CN107714771A - A kind of protective agents of giant salamander abdominal distension disease and preparation method thereof - Google Patents
A kind of protective agents of giant salamander abdominal distension disease and preparation method thereof Download PDFInfo
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- CN107714771A CN107714771A CN201711199959.2A CN201711199959A CN107714771A CN 107714771 A CN107714771 A CN 107714771A CN 201711199959 A CN201711199959 A CN 201711199959A CN 107714771 A CN107714771 A CN 107714771A
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- abdominal distension
- giant salamander
- protective agents
- sophora
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of protective agents of giant salamander abdominal distension disease, its bulk drug matched by following masses part is made：100 parts of the sophora bud, 190 215 parts of wrinkled giant hyssop, 170 195 parts of myrrh, 190 215 parts of sophora flower, 280 320 parts of rhizoma atractylodis, 140 165 parts of the Radix Astragali, 180 215 parts of the bark of official magnolia, 190 215 parts of toothed burclover, 190 220 parts of Radix Isatidis, 20 30 parts of folium cortex eucommiae.Incompatibility is not present in each material combination in the medicine of the present invention, can substantially reduce the incidence of giant salamander abdominal distension disease, have good preventive and therapeutic action to giant salamander abdominal distension disease, and has no toxic side effect, safe to use, no hazardous drugs residual.
Description
Technical field
It is particularly a kind of to doll's fish belly the present invention relates to medicine of a kind of giant salamander epidemic disease preventing and treating and preparation method thereof
Abdominal distension has medicine of obvious preventive and therapeutic action and preparation method thereof.
Background technology
Giant salamander is subordinate to Yin Sai salamanders section, giant salamander category, is amphibian existing maximum and most precious in the world；It is cried
The sob of acoustic image baby, therefore people are called its " giant salamander "；Giant salamander is commonly called as " big Chinese pepper fish ", and coming from its body has Chinese pepper taste；
Giant salamander is the transitional type for representing fish and reptiles, there is the title of ancient " living fossil ", while giant salamander meat is pure white fresh and tender, fertilizer and
It is oiliness, taste specially fresh, containing abundant nutriment, it is described as in water " living person's ginseng ".
Wild doll's fish resource is endangered, and it is to recover giant salamander natural resources to carry out artificial breeding scale, meets society
The only way of meeting demand；Abdominal distension disease easily occurs in the process giant salamander of cultivation（Also known as Ascites Disease）, symptom floats on for individual
The water surface, action is dull, does not ingest, and eyes become muddy, abdominal distention；Dissection checks, finds hydroabdomen, the rubescent hyperemia of lung；Have
When anus area be also shown excrement adhesion.
For adult fish, because visceralization produces a large amount of ascites, the dosage kanamycins of 10,000 units/kg body weight can be used
Intramuscular injection, gentamicin（20000 units/kilogram）, chloramphenicol, neomycin to this disease also have good therapeutic effect, these medicines are equal
For Western medicine, pharmacological dependence is easily caused, or influence doll's meat quality of fish, it is therefore necessary to a kind of preventing and treating doll's red skin of exploitation
Chinese medicine composition.
The content of the invention
The purpose of the present invention is to overcome the above-mentioned deficiency of prior art and provide a kind of protective agents of giant salamander abdominal distension disease,
Incompatibility is not present in each material combination in the medicine of the present invention, the incidence of giant salamander abdominal distension disease can be substantially reduced, to doll
Fish belly abdominal distension has good preventive and therapeutic action, and has no toxic side effect, safe to use, no hazardous drugs residual.
It is a further object of the present invention to provide a kind of preparation method of said medicine, its technique is simple, its bulk drug is common,
Cheaply.
