CN107569494A - 具有二氟泼尼酯的黄斑水肿治疗用滴眼剂 - Google Patents

具有二氟泼尼酯的黄斑水肿治疗用滴眼剂 Download PDF

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Publication number
CN107569494A
CN107569494A CN201710195879.3A CN201710195879A CN107569494A CN 107569494 A CN107569494 A CN 107569494A CN 201710195879 A CN201710195879 A CN 201710195879A CN 107569494 A CN107569494 A CN 107569494A
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China
Prior art keywords
administration
difluprednate
weeks
day
eye drops
Prior art date
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Pending
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CN201710195879.3A
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English (en)
Chinese (zh)
Inventor
山下英俊
山本祯子
后藤早纪子
阿部佐知
桐井枝里子
奥村敦司
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Yamagata University NUC
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Yamagata University NUC
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Publication of CN107569494A publication Critical patent/CN107569494A/zh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Botany (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201710195879.3A 2009-07-14 2010-07-14 具有二氟泼尼酯的黄斑水肿治疗用滴眼剂 Pending CN107569494A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009-165924 2009-07-14
JP2009165924 2009-07-14
CN2010800027502A CN102170865A (zh) 2009-07-14 2010-07-14 具有二氟泼尼酯的黄斑水肿治疗用滴眼剂

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2010800027502A Division CN102170865A (zh) 2009-07-14 2010-07-14 具有二氟泼尼酯的黄斑水肿治疗用滴眼剂

Publications (1)

Publication Number Publication Date
CN107569494A true CN107569494A (zh) 2018-01-12

Family

ID=42646370

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201710195879.3A Pending CN107569494A (zh) 2009-07-14 2010-07-14 具有二氟泼尼酯的黄斑水肿治疗用滴眼剂
CN201310288639.XA Withdrawn CN103705524A (zh) 2009-07-14 2010-07-14 具有二氟泼尼酯的黄斑水肿治疗用滴眼剂
CN2010800027502A Pending CN102170865A (zh) 2009-07-14 2010-07-14 具有二氟泼尼酯的黄斑水肿治疗用滴眼剂

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201310288639.XA Withdrawn CN103705524A (zh) 2009-07-14 2010-07-14 具有二氟泼尼酯的黄斑水肿治疗用滴眼剂
CN2010800027502A Pending CN102170865A (zh) 2009-07-14 2010-07-14 具有二氟泼尼酯的黄斑水肿治疗用滴眼剂

Country Status (13)

Country Link
US (3) US20110190250A1 (enExample)
EP (1) EP2340014B1 (enExample)
JP (1) JP5579079B2 (enExample)
KR (1) KR101689847B1 (enExample)
CN (3) CN107569494A (enExample)
BR (1) BRPI1005380A2 (enExample)
CA (1) CA2738151C (enExample)
ES (1) ES2405779T3 (enExample)
MX (1) MX2011005043A (enExample)
PL (1) PL2340014T3 (enExample)
RU (1) RU2572707C2 (enExample)
TW (1) TW201105363A (enExample)
WO (1) WO2011007893A1 (enExample)

Families Citing this family (14)

