CN107536746A - A kind of plant extract composition with antisepsis and its preparation method and application - Google Patents
A kind of plant extract composition with antisepsis and its preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind of plant extract composition with antisepsis, including following components in percentage by weight：Fructus psidii guajavae immaturus extract 10 25%；Melaleuca alternifolia extract 20 30%；Long and thin hot pepper berry extract 10 25%；Pasque flower extract 10 25%；Must extractive of usnea 10 25%；The percentage by weight sum of above-mentioned each component is 100%.This has that the plant extract composition of antisepsis is non-stimulated, not sensitization, and broad-spectrum antibacterial, fungistatic effect protrudes, harmless, has no toxic side effect, can safety applications in cosmetics.The invention also discloses a kind of preparation method of the plant extract composition with antisepsis, step is few, and flow is simple, safe operation.The present invention discloses a kind of Essence and preparation method thereof again, and good antimicrobial effect, scope of restraining fungi is wide, nontoxic non-stimulated, safe to use；Preparation process is few, and flow is simple, safe operation.
Description
Technical field
The present invention relates to cosmetic technical field, more particularly to a kind of plant extract composition with antisepsis and its
Preparation method and application.
Background technology
Containing abundant amino acid, protein, collagen, vitamin, moisture etc. in cosmetics, these maintenance compositions are simultaneously
It is bacterium, microbial growth " Nutrient medium ", the microorganism in environment is once enter, you can rapid breeding, destroys the sense of product
Official's quality, damage the health of consumer.In recent years, natural material used in cosmetics industry and various functions additive day
Become to increasing, product is more easy to be corroded by Institute of Micro-biology.With the development and growth in the living standard of social economy, the product of consumer
Awareness of safety constantly strengthens, and the Anticorrosion of cosmetics is increasingly taken seriously.Therefore, a good antibacterial system, for
It is essential for cosmetic product.
The preservative of cosmetics is mainly based on chemical synthesis composition at present, such as：Methylisothiazolinone, methyl hydroxybenzoate,
Ethyl hydroxy benzoate, DMDMH hydantoins, diazonium imidazolidinyl urea, IPBC, phenoxetol, cloth
Luo Boer etc..There are many problems in the raw material of chemical synthesis, wherein security causes everybody concern in use.Such as Europe
Alliance is it has been proposed that without using methylisothiazolinone, because clinical data shows that methylisothiazolinone is irritating to the skin work
With；Show in research in recent years, paraben preservative has potential estrogen active, exists and causes essence
Sub- vigor reduces, causes infertile risk；The preservatives such as diazonium imidazolidinyl urea, Bronopol are Form aldehyde release bodies, and formaldehyde is
A kind of carcinogen.That is, artificial synthesized preservative can bring hiding injury to consumer.
This is corresponding, and the preservative of plant origin has the characteristics of renewable, to stimulate small, safe, effect to protrude.
It is anticipated that the preservative in the preservative replacement petrochemical industry source in cosmetics using plant origin will be following cosmetic
The developing direction of product.
But there is following defect in existing plant origin preservative：Application study in terms of cosmetics anti-corrosion is more
Single, the color is too dark and raw material is highly seasoned for a part of natural anticorrosion composition, broad spectrum antibacterial is poor compared with chemical preservative, and some even can
Bring allergy, it is impossible to complete substituted chemistry synthetic preservative.
The content of the invention
For overcome the deficiencies in the prior art, an object of the present invention is to provide a kind of plant with antisepsis
Composition is extracted, non-stimulated, not sensitization, broad-spectrum antibacterial, fungistatic effect protrudes, harmless, has no toxic side effect, can answer safely
For in cosmetics.
The second object of the present invention is to provide a kind of preparation method of the plant extract composition with antisepsis, walked
Rapid few, flow is simple, safe operation.
The third object of the present invention is to provide a kind of Essence, and good antimicrobial effect, scope of restraining fungi is wide, nontoxic stingless
Swash, it is safe to use.
The fourth object of the present invention is to provide a kind of preparation method of Essence, and step is few, and flow is simple, operation peace
Entirely.
An object of the present invention adopts the following technical scheme that realization：
A kind of plant extract composition with antisepsis, including following components in percentage by weight：
Fructus psidii guajavae immaturus extract 10-25%；Melaleuca alternifolia extract 20-30%；
Long and thin hot pepper berry extract 10-25%；Pasque flower extract 10-25%；
Must extractive of usnea 10-25%；
The percentage by weight sum of above-mentioned each component is 100%.
