CN107530049B - 支持成像的斑块切除设备 - Google Patents

支持成像的斑块切除设备 Download PDF

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Publication number
CN107530049B
CN107530049B CN201680022621.7A CN201680022621A CN107530049B CN 107530049 B CN107530049 B CN 107530049B CN 201680022621 A CN201680022621 A CN 201680022621A CN 107530049 B CN107530049 B CN 107530049B
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CN
China
Prior art keywords
catheter body
catheter
cutting
cutter
imaging
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Active
Application number
CN201680022621.7A
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English (en)
Chinese (zh)
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CN107530049A (zh
Inventor
D·罗韦
P·埃斯库德罗
A·庞博
T·史密斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Philips Image Guided Therapy Corp
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Koninklijke Philips NV
Philips Image Guided Therapy Corp
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Publication of CN107530049A publication Critical patent/CN107530049A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
    • A61B17/320758—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with a rotating cutting instrument, e.g. motor driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
    • A61B8/4488—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer the transducer being a phased array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00681—Aspects not otherwise provided for
    • A61B2017/00685—Archimedes screw
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22038—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with a guide wire
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22038—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for with a guide wire
    • A61B2017/22042—Details of the tip of the guide wire
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/06—Measuring instruments not otherwise provided for
    • A61B2090/064—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/373—Surgical systems with images on a monitor during operation using light, e.g. by using optical scanners
    • A61B2090/3735—Optical coherence tomography [OCT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
    • A61B2090/3782—Surgical systems with images on a monitor during operation using ultrasound transmitter or receiver in catheter or minimal invasive instrument
    • A61B2090/3784—Surgical systems with images on a monitor during operation using ultrasound transmitter or receiver in catheter or minimal invasive instrument both receiver and transmitter being in the instrument or receiver being also transmitter

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Surgical Instruments (AREA)
  • Endoscopes (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
CN201680022621.7A 2015-02-20 2016-01-29 支持成像的斑块切除设备 Active CN107530049B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562118585P 2015-02-20 2015-02-20
US62/118,585 2015-02-20
PCT/IB2016/050448 WO2016132241A1 (en) 2015-02-20 2016-01-29 Atherectomy apparatus with imaging

Publications (2)

Publication Number Publication Date
CN107530049A CN107530049A (zh) 2018-01-02
CN107530049B true CN107530049B (zh) 2021-06-04

Family

ID=55299699

Family Applications (1)

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CN201680022621.7A Active CN107530049B (zh) 2015-02-20 2016-01-29 支持成像的斑块切除设备

Country Status (5)

Country Link
US (1) US12226117B2 (enExample)
EP (1) EP3258863B1 (enExample)
JP (1) JP6772161B2 (enExample)
CN (1) CN107530049B (enExample)
WO (1) WO2016132241A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11135454B2 (en) 2015-06-24 2021-10-05 The Regents Of The University Of Michigan Histotripsy therapy systems and methods for the treatment of brain tissue
US11648424B2 (en) 2018-11-28 2023-05-16 Histosonics Inc. Histotripsy systems and methods
US11813485B2 (en) 2020-01-28 2023-11-14 The Regents Of The University Of Michigan Systems and methods for histotripsy immunosensitization
US12318636B2 (en) 2022-10-28 2025-06-03 Histosonics, Inc. Histotripsy systems and methods
US12343568B2 (en) 2020-08-27 2025-07-01 The Regents Of The University Of Michigan Ultrasound transducer with transmit-receive capability for histotripsy
US12446905B2 (en) 2023-04-20 2025-10-21 Histosonics, Inc. Histotripsy systems and associated methods including user interfaces and workflows for treatment planning and therapy

