CN107638504A - A kind of heat-clearing cough-relieving oral liquid for children and preparation method thereof - Google Patents
A kind of heat-clearing cough-relieving oral liquid for children and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to pharmaceutical technology field, and in particular to a kind of heat-clearing cough-relieving oral liquid for children and preparation method thereof.Heat-clearing cough-relieving oral liquid for children of the present invention, including following raw material：The capsule of weeping forsythia, Fermented Soybean, peppermint, schizonepeta, stir-baked FRUCTUS GARDENIAE, rheum officinale, sweet wormwood, the radix paeoniae rubrathe, betel nut, the bark of official magnolia, the Radix Astragali, the tuber of pinellia, radix bupleuri, loguat leaf, fritillaria thunbergii, giant knotweed, sweetener, acidity regulator and preservative.Heat-clearing cough-relieving oral liquid for children of the present invention has good inhibiting effect, and the duration longer purpose that can reach quick treatment disease for fever caused by infection caused by noninfectious fever caused by 2,4 dinitrophenol and bacterial endotoxin；Improved significantly for the symptom such as heating, cough, pharyngalgia and throat bleeding caused by infantile acute upper respiratory infection.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of heat-clearing cough-relieving oral liquid for children and preparation method thereof.
Background technology
Traditional Chinese medicine thinks that fever in children enters innerization heat mainly due to being invaded by exogenous pathogen,invasion of exogenous pathogen, caused by exuberant evil_heat.Children's skin is soft
It is tender, interspaces of skin and muscles being loose, defend outer technical ability not admittedly, such as abrupt change of climate, changes in temperature imbalance, disease and evil is easy to take advantage of a weak point.It is wind in wind-heat
The heresy of heat enters from mouth and nose, attacks the part of the body cavity above the diaphragm housing the heart and lungs, and its aversion to cold witness is of short duration, and immediately occurs that high fever, cough, thirsty, pharyngalgia, tongue be red, arteries and veins
The diseases such as number.This between gas is defended, controls the suitable pungent table that cools completely to be evil, clear to expel the heat-evil.I.e. the sweating of Tianjin Tianjin and evil antipyretic move back.Follow enabling by
Steal, the principle of reatment that eliminating evil peace is positive, heresy is had outlet, do not make its disease and evil go deep into.
The treatment for cold in children is broadly divided into western medical treatment and Chinese traditional treatment at present.Western medical treatment is mainly with antibiosis
Based on element, antihistamine are wanted, these drug side-effects are more, and some even can cause serious adverse reaction, to the healthy extensive of children
It is multiple totally unfavorable；The traditional Chinese medical science is in terms of cold in children is treated, and mainly based on Chinese patent drug, not only dosage is big, drug absorption is slow, and suffers from
Person's acceptance level is poor, does not feel any better for a long time, and often delay treatment aggravates disease.
Chinese patent CN1049283A discloses a kind of preparation method of cough medicine containing bear's bile, and the monarch drug in a prescription during it is formulated is bear
Courage, bulbus fritillariae cirrhosae, adjuvant are semen armeniacae amarae, honey etc..Cough-relieving is made by appropriate proportioning after being extracted with warm water dissolution method in bear gall
Medicine, it instead of with drained bear bile and kill snake and take courage, solve the problems, such as snake gall lack of material, protect the ecological balance, but it is not
Foot part is only being applicable fritillaria and almond juice, its clearing and antitussive resolve phlegm effect deficiency in prescription compatibility of medicines.
Chinese patent CN1548113A discloses a kind of bezoar-shake bile-fritillary ball and preparation method thereof, and the ball is at existing dose
Technological innovation in type, with drug release rate is fast, bioavilability is high, excitant is small, divided dose is accurate, takes, be easy to carry
The advantages that, active material in snake bile is preferably saved, the detection of heavy metal, arsenic is added in quality standard, due to
Its reasonable recipe, it is evident in efficacy for exogenous cough, but it is disadvantageous in that in prescription and has used snake gall, it is necessary to kills snake and takes courage
Scarcity of resources, destroy the ecological balance.
