, is prepared into pharmaceutical preparation, including lotion.
Embodiment 5
Cloves 5.8kg, kuh-seng 100kg, saussurea involucrata 5.2kg, Chinese violet 5.2kg, safflower 5.6kg, peppermint 5.2kg, ice
Piece 5.2kg, tea oil 5.8kg, Seabuckthorm Seed Oil 5.3kg, rare earth 5.0kg, vitamin 5.0kg, bletilla striata 5.4kg, frutus cnidii
5.4kg, Asian puccoon 5.0kg, honeysuckle 5.0kg, bark of ash 5.0kg, Radix Isatidis 5.0kg, golden cypress 5.1kg, purslane 5.0kg, the coptis
5.0kg, Golden Larch Bark 5.0kg, pericarpium zanthoxyli 5.0kg, folium isatidis 5.0kg, giant knotweed 5.0kg, Commeline communis 5.0kg, Chinese prickly ash 5.0kg, dark plum
5.0kg, pearl 7.5kg, folium artemisiae argyi 5.2kg, motherwort 6.2kg, dandelion 7.0kg, sweet wormwood 5.8kg.
Preparation method：Except peppermint, borneol, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, pearl, remaining Chinese medicine flavour of a drug is taken
Crush, it is 60% ethanol solution 3000L to add concentration, is decocted 3 hours, and filtering, filtrate is standby, and it is 55% second to take residue to add concentration
Alcoholic solution 1960L, peppermint is added, decocted 1.5 hours, filtering, merge filtrate twice, add borneol, dissolving is complete, stands, mistake
Filter, filtrate are concentrated and dried, and obtain extract, add tea oil, tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, the pearl crushed
Powder, mixing is complete, closed preservation, obtains raw material, adds raw materials into pharmaceutic adjuvant, is prepared into pharmaceutical preparation, including lotion.
In embodiment described above, using cloves and kuh-seng as side in monarch drug in a prescription, using saussurea involucrata, Chinese violet as ministerial drug, with safranine
Flower, peppermint, borneol adjutant, for the disease such as gynaecology's bacterium infection, viral infection, trichomonas infection, antitumor.According to clinical condition
Shape, following flavour of a drug are added to use medicine：Tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, the bletilla striata, frutus cnidii, Asian puccoon, gold and silver
Flower, the bark of ash, Radix Isatidis, golden cypress, purslane, the coptis, Golden Larch Bark, pericarpium zanthoxyli, folium isatidis, giant knotweed, Commeline communis, Chinese prickly ash, dark plum, treasure
Pearl, folium artemisiae argyi, motherwort, dandelion, sweet wormwood.
4 raw material sources of the present invention of table
The embodiment is including but not limited to above-mentioned.
Claims (10)
1. a kind of pharmaceutical composition, it is characterised in that pharmaceutical composition is prepared by following raw materials：Cloves, kuh-seng, saussurea involucrata, pale reddish brownly
Fourth.
2. a kind of pharmaceutical composition according to claim 1, wherein pharmaceutical composition are prepared by following raw materials：Cloves, it is bitter
Ginseng, saussurea involucrata, Chinese violet, safflower, peppermint, borneol；Wherein cloves and kuh-seng are monarch drug in a prescription, and saussurea involucrata, Chinese violet are ministerial drug, are hidden
Safflower, peppermint, borneol are adjutant.
3. a kind of pharmaceutical composition according to claim 1, wherein cloves 3-6 parts by weight, kuh-seng 85-105 parts by weight, snow
Lotus 3.0-5.5 parts by weight, Chinese violet 3.0-5.5 parts by weight.
4. a kind of pharmaceutical composition according to claim 2, wherein pharmaceutical composition are prepared by following raw materials：Cloves 3-6
Parts by weight, kuh-seng 85-105 parts by weight, saussurea involucrata 3.0-5.5 parts by weight, Chinese violet 3.0-5.5 parts by weight, safflower 3.0-6.0
Parts by weight, peppermint 3.5-5.5 parts by weight, borneol 3.5-5.5 parts by weight.
