CN107532121A - 用于厌氧微生物的培养装置 - Google Patents
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- C12Q1/06—Quantitative determination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/04—Flat or tray type, drawers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/20—Material Coatings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/34—Internal compartments or partitions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/06—Plates; Walls; Drawers; Multilayer plates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
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- Organic Chemistry (AREA)
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- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Clinical Laboratory Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201562154299P | 2015-04-29 | 2015-04-29 | |
| US62/154,299 | 2015-04-29 | ||
| PCT/US2016/029306 WO2016176176A1 (en) | 2015-04-29 | 2016-04-26 | Culture device for anaerobic microorganisms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107532121A true CN107532121A (zh) | 2018-01-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680024743.XA Pending CN107532121A (zh) | 2015-04-29 | 2016-04-26 | 用于厌氧微生物的培养装置 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20180094291A1 (enExample) |
| EP (1) | EP3289062A1 (enExample) |
| JP (1) | JP6920212B2 (enExample) |
| KR (1) | KR102645495B1 (enExample) |
| CN (1) | CN107532121A (enExample) |
| BR (1) | BR112017023011B1 (enExample) |
| WO (1) | WO2016176176A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107532126A (zh) * | 2015-04-29 | 2018-01-02 | 3M创新有限公司 | 具有二氧化碳发生剂的薄膜培养装置 |
| CN109576130A (zh) * | 2018-12-18 | 2019-04-05 | 东北农业大学 | 人为制造微氧环境纯化微氧细菌的装置 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102664258B1 (ko) * | 2015-04-23 | 2024-05-07 | 비디 키에스트라 비.브이. | 콜로니 콘트라스트 수집 |
| US11072771B2 (en) | 2015-09-28 | 2021-07-27 | 3M Innovative Properties Company | Self-contained anaerobic culture device with microcompartments |
| US20190345432A1 (en) * | 2016-11-28 | 2019-11-14 | Jnc Corporation | Culture equipment of microorganisms and method for counting number of microorganisms using same |
| CN107418887A (zh) * | 2017-09-15 | 2017-12-01 | 厦门安捷致善医学数据科技有限公司 | 一种粪便微生物提取过程中配置厌氧装置 |
| WO2019116259A1 (en) | 2017-12-13 | 2019-06-20 | 3M Innovative Properties Company | Water-reconstitutable culture medium resistant to liquefaction by microorganisms |
| CN109371098A (zh) * | 2018-11-14 | 2019-02-22 | 浙江海洋大学 | 一种石油腐蚀性微生物检测工具箱用微生物活性显色增强方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996038533A1 (en) * | 1995-06-02 | 1996-12-05 | Minnesota Mining And Manufacturing Company | Surface colony counting device and method of use |
| US20040023316A1 (en) * | 1998-10-29 | 2004-02-05 | Christian Reiter | New method for detecting acid-resistant microorganisms in the stool |
| WO2005108545A2 (en) * | 2004-04-23 | 2005-11-17 | Cryovac, Inc. | Devices for culturing anaerobic microorganisms and methods of using the same |
| US20120094327A1 (en) * | 2009-06-15 | 2012-04-19 | Young Robert F | Detection of acid-producing bacteria |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3338794A (en) | 1964-11-23 | 1967-08-29 | Swift & Co | Culturing anaerobic bacteria |
| JPS5739776A (en) * | 1980-08-20 | 1982-03-05 | Mitsubishi Gas Chem Co Inc | Cultivation of anaerobic bacteria |
| US4565783A (en) | 1981-01-27 | 1986-01-21 | Minnesota Mining And Manufacturing Company | Dry culture media |
| JPS5856679A (ja) * | 1981-09-30 | 1983-04-04 | Meito Kk | 嫌気性菌培養方法及び雰囲気調整剤 |
| US5034331A (en) * | 1981-12-04 | 1991-07-23 | Fairleigh Dickinson Laboratories, Inc. | Compositions and methods for culturing microorganisms requiring special gaseous environments |
| US5089413A (en) | 1989-05-19 | 1992-02-18 | Minnesota Mining And Manufacturing Company | Method and apparatus for culturing with microbiological dry culture medium |
| US5232838A (en) | 1991-12-09 | 1993-08-03 | Minnesota Mining And Manufacturing Company | Culture media device and method of use |
| JPH0775545A (ja) * | 1993-09-09 | 1995-03-20 | Mitsubishi Gas Chem Co Inc | 嫌気性細菌簡易培養袋及びこれを用いた嫌気性細菌培養法 |
| US5830746A (en) * | 1994-05-04 | 1998-11-03 | Oxyrase, Inc. | Apparatus and method for growing anaerobic microorganisms |