Common Sweetening agents such as saccharin, honey element, neotame etc., wherein saccharin are more to be existed in the form of saccharin sodium, its sweet tea
Spend for 300-500 times of sucrose, shortcoming is weak flavor, has rear hardship, potential toxicity problem be present when largely using；Honey element
Sweet taste is pure, and sugariness is 30-40 times of sucrose, its 10% aqueous solution in neutrality, to heat, light, air-stable, but its apply when
There is also potential toxicity problem, using by a definite limitation；The sweet taste of neotame is pure, fresh and clean, similar to Aspartame,
Sugariness is 8000-10000 times of sucrose, and contained nutriment is easy to be absorbed by the body, but the stability of monomer is paid no attention to
Think.As can be seen here merely using the solution of the less desirable sweetener of artificial synthesis edulcorant.
The content of the invention
To solve problems of the prior art, the present invention provides a kind of children's fermented soya beans, salted or other wise and sticks up antipyretic oral liquid and its preparation side
Method.
A kind of heat-clearing cough-relieving oral liquid for children of the present invention, including the raw material of following components and its parts by weight：
Capsule of weeping forsythia 2-6 parts, Fermented Soybean 2-4 parts, peppermint 1-3 parts, schizonepeta 1-3 parts, stir-baked FRUCTUS GARDENIAE 1-4 parts, rheum officinale 1-3 parts, sweet wormwood
2-4 parts, radix paeoniae rubrathe 1-3 parts, betel nut 1-3 parts, bark of official magnolia 2-5 parts, Radix Astragali 2-4 parts, tuber of pinellia 1-5 parts, radix bupleuri 1-3 parts, loguat leaf 3-5
Part, fritillaria thunbergii 1-3 parts, giant knotweed 1-3 parts, sweetener 1-2 parts, acidity regulator 1-2 parts and preservative 0.1-0.3 parts.
Preferably, described heat-clearing cough-relieving oral liquid for children, it is prepared by the raw material of following components and its parts by weight：
4 parts of the capsule of weeping forsythia, 3 parts of Fermented Soybean, 2 parts of peppermint, 2 parts of schizonepeta, 2.5 parts of stir-baked FRUCTUS GARDENIAE, 2 parts of rheum officinale, 3 parts of sweet wormwood, the radix paeoniae rubrathe 2
Part, 2 parts of betel nut, 3.5 parts of the bark of official magnolia, 3 parts of the Radix Astragali, 3 parts of the tuber of pinellia, 2 parts of radix bupleuri, 4 parts of loguat leaf, 2 parts of fritillaria thunbergii, 2 parts of giant knotweed, sweet taste
0.2 part of 1.5 parts of agent, 1.5 parts of acidity regulator and preservative.
Preferably, described sweetener is glycyrrhizin, honey and sodium cyclamate in mass ratio 2:3:5 compositions.
Preferably, the preparation method of described glycyrrhizin comprises the following steps：
(1) 450ml absolute ethyl alcohol continuous flow upstream ultrasonic extraction 3h are used after radix glycyrrhizae 150g crushed into 80 mesh sieves, radix glycyrrhizae is obtained and carries
Take liquid；
(2) precipitate A is filtered to obtain after the licorice extract that step (1) obtains being adjusted into pH=2.5 with citric acid, to what is obtained
Precipitate B is filtered to obtain after adding 600ml ether microwave abstractings 30min in precipitate A；
(3) the ethanol solution ultrasonic extraction that 400ml volume fractions are 70% is added in the precipitate B obtained to step (2)
20min, the filtrate being filtrated to get are concentrated to give thick glycyrrhizin；
(4) 60 DEG C of water of 300ml are added in the thick glycyrrhizin obtained to step (3), adding citric acid is adjusted to pH=0.25,
With 1.5BV/h flow velocitys by macroporous absorbent resin, eluted successively with water, the ethanol solution that volume fraction is 30%, collect elution
Liquid evaporated under reduced pressure produces.