The technical scheme is that：A kind of protective agents of giant salamander abdominal distension disease, it is matched by following masses part
Bulk drug is made：100 parts of the sophora bud, wrinkled giant hyssop 190-215 parts, myrrh 170-200 parts, sophora flower 190-215 parts, rhizoma atractylodis 280-320 parts,
Radix Astragali 140-165 parts, bark of official magnolia 180-215 parts, toothed burclover 190-215 parts, Radix Isatidis 190-220 parts, folium cortex eucommiae 20-30 parts.
Its further preferred mass part, which matches, is：100 parts of the sophora bud, wrinkled giant hyssop 190-210 parts, myrrh 170-195 parts, sophora flower
190-210 parts, rhizoma atractylodis 280-315 parts, Radix Astragali 140-160 parts, bark of official magnolia 180-210 parts, toothed burclover 190-210 parts, Radix Isatidis 190-
215, folium cortex eucommiae 22-30 parts.
Its further preferred mass part, which matches, is：100 parts of the sophora bud, wrinkled giant hyssop 190-205 parts, myrrh 170-190 parts, sophora flower
190-205 parts, rhizoma atractylodis 290-315 parts, Radix Astragali 140-155 parts, bark of official magnolia 190-210 parts, toothed burclover 190-205 parts, Radix Isatidis 190-
210 parts, folium cortex eucommiae 25-30 parts.
Its further preferred mass part, which matches, is：100 parts of the sophora bud, wrinkled giant hyssop 190-200 parts, myrrh 170-190 parts, sophora flower
190-200 parts, rhizoma atractylodis 290-310 parts, Radix Astragali 145-155 parts, bark of official magnolia 195-210 parts, toothed burclover 195-205 parts, Radix Isatidis 190-
205 parts, folium cortex eucommiae 25-29 parts.
Its further preferred mass part, which matches, is：100 parts of the sophora bud, wrinkled giant hyssop 195-200 parts, myrrh 180-190 parts, sophora flower
195-200 parts, rhizoma atractylodis 300-310 parts, Radix Astragali 145-150 parts, bark of official magnolia 200-210 parts, toothed burclover 195-200 parts, Radix Isatidis 200-
205 parts, 25 parts of folium cortex eucommiae.
Its further preferred mass part, which matches, is：It is 100 parts of the sophora bud, 200 parts of wrinkled giant hyssop, 180 parts of myrrh, 200 parts of sophora flower, grey
300 parts of art, 150 parts of the Radix Astragali, 200 parts of the bark of official magnolia, 200 parts of toothed burclover, 200 parts of Radix Isatidis, 25 parts of folium cortex eucommiae.
The present invention another technical scheme be：A kind of preparation method of the protective agents of giant salamander abdominal distension disease, it is mainly wrapped
Include following steps：
The first step：The raw material weight of batch production is calculated by formula rate；
Second step:The raw material for calculating batch production is positioned in stirring container, is soaked in water 3-5 hours, the use of its reclaimed water
Measure as 10 times of Chinese medicine gross weight, warm fire heating is burnt to seething with excitement, and endures 15-20 minutes, and after being then incubated 3 hours, then warm fire heating is burnt
To boiling, 25-30 minutes are endured；
3rd step：Centrifugal filtration is carried out, filtered fluid is after 2-3 hours are precipitated, second of centrifugal filtration；Filtered fluid is doll
The protective agents of fish belly abdominal distension.
The primary raw material medicine that the present invention uses is described as follows.
The sophora bud：Sophora bud broad sense is for legume Chinese scholartree（Sophora japonica L.）Dry flower and flower；Sophora bud master
The ground such as Henan, Shandong, Shanxi, Shaanxi, Anhui, Hebei, Jiangsu, Guizhou are originated in, the ground such as Ningxia, Gansu has also been advised in recent years
Also there are the plantation of large area in mould, Vietnam；Summer flower harvests its bud when not open, is referred to as " sophora bud "；The flowers are in blossom harvests when putting, and is referred to as
" sophora flower "；Branch, stalk and the impurity of inflorescence are removed after harvesting, is dried in time, life is used, fries and use or fry charcoal use；The present invention the sophora bud be
The golden Chinese scholartree sophora bud.