Further, including in percentage by weight following components：
Fructus psidii guajavae immaturus extract 18%；Melaleuca alternifolia extract 29%；
Long and thin hot pepper berry extract 18%；Pasque flower extract 17%；
Must extractive of usnea 18%.
The second object of the present invention adopts the following technical scheme that realization：
A kind of preparation method of the plant extract composition with antisepsis, is prepared in accordance with the following methods：It will match somebody with somebody
Fructus psidii guajavae immaturus extract, Melaleuca alternifolia extract, long and thin hot pepper berry extract, pasque flower extract and the palpus sunglo just measured
Extract, which adds, to be stirred under vacuum in pot, is stirred, vacuum outgas 20min, is produced the plant extract composition.
The third object of the present invention adopts the following technical scheme that realization：
A kind of Essence, including following components in percentage by weight：
The percentage by weight sum of above-mentioned each component is 100%.
Further, the NMF includes glycerine, propane diols and butanediol, and glycerine, propane diols and butanediol are described
Percentage by weight difference in Essence is as follows：Glycerine 1-5%；Propane diols 1-5%；Butanediol 1-5%；The nutritional agents is swallow
Aleuronat extract；The thickener is carbomer；The pH adjusting agent is triethanolamine；The solvent is water.
Further, including in percentage by weight following components：
The percentage by weight sum of above-mentioned each component is 100%.
Further, including in percentage by weight following components：
The percentage by weight sum of above-mentioned each component is 100%.
Further, including in percentage by weight following components：
The percentage by weight sum of above-mentioned each component is 100%.
The fourth object of the present invention adopts the following technical scheme that realization：
A kind of preparation method of Essence, including,
Sterilization steps：The solvent of formula ratio is added and is stirred under vacuum in pot, heat sterilization, is then cooled down；
Once add step：Under agitation, the NMF of formula ratio is added, obtains the first mixture；
Secondary addition step：The thickener of formula ratio is added, stirring, homogeneous, obtains the second mixture；
Vacuum outgas step：Vacuum outgas, obtain the 3rd mixture；
Step is added three times：Under agitation, nutritional agents, pH adjusting agent, essence, the Fructus psidii guajavae immaturus for adding formula ratio carry
Thing, Melaleuca alternifolia extract, long and thin hot pepper berry extract, pasque flower extract and palpus extractive of usnea are taken, is stirred,
Obtain the Essence.
Further, in the sterilization steps, the solvent of formula ratio is added and is stirred under vacuum in pot, is heated to 85-90
DEG C, sterilize 30min, is subsequently cooled to 30-35 DEG C；
Once added described in step, maintain mixing speed 55-60r/min, add the NMF of formula ratio, stirring
20-25min, obtain the first mixture；
In the secondary addition step, the thickener of formula ratio is added, setting mixing speed is 30-35r/min, homogeneous
3-5min, obtain the second mixture；
In the vacuum outgas step, vacuum outgas 20-25min, the 3rd mixture is obtained；
Added three times in step described, under conditions of low whipping speed is 20-25r/min, add the nutrition of formula ratio
Agent, pH adjusting agent, essence, Fructus psidii guajavae immaturus extract, Melaleuca alternifolia extract, long and thin hot pepper berry extract, pasque flower carry
Thing and palpus extractive of usnea are taken, stirs, obtains the Essence.
