CN107596064A - A kind of medicine for treating acute nephritis and preparation method thereof - Google Patents
A kind of medicine for treating acute nephritis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of medicine for treating acute nephritis and preparation method thereof, its mainly by pomegranate root, Chinese yam, radix rehmanniae recen, the Radix Astragali, the radix paeoniae rubrathe, field thistle, Poria cocos, moutan bark, fructus polygoni orientalis, cortex acanthopanacis, the shell of areca nut, dried orange peel, plantain seed, rhizoma alismatis, windproof be prepared according to a certain weight ratio, medicine of the present invention has invigorating the spleen, reinforces the kidney, Li Shui, excreting dampness, promoting blood circulation, the function of heat-clearing are quick for treating acute nephritis, good effect, do not recur.
Description
Technical field
The present invention relates to a kind of medicine for treating acute nephritis and preparation method thereof, belongs to the field of Chinese medicines.
Technical background
Acute nephritis is one group of primary glomerulonephritis using acute nephritic syndrome as main clinical manifestation, is common in
After streptococcal infection, and other bacteriums, virus and parasitic infection can also cause.The traditional Chinese medical science then thinks that acute nephritis is general with geomantic omen
Excessively, wind-heat, retention of damp-heat in the interior are relevant.Because western medicine side effect is big, therefore people are to the Chinese medicines of effectively treatment acute nephritis
There is great demand in thing, up to now, it has not been found that the relevant report on the present invention.
The content of the invention
The present inventor according to theory of traditional Chinese medical science research and clinical test checking repeatedly, have found finally effectively treat it is acute
The medicine of ephritis, so as to complete the present invention.
It is an object of the invention to provide a kind of Chinese medicine composition of effectively treatment acute nephritis.
Another object of the present invention just there is provided the preparation method of the Chinese medicine composition.
Medicine of the present invention is selection pomegranate root, Chinese yam, radix rehmanniae recen, the Radix Astragali, the radix paeoniae rubrathe, field thistle, Poria cocos, moutan bark, prince ' s-feather
Son, cortex acanthopanacis, the shell of areca nut, dried orange peel, plantain seed, rhizoma alismatis, windproof, cicada slough, cordate houttuynia, the capsule of weeping forsythia, motherwort are combined preparation,
Each efficacy of drugs is caused to produce synergy these drug regimens, so as to effectively treat acute nephritis.Wherein select stone
Pomegranate root is because its nature and flavor is bitter, temperature, has desinsection, puckery intestines, the function of stop-band, controls roundworm, tapeworm, chronic diarrhea, protracted dysentery, red leukorrhea
Under.It is because its nature and flavor is sweet from Chinese yam, puts down, enter lung, spleen, kidney channel, have invigorating the spleen, tonifying lung, reinforce the kidney, the function of strengthening the essence, control insufficiency of the spleen
Diarrhea, protracted dysentery, cough due to consumptive disease, quench one's thirst, under seminal emission, band, frequent urination.It is because its nature and flavor is sweet from radix rehmanniae recen, trembles with fear, the thoughts of returning home,
Liver and kidney channel, there is clearing heat and cooling blood, yin-nourishing, the function of promoting the production of body fluid, control pyreticosis polydipsia, yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, Heat Diabetes, tell
Blood, bleeding from five sense organs or subcutaneous tissue, spot dermexanthesis.It is the tepor because its nature and flavor is sweet from the Radix Astragali, enters lung, the spleen channel, raw with beneficial to solid table is defended, Li Shui disappears
Swollen, eliminating toxic, the function of myogenic controls spontaneous perspiration, night sweat, blood-arthralgia, edema, and ulcer is not burst or burst and holds back long；The function of using and have bowl spares benefit is processed,
Control internal injury overstrain, splenasthenic diarrhea, prolapse of the anus, deficiency of vital energy blood takes off, and collapses band and the disease of all laboured breathing deficiency of blood.It is from the radix paeoniae rubrathe because its nature and flavor
Hardship, it is slightly cold, return liver warp, has clearing heat and cooling blood, the function of blood stasis removing analgesic, control epidemic heat syndrome and go mad, hematemesis and epistaxis, red eye, swell pain, the liver depression side of body
Bitterly, closed dysmenorrhea , Epilepsy lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle swells sore.It is because its nature and flavor is pungent from field thistle, temperature, enters spleen, stomach two passes through,
