CN107714546A - A kind of toothpaste and its production method for suppressing helicobacter pylori in oral cavity - Google Patents
A kind of toothpaste and its production method for suppressing helicobacter pylori in oral cavity Download PDFInfo
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- CN107714546A CN107714546A CN201711064684.1A CN201711064684A CN107714546A CN 107714546 A CN107714546 A CN 107714546A CN 201711064684 A CN201711064684 A CN 201711064684A CN 107714546 A CN107714546 A CN 107714546A
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- CN
- China
- Prior art keywords
- toothpaste
- extract
- lichens
- toothpaste according
- helicobacter pylori
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Abstract
The invention discloses a kind of toothpaste and its production method for suppressing helicobacter pylori in oral cavity, the toothpaste is made up of 20 55% frosting agents, 0.1 1.0% thickener, 10 30% NMFs, 0.5 5.0% sapindoside, 0.1 2.0% essential oil, 0.05 0.50% sweetener, 0.5% preservative, 1 10% lichens extract, 1 10% volatile clove oil, 1 10% hedgehog fungus extract and water.The toothpaste of the present invention contains sapindoside, lichens extract, volatile clove oil, hedgehog fungus extract, can effectively suppress helicobacter pylori, protects oral hygiene, prevents the generation of stomach trouble.
Description
Technical field
The invention belongs to cosmetic field, and in particular to a kind of to suppress the toothpaste of helicobacter pylori and its life in oral cavity
Production method.
Background technology
Helicobacter pylori is a kind of Gram-negative, microaerophilic, bendability bacillus.Nearly more than 20 years
Research finds, stomach is the important storage of helicobacter pylori, and it is chronic active gastritis, peptic ulcer, the master of stomach cancer
Want pathogenic factor.
In recent years, many scholars think that oral cavity is helicobacter pylori in an important clustering area in addition to stomach, one
Cause the generation of oral cavity and disease of stomach under fixed condition, substantial amounts of research both at home and abroad shows with its tooth of the patient of DD
Have the presence of helicobacter pylori in bacterial plaque, its morphology, biochemical characteristic and immunological characteristic with the pylorus spiral in gastric mucosa
Bacillus it is similar, helicobacter pylori in the stomach of same patient and intraoral helicobacter pylori are carried out on Genotyping
It was found that they have significant homology.
Helicobacter pylori in oral cavity be present, be mainly distributed in the chip of bacterial plaque, saliva, tongue, pars oralis pharyngis, by point
The number of cloth quantity is the chip of bacterial plaque, saliva, tongue, pars oralis pharyngis successively.Song Q are detected in bacterial plaque and saliva with PCR
Helicobacter pylori, as a result find in bacterial plaque, the survival rate of helicobacter pylori is most particularly in the bacterial plaque ground one's teeth in sleep
Height, this is probably the reason for bacterial plaque is close with gastric mucosa surface environment.
The clinical treatment of helicobacter pylori is commonly divided into proton pump inhibitor or bismuth agent plus CLA, first
Three or quadruple chemotherapy of the 2-3 kinds in the antibiotic such as nitre azoles, Amoxicillin and tetracycline, its higher cure rate have reached
Common recognition.But gradually highlighted with the development to Eradicative therapy for Helicobacter pylori, the problems such as its drug resistance and drug side-effect
Out.Therefore it is that researcher needs urgently to solve the problems, such as to find new natural antibacterial product.
The content of the invention
In order to overcome the helicobacter pylori resistance problems caused by existing treatment method, primary and foremost purpose of the invention
In a kind of toothpaste containing natural extract, that helicobacter pylori in oral cavity can be suppressed of offer.
Another object of the present invention is to provide the production method of above-mentioned toothpaste.
The purpose of the present invention is achieved through the following technical solutions：
A kind of toothpaste, it is made by the composition of following mass percent：
Preferably, toothpaste of the invention is made by the composition of following mass percent：
Described frosting agent is calcium carbonate and/or silica；
Described thickener is sodium carboxymethylcellulose and/or Arabic gum；
Described NMF is glycerine and/or sorbierite；
The preferred saccharin sodium of described sweetener；
Described preservative preferred sodium benzoate；
Sapindoside is a kind of natural nonionic surface active agent, can reduce the surface tension of water, foaming abundancy,
Feel is fine and smooth, and strong detergency, excitant is small, has the effect of bactericidal antiphlogistic；Compared with other nonionic tables are lived, show to deep and remote
The excellent inhibition of door pylori；
Described lichens extract is made by following methods：
Lichens after crushing is extracted more than 24 hours with organic solvent, extraction is multiple, merges extract solution, and rotary evaporation is dense
Contracting obtains lichens extract；
Described lichens is blood-snow tea, long sunglo, deer reindeer moss, long sunglo or frog skin；
The preferred acetone of described organic solvent or methanol；
By the antibacterial experiment in vitro discovery to helicobacter pylori, with the blood-snow tea extraction fungistatic effect of acetone extraction
Most preferably, MIC is minimum, is 7.5mg/ml；
Volatile clove oil has inhibitory action to helicobacter pylori.Eugenol is the main component of volatile clove oil, and it is changed
Structure is 2- methoxyl group -4- chavicols, and the phenolic hydroxyl group on aromatic rings has strong activity, may be with helicobacter pylori
The active group of some enzymes combines, and destroys eubolism function, so as to influence microorganism growth.
