CN107669620A - Scar proliferation lipidosome gel and preparation method thereof after one kind operation more - Google Patents

Scar proliferation lipidosome gel and preparation method thereof after one kind operation more Download PDF

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CN107669620A
CN107669620A CN201710987785.XA CN201710987785A CN107669620A CN 107669620 A CN107669620 A CN 107669620A CN 201710987785 A CN201710987785 A CN 201710987785A CN 107669620 A CN107669620 A CN 107669620A
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lipidosome gel
scar
scar proliferation
lipidosome
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芮志行
王之霖
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/324—Boswellia, e.g. frankincense
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/75—Rutaceae (Rue family)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The present invention relates to scar proliferation lipidosome gel after one kind operation more and preparation method thereof, belong to medical nursing technique field.The present invention utilizes Asian puccoon cool blood scattered silt, moisturizing relieves pain, improve skin blood circulation, promote the effect of Transdermal absorption, again with myrrh, frankincense, Ligusticum wallichii is auxiliary, and utilize Radix Angelicae Sinensis, safflower cold dispelling promoting blood circulation and stopping pain, lopseed, Radix Aconiti, it is windproof, Chinese prickly ash dispel be detained channels and collaterals wind-cold damp pathogen and analgesic, borneol moisturizing skin care, again with anti-inflammatory, detumescence, the strong mineral matter mixing of osmosis, collaboration accelerates collagen degradation, suppress the Artesunate of extrtacellular matrix deposition, and lipidosome gel is made, promote the solidification of protein in blood and cell, the abnormal path at blocking lesion position, cause the solidification of diseased region itself, it is withered, come off, and improve local blood circulation and the peripheral termination of nerve, play antipruritic, anti-inflammatory, analgesic effect, suppress cicatricial tissue hyperplasia.

Description

Scar proliferation lipidosome gel and preparation method thereof after one kind operation more
Technical field
The present invention relates to scar proliferation lipidosome gel after one kind operation more and preparation method thereof, belongs to medicine nursing skill Art field.
Background technology
Skin hyperplasia scar (hypertrophicscars, HS) is one of clinically common disease, often can different journeys Degree ground influences the appearance and function of patient, and processing is intractable.Cicatricial tissue is a kind of natural product in human body processes of wound repair, Damage as deep as corium and hypodermis by scar, it is necessary to repaired, but hyperplastic scar and keloid mechanical resistance epistasis Weaken, form the obstacle that oxygen and nutriment exchange, and usually cause the deformity and work(of damaged tissues due to shrinking and pulling Energy obstacle, therefore usually need operative treatment.Any kind of biology, chemically or physically damage can all induce in vivo chain body fluid- Cell effect, so as to cause the fibroproliferative inflammatory process to be played a major role with fibrin.
In wound healing process, caused by many reasons, cell component hyper-proliferative based on fibroblast, with Extrtacellular matrix deposition based on collagen is excessive, then can cause the formation of hyperplastic scar.Hyperplastic scar is one serious Public health problem.Burnt degree HS average attack rate is 62%, Post operation 54%.HS is in gradual, invasion and attack formula development, performance For obstinate pruritus, the impaired even canceration of image, serious physiology and mental handicape are easily caused.Preventing and treating HS turns into skin repair The emphasis with burn treating is rebuild, its immunotherapy targeted autoantibody is always one of problem of modern medicine.
With the progress of society, how people effectively reduce Post operation scar to personal requirement more and more higher attractive in appearance The formation of trace hyperplasia, it appears most important.Particularly neck etc. is exposed to public's wound within the vision, not only influences patient Surface, bring adverse effect to marriage, work and life, while the interpersonal Communication barrier of patient can be caused, feel oneself inferior, be timid Deng mental disease.Chest, abdomen, limb wound hyperplastic scar influence patient because causing the discomforts such as hyperemia, pain with frictions such as clothings Quality of life.
Therefore, be badly in need of exploitation it is a kind of it is easy to use, simple to operate, quick, cure rate is high, it is cheap, have no side effect The advantages that, and the medicament for the treatment of hyperplastic scar that can voluntarily use at home.