Compared with prior art, the beneficial effects of the present invention are：
(1) the plant extract composition provided by the present invention with antisepsis, including guava (PSIDIUM
GUAJAVA) berry extract, Melaleuca alternifolia (MELALEUCA ALTERNIFOLIA) extract, long and thin hot pepper (ZANTHOXYLUM
PIPERITUM) berry extract, pasque flower (PULSATILLA KOREANA EXTRACT) extract, palpus sunglo (USNEA
This 5 kinds of extracted form natural plant compositions of BARBATA (LICHEN) extract, this 5 kinds of components compatibilities are proper, and collaboration plays antibacterial anti-corrosion
Effect：
The sweet temperature of Fructus psidii guajavae immaturus extract and it is puckery and contain tannin, tannin class is a kind of baroque phenolic compound,
Widely distributed in plant, especially to be more in bark, the tannin class in Fructus psidii guajavae immaturus is to staphylococcus aureus, Fu Shi dysentery bars
Bacterium, salmonella, Escherichia coli have obvious bacteriostasis, and significantly inhibit effect to 5 alpha-reductases, can suppress
The excessive secretion of grease, propionibacterium acnes is eliminated, effect is rapid, safety；Melaleuca alternifolia extract can treat skin
Wound infection, there is good broad-spectrum sterilization fungistatic effect；Long and thin hot pepper berry extract contains a variety of unrighted acids, has local
The effect of anesthesia and confrontation Escherichia coli, shigella dysenteriae, corynebacteria, dermatophyte etc.；Pasque flower extract has anti-
Works such as tumour, enhancing immunologic function, anti-inflammatory, resisting pathogenic microbes, anti parasitic, liver protection, toxicity and treatment endotoxemia etc.
Effect, it is widely used in antiinflammatory in Korean traditional medicine, treats dysentery, hemorrhoid, colitis, toothache and other bacteriums are together
Symptom；Palpus extractive of usnea is a kind of natural extract from lichens tree, and its main component usnic acid is considered as one
Kind potent antibiotic and antiseptic, prevent bacterium and fungi from giving birth to as natural antiseptic agent in cosmetics and personal care articles
Long, it has broad-spectrum antiseptic effect, is believed to effectively antagonize all gram-positive bacterias and pulmonary tuberculosis bacterium.
There is the plant extract composition of antisepsis to be free of conventional chemical preservative, non-stimulated to human body, nontoxic pair for this
Effect, will not cause allergy, and the equal source of all the components is natural, thoroughly compensate for commercially available cosmetic product and use chemical preservative
Open defect.In addition, should be steady to the physics of light, heat, oxygen with the active component in the plant extract composition of antisepsis
It is qualitative good, its antiseptic activity, favorable anti-corrosion effect can be fully kept during circulation.
(2) Essence provided by the present invention, antibacterial favorable anti-corrosion effect, skin will not be caused to stimulate, safety in utilization
It is high.
(3) it is provided by the present invention with the plant extract composition of antisepsis and the preparation method of Essence, step
Few, flow is simple, safe operation
Embodiment
Below, with reference to embodiment, the present invention is described further, it is necessary to which explanation is, what is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
A kind of plant extract composition with antisepsis, including following components in percentage by weight：
Fructus psidii guajavae immaturus extract 10-25%；Melaleuca alternifolia extract 20-30%；
Long and thin hot pepper berry extract 10-25%；Pasque flower extract 10-25%；
Must extractive of usnea 10-25%；
The percentage by weight sum of above-mentioned each component is 100%.
A kind of preparation method of the plant extract composition with antisepsis, is prepared in accordance with the following methods：It will match somebody with somebody
Fructus psidii guajavae immaturus extract, Melaleuca alternifolia extract, long and thin hot pepper berry extract, pasque flower extract and the palpus sunglo just measured
Extract, which adds, to be stirred under vacuum in pot, is stirred, vacuum outgas 20min, is produced plant extract composition.
A kind of Essence, including following components in percentage by weight：
The percentage by weight sum of above-mentioned each component is 100%.
As further embodiment, NMF includes glycerine, propane diols and butanediol, glycerine, propane diols and fourth two
Percentage by weight difference of the alcohol in Essence is as follows：Glycerine 1-5%；Propane diols 1-5%；Butanediol 1-5%；Nutritional agents is swallow
Aleuronat extract；Thickener is carbomer；PH adjusting agent is triethanolamine；Solvent is water.
The Essence that the embodiment of the present invention is provided, including Fructus psidii guajavae immaturus extract, Melaleuca alternifolia extract, long and thin hot pepper
Berry extract, pasque flower extract, must extractive of usnea this 5 kinds of active components, this 5 kinds of components compatibilities are proper, collaboration hair
Wave antisepsis：
The sweet temperature of Fructus psidii guajavae immaturus extract and it is puckery and contain tannin, tannin class is a kind of baroque phenolic compound,
Widely distributed in plant, especially to be more in bark, the tannin class in Fructus psidii guajavae immaturus is to staphylococcus aureus, Fu Shi dysentery bars
Bacterium, salmonella, Escherichia coli have obvious bacteriostasis, and significantly inhibit effect to 5 alpha-reductases, can suppress
The excessive secretion of grease, propionibacterium acnes is eliminated, effect is rapid, safety；Melaleuca alternifolia extract can treat skin
Wound infection, there is good broad-spectrum sterilization fungistatic effect；Long and thin hot pepper berry extract contains a variety of unrighted acids, has local
The effect of anesthesia and confrontation Escherichia coli, shigella dysenteriae, corynebacteria, dermatophyte etc.；Pasque flower extract has anti-
Works such as tumour, enhancing immunologic function, anti-inflammatory, resisting pathogenic microbes, anti parasitic, liver protection, toxicity and treatment endotoxemia etc.