Volatile clove oil preparation technology is as follows：
Take cloves pulverizing medicinal materials to take 100g to put in flask into particle diameter 0.18mm (80 mesh) coarse powder, add 8 times of amount water immersion 24h,
Volatile oil extractor is connected, heating, keeps micro-boiling, the amount to volatile oil is not further added by, and separates volatile oil, is added isometric anhydrous
Anhydrous sodium sulfate drying is used after ethanol, 40 DEG C are recovered under reduced pressure ethanol, weigh volatilization oil quality, and survey using high performance liquid chromatography
Determine the content of eugenol in volatile oil, the standby rearmounted use of lucifuge sealing.The dregs of a decoction of volatile oil have been extracted, have continued extraction 2 times, water with water
Extract solution is filtered, and the rearmounted vacuum drying chamber that is concentrated under reduced pressure is dried, and claims quality, and finely ground, sealing is standby.
Small-molecule active substance in Hericium erinaceus mainly includes erinacine, Hericium erinaceus (Bull. Ex Fr.) Pers. Ketone, Diterpenes, sterols, fat
The material such as acid and its esters, there is enhancing body immunity, anticancer, anti-oxidant and other effects, in terms of helicobacter pylori is suppressed
Also there is obvious effect.
The preparation method of toothpaste of the present invention comprises the following steps：
Thickener is added in NMF and is uniformly dispersed, adds water, frosting agent, sapindoside, temperature control is at 80-85 DEG C
It is uniformly dispersed, essential oil, sweetener, preservative, lichens extract, volatile clove oil and Hericium erinaceus extraction is added after being cooled to 45 DEG C
Thing, stir, filtering and discharging.
The present invention is had the following advantages relative to prior art and effect：
The toothpaste of the present invention contains sapindoside, lichens extract, volatile clove oil, hedgehog fungus extract, Neng Gouyou
Effect suppresses helicobacter pylori, protects oral hygiene, prevents the generation of stomach trouble.
Embodiment
With reference to embodiment, the present invention is described in further detail, but the implementation of the present invention is not limited to this.
The formulation of tooth-paste of each embodiment and comparative example is shown in Table 1：
Table 1：Formulation of tooth-paste
Note：Lichens extract used, wherein solid content are 100mg/mL；
Medical patient 90 is chosen, wherein man 45, female 45 is age 24-60 year, average 35 years old.All patients 3 months
Antibiotic and proton pump inhibitor, bismuth preparation medicine are not taken inside.
The oral cavity H. pylori dientification of bacteria：
Draw 0.01ml salivas and insert in urease reagent 37 DEG C, reagent becomes red or aubergine as the positive after about 1min
(urease experiment)；
3%H is added dropwise on slide2O2, continuously bubble formation can be seen by drawing after 0.01ml salivas are inserted
(catalase is also known as catalase test)；
Draw 0.01ml salivas to be placed on the filter paper for being soaked with oxidase reagent, occur deep blue-black (oxygen in contact site
Change enzyme test).
3 kinds of experimental identification results are positive more than, provable to contain helicobacter pylori.
Experimental method：90 patients are divided into 9 groups, respectively using the toothpaste of 3 embodiments and 6 comparative examples, it is early, in,
Evening is brushed teeth three times with toothpaste, is used continuously 15 days, is then done the oral cavity H. pylori dientification of bacteria.Therapeutic effect is as shown in table 2：
Table 2：Therapeutic effect
| Healing number | |
| Embodiment 1 | 9 |
| Comparative example 1 | 1 |
| Comparative example 2 | 1 |
| Comparative example 3 | 1 |
| Comparative example 4 | 4 |
| Comparative example 5 | 6 |
| Comparative example 6 | 4 |
| Comparative example 7 | 1 |
| Embodiment 2 | 9 |
| Embodiment 3 | 7 |
Note：Described healing refers to that three testing results are no longer all positive；
The experiment of table 2 shows：When comprising only lichens extract, volatile clove oil, hedgehog fungus extract wherein one in component
During kind (comparative example 1-3), not obvious the effect of suppressing helicobacter pylori, it is seldom to cure number.