The content of the invention
The technical problems to be solved by the invention：The problem of for hyperplastic scar reconstruction and burn treating difficulty, this Invention provides rear scar proliferation lipidosome gel of a kind of operation and preparation method thereof.
In order to solve the above technical problems, the technical solution adopted by the present invention is：
Scar proliferation lipidosome gel after one kind operation more, it is characterised in that the lipidosome gel is former by following weight parts Material：1 ~ 2 part of lecithin, 1 ~ 2 part of cholesterol, 1 ~ 2 part of octadecylamine, 30 ~ 50 parts of absolute ethyl alcohols, 10 ~ 20 parts of prescriptions of traditional Chinese medicine liquid, 3 ~ 5 Part Carbomer-940,3 ~ 5 parts of mixed with propylene glycol uniformly adjust pH to 6.5 ~ 7.0 and are made afterwards.
The prescriptions of traditional Chinese medicine liquid is by Asian puccoon, myrrh, frankincense, Ligusticum wallichii, Radix Angelicae Sinensis, safflower, lopseed, Radix Aconiti, windproof, colored Green pepper, borneol, sodium chloride, sodium sulphate, magnesium sulfate, calcium sulfate, Artesunate, water boiling concentration is added to be made.
The parts by weight of each raw material of prescriptions of traditional Chinese medicine liquid are：20 ~ 30 portions of Asian puccoons, 10 ~ 15 parts of myrrhs, 10 ~ 15 parts of frankincenses, 10 ~ 15 parts of Ligusticum wallichiis, 10 ~ 15 parts of Radix Angelicae Sinensis, 10 ~ 15 parts of safflowers, 10 ~ 15 portions of lopseeds, 10 ~ 15 parts of Radix Aconitis, 10 ~ 15 parts are windproof, 10 ~ 15 portions of Chinese prickly ashes, 10 ~ 15 parts of borneols, 10 ~ 15 parts of sodium chloride, 10 ~ 15 parts of sodium sulphate, 5 ~ 10 parts of magnesium sulfate, 5 ~ 10 parts of calcium sulfate, 5 ~ 10 parts of Artesunates.
The boiling concentration is evaporation and concentration to the 20 ~ 30% of stoste volume.
The well mixed process disperses 20 ~ 30min to be heated to 50 ~ 60 DEG C, with 300W ultrasonic echographies.
Scar proliferation lipidosome gel after a kind of described operation more, it is characterised in that specifically preparation process is：
1）Raw material is weighed by formula ratio；
2）By Asian puccoon, myrrh, frankincense, Ligusticum wallichii, Radix Angelicae Sinensis, safflower, lopseed, Radix Aconiti, windproof, Chinese prickly ash, borneol, sodium chloride, sulphur Sour sodium, magnesium sulfate, calcium sulfate, Artesunate, add water boiling and be concentrated by evaporation；
3) lecithin, cholesterol, octadecylamine, the well mixed rear and prescriptions of traditional Chinese medicine liquid of absolute ethyl alcohol are heated to 50 ~ 60 DEG C, ultrasound It is scattered, obtain dispersion liquid；
4）Carbomer-940, propane diols are added into dispersion liquid, adjusts pH to 6.5 ~ 7.0 after being well mixed, scar after must performing the operation more Trace hyperplasia lipidosome gel.