There is middle benefit gas, lower gas, anti-inflammatory, the function of desinsection, control vomiting and diarrhoea, trusted subordinate's distending pain, malignant boil pyogenic infections sore, poisonous insect flood dragon wound.Be from Poria cocos because
Its property slightly sweet flavor, put down, enter the heart, spleen, lung channel, have eliminating dampness and diuresis, beneficial spleen and stomach, the function of antitoxic heart-soothing and sedative, control difficult urination oedema
Distending pain, phlegm and retained fluid cough is inverse, the sound of vomiting of vomitting, diarrhea, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.From moutan bark worked hard because of its nature and flavor, it is cool, enter
The heart, liver and kidney channel, there are heat-clearing, cool blood, and blood, the function of dispersing blood stasis, control heat invading xuefen, send out spot , Jing Epilepsy, tell, be defeated in battle, have blood in stool, hectic fever due to yin labor
Heat, Amenorrhea , Disorder lumps in the abdomen, large carbuncle, flutters damage.It is because its nature and flavor is salty from fructus polygoni orientalis, trembles with fear have the broken product of dispersing blood stasis, the work(of invigorating spleen to remove dampness
Can, Xie Fu Disorder products are controlled, ascites, are had a stomach-ache, deficiency of food abdominal distension, pinkeye, sore swells, scrofula.It is the temperature because its nature and flavor is pungent from cortex acanthopanacis,
Entering liver and kidney channel, there is wind-damp dispelling, strengthen the bone, the function of blood circulation and promoting silt, control wind-cold-dampness arthralgia, muscles and bones contraction is anxious, pain in the back, impotence, flaccidity of lower limbs,
Children's retardation of walking, oedema, tinea pedis, sore subcutaneous ulcer pyogenic infections, bruise internal lesion caused by overexertion.It is the tepor because its nature and flavor is pungent from the shell of areca nut, enters spleen, stomach, big
Small intestinl channel, in having lower gas wide, the function of water-filling, control gastral cavity abdomen swollen ruffian, tinea pedis, oedema.Be from dried orange peel because its is bitter in taste, pungent,
Temperature, return lung, the spleen channel, there is regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm function, control chest gastral cavity turgor, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.From Chinese herbaceous peony
Son is because its nature and flavor is sweet, trembles with fear, enters kidney, bladder warp, favourable water, heat-clearing, improving eyesight, the function of eliminating the phlegm, controls urinary obstruction, stranguria with turbid discharge,
Under band, hematuria, summer-heat and damp rush down dysentery, cough ant phlegm, arthritis with fixed pain caused by dampness, hot eyes hides from view.It is because its nature and flavor is sweet from rhizoma alismatis, trembles with fear, enter bladder warp,
Favourable water, excreting dampness, the function of expelling the heat-evil, difficult urination is controlled, oedema anus is expired, vomiting, rush down dysentery, phlegm and retained fluid, tinea pedis, gonorrhoea, hematuria.From
Windproof is because its property acrid-sweet flavor, temperature, enters bladder, lung, the spleen channel, delivers, wind-dispelling, victory is wet, the function of analgesic, controls diseases caused by external factors wind
Cold, headache, dizzy, Xiang Qiang, wind-cold-dampness arthralgia, skeletal pain, four limbs contraction is anxious, lockjaw.From cicada slough be because its property sweet-salty,
It is cool, enter lung, Liver Channel, have dissipate wind-heat, facilitaing lung, determine the function of convulsion, control affection of exogenous wind-heat, cough sound is mute, measles without adequate eruption, rubella scabies
Itch, little Jing Epilepsy, hot eyes, ocular, furuncle swelling toxin, lockjaw.It is because its nature and flavor is pungent from cordate houttuynia, trembles with fear, enter meridian of Hand-TAI YIN,
There is clearing heat and detoxicating, the function of inducing diuresis to remove edema, control pneumonia, lung abscess, hot dysentery, malaria, oedema, gonorrhoea, leukorrhea, carbuncle swells, hemorrhoid, take off
Anus, eczema, the favus of the scalp, mange.Be from the capsule of weeping forsythia because its is bitter in taste, it is cool, enter the heart, liver, gallbladder channel, there is heat-clearing, detoxify, dissipating bind, disappear
It is swollen, control warm, erysipelas, macula, large carbuncle pyogenic infections, scrofula, urine leaching closes.From motherwort worked hard because of its nature and flavor, it is cool, enter the heart
Bag, Liver Channel, have promoting blood circulation, dissolving stasis, menstruation regulating, the function for the water that disappears, control irregular menstruation, control and Lou have difficult labour, placenta retension, postpartum anemic fainting, the stasis of blood
Hemoperitoneum pain, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle swells sore.
