CN107669547A - A kind of bacteriostatic hand sanitizer containing purslane and preparation method thereof - Google Patents
A kind of bacteriostatic hand sanitizer containing purslane and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The present invention provides a kind of bacteriostatic hand sanitizer containing purslane and preparation method thereof, belongs to daily article for washing technical field.The bacteriostatic hand sanitizer is made of following raw material：6 10 parts of Cocoamidopropyl betaine, 48 parts of APES, 35 parts of isopropyl palmitate, 13 parts of hyaluronic acid, 24 parts of sodium chloride, 25 parts of maltitol, 0.3 0.8 parts of purslane extract, 0.03 0.06 parts of glycyrrhizic acid, 70 90 parts of water.The hand cleanser of the present invention has preferable degerming fungistatic effect, and safety is gentle, safer to human body.
Description
【Technical field】
The present invention relates to daily article for washing technical field, and in particular to a kind of bacteriostatic hand sanitizer and its system containing purslane
Preparation Method.
【Background technology】
In daily life, the both hands of people are readily accessible bacterium, dirt, and if can not in time, effectively clean
Hand, then it may endanger health.For the special occupation crowd such as doctor, nurse, hand cleaning more seems
It is particularly important.There is evening as a kind of new hand cleaning product, compared with traditional cleaning supplies such as perfumed soap, soap in hand cleanser, but
Its because have the characteristics that easy to use, time saving water-saving, avoid cross-infection, it is easily stored, reduce nature consumption, therefore by more next
More consumers' likes.However, current market sales of hand cleanser still based on chemical products, with the addition of bactericide and
The composition that preservative etc. is harmful to people's body, can also remain minimal amount of chemical substance, accumulate over a long period after having cleaned, can be to people
Body damages.Research shows that the chemical detergent toxin into human body can decline calcium ion concentration in blood, blood acid
Change, make people easily tired；These toxin can also reduce the functions of expelling toxin of liver, immunity degradation, liver cell lesion aggravation, tool
There is stronger cancer induction property.In addition, washing, rinsing liquid are discharged to sewer, biodegradability is poor, also can cause one to environment
Determine the pollution of degree.Therefore, in the market there is an urgent need to it is a kind of have cleaning capacity, do not stimulate skin, being capable of degerming antibacterial temperature
With type hand cleanser.
Purslane (scientific name：Portulaca oleracea L.) annual herb plant, purslane herb is interior to contain sterilization
The composition of anti-inflammatory, herb hyoscine have clearing heat and promoting diuresis, removing toxicity for detumescence, anti-inflammatory, quenched the thirst, diuresis；Containing antibacterial in purslane
Composition, however, the research work extracted at present to purslane, has focused largely on extraction and apply its polysaccharide component, to it
The correlative study that antipathogenic composition is carried out is less.Present inventor by research have found one kind extract from purslane it is antibacterial
The method of composition, but when the antipathogenic composition extracted is applied in cleaning product, find its solubility in water very
Small, solubility increases with the rise of ambient temperature in water, but amplification unobvious.Therefore, want purslane antipathogenic composition
Applied in hand cleanser, it is also necessary to find suitable system, increase the content of purslane antipathogenic composition in hand cleanser, washed with improving
The fungistatic effect of hand liquid.
【The content of the invention】
The goal of the invention of the present invention is：For above-mentioned problem, there is provided a kind of bacteriostatic hand sanitizer containing purslane
And preparation method thereof, hand cleanser of the invention has preferable degerming fungistatic effect, and safety is gentle, compares human body peace
Entirely.
To achieve these goals, the technical solution adopted by the present invention is as follows：
A kind of bacteriostatic hand sanitizer containing purslane, it is made of following raw material：Cocoamidopropyl betaine
6-10 parts, APES 4-8 parts, isopropyl palmitate 3-5 parts, hyaluronic acid 1-3 parts, sodium chloride 2-4 parts, malt
Sugar alcohol 2-5 parts, purslane extract 0.3-0.8 parts, glycyrrhizic acid 0.03-0.06 parts, water 70-90 parts.