Effect, it is widely used in antiinflammatory in Korean traditional medicine, treats dysentery, hemorrhoid, colitis, toothache and other bacteriums are together
Symptom；Palpus extractive of usnea is a kind of natural extract from lichens tree, and its main component usnic acid is considered as one
Kind potent antibiotic and antiseptic, prevent bacterium and fungi from giving birth to as natural antiseptic agent in cosmetics and personal care articles
Long, it has broad-spectrum antiseptic effect, is believed to effectively antagonize all gram-positive bacterias and pulmonary tuberculosis bacterium.
The Essence is free of conventional chemical preservative, broad-spectrum antibacterial, non-stimulated to human body, have no toxic side effect, and will not cause
Allergy, the equal source of all the components is natural, thoroughly compensate for the open defect that commercially available cosmetic product uses chemical preservative.This
Outside, the active component in the Essence is good to light, heat, the physical stability of oxygen, can fully keep it anti-during circulation
Rotten activity, favorable anti-corrosion effect.
A kind of preparation method of Essence, including,
Sterilization steps：The solvent of formula ratio is added and is stirred under vacuum in pot, heat sterilization, is then cooled down；
Once add step：Under agitation, the NMF of formula ratio is added, obtains the first mixture；
Secondary addition step：The thickener of formula ratio is added, stirring, homogeneous, obtains the second mixture；
Vacuum outgas step：Vacuum outgas, obtain the 3rd mixture；
Step is added three times：Under agitation, nutritional agents, pH adjusting agent, essence, the Fructus psidii guajavae immaturus for adding formula ratio carry
Thing, Melaleuca alternifolia extract, long and thin hot pepper berry extract, pasque flower extract and palpus extractive of usnea are taken, is stirred,
Obtain Essence.
As further embodiment, in sterilization steps, the solvent of formula ratio is added and is stirred under vacuum in pot, heating
To 85-90 DEG C, sterilize 30min, is subsequently cooled to 30-35 DEG C；Once adding in step, maintaining mixing speed 55-60r/
Min, the NMF of formula ratio is added, stir 20-25min, obtain the first mixture；In secondary addition step, formula is added
The thickener of amount, setting mixing speed are 30-35r/min, homogeneous 3-5min, obtain the second mixture；In vacuum outgas step
In, vacuum outgas 20-25min, obtain the 3rd mixture；Adding three times in step, low whipping speed is 20-25r/min's
Under the conditions of, add the nutritional agents of formula ratio, pH adjusting agent, essence, Fructus psidii guajavae immaturus extract, Melaleuca alternifolia extract, the Qin
Green pepper berry extract, pasque flower extract and palpus extractive of usnea, stir, obtain Essence.
It is specific embodiment of the present invention below, used raw material, equipment etc. remove special limit in the following embodiments
It can be obtained outside fixed by buying pattern.
Embodiment 1-3
A kind of Essence, including Fructus psidii guajavae immaturus extract, Melaleuca alternifolia extract, long and thin hot pepper berry extract, Korea are white
Head father-in-law extract, palpus extractive of usnea, glycerine, propane diols, butanediol, avenin extract, carbomer, triethanolamine, perfume (or spice)
Essence and water；The apparatus of above-mentioned various composition is as shown in table 1 below.