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Publication number Priority date Publication date Assignee Title
JP5902100B2 (ja) * 2011-01-14 2016-04-13 株式会社エス・ディー・エス バイオテック 4−(3−ブチニル)アミノピリミジン誘導体を含む農園芸用有害生物防除剤組成物
US20140018402A1 (en) * 2011-03-30 2014-01-16 Catholic University Industry Academic Cooperation Foundation Pharmaceutical composition for preventing or treating macular degeneration
CN103130857A (zh) * 2011-11-30 2013-06-05 天津金耀集团有限公司 二氟泼尼酯ⅱ晶型及其制备方法
CN103130859B (zh) * 2011-11-30 2015-12-02 天津金耀集团有限公司 二氟泼尼酯晶型i及其制备方法
EP2956144B1 (en) * 2013-02-15 2017-11-22 Senju Pharmaceutical Co., Ltd. Difluprednate emulsion composition containing zinc
US9440963B2 (en) * 2013-03-15 2016-09-13 Aerpio Therapeutics, Inc. Compositions, formulations and methods for treating ocular diseases
WO2015197594A2 (de) 2014-06-23 2015-12-30 Schott Ag Elektrisches speichersystem enthaltend ein scheibenförmiges diskretes element, scheibenförmiges diskretes element sowie verfahren zu dessen herstellung und dessen verwendung
WO2016087311A2 (de) 2014-12-01 2016-06-09 Schott Ag Elektrisches speichersystem mit einem scheibenförmigen diskreten element, diskretes scheibenförmiges element, verfahren zu dessen herstellung sowie dessen verwendung
EP3302382A4 (en) * 2015-05-29 2019-02-20 Allergan, Inc. IMPLANT FOR THE TREATMENT OF OCULAR DISEASE
RU2661621C2 (ru) * 2016-12-19 2018-07-17 Александр Николаевич Епихин Способ пролонгации и усиления терапевтического эффекта действия ингибиторов ангиогенеза при лечении неоваскулярных форм макулярных дегенераций
CN108014172A (zh) * 2017-12-29 2018-05-11 广州仁恒医药科技股份有限公司 一种含有二氟泼尼酯的药物组合物及其制备方法
KR20210012346A (ko) 2019-07-25 2021-02-03 심낙범 미세먼지 눈꺼풀 세정스틱
AU2020345915A1 (en) * 2019-09-11 2022-03-24 Adverum Biotechnologies, Inc. Methods of treating ocular neovascular diseases using AAV2 variants encoding aflibercept
US20210100856A1 (en) * 2019-09-11 2021-04-08 Adverum Biotechnologies, Inc. Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0878197A1 (en) * 1997-05-14 1998-11-18 Senju Pharmaceutical Co., Ltd. Compositions containing difluprednate
US20090105245A1 (en) * 2006-12-21 2009-04-23 Bingaman David P Methods for treating macular edema and ocular angiogenesis using an anti-inflammatory agent and a receptor tyrosine kinase inhibitor

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US5556848A (en) 1993-12-27 1996-09-17 Senju Pharmaceutical Co., Ltd. Ophthalmic suspension containing diflupredonate
JP3781792B2 (ja) 1993-12-27 2006-05-31 千寿製薬株式会社 ジフルプレドナート含有点眼用懸濁液剤
JP3410364B2 (ja) 1997-05-14 2003-05-26 千寿製薬株式会社 ジフルプレドナート含有組成物
US20050048099A1 (en) * 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
CA2516782A1 (en) * 2003-02-20 2004-09-02 Alcon, Inc. Use of steroids to treat ocular disorders
US20050226814A1 (en) * 2004-04-13 2005-10-13 Bausch & Lomb Incorporated Diagnostic method and kit for implantation of a sustained release drug-delivery implant with a steroid
CA2573668A1 (en) * 2004-07-12 2006-02-16 Allergan, Inc. Ophthalmic compositions and methods for treating ophthalmic conditions
WO2006082588A2 (en) * 2005-02-07 2006-08-10 Pharmalight Inc. Method and device for ophthalmic administration of active pharmaceutical ingredients
CA2620346A1 (en) 2005-08-25 2007-03-01 Psivida Inc. Control of induced elevated intraocular pressure

Patent Citations (2)

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EP0878197A1 (en) * 1997-05-14 1998-11-18 Senju Pharmaceutical Co., Ltd. Compositions containing difluprednate
US20090105245A1 (en) * 2006-12-21 2009-04-23 Bingaman David P Methods for treating macular edema and ocular angiogenesis using an anti-inflammatory agent and a receptor tyrosine kinase inhibitor

Also Published As

Publication number Publication date
MX2011005043A (es) 2011-06-01
BRPI1005380A2 (pt) 2016-02-10
US9949926B2 (en) 2018-04-24
JP2012533517A (ja) 2012-12-27
PL2340014T3 (pl) 2013-09-30
EP2340014A1 (en) 2011-07-06
CA2738151A1 (en) 2011-01-20
KR20120040683A (ko) 2012-04-27
KR101689847B1 (ko) 2016-12-26
WO2011007893A1 (en) 2011-01-20
US20180133153A1 (en) 2018-05-17
RU2011125640A (ru) 2013-08-20
RU2572707C2 (ru) 2016-01-20
CN102170865A (zh) 2011-08-31
TW201105363A (en) 2011-02-16
JP5579079B2 (ja) 2014-08-27
ES2405779T3 (es) 2013-06-03
EP2340014B1 (en) 2013-04-24
US10092514B2 (en) 2018-10-09
CN103705524A (zh) 2014-04-09
US20150190340A1 (en) 2015-07-09
US20110190250A1 (en) 2011-08-04
CA2738151C (en) 2017-02-28

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Application publication date: 20180112