In the present invention, it is preferable that described bacteriostatic hand sanitizer is made of following raw material：Cocamidopropyl propyl amide
8 parts of glycine betaine, 6 parts of APES, 4 parts of isopropyl palmitate, 2 parts of hyaluronic acid, 3 parts of sodium chloride, maltitol 4
Part, 0.5 part of purslane extract, 0.05 part of glycyrrhizic acid, 85 parts of water.
In the present invention, it is preferable that the purslane extract is obtained by following steps：
(1) by purslane herb impurity elimination, dry to anhydrous, then crush, be screened to 50~60 mesh, obtain purslane powder；
(2) purslane powder is placed in the ethanol water that hydrochloric volumetric concentration is 55~60%, with power 125
~175W ultrasonic wave extracts at 55~60 DEG C and obtains ethanol extract；
(3) said extracted liquid is concentrated under reduced pressure into no alcohol taste, adds water to be configured to 9-12mg/ml crude extract solution, it is excessive
Hole resin adsorption, using water cleaning macroreticular resin of the dosage more than 5BV after crude extract solution is excessively complete, then use pH value for 5~6 and
Acetonitrile: the mixed liquor that the volume ratio of n-butanol is 1: 6-8 is eluant, eluent, and elution is afforded with 5~7BV/h elution rate
Liquid；
(4) frozen drying obtains purslane antipathogenic composition after the eluent is concentrated.
In the present invention, it is preferable that the liquid-solid ratio of ethanol water and the purslane powder described in step (2) is 5-8:
1, the mass fraction of the hydrochloric acid contained by ethanol water is 0.5-0.8%.
The present invention also provides the preparation method of above-mentioned bacteriostatic hand sanitizer, comprises the following steps:
(1) 50-80% water is added into reactor, is then heated to 75-85 DEG C, then by APES and
Cocoamidopropyl betaine is dissolved in hot water, obtains solution a；
(2) isopropyl palmitate, maltitol are added into solution a, stirring and dissolving obtains solution b；
(3) water of hyaluronic acid, purslane extract, glycyrrhizic acid, surplus is mixed, stirring and dissolving, obtains solution c；
(4) solution b is cooled to 35-40 DEG C, solution b is mixed with solution c, add sodium chloride and the water of surplus, stirring
Uniformly, the bacteriostatic hand sanitizer is produced.
In summary, by adopting the above-described technical solution, the beneficial effects of the invention are as follows：
1st, the present invention adds maltitol in hand cleanser, acts not only as NMF, and because its addition can be with
Purslane extract is sufficiently solubilized in hand cleanser, increase the content of purslane extract in hand cleanser, keep hand cleanser
Storage stability, so as to improve the fungistatic effect of hand cleanser.
2nd, the present invention by using acidic ethanol, the concentration of control ethanol and dosage, is led in the extraction process of purslane
The step of crossing using washing, macroporous resin adsorption, acetonitrile and n-butanol mixing elution, and by controlling the speed of macroreticular resin
Can flow, optimize purifying technique, more can targetedly obtain the antibacterial activity composition in purslane, obtained extract antibacterial
It is active more preferable.
3rd, glycyrrhizic acid is also a kind of raw material with multiple functions such as antibacterial, anti-inflammatory, removing toxic substances, deodorizations, and the present invention is by big
Experiment sieving is measured, finds that the effect of Synergistic can be produced purslane extract and glycyrrhizic acid compounding use into, increase is antibacterial
Effect.
【Embodiment】
In order to more clearly express the present invention, below by way of specific embodiment, the invention will be further described.