5. according to a kind of pharmaceutical composition described in claim any one of 1-4, it is characterised in that pharmaceutical composition contains following
Raw material is one or more of：Tea oil, Seabuckthorm Seed Oil, rare earth, vitamin, the bletilla striata, frutus cnidii, Asian puccoon, honeysuckle, the bark of ash, plate are blue
Root, golden cypress, purslane, the coptis, Golden Larch Bark, pericarpium zanthoxyli, folium isatidis, giant knotweed, Commeline communis, Chinese prickly ash, dark plum, pearl, folium artemisiae argyi, benefit are female
Grass, dandelion, sweet wormwood.
6. a kind of pharmaceutical composition according to claim any one of 1-4 is in antibacterial, anti-trichomonal, antiviral drugs is prepared
Application.
A kind of 7. application of the pharmaceutical composition according to claim 5 in antibacterial, anti-trichomonal, antiviral drugs is prepared.
8. according to a kind of pharmaceutical composition described in claim any one of 1-4, it is characterised in that what pharmaceutical composition was prepared into
Pharmaceutical preparation.
9. a kind of pharmaceutical composition according to claim 5, it is characterised in that pharmaceutical composition is prepared into pharmaceutical preparation.
10. according to a kind of pharmaceutical composition described in claim any one of 1-4, it is characterised in that pharmaceutical composition is by following originals
It is prepared by material：Cloves 3-6 parts by weight, kuh-seng 85-105 parts by weight, saussurea involucrata 3.0-5.5 parts by weight, Chinese violet 3.0-5.5 weight
Part, safflower 3.0-6.0 parts by weight, peppermint 3.5-5.5 parts by weight, borneol 3.5-5.5 parts by weight, tea oil 4-6 parts by weight, sand
Spine seed oil 3-5.5 parts by weight, rare earth 3-5.2 parts by weight, vitamin 3-5.2 parts by weight, bletilla striata 4.5-5.5 parts by weight, frutus cnidii
4.5-5.5 parts by weight, Asian puccoon 3.0-5.2 parts by weight, honeysuckle 3.0-5.2 parts by weight, bark of ash 3.0-5.2 parts by weight, Radix Isatidis
3.0-5.2 parts by weight, golden cypress 3.0-5.2 parts by weight, purslane 3.0-5.2 parts by weight, coptis 3.0-5.2 parts by weight, Golden Larch Bark
3.0-5.2 parts by weight, pericarpium zanthoxyli 3.0-5.2 parts by weight, folium isatidis 3.0-5.2 parts by weight, giant knotweed 3.0-5.2 parts by weight, Commeline communis
3.0-5.2 parts by weight, Chinese prickly ash 3.0-5.2 parts by weight, dark plum 3.0-5.2 parts by weight, pearl 5.0-8.0 parts by weight, folium artemisiae argyi 3.8-
5.5 parts by weight, motherwort 3.5-6.5 parts by weight, dandelion 5.6-7.3 parts by weight, sweet wormwood 3.0-6.0 parts by weight.
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| CN109288934A (en) * | 2018-11-30 | 2019-02-01 | 康凤岐 | A kind of hemorrhoid Chinese materia medica preparation |
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| CN111658586A (en) * | 2020-06-29 | 2020-09-15 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with mite and acne removing functions and preparation method and application thereof |
| CN111991346A (en) * | 2020-09-04 | 2020-11-27 | 闫聪聪 | Gel dressing for preventing and treating human papilloma virus infection and preparation method thereof |
| CN116350739B (en) * | 2023-04-07 | 2024-04-02 | 成都市第三人民医院 | Traditional Chinese medicine composition for treating bacterial vaginitis and preparation method thereof |
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| CN1128633C (en) * | 2001-03-28 | 2003-11-26 | 刘杰龙 | Exterior-applied medicine for treating gynopathy |
| CN1251702C (en) * | 2003-06-27 | 2006-04-19 | 广州汉方现代中药研究开发有限公司 | Externally applied medicine for treating women's inflammation and its prepn process |
| CN1325083C (en) * | 2005-10-24 | 2007-07-11 | 高欲林 | Medicinal composition for removing dampness to relieve itching and its preparation method and uses |
| CN101195008B (en) * | 2006-12-05 | 2010-08-18 | 来柏龄 | Cattail pollen skin cleaning agent for treating gynecology disease and technique of preparing the same thereof |
| CN109432253A (en) * | 2013-03-11 | 2019-03-08 | 肖鸣春 | Medicine for warming and resolving cold-phlegm is preparing the application in antimycotic drug or health care product |
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