The embodiment 1-3 of table 1 and the Essence of comparative example 1 formula table
| Material name | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 |
| Water | T0 100 | T0 100 | T0 100 | T0 100 |
| Glycerine | 5 | 5 | 5 | 5 |
| Propane diols | 5 | 5 | 5 | 5 |
| Butanediol | 3 | 3 | 3 | 3 |
| Avenin extract | 0.3 | 0.3 | 0.3 | 0.3 |
| Fructus psidii guajavae immaturus extract | 0.3 | 0.2 | 0.1 | 0 |
| Melaleuca alternifolia extract | 0.5 | 0.3 | 0.1 | 0 |
| Long and thin hot pepper berry extract | 0.3 | 0.2 | 0.1 | 0 |
| Pasque flower extract | 0.3 | 0.2 | 0.1 | 0 |
| Must extractive of usnea | 0.3 | 0.2 | 0.1 | 0 |
| Carbomer | 0.2 | 0.2 | 0.2 | 0.2 |
| Triethanolamine | 0.2 | 0.2 | 0.2 | 0.2 |
| Essence | 0.1 | 0.1 | 0.1 | 0.1 |
The preparation method of Essence is as follows：
Sterilization steps：The water of formula ratio is added and is stirred under vacuum in pot, is heated to 88 DEG C, sterilize 30min, is subsequently cooled to
32℃；
Once add step：Mixing speed 58r/min is maintained, adds the NMF of formula ratio, stirs 23min, obtains the
One mixture；
Secondary addition step：The carbomer of formula ratio is added, setting mixing speed is 32r/min, homogeneous 3.5min, is obtained
Second mixture；
Vacuum outgas step：Vacuum outgas 22min, obtain the 3rd mixture；
Step is added three times：Low whipping speed be 22r/min under conditions of, add formula ratio avenin extract,
Triethanolamine, essence, Fructus psidii guajavae immaturus extract, Melaleuca alternifolia extract, long and thin hot pepper berry extract, pasque flower extract
With palpus extractive of usnea, stir, obtain Essence.
Then, discharge, stand, after the assay was approved, filling, packaging, coding；After the assay was approved, be put in storage.
Comparative example 1
The difference of comparative example 1 and embodiment 1 is：The difference (referring to table 1) of formula, does not contain embodiment 1-3's
Plant extract composition；
Other are same as Example 1.
Comparative example 2
Certain commercially available brand chemical preservative Essence.
Effect assessment and performance detection
1st, antimicrobial preservation challenge is tested
Subjects：E.coli (Escherichia coli), P.aeruginosa (Pseudomonas aeruginosa), C.Albicans (white beads
Bacterium), S.aureus (staphylococcus aureus), A.niger (black-koji mould)；
Method of testing：The experiment follows CTFA challenge requirement of experiment.At the beginning of research, all samples are first connect
Kind, 24h samplings, it is inoculated with weekly once, continuous 4 times, the test period is 28 days.4 weeks after starting is challenged, sample was carried out again
Challenge test, it then follows same sample test method.
Test specimen：Embodiment 1-3 and comparative example 1 Essence.
Result of the test is as shown in table 2 below：
The antimicrobial preservation of the embodiment 1-3 of table 2 and the Essence of comparative example 1 challenges experimental result record sheet
Remarks：" * * * " represent that bacterium is too many, do not count in form；"-" represents serious pollution, does not do repetition challenge.
It can be obtained from the data in table 2, the Essence that 1-3 of the embodiment of the present invention is provided is to Escherichia coli, Pseudomonas aeruginosa, white
Candida albicans, staphylococcus aureus and black-koji mould have good inhibition, play good antisepsis.And comparative example
Plant extract composition of 1 Essence due to not adding embodiment 1-3, hardly plays any fungistatic effect, bacterial growth
Quickly.
2nd, skin irritation is tested
Cutaneous safety assessment is made with chick chorioallantoic membrane experiment
Experimental method：Beijing Cold boiled chicken hatching egg is selected, cleans, uses l：1000 benzalkonium bromides (bromogeramine) liquid soaks 3min,
Put in 38 DEG C of incubators and be incubated.Instar chicken embryo on the 12nd, marks air chamber and the position of foetus under ovoscopy lamp, and near the position of foetus without big blood vessel at
Draw a mark.With the tincture of iodine, at ethanol disinfection plenum roof and mark, then an aperture is bored in plenum roof, while with grinding egg apparatus
Chorion is ground into a slight crack parallel with the longitudinal axis at mark, does not injure shell membrane.Ovum is kept flat, gently removed chorion at slight crack
Fall, do not injure shell membrane, in puncturing a crack on shell membrane but not injuring following CAM, sterile saline one is added dropwise and drips
In on shell membrane.Slowly gas room air is sucked at the aperture of air chamber end with rubber pacifier, causes air chamber negative pressure, now visible life
Manage salt solution to sink, CAM sink, and forms artifical-air cell between shell membrane and chorioallantoic membrane.The shell membrane on artifical-air cell is opened,
The CAM at this is exposed, the silicon of the diameter 10mm after a sterilization is put at the chorion projection between two vitelline veins
Glue retainer ring, 0.5ml sample liquids are added dropwise in ring on CAM, are sealed with strile gauze dressing.By chicken embryo accumbency, trained in 38 DEG C
Support and be incubated in case, it is impossible to stir, in case artifical-air cell shifts.Taken out after 30min.With the tincture of iodine, ethanol disinfection inoculation position and four
In week, tear chorion at closing off, observation chick chorioallantoic membrane injury of blood vessel degree is sentenced with aseptic nipper enlarged openings.To reduce
Random error, the degree of accuracy of experiment is improved, every group is done balance test with 10 eggs, is removed maximin and then is averaged
Value.To prevent later stage germ contamination, experimental products be all now beat it is used.