Embodiment 1
It is as follows that this example prepares the step of bacteriostatic hand sanitizer：
1st, purslane antipathogenic composition is extracted
(1) by purslane herb impurity elimination, at a temperature of 40~50 DEG C freeze-day with constant temperature to anhydrous, then crush, be screened to 50~
60 mesh, obtain purslane powder；
(2) purslane powder is placed in the ethanol water that hydrochloric volumetric concentration is 55%, control ethanol is water-soluble
The mass fraction of hydrochloric acid contained by liquid is 0.5%, and the liquid-solid ratio for controlling ethanol water and purslane powder is 5: 1；With power
125W ultrasonic wave extracts at 55 DEG C and obtains ethanol extract；
(3) said extracted liquid is concentrated under reduced pressure into no alcohol taste, adds water to be configured to 9mg/ml crude extract solution, with 5.2BV/
H speed crosses macroreticular resin D101 absorption, and the excessively complete rear water for being more than 5BV using dosage of crude extract solution cleans macroreticular resin, then
PH value is used as 5 and acetonitrile: the mixed liquor that the volume ratio of n-butanol is 1: 6 is eluant, eluent, is eluted with 5BV/h elution rate
To eluent；
(4) frozen drying obtains purslane antipathogenic composition after the eluent is concentrated.
2nd, bacteriostatic hand sanitizer is prepared
The formula of bacteriostatic hand sanitizer is：6 parts of Cocoamidopropyl betaine, 4 parts of APES,
3 parts of isopropyl palmitate, 1 part of hyaluronic acid, 2 parts of sodium chloride, 2 parts of maltitol, 0.3 part of purslane extract, glycyrrhizic acid
0.03 part, 70 parts of water.
(1) 50% water is added into reactor, 75 DEG C is then heated to, then by APES and cocounut oil acyl
Amine CAB is dissolved in hot water, obtains solution a；
(2) isopropyl palmitate, maltitol are added into solution a, stirring and dissolving obtains solution b；
(3) water of hyaluronic acid, purslane extract, glycyrrhizic acid, surplus is mixed, stirring and dissolving, obtains solution c；
(4) solution b is cooled to 35 DEG C, solution b is mixed with solution c, add sodium chloride and the water of surplus, stirring is equal
It is even, produce the bacteriostatic hand sanitizer.
Embodiment 2
It is as follows that this example prepares the step of bacteriostatic hand sanitizer：
1st, purslane antipathogenic composition is extracted
(1) by purslane herb impurity elimination, at a temperature of 40~50 DEG C freeze-day with constant temperature to anhydrous, then crush, be screened to 50~
60 mesh, obtain purslane powder；
(2) purslane powder is placed in the ethanol water that hydrochloric volumetric concentration is 58%, control ethanol is water-soluble
The mass fraction of hydrochloric acid contained by liquid is 0.6%, and the liquid-solid ratio for controlling ethanol water and purslane powder is 6: 1；With power
150W ultrasonic wave extracts at 58 DEG C and obtains ethanol extract；
(3) said extracted liquid is concentrated under reduced pressure into no alcohol taste, adds water to be configured to 10mg/ml crude extract solution, with 4BV/h
Speed cross macroreticular resin H-103 absorption, using water cleaning macroreticular resin of the dosage more than 5BV after crude extract solution is excessively complete, then
PH value is used as 5.5 and acetonitrile: the mixed liquor that the volume ratio of n-butanol is 1: 7 is eluant, eluent, eluted with 6BV/h elution rate
Obtain eluent；
(4) frozen drying obtains purslane anti-inflammation components after the eluent is concentrated.
2nd, bacteriostatic hand sanitizer is prepared
The formula of bacteriostatic hand sanitizer is：8 parts of Cocoamidopropyl betaine, 6 parts of APES,
4 parts of isopropyl palmitate, 2 parts of hyaluronic acid, 3 parts of sodium chloride, 4 parts of maltitol, 0.5 part of purslane extract, glycyrrhizic acid
0.05 part, 85 parts of water.