Preferably, described acidity regulator is citric acid.
Further preferably, described preservative is sodium benzoate.
In addition, present invention also offers a kind of preparation method of heat-clearing cough-relieving oral liquid for children, comprise the following steps：
S1, each raw material is weighed by weight, it is standby that each raw material crushed into 40 mesh sieves；
S2, the water for taking 6-10 times of material medicine gross weight, add the capsule of weeping forsythia, Fermented Soybean, peppermint, schizonepeta, stir-baked FRUCTUS GARDENIAE, rheum officinale,
Sweet wormwood, the radix paeoniae rubrathe and betel nut decoct 20-30min, add the bark of official magnolia, the Radix Astragali, the tuber of pinellia, radix bupleuri, loguat leaf, fritillaria thunbergii and giant knotweed, decoct
40-60min is boiled, is filtered to get filtrate and the dregs of a decoction；
The 3-6 times of absolute ethyl alcohol measured is added in S3, the dregs of a decoction obtained to step S2, refluxing extraction 1-3h, is collected after cooling
Extract solution；
S4, the extract solution that the obtained filtrates of step S2 and step S3 obtain is concentrated into relative density at 50-70 DEG C respectively
Thick paste and mixing for 1.10-1.20；
Its gross weight 5- is added after adding sweetener, acidity regulator and preservative in S5, the medicinal extract obtained to step S4
The water of 10 times of amounts, stirs, and refrigerates 24-36h, embedding sterilizing, produces.
Sodium cyclamate (No. CAS：It is 139-05-9) white crystalline powder, sweet, it is readily soluble available for medicinal auxiliary in water
Material and flavouring；Citric acid (No. CAS：It is 77-92-9) a kind of importantOrganic acid, also known as citric acid is clear crystal, Chang Han
One moleculeThe crystallization water, it is odorless, have very strong tart flavour, and soluble in water.
Glycyrrhizin is the active ingredient of radix glycyrrhizae sweet taste, is a kind of very promising pure natural sweetener, has sugariness
High and low heat energy, safe and non-toxic and stronger medicinal health care function, it is that hypertension, obesity, diabetes and cardiac use
Most preferable sweetener, can make up the sweeteners such as sucrose essence induce above-mentioned disease the drawbacks of.
Compared with prior art, the technical advantages of the present invention are that：Heat-clearing cough-relieving oral liquid for children pair prepared by the present invention
There is good suppression in fever caused by infection caused by noninfectious fever caused by 2,4- dinitrophenol and bacterial endotoxin
Effect, and the duration longer purpose that can reach quick treatment disease, so as to improve the security of clinical application and effectively
Property；Heat-clearing cough-relieving oral liquid for children prepared by the present invention caused by infantile acute upper respiratory infection for generating heat, coughing, pharyngalgia
Improved significantly with symptoms such as throat bleedings.
Embodiment
Below by specific embodiment, the present invention is described further, and these embodiments are only used for the purpose of illustration,
It is not intended to limit protection scope of the present invention.
Embodiment 1-3, comparative example 1-3
Table 1 lists the raw material composition and its again of 1-3 of the embodiment of the present invention and comparative example 1-3 heat-clearing cough-relieving oral liquid for children
Measure number.
The raw material of the embodiment of table 1 and comparative example heat-clearing cough-relieving oral liquid for children forms and parts by weight
A kind of 1 heat-clearing cough-relieving oral liquid for children of embodiment
The preparation method of described glycyrrhizin comprises the following steps：
(1) 450ml absolute ethyl alcohol continuous flow upstream ultrasonic extraction 3h are used after radix glycyrrhizae 150g crushed into 80 mesh sieves, radix glycyrrhizae is obtained and carries
Take liquid；
(2) precipitate A is filtered to obtain after the licorice extract that step (1) obtains being adjusted into pH=2.5 with citric acid, to what is obtained
Precipitate B is filtered to obtain after adding 600ml ether microwave abstractings 30min in precipitate A；
(3) the ethanol solution ultrasonic extraction that 400ml volume fractions are 70% is added in the precipitate B obtained to step (2)
20min, the filtrate being filtrated to get are concentrated to give thick glycyrrhizin；
(4) 60 DEG C of water of 300ml are added in the thick glycyrrhizin obtained to step (3), adding citric acid is adjusted to pH=0.25,
With 1.5BV/h flow velocitys by macroporous absorbent resin, eluted successively with water, the ethanol solution that volume fraction is 30%, collect elution
Liquid evaporated under reduced pressure produces.