Wrinkled giant hyssop：Also known as blending, grey announcement, mountain fennel etc., belong to tubular flower mesh,【Function is with curing mainly】Eliminate dampness with aromatics, and middle preventing or arresting vomiting,
Deliver relieving summer-heat；For turbi damp obstructing in middle-JIAO, the vomiting of gastral cavity ruffian, summer-heat and damp exterior syndrome, damp-warm syndrome from the beginning of, burnout of generating heat, uncomfortable in chest not relax, cold-dampness closes heat,
Stomachache is vomited and diarrhoea, nasosinusitis headache.
Myrrh：Chinese medicine name, it is olive subject plant Chinese violet tree Commiphora myrrha Engl. or Ha Didingshu
Commiphora molmol Engl. dry resin；It is divided into natural myrrh and gum opoponax；It is distributed in Somalia, Ethiopia Russia
Than sub- and Arabia Peninsula south and other places；With scattered stasis pain, the effect of detumescence and promoting granulation；It is usually used in chest impediment and cardialgia, gastral cavity pain,
The treatment of the illnesss such as dysmenorrhoea Amenorrhea, postpartum stasis , Disorder lump in the abdomen is suffered from abdominal pain, arthralgia pain due to rheumatism, traumatic injury, carbuncle swells sore.
Sophora flower：Also known as robiniae,flos, the robiniae,flos of broad sense refers to the flower and alabastrum of legume, but typically claims open flower
For " sophora flower ", also referred to as " Chinese scholartree stamen ", bud is then referred to as " sophora bud "；Chang Zhi is generally cultivated, mainly existed in room side, roadside all over China
The north, it is more using loess plateau and the North China Plain, is typically bloomed in annual 4, May, the florescence is generally 10-15 days or so.
Rhizoma atractylodis：Perennial herb；Stem list is raw or fasciation, stem branch are dredged by arachnoid hair；Rhizoma atractylodis root-like stock is used as medicine, have eliminating dampness,
Change turbid, analgesic effect.
The Radix Astragali：《Compendium of Materia Medica》In also known as wear crushed grain, wear mulberry, grass, hundred, the prince's descendants, (" stilbene " original work are " over sixty years of age ")；Smell
(root) is sweet, tepor, nontoxic；Cure mainly:Urinary obstruction, wine subcutaneous ulcer Huang disease, gonorrhoea, sallow terribly thirsty, old people constipation, blood strangury, drench, tell less
Blood, cough purulence hemoptysis, lung carbuncle, fetal irritability, the moon are made soaked with sweat and itched；Have tonifying middle-Jiao and Qi arrest sweating, control chronic nephritis, the albumen that disappears, solution taking poison and growing muscle due,
Strengthen the spleen and stomach and other effects；The Chinese medicine Radix Astragali is leguminous herbaceous plant's astragalus mongolicus, the root of Astragalus membranacus, has invigorating qi for strengthening superficies, profit
Water detumescence, pus draining and toxin expelling, myogenic and other effects；The Radix Astragali is more containing saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper etc.
Kind trace element；There are enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, decompression and wide antibacterial action.
The bark of official magnolia：The purple Piao of alias, purple plain, warm Piao of oil etc., are Magnoliaceae, magnolia in the range of botany；Bark of official magnolia decoction
There is inhibitory action to dermatophytes such as trichophyton, Trichophyton concentricum, Trichophyton rubrums to cariogenic pathogen-deformation chain
The experiment of coccus shows that bark of official magnolia oral toxicity was both small, and has efficient quick sterilization to act on.