When three kinds of active components increase to two kinds in formulation of tooth-paste, the number increase (such as comparative example 4-6) of healing, and
When lichens extract and hedgehog fungus extract compound, low dosage effect is better than lichens extract and compounded with volatile clove oil.
When three compounds, effect preferably (embodiment 1), continues to increase proportions, effect is not obviously improved (strictly according to the facts
Apply example 2).
Embodiment 3 is 1% sapindoside of addition, cures number and is reduced compared to embodiment 1 (2% sapindoside of addition)
, show that sapindoside not only has cleaning action, also have the function that to suppress helicobacter pylori.
Comparative example 7 is comparative example, does not add the effect of active component does not suppress helicobacter pylori in oral cavity.
In summary, when the ratio of sapindoside, lichens extract, volatile clove oil, hedgehog fungus extract is 2:2:
5:Effect is best when 2, has cooperative effect.
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification,
Equivalent substitute mode is should be, is included within protection scope of the present invention.
Claims (10)
1. a kind of toothpaste, it is characterised in that be made by the composition of following mass percent：
2. toothpaste according to claim 1, it is characterised in that be made by the composition of following mass percent：
3. toothpaste according to claim 1 or 2, it is characterised in that：Described frosting agent is calcium carbonate and/or titanium dioxide
Silicon.
4. toothpaste according to claim 1 or 2, it is characterised in that：Described thickener be sodium carboxymethylcellulose and/or
Arabic gum.
5. toothpaste according to claim 1 or 2, it is characterised in that：Described NMF is glycerine and/or sorbierite.
6. toothpaste according to claim 1 or 2, it is characterised in that：Described sweetener is saccharin sodium.
7. toothpaste according to claim 1 or 2, it is characterised in that：Described preservative is sodium benzoate.
8. toothpaste according to claim 1 or 2, it is characterised in that：
Described lichens extract is made by following methods：
Lichens after crushing is extracted more than 24 hours with organic solvent, extraction is multiple, merges extract solution, and rotary evaporation is concentrated to give
To lichens extract.
9. toothpaste according to claim 8, it is characterised in that：
Described lichens is blood-snow tea, long sunglo, deer reindeer moss, long sunglo or frog skin；
Described organic solvent is acetone or methanol.
10. the preparation method of the toothpaste described in claim any one of 1-9, it is characterised in that comprise the following steps：
Thickener is added in NMF and is uniformly dispersed, adds water, frosting agent, sapindoside, temperature control is scattered at 80-85 DEG C
Uniformly, essential oil, sweetener, preservative, lichens extract, volatile clove oil and hedgehog fungus extract are added after being cooled to 45 DEG C,
Stir, filtering and discharging.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711064684.1A CN107714546B (en) | 2017-11-02 | 2017-11-02 | Toothpaste capable of inhibiting helicobacter pylori in oral cavity and production method thereof |
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|---|---|---|---|
| CN201711064684.1A CN107714546B (en) | 2017-11-02 | 2017-11-02 | Toothpaste capable of inhibiting helicobacter pylori in oral cavity and production method thereof |
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| CN107714546A true CN107714546A (en) | 2018-02-23 |
| CN107714546B CN107714546B (en) | 2020-12-29 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108785171A (en) * | 2018-07-17 | 2018-11-13 | 广州市壹美和生物科技有限公司 | A kind of toothpaste and its production method for capableing of suppressing and killing helicobacter pylori |
| RU2708615C1 (en) * | 2019-10-02 | 2019-12-10 | Федеральное государственное автономное образовательное учреждение высшего образования "Северо-Восточный федеральный университет имени М.К.Аммосова" | Method of treating chronic periodontitis |
| RU2708624C1 (en) * | 2019-04-16 | 2019-12-10 | Федеральное государственное автономное образовательное учреждение высшего образования "Северо-Восточный федеральный университет имени М.К.Аммосова" | Method of treating periodontitis |
| CN112168721A (en) * | 2020-09-16 | 2021-01-05 | 海南大学 | Chinese herbal medicine toothpaste containing clove and alpinia oxyphylla volatile oil and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108785171A (en) * | 2018-07-17 | 2018-11-13 | 广州市壹美和生物科技有限公司 | A kind of toothpaste and its production method for capableing of suppressing and killing helicobacter pylori |
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| RU2708615C1 (en) * | 2019-10-02 | 2019-12-10 | Федеральное государственное автономное образовательное учреждение высшего образования "Северо-Восточный федеральный университет имени М.К.Аммосова" | Method of treating chronic periodontitis |
| CN112168721A (en) * | 2020-09-16 | 2021-01-05 | 海南大学 | Chinese herbal medicine toothpaste containing clove and alpinia oxyphylla volatile oil and preparation method thereof |
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| CN107714546B (en) | 2020-12-29 |
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