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017210466A1 (en) 2016-06-03 2017-12-07 Avinger, Inc. Catheter device with detachable distal end
EP3508148B1 (en) * 2016-08-30 2021-06-30 Terumo Kabushiki Kaisha Medical device
WO2018052121A1 (ja) 2016-09-16 2018-03-22 テルモ株式会社 医療デバイス
US20180311508A1 (en) * 2017-03-02 2018-11-01 Circuit Therapeutics, Inc. System for optogenetic therapy
US10987131B2 (en) 2017-05-25 2021-04-27 Coopersurgical, Inc. Tissue containment systems and related methods
WO2019188918A1 (ja) * 2018-03-28 2019-10-03 テルモ株式会社 医療デバイスおよび処置用法
CN112312828B (zh) * 2018-04-19 2025-03-11 阿维格公司 阻塞穿越装置
EP3873360B1 (en) * 2018-11-01 2025-03-19 Koninklijke Philips N.V. Atherectomy devices including pre-shaped and curved distal portions
EP3908194A1 (en) * 2019-01-07 2021-11-17 Koninklijke Philips N.V. Increased flexibility substrate for intraluminal ultrasound imaging assembly
CN113329705A (zh) * 2019-01-21 2021-08-31 皇家飞利浦有限公司 包括血管内成像功能的血管处置系统和设备
WO2020234203A1 (en) * 2019-05-17 2020-11-26 Koninklijke Philips N.V. Atherectomy devices including positive and negative rake angle cutting blades
US12232762B2 (en) 2019-06-18 2025-02-25 Philips Image Guided Therapy Corporation Atherectomy devices including a plurality of distal cutting features
CN113017780B (zh) * 2021-03-02 2022-03-08 哈尔滨医科大学 一种集成超声成像与腔内斑块旋切术的导管系统
CN115040206A (zh) * 2022-06-02 2022-09-13 肖地生 一种用于血管内的旋切装置
CN218651946U (zh) * 2022-07-19 2023-03-21 武汉微新坦医疗科技有限公司 心肌调弯切割装置及系统
CN115429392B (zh) * 2022-10-08 2024-07-23 福州大学 基于超声反馈的血管钙化组织识别及去除装置和使用方法