Embodiment
The drug dose of instant component is also that inventor show that the dosage of each component is following heavy by largely groping to summarize
All there is the effect of preferable in the range of amount：
25-35 grams of pomegranate root, 25-35 grams of Chinese yam, 25-35 grams of radix rehmanniae recen, 25-35 grams of the Radix Astragali, 25-35 grams of the radix paeoniae rubrathe, field thistle 25-35
Gram, 25-35 grams of Poria cocos, 5-15 grams of moutan bark, 5-15 grams of fructus polygoni orientalis, 5-15 grams of cortex acanthopanacis, 5-15 grams of the shell of areca nut, dried orange peel 5-15
Gram, 15-25 grams of plantain seed, 15-25 grams of rhizoma alismatis, windproof 4-8 grams, 10-20 grams of cicada slough, 25-35 grams of cordate houttuynia, 25-35 grams of the capsule of weeping forsythia,
40-50 grams of motherwort.
Preferable amount is：
30 grams of pomegranate root, 30 grams of Chinese yam, 30 grams of radix rehmanniae recen, 30 grams of the Radix Astragali, 30 grams of the radix paeoniae rubrathe, 30 grams of field thistle, 30 grams of Poria cocos, moutan bark
10 grams, 10 grams of fructus polygoni orientalis, 10 grams of cortex acanthopanacis, 10 grams of the shell of areca nut, 10 grams of dried orange peel, 20 grams of plantain seed, 20 grams of rhizoma alismatis, windproof 6 grams,
15 grams of cicada slough, 30 grams of cordate houttuynia, 30 grams of the capsule of weeping forsythia, 45 grams of motherwort.
The preparation method of medicine of the present invention is as follows
First, stock up
1st, pomegranate root：Crude drug is taken, impurity is removed, dries；
2nd, Chinese yam：Net impurity is picked, is soaked in water untill Chinese yam central part softens, is pulled out and slightly dry in the air, section is dried or dried；
3rd, radix rehmanniae recen：Crude drug is taken, removes impurity, is cleaned, is slightly moistened, cut sheet, dries, weeds out chip；
4th, the Radix Astragali：Net impurity is picked, the root head of residual and hollow larger root is removed, is soaked in water, pulls out, cut in time after running through
Piece, dry；
5th, the radix paeoniae rubrathe：Crude drug is taken, impurity is removed, size stepping, cleans, run through, shave, dry, weed out chip；
6th, field thistle：Net impurity is picked, removes root, washing is run through, and segment, is dried；
7th, schizonepeta：Net impurity is picked, is slightly steeped with water, is pulled segment out, dry；
8th, moutan bark：Impurity is picked, removes core, cleans, runs through, cuts into slices, dries；
9th, fructus polygoni orientalis：8-10 extracts fruit ear between the month, dries, and hits fruit down, removes impurity；
10th, cortex acanthopanacis：Net impurity is picked, is eluted with water, after slightly moistening, cuts into slices, dries；
11st, the shell of areca nut：Pick net impurity, rolloff makes soft, beats, weeds out spare；
12nd, dried orange peel：Taking crude drug, remove impurity and the pericarp of blackening, wash quickly is net, softens, chopping, dries or low temperature drying,
Weed out grey bits；
13rd, plantain seed：Impurity is picked, weeds out spare, empty grain；
14th, rhizoma alismatis：Impurity is picked, size stepping, is soaked in water to eighty per cant thoroughly, pulls out, solarization is cool, and vexed profit is uniform to inside and outside humidity,
Section, is dried；
15th, it is windproof：Residual stem is removed, is soaked in water, is pulled out, section is run through, dries；
16th, cicada slough：Impurity is picked, cleans and dries；
17th, cordate houttuynia：Impurity is removed, removes undesirable root, segment is cleaned, dries；
18th, the capsule of weeping forsythia：Net impurity is picked, stranding is opened, except discarding stalk；
19th, motherwort：Impurity is picked, is cleaned, is run through, segment, dry.