The preparation method of described heat-clearing cough-relieving oral liquid for children, comprises the following steps：
S1, each raw material is weighed by weight, it is standby that each raw material crushed into 40 mesh sieves；
S2, the water for taking 6 times of material medicine gross weight, add the capsule of weeping forsythia, Fermented Soybean, peppermint, schizonepeta, stir-baked FRUCTUS GARDENIAE, rheum officinale, green grass or young crops
Wormwood artemisia, the radix paeoniae rubrathe and betel nut decoct 20min, add the bark of official magnolia, the Radix Astragali, the tuber of pinellia, radix bupleuri, loguat leaf, fritillaria thunbergii and giant knotweed, decoct
40min, filters to get filtrate and the dregs of a decoction；
The absolute ethyl alcohol of 3 times of amounts is added in S3, the dregs of a decoction obtained to step S2, refluxing extraction 1h, extraction is collected after cooling
Liquid；
S4, the extract solution that the obtained filtrates of step S2 and step S3 obtain is concentrated into relative density at 50 DEG C respectively it is
1.10 thick paste and mixing；
After glycyrrhizin, honey, sodium cyclamate, citric acid and sodium benzoate being added in S5, the medicinal extract obtained to step S4
The water of 5 times of amounts of its gross weight is added, is stirred, 24h is refrigerated, embedding sterilizing, produces.
A kind of 2 heat-clearing cough-relieving oral liquid for children of embodiment
The preparation method of described glycyrrhizin is similar to Example 1.
The preparation method of described heat-clearing cough-relieving oral liquid for children, comprises the following steps：
S1, each raw material is weighed by weight, it is standby that each raw material crushed into 40 mesh sieves；
S2, the water for taking 8 times of material medicine gross weight, add the capsule of weeping forsythia, Fermented Soybean, peppermint, schizonepeta, stir-baked FRUCTUS GARDENIAE, rheum officinale, green grass or young crops
Wormwood artemisia, the radix paeoniae rubrathe and betel nut decoct 25min, add the bark of official magnolia, the Radix Astragali, the tuber of pinellia, radix bupleuri, loguat leaf, fritillaria thunbergii and giant knotweed, decoct
50min, filters to get filtrate and the dregs of a decoction；
The absolute ethyl alcohol of 4.5 times of amounts is added in S3, the dregs of a decoction obtained to step S2, refluxing extraction 2h, collects and carries after cooling
Take liquid；
S4, the extract solution that the obtained filtrates of step S2 and step S3 obtain is concentrated into relative density at 60 DEG C respectively it is
1.15 thick paste and mixing；
After glycyrrhizin, honey, sodium cyclamate, citric acid and sodium benzoate being added in S5, the medicinal extract obtained to step S4
The water of 7.5 times of amounts of its gross weight is added, is stirred, 30h is refrigerated, embedding sterilizing, produces.
A kind of 3 heat-clearing cough-relieving oral liquid for children of embodiment
The preparation method of described glycyrrhizin is similar to Example 1.