Test object：Embodiment 1-3 and comparative example 1-2 Essence.
Chick chorioallantoic membrane injury of blood vessel degree NC standards of grading：
0 point-reactionless；
1 point-ghost blood vessel occur；
2 points-congested；
There is denumerable tiny blutpunkte (1-10) in 3 points-ring；
Denumerable tiny blood point blutpunkte in 4 points-ring>10 or blutpunkte is noncountable and cover ring inner region is less than 1/8；
There is no blutpunkte in 5 points-ring internal haemorrhage point area coverage 1/8-1/4 or ring but blush area coverage is less than 1/4；
6 points-ring internal haemorrhage point area coverage 1/4-1/2, or it is 1/4-1/ not have blutpunkte but blush area coverage in ring
2；
Bled profusely in 7 points-ring a little or zonule bleeding scope reaches 1/2-3/4.
8 points-ring internal haemorrhage point region>3/4 or incrustation be likely to form.
Stress sexual stimulus：0≤NC≤2；Minimal irritation：2<NC≤3；
Moderate stimulates：3<NC≤5；It is serious to stimulate：NC>5
Test result is as shown in table 3 below：
The skin irritation test result record sheet of the embodiment 1-3 of table 3 and comparative example 1-2 Essence
It can be obtained from the record result of table 3, the Essence of comparative example 1 is non-stimulated due to not containing plant extract composition, but
It is that can be obtained from the record result of table 2, its antibacterial antiseptic effect is very poor.And the excitant of embodiment 1-3 Essence is far smaller than
The Essence (Essence of commercially available conventional chemical preservative) of comparative example 2, will not cause discomfort to skin, use comfortable, peace
Quan Xinggao.
Above-mentioned embodiment is only the preferred embodiment of the present invention, it is impossible to the scope of protection of the invention is limited with this,
The change and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed scope.
Claims (10)
1. a kind of plant extract composition with antisepsis, it is characterised in that below in percentage by weight
Component：
Fructus psidii guajavae immaturus extract 10-25%；Melaleuca alternifolia extract 20-30%；
Long and thin hot pepper berry extract 10-25%；Pasque flower extract 10-25%；
Must extractive of usnea 10-25%；
The percentage by weight sum of above-mentioned each component is 100%.
2. there is the plant extract composition of antisepsis as claimed in claim 1, it is characterised in that including according to weight hundred
Divide the following components than meter：
Fructus psidii guajavae immaturus extract 18%；Melaleuca alternifolia extract 29%；
Long and thin hot pepper berry extract 18%；Pasque flower extract 17%；
Must extractive of usnea 18%.
3. a kind of preparation method of the plant extract composition as claimed in claim 1 or 2 with antisepsis, its feature exist
In being prepared in accordance with the following methods：The Fructus psidii guajavae immaturus extract, Melaleuca alternifolia extract, prickly ash berries of formula ratio are carried
Take thing, pasque flower extract and palpus extractive of usnea to add and be stirred under vacuum in pot, stir, vacuum outgas 20min, i.e.,
Obtain the plant extract composition.
4. a kind of Essence for including the plant extract composition as claimed in claim 1 with antisepsis, its feature exist
In, including following components in percentage by weight：
The percentage by weight sum of above-mentioned each component is 100%.