2nd, prepare
1st, by the pomegranate root after processing, Chinese yam, radix rehmanniae recen, the Radix Astragali, the radix paeoniae rubrathe, field thistle, Poria cocos, moutan bark, fructus polygoni orientalis, slender acanthopanax
Skin, the shell of areca nut, dried orange peel, plantain seed, rhizoma alismatis, windproof, cicada slough, cordate houttuynia, the capsule of weeping forsythia, motherwort are put into decocting container, for the first time
Add 8 times of amounts of water, after soaking 100 minutes, high heat decoction boiling, then with being cooked by slow fire 20 minutes, first time decoction liquor is filtered to obtain, will
First time decoction liquor is poured into container；
2nd, the dregs of a decoction of filtering are added into 6 times of amounts, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor；
3rd, it decoction liquor will be mixed evenly twice, and be divided into 4 doses and take.
Chinese yam has invigorating the spleen in prescription, tonifying lung, reinforces the kidney, and the function of strengthening the essence is monarch drug in a prescription；Rhizoma alismatis Li Shui, excreting dampness, expels the heat-evil；Motherwort
There is promoting blood circulation, dissolving stasis, menstruation regulating, the function for the water that disappears, the two is ministerial drug, and three taste medicines play invigorating the spleen, tonifying lung, reinforced the kidney jointly, strengthening the essence, profit
Water, excreting dampness, purge heat, invigorate blood circulation, the effect of menstruation regulating, treatment acute nephritis effect is comprehensive, and with invigorating the spleen, reinforces the kidney, Li Shui, excreting dampness, live
It can be effected a permanent cure based on blood, the favourable water of plantain seed, heat-clearing, improving eyesight, the function of eliminating the phlegm is adjutant, and field thistle has middle benefit gas, lower gas, anti-inflammatory, killed
The function of worm is to take stopgap measures with remaining all medicines to make medicine.
Medicine of the present invention has invigorating the spleen, reinforces the kidney, Li Shui, excreting dampness, promoting blood circulation, the function of heat-clearing, for treating acute nephritis, treats
Journey is short, quick, non-relapse after healing.
The beneficial effect of medicine of the present invention is expanded on further below by way of test example, these test examples include this hair
The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.
The animal toxicity test report of [test example 1] medicine of the present invention：
Rabbit 30 is taken, male and female dual-purpose, 2.0-2.5kg of body weight, is divided to two groups, every group 15, one of which is tested for overdose
Group, another group is normal amount test group.Super quantity group is 20ml/kg, normal amount 10ml/kg, and administering mode is given for administration by gavage
Medicine, twice daily, 7 days are even served, the reaction of observation administration daily, the results showed that two groups of rabbit activities, diet are normal, and medicine is without bad
Toxic side effect.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1st, general information
Accept acute nephritis out-patient totally 28 for medical treatment.
2nd, diagnostic criteria
Classical symptom is blood urine, albuminuria, oliguresis, edema of lower extremity, Mild or moderate hypertension etc..
3rd, treatment method
From above-mentioned medicament, taken to patient, each taking 1 dose, 3 times a day, 10 days are a course for the treatment of, continuously take 3 treatments
Journey.
4th, efficacy assessment standard
It is effective：Acute nephritis symptom disappears, and constitution recovers normal, recovery from illness；
Take a turn for the better：Patient's blood urine, albuminuria and oliguresis, the phenomenon of edema of lower extremity mitigate, and acute nephritis symptom is clearly better, constitution by
Step recovers normal；
It is invalid：Improvement standard person is not reached.
5th, treatment results（It see the table below）
In above-mentioned treatment, with drug therapy acute nephritis patient 28 of the present invention, as a result effective 20, obvious effective rate is
71.43%, take a turn for the better 6, improvement rate 21.42%, invalid 2, total effective rate 92.85%.
Claims (3)
- A kind of 1. medicine for treating acute nephritis, it is characterised in that：It is made up of the bulk drug in following weight range：25-35 grams of pomegranate root, 25-35 grams of Chinese yam, 25-35 grams of radix rehmanniae recen, 25-35 grams of the Radix Astragali, 25-35 grams of the radix paeoniae rubrathe, field thistle 25-35 Gram, 25-35 grams of Poria cocos, 5-15 grams of moutan bark, 5-15 grams of fructus polygoni orientalis, 5-15 grams of cortex acanthopanacis, 5-15 grams of the shell of areca nut, dried orange peel 5-15 Gram, 15-25 grams of plantain seed, 15-25 grams of rhizoma alismatis, windproof 4-8 grams, 10-20 grams of cicada slough, 25-35 grams of cordate houttuynia, 25-35 grams of the capsule of weeping forsythia, 40-50 grams of motherwort.