(1) 70% water is added into reactor, 80 DEG C is then heated to, then by APES and cocounut oil acyl
Amine CAB is dissolved in hot water, obtains solution a；
(2) isopropyl palmitate, maltitol are added into solution a, stirring and dissolving obtains solution b；
(3) water of hyaluronic acid, purslane extract, glycyrrhizic acid, surplus is mixed, stirring and dissolving, obtains solution c；
(4) solution b is cooled to 38 DEG C, solution b is mixed with solution c, add sodium chloride and the water of surplus, stirring is equal
It is even, produce the bacteriostatic hand sanitizer.
Embodiment 3
It is as follows that this example prepares the step of bacteriostatic hand sanitizer：
1st, purslane antipathogenic composition is extracted
(1) by purslane herb impurity elimination, at a temperature of 40~50 DEG C freeze-day with constant temperature to anhydrous, then crush, be screened to 50~
60 mesh, obtain purslane powder；
(2) purslane powder is placed in the ethanol water that hydrochloric volumetric concentration is 60%, control ethanol is water-soluble
The mass fraction of hydrochloric acid contained by liquid is 0.8%, and the liquid-solid ratio for controlling ethanol water and purslane powder is 8: 1；With power
175W ultrasonic wave extracts at 60 DEG C and obtains ethanol extract；
(3) said extracted liquid is concentrated under reduced pressure into no alcohol taste, adds water to be configured to 12mg/ml crude extract solution, with
3.8BV/h speed crosses macroreticular resin D101 absorption, the excessively complete rear water cleaning macropore tree using dosage more than 5BV of crude extract solution
Fat, then pH value is used as 5 and acetonitrile: the mixed liquor that the volume ratio of n-butanol is 1: 8 is eluant, eluent, with 7BV/h elution rate
Afford eluent；
(4) frozen drying obtains purslane anti-inflammation components after the eluent is concentrated.
2nd, bacteriostatic hand sanitizer is prepared
The formula of bacteriostatic hand sanitizer is：10 parts of Cocoamidopropyl betaine, APES 8
Part, 5 parts of isopropyl palmitate, 3 parts of hyaluronic acid, 4 parts of sodium chloride, 5 parts of maltitol, 0.8 part of purslane extract, glycyrrhizic acid
0.06 part, 90 parts of water.
(1) 80% water is added into reactor, 85 DEG C is then heated to, then by APES and cocounut oil acyl
Amine CAB is dissolved in hot water, obtains solution a；
(2) isopropyl palmitate, maltitol are added into solution a, stirring and dissolving obtains solution b；
(3) water of hyaluronic acid, purslane extract, glycyrrhizic acid, surplus is mixed, stirring and dissolving, obtains solution c；
(4) solution b is cooled to 40 DEG C, solution b is mixed with solution c, add sodium chloride and the water of surplus, stirring is equal
It is even, produce the bacteriostatic hand sanitizer.
Comparative example 1
This example is that the formula of bacteriostatic hand sanitizer is different from the difference of embodiment 3, and maltose is replaced using equivalent water
Alcohol, it is specially：10 parts of Cocoamidopropyl betaine, 8 parts of APES, 5 parts of isopropyl palmitate, hyaluronic acid
3 parts, 4 parts of sodium chloride, 0.8 part of purslane extract, 0.06 part of glycyrrhizic acid, 95 parts of water.
Comparative example 2
This example is that the formula of bacteriostatic hand sanitizer is different from the difference of embodiment 3, without glycyrrhizic acid, is specially：Coconut palm
10 parts of oleamide CAB, 8 parts of APES, 5 parts of isopropyl palmitate, 3 parts of hyaluronic acid, sodium chloride 4
Part, 5 parts of maltitol, 0.86 part of purslane extract, 90 parts of water.
Comparative example 3
The difference of this example and embodiment 3 is that the extracting method of purslane is：By fresh purslane raw material -20
24h is freezed at DEG C, takes the purslane raw material of freezing, breaks into fine powder with food conditioning device, smalls described in weighing 200g is placed in container
In, 250ml pure water is added, mixture heating is boiled to be extracted, after extracting 25 minutes, the centrifugation point under 6000rpm
From 30 minutes, obtain supernatant, supernatant concentration it is dry extract.