The method have the benefit that：
The effect that the present invention is relieved pain using Asian puccoon cool blood scattered silt, moisturizing, improves skin blood circulation, promoting Transdermal absorption, then with Myrrh, frankincense, Ligusticum wallichii are auxiliary, and reinforcement is promoting blood circulation and removing blood stasis, removes necrosis and promote granulation, improves skin blood circulation, promotes Transdermal absorption, and profit With Radix Angelicae Sinensis, safflower cold dispelling promoting blood circulation and stopping pain, lopseed, Radix Aconiti, windproof, Chinese prickly ash dispel be detained channels and collaterals wind-cold damp pathogen and analgesic, ice Piece moisturizing skin care, then mixed with the strong mineral matter of anti-inflammatory, detumescence, osmosis, it is improved cytoactive, cell is again Raw ability is strengthened, and links the dermal layer of the skin fiber being broken caused by wound, adds collagen fibroblast growth rate It hurry up, impaired skin corium is repaired, and collaboration accelerates collagen degradation, suppresses the Artesunate of extrtacellular matrix deposition, and tool is made There is percutaneous drug delivery advantage, promote the Medicated Permeation ability of scar heterogeneousization epidermis, strengthen medicine corium retention performance, penetrating gives Cyclome border meets wound healing to O2The lipidosome gel of demand, promote the solidification of protein in blood and cell, blocking lesion The abnormal path at position, cause solidifying, wither, coming off for diseased region itself, and improve local blood circulation and surrounding god Through tip, antipruritic, anti-inflammatory, analgesic effect are played, suppresses cicatricial tissue hyperplasia.
Embodiment
Take 20 ~ 30g Asian puccoons, 10 ~ 15g myrrhs, 10 ~ 15g frankincenses, 10 ~ 15g Ligusticum wallichiis, 10 ~ 15g Radix Angelicae Sinensis, 10 ~ 15g safflowers, 10 ~ 15g lopseeds, 10 ~ 15g Radix Aconitis, 10 ~ 15g is windproof, 10 ~ 15g Chinese prickly ashes, 10 ~ 15g borneols, 10 ~ 15g sodium chloride, 10 ~ 15g sodium sulphate, 5 ~ 10g magnesium sulfate, 5 ~ 10g calcium sulfate, 5 ~ 10g Artesunates, add in 1 ~ 2L deionized waters, it is heated to 95 ~ 100 DEG C of insulation 1 ~ 2h of boiling, filter to get filtrate and filter residue, are filtered after filter residue is repeated into boiling 1 ~ 3 time, merging filtrate simultaneously evaporates dense Stoste volume 20 ~ 30% is reduced to, obtains prescriptions of traditional Chinese medicine liquid, 1 ~ 2g lecithin is taken, 1 ~ 2g cholesterol, 1 ~ 2g octadecylamines, adds 30 ~ 50g In absolute ethyl alcohol, 10 ~ 20min is stirred with 300 ~ 400r/min, 10 ~ 20g prescriptions of traditional Chinese medicine liquid is added, is heated to 50 ~ 60 DEG C, with 300W ultrasonic echographies disperse 20 ~ 30min, obtain dispersion liquid, addition 3 ~ 5g Carbomer-940s into dispersion liquid, 3 ~ 5g propane diols, 30 ~ 40min is stirred with 300 ~ 400r/min, then mass fraction is added dropwise and adjusts pH to 6.5 ~ 7.0 for 5% sodium hydroxide solution, is gone smoothly The rear scar proliferation lipidosome gel of art.
Example 1
Take 20g Asian puccoons, 10g myrrhs, 10g frankincenses, 10g Ligusticum wallichiis, 10g Radix Angelicae Sinensis, 10g safflowers, 10g lopseeds, 10g Radix Aconitis, 10g It is windproof, 10g Chinese prickly ashes, 10g borneols, 10g sodium chloride, 10g sodium sulphate, 5g magnesium sulfate, 5g calcium sulfate, 5g Artesunates, add 1L In deionized water, 95 DEG C of insulation boiling 1h are heated to, are filtered to get filtrate and filter residue, filtered, merge after filter residue is repeated into boiling 1 time Filtrate is simultaneously concentrated by evaporation to stoste volume 20%, obtains prescriptions of traditional Chinese medicine liquid, is taken 1g lecithin, 1g cholesterol, 1g octadecylamines, is added 30g In absolute ethyl alcohol, 10min is stirred with 300r/min, 10g prescriptions of traditional Chinese medicine liquid is added, is heated to 50 DEG C, surpassed with 300W ultrasonic waves Sound disperses 20min, obtains dispersion liquid, and 3g Carbomer-940s are added into dispersion liquid, 3g propane diols, 30min are stirred with 300r/min, Mass fraction is added dropwise again and adjusts pH to 6.5 for 5% sodium hydroxide solution, scar proliferation lipidosome gel after must performing the operation more.