The preparation method of described heat-clearing cough-relieving oral liquid for children, comprises the following steps：
S1, each raw material is weighed by weight, it is standby that each raw material crushed into 40 mesh sieves；
S2, the water for taking 10 times of material medicine gross weight, add the capsule of weeping forsythia, Fermented Soybean, peppermint, schizonepeta, stir-baked FRUCTUS GARDENIAE, rheum officinale, green grass or young crops
Wormwood artemisia, the radix paeoniae rubrathe and betel nut decoct 30min, add the bark of official magnolia, the Radix Astragali, the tuber of pinellia, radix bupleuri, loguat leaf, fritillaria thunbergii and giant knotweed, decoct
60min, filters to get filtrate and the dregs of a decoction；
The absolute ethyl alcohol of 6 times of amounts is added in S3, the dregs of a decoction obtained to step S2, refluxing extraction 3h, extraction is collected after cooling
Liquid；
S4, the extract solution that the obtained filtrates of step S2 and step S3 obtain is concentrated into relative density at 70 DEG C respectively it is
1.20 thick paste and mixing；
After glycyrrhizin, honey, sodium cyclamate, citric acid and sodium benzoate being added in S5, the medicinal extract obtained to step S4
The water of 10 times of amounts of its gross weight is added, is stirred, 36h is refrigerated, embedding sterilizing, produces.
A kind of 1 heat-clearing cough-relieving oral liquid for children of comparative example
Described glycyrrhizin and the preparation method of heat-clearing cough-relieving oral liquid for children are similar to Example 2.
The difference of comparative example 1 and embodiment 2 is：Without loguat leaf, increase the content of Fermented Soybean.
A kind of 2 heat-clearing cough-relieving oral liquid for children of comparative example
The preparation method of described heat-clearing cough-relieving oral liquid for children is similar to Example 2.
The difference of comparative example 2 and embodiment 2 is：Without glycyrrhizin, i.e. sweetener presses matter by honey and sodium cyclamate
Measure ratio 3:5 compositions.
A kind of 3 heat-clearing cough-relieving oral liquid for children of comparative example
The preparation method of described glycyrrhizin comprises the following steps：
(1) 450ml absolute ethyl alcohol continuous flow upstream ultrasonic extraction 3h are used after radix glycyrrhizae 150g crushed into 80 mesh sieves, radix glycyrrhizae is obtained and carries
Take liquid；
(2) precipitate A is filtered to obtain after the licorice extract that step (1) obtains being adjusted into pH=2.5 with citric acid；
(3) the ethanol solution ultrasonic extraction that 400ml volume fractions are 70% is added in the precipitate A obtained to step (2)
20min, the filtrate being filtrated to get are concentrated to give thick glycyrrhizin；
(4) 60 DEG C of water of 300ml are added in the thick glycyrrhizin obtained to step (3), adding citric acid is adjusted to pH=0.25,
With 1.5BV/h flow velocitys by macroporous absorbent resin, eluted successively with water, the ethanol solution that volume fraction is 30%, collect elution
Liquid evaporated under reduced pressure produces.
The preparation method of described heat-clearing cough-relieving oral liquid for children is similar to Example 2.
The difference of comparative example 3 and embodiment 2 is：Step (2) in the preparation method of glycyrrhizin is obtained into radix glycyrrhizae extraction
The step of liquid is handled with being precipitated as of being obtained after lemon acid for adjusting pH with ether microwave abstracting.
Test example 1：The influence of fever in rabbits is caused to 2,4- dinitrophenol
1. test material：Heat-clearing cough-relieving oral liquid for children prepared by embodiment 1-3 and comparative example 1.
2. subjects：New zealand white rabbit body weight 2.0-2.5kg male and female, Henan Condar experimental animal Co., Ltd
There is provided.Quality certification number：SCXK (Henan) 2011-001, pre- raising one week.
3. test reagent：2,4-DNP, Tianjin chemical reagent factory lot number：20111005；Bacterial endotoxin China
Pharmaceutical biological product calibrating institute lot number：2011-6.
4. test apparatus：MC-3B computer numeral formula clinical thermometers.