| US5601998A (en) | 1994-08-18 | 1997-02-11 | Minnesota Mining & Mfg | Culture medium and device for detection and enumeration of enterobacteriaceae |
| JPH0965894A (ja) * | 1995-08-31 | 1997-03-11 | Takeda Chem Ind Ltd | 真菌の薬剤感受性測定法 |
| US6037022A (en) * | 1997-09-16 | 2000-03-14 | International Paper Company | Oxygen-scavenging filled polymer blend for food packaging applications |
| US7374905B2 (en) * | 2000-11-08 | 2008-05-20 | Oxyrase, Inc. | Medium composition, method and device for selectively enhancing the isolation of anaerobic microorganisms contained in a mixed sample with facultative microorganisms |
| US6689438B2 (en) | 2001-06-06 | 2004-02-10 | Cryovac, Inc. | Oxygen detection system for a solid article |
| US20040101954A1 (en) | 2002-11-27 | 2004-05-27 | Graessle Josef A. | Back side plate illumination for biological growth plate scanner |
| US20040102903A1 (en) | 2002-11-27 | 2004-05-27 | Graessle Josef A. | Biological growth plate scanner |
| US7496225B2 (en) | 2003-09-04 | 2009-02-24 | 3M Innovative Properties Company | Biological growth plate scanner with automated intake |
| JP2007075018A (ja) * | 2005-09-15 | 2007-03-29 | Eiken Chem Co Ltd | Ｃａｍｐｙｌｏｂａｃｔｅｒｃｏｌｉの検出法 |
| JP2007075017A (ja) * | 2005-09-15 | 2007-03-29 | Eiken Chem Co Ltd | Ｃａｍｐｙｌｏｂａｃｔｅｒｊｅｊｕｎｉの検出法 |
| WO2009082667A1 (en) * | 2007-12-21 | 2009-07-02 | 3M Innovative Properties Company | Microbiological systems and methods of fluid sample analysis |
| JP5519960B2 (ja) * | 2009-06-18 | 2014-06-11 | 日水製薬株式会社 | 乳酸菌検出用培地及び検出法 |
| US20120248103A1 (en) * | 2009-12-15 | 2012-10-04 | Olivetti I-Jet S.P.A. | Process for assembling elements containing biological substances |
| JP6000341B2 (ja) * | 2011-05-20 | 2016-09-28 | スリーエム イノベイティブ プロパティズ カンパニー | サルモネラ検出物品及び使用方法 |
| EP2936387A1 (en) * | 2012-12-20 | 2015-10-28 | 3M Innovative Properties Company | Method of detecting gas-producing microbial colonies |
| JP6938151B2 (ja) | 2013-10-24 | 2021-09-22 | スリーエム イノベイティブ プロパティズ カンパニー | 内蔵型嫌気性環境生成培養デバイス及び使用方法 |
| BR112017023140B1 (pt) * | 2015-04-29 | 2021-10-19 | 3M Innovative Properties Company | Dispositivo de cultura e método de detecção de um micro-organismo em uma amostra |
-
2016
- 2016-04-26 KR KR1020177032942A patent/KR102645495B1/ko active Active
- 2016-04-26 WO PCT/US2016/029306 patent/WO2016176176A1/en not_active Ceased
- 2016-04-26 EP EP16725259.2A patent/EP3289062A1/en active Pending
- 2016-04-26 CN CN201680024743.XA patent/CN107532121A/zh active Pending
- 2016-04-26 US US15/569,552 patent/US20180094291A1/en not_active Abandoned
- 2016-04-26 BR BR112017023011-9A patent/BR112017023011B1/pt active IP Right Grant
- 2016-04-26 JP JP2017556553A patent/JP6920212B2/ja active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996038533A1 (en) * | 1995-06-02 | 1996-12-05 | Minnesota Mining And Manufacturing Company | Surface colony counting device and method of use |
| US20040023316A1 (en) * | 1998-10-29 | 2004-02-05 | Christian Reiter | New method for detecting acid-resistant microorganisms in the stool |
| WO2005108545A2 (en) * | 2004-04-23 | 2005-11-17 | Cryovac, Inc. | Devices for culturing anaerobic microorganisms and methods of using the same |
| US20120094327A1 (en) * | 2009-06-15 | 2012-04-19 | Young Robert F | Detection of acid-producing bacteria |
| CN102803504A (zh) * | 2009-06-15 | 2012-11-28 | 3M创新有限公司 | 产酸菌的检测 |
Non-Patent Citations (4)
| Title |
|---|
| 彭珊珊等: "《食品添加剂》", 31 December 2009 * |
| 李代明: "《食品包装学》", 31 December 2008 * |
| 沈岳清等: "《植物生长调节剂与保鲜剂》", 31 December 1990 * |
| 邓舜扬编: "《食品保鲜技术》", 31 December 2006 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107532126A (zh) * | 2015-04-29 | 2018-01-02 | 3M创新有限公司 | 具有二氧化碳发生剂的薄膜培养装置 |
| CN109576130A (zh) * | 2018-12-18 | 2019-04-05 | 东北农业大学 | 人为制造微氧环境纯化微氧细菌的装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018518158A (ja) | 2018-07-12 |
| US20180094291A1 (en) | 2018-04-05 |
| WO2016176176A1 (en) | 2016-11-03 |
| BR112017023011B1 (pt) | 2022-04-05 |
| BR112017023011A2 (pt) | 2018-07-03 |
| JP6920212B2 (ja) | 2021-08-18 |
| EP3289062A1 (en) | 2018-03-07 |
| KR20170138480A (ko) | 2017-12-15 |
| KR102645495B1 (ko) | 2024-03-07 |
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