Performance test：
1st, according to technical requirements in QB/T 2654-2013 annex, to the portion of finished product made from embodiment 1-3 and comparative example 1
Point performance indications are evaluated.Its result is as shown in table 1.Wherein, low-temperature stability is in -3 DEG C~-10 DEG C measure, high-temperature stable
Property 40 DEG C measure.
The performance test results of table 1
From the results shown in Table 1, occur in comparative example 1 due to replacing maltitol using water in product a little outstanding
Float, for purslane extract can not be completely dissolved and it is caused.Illustrate that the present invention uses maltitol, by increasing capacitance it is possible to increase hand cleanser
The content of middle purslane extract, keep the storage stability of hand cleanser.
2nd, according to professional standard QB/T2850-2007 antibacterial bacteriostatic type detergent, fungistatic effect test, activity are carried out
It is 1wt%, action time is 20 minutes, and the specific data that detect are shown in Table 2.
The fungistatic effect test result of table 2
| Bacteriostasis rate (Escherichia coli)/% | Bacteriostasis rate (staphylococcus aureus)/% | |
| Embodiment 1 | 78.9 | 79.8 |
| Embodiment 2 | 83.1 | 83.4 |
| Embodiment 3 | 88.6 | 88.9 |
| Comparative example 1 | 48.2 | 45.5 |
| Comparative example 2 | 58.3 | 58.1 |
| Comparative example 3 | 56.5 | 57.2 |
From the test data of table 2, embodiment 1-3 has more preferable bacteriostasis rate performance compared with comparative example 1-3.It is right
For ratio 1 because purslane extract effective content is few, fungistatic effect is worst, and comparative example 2 is due to without glycyrrhizic acid, it is impossible to assists
With the effect of synergy, comparative example 3 is because, without further extraction, antibacterial component content is few, so suppression in purslane extract
Bacterium effect does not reach preferable effect yet.
Described above is the detailed description for the present invention preferably possible embodiments, but embodiment is not limited to this hair
Bright patent claim, the equal change completed or modification change under the technical spirit suggested by all present invention, all should belong to
Cover the scope of the claims in the present invention.
Claims (5)
1. a kind of bacteriostatic hand sanitizer containing purslane, it is characterised in that be made of following raw material：Coconut oleoyl amine third
Base glycine betaine 6-10 parts, APES 4-8 parts, isopropyl palmitate 3-5 parts, hyaluronic acid 1-3 parts, sodium chloride 2-
4 parts, maltitol 2-5 parts, purslane extract 0.3-0.8 parts, glycyrrhizic acid 0.03-0.06 parts, water 70-90 parts.
2. bacteriostatic hand sanitizer according to claim 1, it is characterised in that be made of following raw material：Cocounut oil acyl
8 parts of amine CAB, 6 parts of APES, 4 parts of isopropyl palmitate, 2 parts of hyaluronic acid, 3 parts of sodium chloride, wheat
4 parts of bud sugar alcohol, 0.5 part of purslane extract, 0.05 part of glycyrrhizic acid, 85 parts of water.
3. bacteriostatic hand sanitizer according to claim 1, it is characterised in that：The purslane extract is obtained by following steps
Arrive：
(1) by purslane herb impurity elimination, dry to anhydrous, then crush, be screened to 50~60 mesh, obtain purslane powder；
(2) by purslane powder be placed in hydrochloric volumetric concentration be 55~60% ethanol water in, with power 125~
175W ultrasonic wave extracts at 55~60 DEG C and obtains ethanol extract；
(3) said extracted liquid is concentrated under reduced pressure into no alcohol taste, adds water to be configured to 9-12mg/ml crude extract solution, cross macropore tree
Fat adsorbs, the excessively complete rear water cleaning macroreticular resin using dosage more than 5BV of crude extract solution, then uses pH value as 5~6 and acetonitrile
: the volume ratio of n-butanol is 1：6-8 mixed liquor is eluant, eluent, and eluent is afforded with 5~7BV/h elution rate；
(4) frozen drying obtains purslane extract after the eluent is concentrated.