5. test method：Body temperature is selected in 38-39 DEG C, and is fluctuated<0.3 DEG C of rabbit 40 is only divided into 4 groups, and the experiment same day surveys
Body temperature based on its average value, the children clearing heat that each group gives corresponding embodiment 1-3 and prepared by comparative example 1 are taken after determining basal body temperature
Cough stopping oral liquor (according to the daily maximum dosage-feeding of 14 years old children, determines that dosage is 1.4g/kg) after converting dose,equivalent, gives
Rabbit dorsal sc injection 2,4-DNP sodium hydroxide solution 20mg/kg, an anus temperature is surveyed every 20min, is carried out
Measure in 180min, more each time short body temperature lift-off value result are as shown in table 2.
Table 2 causes the influence of fever in rabbits to 2,4- dinitrophenol
The heat-clearing cough-relieving oral liquid for children that as can be seen from Table 2 prepared by 1-3 of the embodiment of the present invention is to 2,4- dinitrophenol
The elevated inhibitory action of body temperature be better than comparative example 1, embodiment 1-3 Qingrezhike oral solutions play antipyretic work since 60min
With the duration is up to 180min, and the refrigeration function effect of embodiment 2 is more preferable compared with embodiment 1 and embodiment 3, is of the invention
Preferred embodiment.
Test example 2：Influence to fever in rabbits caused by bacterial endotoxin
1. test material：Heat-clearing cough-relieving oral liquid for children prepared by embodiment 1-3 and comparative example 1.
2. subjects：Body temperature is selected in 38-39 DEG C, and is fluctuated<0.3 DEG C of rabbit 40 is only divided into 4 groups.
3. test method：Body temperature based on its average value is taken after experiment same day measure basal body temperature, each group gives corresponding reality
The heat-clearing cough-relieving oral liquid for children of a 1-3 and the preparation of comparative example 1 is applied (according to the daily maximum dosage-feeding of 14 years old children, conversion etc.
Determine that dosage is 1.4g/kg after imitating dosage), give rabbit ear source intravenous injection bacterial endotoxin normal saline solution 20Eu/kg
(prepared before use), start after 0.5h to determine anus temperature, later every half an hour measure 2 times, more each period body temperature lift-off value,
As a result it is as shown in table 3.
Table 3 causes the influence of fever in rabbits to bacterial endotoxin
From table 3 it can be seen that in the experiment that bacterial endotoxin causes fever in rabbits, the children clearing heat of embodiment 1-3 preparations
Effect of the cough stopping oral liquor in terms of body temperature rise is suppressed is better than 1 group of comparative example, and refrigeration function from 1.5h when just by obvious
Refrigeration function, refrigeration function duration are up to 3h.
Tested in this 2 test models according to different Heating mechanisms：2,4- dinitrophenol fever model category
In noninfectious fever, bacterial endotoxin model belongs to fever caused by infection.Children clearing heat of the present invention is understood from antipyretic result of the test
Cough stopping oral liquor is effective to fever caused by infection and noninfectious fever, and infantile heat-clearing and antitussive prepared by embodiment 1-3 is oral
Liquid is more preferable compared with the effect of comparative example 1 to fever caused by infection and the inhibitory action of noninfectious fever and the duration is longer, Neng Gouda
To the purpose of quick treatment disease, so as to improve the security of clinical application and validity.
Test example 3：Treat the clinical test of infantile acute upper respiratory infection
1. case selection：Infantile acute upper respiratory infection case 350 is selected, is randomly divided into 7 groups of (1 group of control group and 6
Group treatment group) clinical symptoms and the row such as every group of 50 people, infant occurs generating heat, coughed, pharyngalgia, congestion of throat and antiadoncus
Blood routine examination.
2. treatment method：Infantile heat-clearing and antitussive prepared by treatment group oral 1-3 of the embodiment of the present invention and comparative example 1-3 is oral
Liquid (1-5 year 3g；>=6 years old 6g), the oral Shuanghuanglian oral liquid of control group (1-5 year 4g；>=6 years old 8g), 3 days as one therapeutic course.