Toothed burclover：It is the address of the people to bur clover on the ground such as Shanghai, granary, Changshu, bur clover, original name south lucerne vegetables
MedicagohispidaGaertn has Ye Sanchi, such as reversed cardioid, and tip slightly circle or recessed top have sawtooth, and the surface of leaf is in dense
Green, stalk is extremely short, main root length, multi-branched；Stem is generally vertical, near hairless, high 30-100 centimetres；Compound leaf has 3 leaflets, and leaflet falls
Avette or lanceolar, long 1-2 centimetres, wide about 0.5 centimetre, nose-circle, middle rib slightly protrudes, and first half leaf has a sawtooth, and base portion is narrow
Wedge shape；Stipule narrow lanceolar, full edge；Raceme axillary, flower 8-25；Pod spiral shape, stingless, top has point to expose nozzle；In river
The production of the province of Zhejiang two is special more；Toothed burclover is legume, often edible shell of seaear element can balanced human pH-value.
Radix Isatidis:Alias indigo-blue, indigo root, manyflower glorybower root；For the dry root of cruciferae isatis, generally in the autumn
Ji Jinhang is excavated, and can be used as medicine after processing；Its is cold in nature, and taste is first bitter after micro- sweet tea, has clearing heat and detoxicating, preventing cold, the work(of relieving sore-throat
Effect；It is mainly used in treating the diseases such as the dark reddish purple dark, scarlet fever of febrile virulent maculae, tongue.
Folium cortex eucommiae：For Eucommiaceae plant bark of eucommia Eucommia ulmoides Oliv. dried leaf, summer, two season of autumn branches and leaves
Harvest, dry or low temperature drying when luxuriant；Function is with curing mainly：Filling liver kidney, strengthening the bones and muscles；For kidney deficiency and liver, have a dizzy spell, waist and knee
Ache, muscles and bones impotence.
Incompatibility is not present in each material combination in the medicine of the present invention, can substantially reduce the generation of giant salamander abdominal distension disease
Rate, there is good preventive and therapeutic action to giant salamander abdominal distension disease, and have no toxic side effect, safe to use, no hazardous drugs are residual
Stay.
The medicine application method of the present invention：During nursing, every 100 kilograms of bait, the preventing and treating of 200 grams of giant salamander abdominal distension diseases is weighed
Medicine, then by the medicine with appropriate water to mixing up, then add bait in, mix, feed immediately, 2 days feed 1 time, 10 days
For a course for the treatment of, one course for the treatment of of this medicine can be fed every 20 days.
In order to illustrate more clearly of the present invention, following examples are enumerated, but its scope to invention is without any restrictions.
Embodiment
Embodiment 1
The preparation method of giant salamander abdominal distension medicine is prevented and treated, it mainly comprises the following steps：
The first step:Weigh sophora bud 100g, wrinkled giant hyssop 200g, myrrh 180g, sophora flower 200g, rhizoma atractylodis 300g, Radix Astragali 150g, the bark of official magnolia
25 parts of 200g, toothed burclover 200g, Radix Isatidis 200g, folium cortex eucommiae；
Second step:Raw material is positioned in stirring container, is soaked in water 4 hours, the dosage of its reclaimed water is the 10 of Chinese medicine gross weight
Times, warm fire heating is burnt to seething with excitement, and endures 15-20 minutes, and after being then incubated 3 hours, then warm fire heating is burnt to seething with excitement, and is endured 25 minutes；
3rd step:Centrifugal filtration is carried out, filtered fluid is after 2 hours precipitations, second of centrifugal filtration；Filtered fluid is the giant salamander
The protective agents of abdominal distension disease.
Application method：When feeding every time, every 100 kilograms of bait mixed up, 200 grams of the present embodiment giant salamander abdominal distension diseases are weighed
Protective agents, then add bait in, mix, feed immediately, 2 days feed 1 time, 10 days are a course for the treatment of, can be every 20
It feeds one course for the treatment of of this medicine.