4. bacteriostatic hand sanitizer according to claim 3, it is characterised in that：Ethanol water and institute described in step (2)
The liquid-solid ratio for stating purslane powder is 5-8：1, the mass fraction of the hydrochloric acid contained by ethanol water is 0.5-0.8%.
5. the preparation method of the bacteriostatic hand sanitizer according to any one of claim 1-4, it is characterised in that including following step
Suddenly:
(1) 50-80% water is added into reactor, 75-85 DEG C is then heated to, then by APES and cocounut oil
Amido propyl betaine is dissolved in hot water, obtains solution a；
(2) isopropyl palmitate, maltitol are added into solution a, stirring and dissolving obtains solution b；
(3) water of hyaluronic acid, purslane extract, glycyrrhizic acid, surplus is mixed, stirring and dissolving, obtains solution c；
(4) solution b is cooled to 35-40 DEG C, solution b is mixed with solution c, added sodium chloride and the water of surplus, stir,
Produce the bacteriostatic hand sanitizer.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108670897A (en) * | 2018-05-29 | 2018-10-19 | 安徽省银锂子生物科技发展有限公司 | A kind of Efficient antibacterial wet tissue composition and preparation method thereof |
| WO2021143208A1 (en) * | 2020-01-14 | 2021-07-22 | 浙江神英科技股份有限公司 | Method for preparing hand wash having ultra-strong decontamination effect |
| CN113288842A (en) * | 2021-07-15 | 2021-08-24 | 厦门力嘉诚生物科技有限公司 | Hyaluronic acid skin-moistening bacteriostatic hand sanitizer and preparation method thereof |
| CN114712281A (en) * | 2022-04-07 | 2022-07-08 | 扬州大学 | Supercritical CO2Extracted plant extract and its preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1101548A (en) * | 1993-10-15 | 1995-04-19 | 向心斗 | Natural waterless anti-chap agent for washing hand |
| CN104207998A (en) * | 2014-09-11 | 2014-12-17 | 吴岳泽 | Flos sophorae hand-washing solution and preparation method thereof |
-
2017
- 2017-10-24 CN CN201710999095.6A patent/CN107669547B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1101548A (en) * | 1993-10-15 | 1995-04-19 | 向心斗 | Natural waterless anti-chap agent for washing hand |
| CN104207998A (en) * | 2014-09-11 | 2014-12-17 | 吴岳泽 | Flos sophorae hand-washing solution and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 徐祝封等: "《中药理化鉴定》", 30 June 1997, 中国中医药出版社 * |
| 范红俊: "《化学基础》", 31 July 2017, 中国矿业大学出版社 * |
| 邵颖: "《食品生物化学》", 31 August 2015, 中国轻工业出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108670897A (en) * | 2018-05-29 | 2018-10-19 | 安徽省银锂子生物科技发展有限公司 | A kind of Efficient antibacterial wet tissue composition and preparation method thereof |
| WO2021143208A1 (en) * | 2020-01-14 | 2021-07-22 | 浙江神英科技股份有限公司 | Method for preparing hand wash having ultra-strong decontamination effect |
| CN113288842A (en) * | 2021-07-15 | 2021-08-24 | 厦门力嘉诚生物科技有限公司 | Hyaluronic acid skin-moistening bacteriostatic hand sanitizer and preparation method thereof |
| CN114712281A (en) * | 2022-04-07 | 2022-07-08 | 扬州大学 | Supercritical CO2Extracted plant extract and its preparation method and application |
| CN114712281B (en) * | 2022-04-07 | 2023-12-08 | 扬州大学 | Supercritical CO 2 Extracted plant extract and preparation method and application thereof |
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