3. curative effect is observed：Record heating, cough, pharyngalgia, congestion of throat, the observation of antiadoncus improvement situation before and after treatment
Clinical symptoms and physical and chemical index improve situation.Clinical development standard：1. cure：Temperature recovery is normal in medication 72h, observes 72h
No longer go up, the symptom such as cough, pharyngalgia, congestion of throat, antiadoncus disappears, and abnormal blood picture index recovers normal；It is 2. effective：
Temperature recovery is normal in medication 72h, and observation 72h no longer gos up, the big portion of the symptom such as cough, pharyngalgia, congestion of throat, antiadoncus
Divide and disappear, abnormal blood picture index is close to normally；It is 3. effective：Medication 72h body temperature has declined or has been down to normal and has gone up, cough
Cough, pharyngalgia, congestion of throat, antiadoncus symptom partial disappearance, abnormal blood picture index makes moderate progress；It is 4. invalid：Do not meet with
Upper index.
In addition carrying out organoleptic properties scoring to Chinese medicine preparation prepared by embodiment 1-3 and comparative example 1-3 respectively, (scoring is marked
It is accurate：0-10, fraction is higher to represent that Chinese medicine preparation mouthfeel is better), as a result as shown in table 4.
Table 4 is treated infantile acute upper respiratory infection curative effect and compared
As can be seen from Table 4 in terms of relief of symptoms and the shortening course of disease, children clearing heat prepared by 1-3 of the embodiment of the present invention stops
Cough oral liquid for the therapeutic effect of the symptoms such as cough, pharyngalgia, congestion of throat and antiadoncus be significantly better than that control group and
Comparative example 1-3 groups.The total effective rate of heat-clearing cough-relieving oral liquid for children prepared by additional embodiment 2 is higher than embodiment 1 and embodiment
3, it is the preferred embodiments of the present invention.
It the above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
The limitation of the present invention, protection scope of the present invention should be defined by claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these change
Enter and retouch and also should be regarded as protection scope of the present invention.
Claims (7)
- A kind of 1. heat-clearing cough-relieving oral liquid for children, it is characterised in that the raw material including following components and its parts by weight：Capsule of weeping forsythia 2-6 parts, Fermented Soybean 2-4 parts, peppermint 1-3 parts, schizonepeta 1-3 parts, stir-baked FRUCTUS GARDENIAE 1-4 parts, rheum officinale 1-3 parts, sweet wormwood 2-4 Part, radix paeoniae rubrathe 1-3 parts, betel nut 1-3 parts, bark of official magnolia 2-5 parts, Radix Astragali 2-4 parts, tuber of pinellia 1-5 parts, radix bupleuri 1-3 parts, loguat leaf 3-5 parts, Zhejiang Fritillaria 1-3 parts, giant knotweed 1-3 parts, sweetener 1-2 parts, acidity regulator 1-2 parts and preservative 0.1-0.3 parts.
- 2. heat-clearing cough-relieving oral liquid for children according to claim 1, it is characterised in that by following components and its parts by weight Raw material be prepared：4 parts of the capsule of weeping forsythia, 3 parts of Fermented Soybean, 2 parts of peppermint, 2 parts of schizonepeta, 2.5 parts of stir-baked FRUCTUS GARDENIAE, 2 parts of rheum officinale, 3 parts of sweet wormwood, 2 parts of the radix paeoniae rubrathe, Bin Bulky 2 parts, 3.5 parts of the bark of official magnolia, 3 parts of the Radix Astragali, 3 parts of the tuber of pinellia, 2 parts of radix bupleuri, 4 parts of loguat leaf, 2 parts of fritillaria thunbergii, 2 parts of giant knotweed, sweetener 1.5 0.2 part of part, 1.5 parts of acidity regulator and preservative.
- 3. heat-clearing cough-relieving oral liquid for children according to claim 1 or 2, it is characterised in that described sweetener is radix glycyrrhizae Glucin, honey and sodium cyclamate in mass ratio 2:3:5 compositions.