- 2. medicine according to claim 1, wherein the dosage of each bulk drug is：30 grams of pomegranate root, 30 grams of Chinese yam, 30 grams of radix rehmanniae recen, 30 grams of the Radix Astragali, 30 grams of the radix paeoniae rubrathe, 30 grams of field thistle, 30 grams of Poria cocos, moutan bark 10 grams, 10 grams of fructus polygoni orientalis, 10 grams of cortex acanthopanacis, 10 grams of the shell of areca nut, 10 grams of dried orange peel, 20 grams of plantain seed, 20 grams of rhizoma alismatis, windproof 6 grams, 15 grams of cicada slough, 30 grams of cordate houttuynia, 30 grams of the capsule of weeping forsythia, 45 grams of motherwort.
- 3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：（One）Stock（1）Pomegranate root：Crude drug is taken, impurity is removed, dries；（2）Chinese yam：Net impurity is picked, is soaked in water untill Chinese yam central part softens, is pulled out and slightly dry in the air, section is dried or dried；（3）Radix rehmanniae recen：Crude drug is taken, removes impurity, is cleaned, is slightly moistened, cut sheet, dries, weeds out chip；（4）The Radix Astragali：Net impurity is picked, the root head of residual and hollow larger root is removed, is soaked in water, pulls out, cut in time after running through Piece, dry；（5）The radix paeoniae rubrathe：Crude drug is taken, impurity is removed, size stepping, cleans, run through, shave, dry, weed out chip；（6）Field thistle：Net impurity is picked, removes root, washing is run through, and segment, is dried；（7）Schizonepeta：Net impurity is picked, is slightly steeped with water, is pulled segment out, dry；（8）Moutan bark：Impurity is picked, removes core, cleans, runs through, cuts into slices, dries；（9）Fructus polygoni orientalis：8-10 extracts fruit ear between the month, dries, and hits fruit down, removes impurity；（10）Cortex acanthopanacis：Net impurity is picked, is eluted with water, after slightly moistening, cuts into slices, dries；（11）The shell of areca nut：Pick net impurity, rolloff makes soft, beats, weeds out spare；（12）Dried orange peel：Taking crude drug, remove impurity and the pericarp of blackening, wash quickly is net, softens, chopping, dries or low temperature drying, Weed out grey bits；（13）Plantain seed：Impurity is picked, weeds out spare, empty grain；（14）Rhizoma alismatis：Impurity is picked, size stepping, is soaked in water to eighty per cant thoroughly, pulls out, solarization is cool, and vexed profit is uniform to inside and outside humidity, Section, is dried；（15）It is windproof：Residual stem is removed, is soaked in water, is pulled out, section is run through, dries；（16）Cicada slough：Impurity is picked, cleans and dries；（17）Cordate houttuynia：Impurity is removed, removes undesirable root, segment is cleaned, dries；（18）The capsule of weeping forsythia：Net impurity is picked, stranding is opened, except discarding stalk；（19）Motherwort：Impurity is picked, is cleaned, is run through, segment, dry；（Two）Prepare（1）By the pomegranate root after processing, Chinese yam, radix rehmanniae recen, the Radix Astragali, the radix paeoniae rubrathe, field thistle, Poria cocos, moutan bark, fructus polygoni orientalis, slender acanthopanax Skin, the shell of areca nut, dried orange peel, plantain seed, rhizoma alismatis, windproof, cicada slough, cordate houttuynia, the capsule of weeping forsythia, motherwort are put into decocting container, add 8 times of water Amount, after soaking 100 minutes, high heat decoction boiling, then with being cooked by slow fire 20 minutes, first time decoction liquor is filtered to obtain, will be for the first time Decoction liquor is poured into container；（2）The dregs of a decoction of filtering are added into 6 times of amounts of water, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second of decoction liquor；（3）It decoction liquor will be mixed evenly twice, and be divided into 4 doses and take.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20120093632A (en) * | 2011-02-15 | 2012-08-23 | 조신영 | Phamaceutical composition for prevention or treatment of nephritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120093632A (en) * | 2011-02-15 | 2012-08-23 | 조신영 | Phamaceutical composition for prevention or treatment of nephritis |
Non-Patent Citations (3)
| Title |
|---|
| 张时文: "急性肾炎中医诊治思路探析", 《辽宁中医药大学学报》 * |
| 施杞: "《现代中医药应用与研究大系第8卷儿科》", 31 December 1995, 上海中医药大学出版社 * |
| 王宝林: "《中医特效处方集》", 30 April 2017, 中医古籍出版社 * |
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Application publication date: 20180119 |