Example 2
Take 25g Asian puccoons, 12g myrrhs, 12g frankincenses, 12g Ligusticum wallichiis, 12g Radix Angelicae Sinensis, 12g safflowers, 12g lopseeds, 12g Radix Aconitis, 12g It is windproof, 12g Chinese prickly ashes, 12g borneols, 12g sodium chloride, 12g sodium sulphate, 8g magnesium sulfate, 8g calcium sulfate, 8g Artesunates, add 1L In deionized water, 98 DEG C of insulation boiling 1h are heated to, are filtered to get filtrate and filter residue, filtered, merge after filter residue is repeated into boiling 2 times Filtrate is simultaneously concentrated by evaporation to stoste volume 25%, obtains prescriptions of traditional Chinese medicine liquid, is taken 1g lecithin, 1g cholesterol, 1g octadecylamines, is added 40g In absolute ethyl alcohol, 15min is stirred with 350r/min, 15g prescriptions of traditional Chinese medicine liquid is added, is heated to 55 DEG C, surpassed with 300W ultrasonic waves Sound disperses 25min, obtains dispersion liquid, and 4g Carbomer-940s are added into dispersion liquid, 4g propane diols, 35min are stirred with 350r/min, Mass fraction is added dropwise again and adjusts pH to 6.8 for 5% sodium hydroxide solution, scar proliferation lipidosome gel after must performing the operation more.
Example 3
Take 30g Asian puccoons, 15g myrrhs, 15g frankincenses, 15g Ligusticum wallichiis, 15g Radix Angelicae Sinensis, 15g safflowers, 15g lopseeds, 15g Radix Aconitis, 15g It is windproof, 15g Chinese prickly ashes, 15g borneols, 15g sodium chloride, 15g sodium sulphate, 10g magnesium sulfate, 10g calcium sulfate, 10g Artesunates, add In 2L deionized waters, 100 DEG C of insulation boiling 2h are heated to, are filtered to get filtrate and filter residue, filtered after filter residue is repeated into boiling 3 times, Merging filtrate is simultaneously concentrated by evaporation to stoste volume 30%, is obtained prescriptions of traditional Chinese medicine liquid, is taken 2g lecithin, 2g cholesterol, 2g octadecylamines, add Enter in 50g absolute ethyl alcohols, 20min is stirred with 400r/min, 20g prescriptions of traditional Chinese medicine liquid is added, is heated to 60 DEG C, with 300W ultrasounds Ripple ultrasonic disperse 30min, obtains dispersion liquid, and 5g Carbomer-940s are added into dispersion liquid, 5g propane diols, are stirred with 400r/min 40min, then mass fraction is added dropwise and adjusts pH to 7.0 for 5% sodium hydroxide solution, scar proliferation is coagulated with liposome after must performing the operation more Glue.
Reference examples：Taken out stitches after wound healing discharge, clear-cutting forestland.
Curative effect judges：Each follow-up in 6 weeks and 6 months 1 time after wound healing is taken out stitches.Effectively：Local wound is flat, soft, skin Color is normal, and without pain symptom of itching, local skin protrudes without protuberance；Or though there is slight scar proliferation in local wound region, takes out stitches Follow-up in 6 months afterwards, skin calms down completely at scar proliferation, soft texture, and color is close to normal, the sense of discomfort such as no sufferings.It is invalid： Local wound rubicundity, local proliferation, with pain symptom of itching；Or follow-up in 6 months after taking out stitches, scar apparently higher than skin, its Thickness is more than 2mm, and hyperplasia exceedes original focus scope, and with pain symptom of itching.