- 4. heat-clearing cough-relieving oral liquid for children according to claim 3, it is characterised in that the preparation side of described glycyrrhizin Method comprises the following steps：(1) 450ml absolute ethyl alcohol continuous flow upstream ultrasonic extraction 3h are used after radix glycyrrhizae 150g crushed into 80 mesh sieves, obtain radix glycyrrhizae extraction Liquid；(2) precipitate A is filtered to obtain after the licorice extract that step (1) obtains being adjusted into pH=2.5 with citric acid, to obtained precipitation Precipitate B is filtered to obtain after adding 600ml ether microwave abstractings 30min in A；(3) the ethanol solution ultrasonic extraction 20min that 400ml volume fractions are 70% is added in the precipitate B obtained to step (2), The filtrate being filtrated to get is concentrated to give thick glycyrrhizin；(4) 60 DEG C of water of 300ml are added in the thick glycyrrhizin obtained to step (3), adding citric acid is adjusted to pH=0.25, with 1.5BV/h flow velocitys are eluted with water, the ethanol solution that volume fraction is 30% by macroporous absorbent resin, collect eluent successively Evaporated under reduced pressure produces.
- 5. heat-clearing cough-relieving oral liquid for children according to claim 1 or 2, it is characterised in that described acidity regulator is Citric acid.
- 6. heat-clearing cough-relieving oral liquid for children according to claim 1 or 2, it is characterised in that described preservative is benzene first Sour sodium.
- 7. the preparation method of the heat-clearing cough-relieving oral liquid for children according to claim any one of 1-6, it is characterised in that including Following steps：S1, each raw material is weighed by weight, it is standby that each raw material crushed into 40 mesh sieves；S2, the water for taking 6-10 times of material medicine gross weight, add the capsule of weeping forsythia, Fermented Soybean, peppermint, schizonepeta, stir-baked FRUCTUS GARDENIAE, rheum officinale, sweet wormwood, The radix paeoniae rubrathe and betel nut decoct 20-30min, add the bark of official magnolia, the Radix Astragali, the tuber of pinellia, radix bupleuri, loguat leaf, fritillaria thunbergii and giant knotweed, decoct 40- 60min, filters to get filtrate and the dregs of a decoction；The 3-6 times of absolute ethyl alcohol measured is added in S3, the dregs of a decoction obtained to step S2, refluxing extraction 1-3h, extraction is collected after cooling Liquid；S4, the extract solution that the obtained filtrates of step S2 and step S3 obtain is concentrated into relative density at 50-70 DEG C respectively it is 1.10-1.20 thick paste and mixing；5-10 times of its gross weight is added after adding sweetener, acidity regulator and preservative in S5, the medicinal extract obtained to step S4 The water of amount, stirs, and refrigerates 24-36h, embedding sterilizing, produces.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109223930A (en) * | 2018-10-19 | 2019-01-18 | 济川药业集团有限公司 | A kind of medical syrup and preparation method thereof for treating children's wind-heat cold |
| CN112386646A (en) * | 2019-08-13 | 2021-02-23 | 济川药业集团有限公司 | Pharmaceutical composition and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1733182A (en) * | 2005-08-17 | 2006-02-15 | 江苏济川制药有限公司 | Medicine composition for curing exogenous fever and process for preparing the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1733182A (en) * | 2005-08-17 | 2006-02-15 | 江苏济川制药有限公司 | Medicine composition for curing exogenous fever and process for preparing the same |
Non-Patent Citations (1)
| Title |
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| 杨和钧: "甘草甜素的用途和制法", 《黎明化工》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109223930A (en) * | 2018-10-19 | 2019-01-18 | 济川药业集团有限公司 | A kind of medical syrup and preparation method thereof for treating children's wind-heat cold |
| CN109223930B (en) * | 2018-10-19 | 2021-08-03 | 济川药业集团有限公司 | Medicinal syrup for treating wind-heat type common cold of children and preparation method thereof |
| CN112386646A (en) * | 2019-08-13 | 2021-02-23 | 济川药业集团有限公司 | Pharmaceutical composition and preparation method and application thereof |
| CN112386646B (en) * | 2019-08-13 | 2022-04-12 | 济川药业集团有限公司 | Pharmaceutical composition and preparation method and application thereof |
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