Embodiment 2-14, comparative example 1-2
Embodiment 2-12 is in addition to raw material mass mixture ratio is different from embodiment 1, its raw material type and step of preparation process and use
Method is identical with embodiment 1, and comparative example 1 is that the bark of official magnolia is eliminated on the basis of embodiment 1, and comparative example 2 is in embodiment 1
On the basis of eliminate rhizoma atractylodis, raw material and quality used in embodiment 1-12, comparative example 1-2 as shown in Table 1 below, below
Table 1 shows raw material and quality used in embodiment 1-12, comparative example 1-2.
Table 1, unit of gram
。
Clinical practice one：
Hengyang giant salamander plant, 6 months giant salamanders morbidity of nursing, action is dull, does not ingest, and eyes become muddy, and belly is swollen
It is swollen, giant salamander abdominal distension disease is determined as by clinical and laboratory diagnosis；600 sick giant salamanders are selected, the sick giant salamander is randomly divided into
15 groups, every group 40, treated respectively with embodiment 1-12, the made medicines of comparative example 1-2 and kanamycins（Control group）Controlled
Treat, after medication 10 days, got well using the giant salamander more than 95% of the made drug therapy of the present invention, kanamycins treatment group controls
The giant salamander 70% for the treatment of gets well, as a result such as table 2.
Table 2
The medicine of the present invention has significant therapeutic effect to giant salamander abdominal distension disease it can be seen from table 2, and cure rate, which is higher than, blocks that
Mycin treatment group.
Clinical practice two：
In order to prove effect of the present invention to the giant salamander, repeatedly examination feeding experiment is carried out in the doll fish farm that epidemic situation occurs, is chosen
Large-scale 600 giant salamander young of giant salamander plant, body weight size, health status are basically identical, are randomly divided into 15 groups, every group 40
Only；Wherein 14 groups are experimental group, the bait that medicine described in feeding embodiment 1-12, comparative example 1-2 is made into respectively, twice daily,
Continuous 10 days, a course for the treatment of was fed every 20 days；Another group is control group, and feeding is not added with the identical bait of medicine, 15 groups of giant salamanders
Nursing number, feeding volume, nursing time all same；Contrast the various performance indications of 15 groups of giant salamanders, average value such as table 3；40
After it, 15 groups of giant salamander situations such as table 3.
Table 3
。
It can be evident that from table, the experimental group giant salamander is after continuous feeding bait provided by the invention, weightening
It is obvious compared with control group increase, and the experimental group giant salamander, compared with control group honey stomach, energetic, state is good, no giant salamander abdominal distension disease
Occur.
So the present invention is not limited to the protective agents as giant salamander abdominal distension disease, as long as composition of raw materials and phase of the present invention
Same or equivalent medicine is just fallen within the scope and spirit of the invention；By the preventing and treating of the preventing and treating giant salamander abdominal distension disease with the present invention
The raw material of medicine same recipe is made any Chinese medicine preparation and also fallen within the scope and spirit of the invention, as long as that is, raw material is matched somebody with somebody
It is square just to be fallen within the scope and spirit of the invention with identical medicine of the present invention.
Claims (7)
1. a kind of protective agents of giant salamander abdominal distension disease, it is characterised in that its bulk drug matched by following masses part is made：
100 parts of the sophora bud, wrinkled giant hyssop 190-215 parts, myrrh 170-200 parts, sophora flower 190-215 parts, rhizoma atractylodis 280-320 parts, Radix Astragali 140-165
Part, bark of official magnolia 180-215 parts, toothed burclover 190-215 parts, Radix Isatidis 190-220 parts, folium cortex eucommiae 20-30 parts.
2. the protective agents of giant salamander abdominal distension disease according to claim 1, it is characterised in that 100 parts of the sophora bud, wrinkled giant hyssop 190-
210 parts, myrrh 170-195 parts, sophora flower 190-210 parts, rhizoma atractylodis 280-315 parts, Radix Astragali 140-160 parts, bark of official magnolia 180-210 parts,
Toothed burclover 190-210 parts, Radix Isatidis 190-215 parts, folium cortex eucommiae 22-30 parts.