Example and reference examples are contrasted, as a result as shown in table 1：
Table 1
Example 1 Example 2 Example 3 Reference examples
6 weeks efficient % after taking out stitches 57.11 58.65 59.23 47.83
6 months efficient % after taking out stitches 96.15 96.37 97.03 84.06
As seen from the above table, the rear scar proliferation lipidosome gel of the operation that prepared by the present invention is quick, cure rate is high, is worth pushing away It is wide to use.

Claims (6)

1. scar proliferation lipidosome gel after one kind operation more, it is characterised in that the lipidosome gel is by following weight parts Raw material：1 ~ 2 part of lecithin, 1 ~ 2 part of cholesterol, 1 ~ 2 part of octadecylamine, 30 ~ 50 parts of absolute ethyl alcohols, 10 ~ 20 parts of prescriptions of traditional Chinese medicine liquid, 3 ~ 5 parts of Carbomer-940s, 3 ~ 5 parts of mixed with propylene glycol uniformly adjust pH to 6.5 ~ 7.0 and are made afterwards.
2. scar proliferation lipidosome gel after a kind of operation more as claimed in claim 1, it is characterised in that at the Chinese medicine Square liquid is by Asian puccoon, myrrh, frankincense, Ligusticum wallichii, Radix Angelicae Sinensis, safflower, lopseed, Radix Aconiti, windproof, Chinese prickly ash, borneol, sodium chloride, sulfuric acid Sodium, magnesium sulfate, calcium sulfate, Artesunate, water boiling concentration is added to be made.
3. scar proliferation lipidosome gel after a kind of operation more as claimed in claim 2, it is characterised in that at the Chinese medicine The parts by weight of square each raw material of liquid are：20 ~ 30 portions of Asian puccoons, 10 ~ 15 parts of myrrhs, 10 ~ 15 parts of frankincenses, 10 ~ 15 parts of Ligusticum wallichiis, 10 ~ 15 parts Radix Angelicae Sinensis, 10 ~ 15 parts of safflowers, 10 ~ 15 portions of lopseeds, 10 ~ 15 parts of Radix Aconitis, 10 ~ 15 parts windproof, 10 ~ 15 portions of Chinese prickly ashes, 10 ~ 15 parts Borneol, 10 ~ 15 parts of sodium chloride, 10 ~ 15 parts of sodium sulphate, 5 ~ 10 parts of magnesium sulfate, 5 ~ 10 parts of calcium sulfate, 5 ~ 10 parts of Artesunates.
4. scar proliferation lipidosome gel after a kind of operation more as claimed in claim 2, it is characterised in that the boiling is dense It is condensed to be concentrated by evaporation to the 20 ~ 30% of stoste volume.
5. scar proliferation lipidosome gel after a kind of operation more as claimed in claim 1, it is characterised in that the mixing is equal Even process disperses 20 ~ 30min to be heated to 50 ~ 60 DEG C, with 300W ultrasonic echographies.
6. scar proliferation lipidosome gel after a kind of operation more as described in claim 1 ~ 5 any one, it is characterised in that Specifically preparation process is：
1）Raw material is weighed by formula ratio；
2）By Asian puccoon, myrrh, frankincense, Ligusticum wallichii, Radix Angelicae Sinensis, safflower, lopseed, Radix Aconiti, windproof, Chinese prickly ash, borneol, sodium chloride, sulphur Sour sodium, magnesium sulfate, calcium sulfate, Artesunate, add water boiling and be concentrated by evaporation；
3) lecithin, cholesterol, octadecylamine, the well mixed rear and prescriptions of traditional Chinese medicine liquid of absolute ethyl alcohol are heated to 50 ~ 60 DEG C, ultrasound It is scattered, obtain dispersion liquid；
4）Carbomer-940, propane diols are added into dispersion liquid, adjusts pH to 6.5 ~ 7.0 after being well mixed, scar after must performing the operation more Trace hyperplasia lipidosome gel.
CN201710987785.XA 2017-10-21 2017-10-21 Scar proliferation lipidosome gel and preparation method thereof after one kind operation more Withdrawn CN107669620A (en)

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Application publication date: 20180209