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5000185A (en) 1986-02-28 1991-03-19 Cardiovascular Imaging Systems, Inc. Method for intravascular two-dimensional ultrasonography and recanalization
US4794931A (en) 1986-02-28 1989-01-03 Cardiovascular Imaging Systems, Inc. Catheter apparatus, system and method for intravascular two-dimensional ultrasonography
US4841977A (en) 1987-05-26 1989-06-27 Inter Therapy, Inc. Ultra-thin acoustic transducer and balloon catheter using same in imaging array subassembly
US4917097A (en) 1987-10-27 1990-04-17 Endosonics Corporation Apparatus and method for imaging small cavities
US4951677A (en) 1988-03-21 1990-08-28 Prutech Research And Development Partnership Ii Acoustic imaging catheter and the like
US5226909A (en) * 1989-09-12 1993-07-13 Devices For Vascular Intervention, Inc. Atherectomy device having helical blade and blade guide
US5240003A (en) 1989-10-16 1993-08-31 Du-Med B.V. Ultrasonic instrument with a micro motor having stator coils on a flexible circuit board
NL8902559A (nl) 1989-10-16 1991-05-16 Du Med Bv Intra-luminale inrichting.
US5095911A (en) 1990-05-18 1992-03-17 Cardiovascular Imaging Systems, Inc. Guidewire with imaging capability
US5135486A (en) 1990-08-31 1992-08-04 Endosonics Corporation Self-venting balloon dilitation catheter
US5167233A (en) 1991-01-07 1992-12-01 Endosonics Corporation Dilating and imaging apparatus
US5353798A (en) 1991-03-13 1994-10-11 Scimed Life Systems, Incorporated Intravascular imaging apparatus and methods for use and manufacture
US5243988A (en) 1991-03-13 1993-09-14 Scimed Life Systems, Inc. Intravascular imaging apparatus and methods for use and manufacture
US6111645A (en) 1991-04-29 2000-08-29 Massachusetts Institute Of Technology Grating based phase control optical delay line
DE69227902T3 (de) 1991-04-29 2010-04-22 Massachusetts Institute Of Technology, Cambridge Vorrichtung für optische abbildung und messung
US6134003A (en) 1991-04-29 2000-10-17 Massachusetts Institute Of Technology Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope
US5183048A (en) 1991-06-24 1993-02-02 Endosonics Corporation Method and apparatus for removing artifacts from an ultrasonically generated image of a small cavity
US5373845A (en) 1992-05-22 1994-12-20 Echo Cath, Ltd. Apparatus and method for forward looking volume imaging
US5373849A (en) 1993-01-19 1994-12-20 Cardiovascular Imaging Systems, Inc. Forward viewing imaging catheter
US5368037A (en) 1993-02-01 1994-11-29 Endosonics Corporation Ultrasound catheter
US5453575A (en) 1993-02-01 1995-09-26 Endosonics Corporation Apparatus and method for detecting blood flow in intravascular ultrasonic imaging
US6381350B1 (en) 1999-07-02 2002-04-30 The Cleveland Clinic Foundation Intravascular ultrasonic analysis using active contour method and system
WO2001015609A1 (en) * 1999-08-31 2001-03-08 Fox Hollow Technologies Atherectomy catheter with a rotating and telescoping cutter
US6200268B1 (en) 1999-09-10 2001-03-13 The Cleveland Clinic Foundation Vascular plaque characterization
US7359554B2 (en) 2002-08-26 2008-04-15 Cleveland Clinic Foundation System and method for identifying a vascular border
US7074188B2 (en) 2002-08-26 2006-07-11 The Cleveland Clinic Foundation System and method of characterizing vascular tissue
US7734332B2 (en) * 2002-10-18 2010-06-08 Ariomedica Ltd. Atherectomy system with imaging guidewire
US7175597B2 (en) 2003-02-03 2007-02-13 Cleveland Clinic Foundation Non-invasive tissue characterization system and method
US6943881B2 (en) 2003-06-04 2005-09-13 Tomophase Corporation Measurements of optical inhomogeneity and other properties in substances using propagation modes of light
ES2564694T3 (es) * 2003-09-12 2016-03-28 Vessix Vascular, Inc. Sistema de remodelación y / o ablación excéntrica seleccionable de material ateroesclerótico
US7215802B2 (en) 2004-03-04 2007-05-08 The Cleveland Clinic Foundation System and method for vascular border detection
US7397935B2 (en) 2004-05-10 2008-07-08 Mediguide Ltd. Method for segmentation of IVUS image sequences
WO2006058049A1 (en) 2004-11-24 2006-06-01 The General Hospital Corporation Common-path interferometer for endoscopic oct
CA2602662A1 (en) 2005-03-30 2006-10-05 Lumend, Inc. Catheter systems for crossing total occlusions in vasculature
NZ560529A (en) * 2005-05-12 2010-01-29 Compumedics Medical Innovation Ultrasound diagnosis and treatment apparatus
EP1887946A2 (en) 2005-06-06 2008-02-20 The Board Of Regents, The University Of Texas System Oct using spectrally resolved bandwidth
EP1933704B1 (en) 2005-10-13 2019-01-09 Volcano Corporation Component-based catheter lab intravascular ultrasound system
WO2007047974A2 (en) 2005-10-20 2007-04-26 Board Of Regents, The University Of Texas System Rotating optical catheter tip for optical coherence tomography
US8125648B2 (en) 2006-06-05 2012-02-28 Board Of Regents, The University Of Texas System Polarization-sensitive spectral interferometry
US20090018566A1 (en) * 2006-06-30 2009-01-15 Artheromed, Inc. Atherectomy devices, systems, and methods
US9314263B2 (en) * 2006-06-30 2016-04-19 Atheromed, Inc. Atherectomy devices, systems, and methods
US8289284B2 (en) 2007-08-09 2012-10-16 Volcano Corporation Controller user interface for a catheter lab intravascular ultrasound system
US8108030B2 (en) 2006-10-20 2012-01-31 Board Of Regents, The University Of Texas System Method and apparatus to identify vulnerable plaques with thermal wave imaging of heated nanoparticles
US7929148B2 (en) 2007-01-23 2011-04-19 Volcano Corporation Optical coherence tomography implementation apparatus and method of use
AU2008271034A1 (en) * 2007-06-29 2009-01-08 Atheromed, Inc. Atherectomy devices, systems, and methods
US10219780B2 (en) 2007-07-12 2019-03-05 Volcano Corporation OCT-IVUS catheter for concurrent luminal imaging
WO2009023635A1 (en) 2007-08-10 2009-02-19 Board Of Regents, The University Of Texas System Forward-imaging optical coherence tomography (oct) systems and probe
US7787127B2 (en) 2007-10-15 2010-08-31 Michael Galle System and method to determine chromatic dispersion in short lengths of waveguides using a common path interferometer
US8784440B2 (en) * 2008-02-25 2014-07-22 Covidien Lp Methods and devices for cutting tissue
WO2009140534A2 (en) 2008-05-15 2009-11-19 Silicon Valley Medical Instruments, Inc. Ivus system with rotary capacitive coupling
EP2429423B1 (en) * 2009-05-14 2015-11-11 Covidien LP Easily cleaned atherectomy catheters
CN104490454A (zh) * 2009-12-02 2015-04-08 泰科保健集团有限合伙公司 用于切割组织的方法和装置
CA2803992C (en) * 2010-07-01 2018-03-20 Avinger, Inc. Atherectomy catheters with longitudinally displaceable drive shafts
EP2637567B1 (en) * 2010-11-11 2017-03-08 Covidien LP Flexible debulking catheters with imaging and methods of manufacture
WO2013056262A1 (en) * 2011-10-13 2013-04-18 Atheromed, Inc. Atherectomy apparatus, systems and methods
JP6591895B2 (ja) 2013-01-08 2019-10-16 ボルケーノ コーポレイション 音響断層撮影方法
US20140276059A1 (en) * 2013-03-12 2014-09-18 Volcano Corporation Externally imaging a body structure within a patient
US20140276015A1 (en) * 2013-03-14 2014-09-18 Volcano Corporation Devices and methods for imaging and crossing occluded vessels
CN105705101B (zh) * 2013-07-31 2019-11-29 阿瑟罗迈德公司 斑块切除装置
CN103462646B (zh) * 2013-09-17 2014-12-10 浙江大学 一种集成血管内超声（ivus）影像和数字减影(dsa)影像的一体化离线处理系统