3. the protective agents of giant salamander abdominal distension disease according to claim 1, it is characterised in that 100 parts of the sophora bud, wrinkled giant hyssop 190-
205 parts, myrrh 170-190 parts, sophora flower 190-205 parts, rhizoma atractylodis 290-315 parts, Radix Astragali 140-155 parts, bark of official magnolia 190-210 parts,
Toothed burclover 190-205 parts, Radix Isatidis 190-210 parts, folium cortex eucommiae 25-30 parts.
4. the protective agents of giant salamander abdominal distension disease according to claim 1, it is characterised in that 100 parts of the sophora bud, wrinkled giant hyssop 190-
200 parts, myrrh 170-190 parts, sophora flower 190-200 parts, rhizoma atractylodis 290-310 parts, Radix Astragali 145-155 parts, bark of official magnolia 195-210 parts,
Toothed burclover 195-205 parts, Radix Isatidis 190-205 parts, folium cortex eucommiae 25-29 parts.
5. the protective agents of giant salamander abdominal distension disease according to claim 1, it is characterised in that 100 parts of the sophora bud, wrinkled giant hyssop 195-
200 parts, myrrh 180-190 parts, sophora flower 195-200 parts, rhizoma atractylodis 300-310 parts, Radix Astragali 145-150 parts, bark of official magnolia 200-210 parts,
Toothed burclover 195-200 parts, Radix Isatidis 200-205 parts, 25 parts of folium cortex eucommiae.
6. the protective agents of giant salamander abdominal distension disease according to claim 1, it is characterised in that 100 parts of the sophora bud, wrinkled giant hyssop 200
Part, 180 parts of myrrh, 200 parts of sophora flower, 300 parts of rhizoma atractylodis, 150 parts of the Radix Astragali, 200 parts of the bark of official magnolia, 200 parts of toothed burclover, 200 parts of Radix Isatidis, Du
25 parts of Zhong Ye.
7. the preparation method of the protective agents of giant salamander abdominal distension disease according to claim 1, it is characterized in that：It is mainly included such as
Lower step：
The first step:The raw material weight of batch production is calculated by formula rate；
Second step:The raw material for calculating batch production is positioned in stirring container, is soaked in water 3-5 hours, the use of its reclaimed water
Measure as 10 times of Chinese medicine gross weight, warm fire heating is burnt to seething with excitement, and endures 15-20 minutes, and after being then incubated 3 hours, then warm fire heating is burnt
To boiling, 25-30 minutes are endured；
3rd step:Centrifugal filtration is carried out, filtered fluid is after 2-3 hours are precipitated, second of centrifugal filtration；Filtered fluid is doll
The protective agents of fish belly abdominal distension.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103212007A (en) * | 2013-04-28 | 2013-07-24 | 赵道全 | Traditional Chinese medicine preparation for treating abdominal distension of giant salamanders and preparation method of preparation |
| CN104381701A (en) * | 2014-12-05 | 2015-03-04 | 无为县清源特种水产养殖专业合作社 | Compound feed for promoting young giant salamander growth at larval stage |
-
2017
- 2017-11-27 CN CN201711199959.2A patent/CN107714771A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103212007A (en) * | 2013-04-28 | 2013-07-24 | 赵道全 | Traditional Chinese medicine preparation for treating abdominal distension of giant salamanders and preparation method of preparation |
| CN104381701A (en) * | 2014-12-05 | 2015-03-04 | 无为县清源特种水产养殖专业合作社 | Compound feed for promoting young giant salamander growth at larval stage |
Non-Patent Citations (1)
| Title |
|---|
| 乔志刚: "《现代渔业提升工程•水产标准化健康养殖丛书 大鲵标准化健康养殖技术》", 31 July 2015, 中原农民出版社 * |
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Application publication date: 20180223 |