5. Essence as claimed in claim 4, it is characterised in that the NMF includes glycerine, propane diols and butanediol, sweet
The percentage by weight difference of oil, propane diols and butanediol in the Essence is as follows：Glycerine 1-5%；Propane diols 1-5%；Fourth
Glycol 1-5%；
The nutritional agents is avenin extract；The thickener is carbomer；The pH adjusting agent is triethanolamine；It is described
Solvent is water.
6. Essence as claimed in claim 4, it is characterised in that including following components in percentage by weight：
The percentage by weight sum of above-mentioned each component is 100%.
7. Essence as claimed in claim 4, it is characterised in that including following components in percentage by weight：
The percentage by weight sum of above-mentioned each component is 100%.
8. Essence as claimed in claim 4, it is characterised in that including following components in percentage by weight：
The percentage by weight sum of above-mentioned each component is 100%.
A kind of 9. preparation method of Essence as claimed in claim 4, it is characterised in that including,
Sterilization steps：The solvent of formula ratio is added and is stirred under vacuum in pot, heat sterilization, is then cooled down；
Once add step：Under agitation, the NMF of formula ratio is added, obtains the first mixture；
Secondary addition step：The thickener of formula ratio is added, stirring, homogeneous, obtains the second mixture；
Vacuum outgas step：Vacuum outgas, obtain the 3rd mixture；
Step is added three times：Under agitation, nutritional agents, pH adjusting agent, essence, the Fructus psidii guajavae immaturus for adding formula ratio extract
Thing, Melaleuca alternifolia extract, long and thin hot pepper berry extract, pasque flower extract and palpus extractive of usnea, stir, obtain
To the Essence.
10. the preparation method of Essence as claimed in claim 9, it is characterised in that in the sterilization steps, by formula ratio
Solvent add and be stirred under vacuum in pot, be heated to 85-90 DEG C, sterilize 30min, is subsequently cooled to 30-35 DEG C；
Once added described in step, maintain mixing speed 55-60r/min, add the NMF of formula ratio, stir 20-
25min, obtain the first mixture；
In the secondary addition step, the thickener of formula ratio is added, setting mixing speed is 30-35r/min, homogeneous 3-
5min, obtain the second mixture；
In the vacuum outgas step, vacuum outgas 20-25min, the 3rd mixture is obtained；
Added three times in step described, under conditions of low whipping speed is 20-25r/min, add nutritional agents, the pH of formula ratio
Conditioning agent, essence, Fructus psidii guajavae immaturus extract, Melaleuca alternifolia extract, long and thin hot pepper berry extract, pasque flower extract and
Palpus extractive of usnea, stirs, obtains the Essence.
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| CN201710591191.7A CN107536746A (en) | 2017-07-19 | 2017-07-19 | A kind of plant extract composition with antisepsis and its preparation method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109106653A (en) * | 2018-10-31 | 2019-01-01 | 广州艾蓓生物科技有限公司 | A kind of flushing-free antiseptic hand washing gel and preparation method thereof |
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| CN102949460A (en) * | 2012-06-29 | 2013-03-06 | 上海莱博生物科技有限公司 | Application of melaleuca alternifolia oil and preparation thereof |
| CN105919903A (en) * | 2016-06-29 | 2016-09-07 | 程楹闳 | Herbal preservative composition, freckle-removing facial mask and preparation method of freckle-removing facial mask |
| WO2016147142A1 (en) * | 2015-03-18 | 2016-09-22 | Anjon Biologics, Inc. | Anti-pathogenic compositions |
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| CN102949460A (en) * | 2012-06-29 | 2013-03-06 | 上海莱博生物科技有限公司 | Application of melaleuca alternifolia oil and preparation thereof |
| WO2016147142A1 (en) * | 2015-03-18 | 2016-09-22 | Anjon Biologics, Inc. | Anti-pathogenic compositions |
| CN105919903A (en) * | 2016-06-29 | 2016-09-07 | 程楹闳 | Herbal preservative composition, freckle-removing facial mask and preparation method of freckle-removing facial mask |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109106653A (en) * | 2018-10-31 | 2019-01-01 | 广州艾蓓生物科技有限公司 | A kind of flushing-free antiseptic hand washing gel and preparation method thereof |
| CN109106653B (en) * | 2018-10-31 | 2021-06-15 | 广州艾蓓生物科技有限公司 | Washing-free disinfection hand washing gel and preparation method thereof |
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