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12220602B2 (en) 2015-06-24 2025-02-11 The Regents Of The University Of Michigan Histotripsy therapy systems and methods for the treatment of brain tissue
US11135454B2 (en) 2015-06-24 2021-10-05 The Regents Of The University Of Michigan Histotripsy therapy systems and methods for the treatment of brain tissue
US12420118B2 (en) 2018-11-28 2025-09-23 Histosonics, Inc. Histotripsy systems and methods
US11813484B2 (en) 2018-11-28 2023-11-14 Histosonics, Inc. Histotripsy systems and methods
US11980778B2 (en) 2018-11-28 2024-05-14 Histosonics, Inc. Histotripsy systems and methods
US11648424B2 (en) 2018-11-28 2023-05-16 Histosonics Inc. Histotripsy systems and methods
US12491384B2 (en) 2018-11-28 2025-12-09 Histosonics, Inc. Histotripsy systems and methods
US12491382B2 (en) 2018-11-28 2025-12-09 Histosonics, Inc. Histotripsy systems and methods
US11813485B2 (en) 2020-01-28 2023-11-14 The Regents Of The University Of Michigan Systems and methods for histotripsy immunosensitization
US12343568B2 (en) 2020-08-27 2025-07-01 The Regents Of The University Of Michigan Ultrasound transducer with transmit-receive capability for histotripsy
US12318636B2 (en) 2022-10-28 2025-06-03 Histosonics, Inc. Histotripsy systems and methods
US12390665B1 (en) 2022-10-28 2025-08-19 Histosonics, Inc. Histotripsy systems and methods
US12446905B2 (en) 2023-04-20 2025-10-21 Histosonics, Inc. Histotripsy systems and associated methods including user interfaces and workflows for treatment planning and therapy

Also Published As

Publication number Publication date
US12226117B2 (en) 2025-02-18
JP6772161B2 (ja) 2020-10-21
EP3258863B1 (en) 2020-09-16
WO2016132241A1 (en) 2016-08-25
EP3258863A1 (en) 2017-12-27
JP2018511361A (ja) 2018-04-26
CN107530049A (zh) 2018-01-02
US20160242808A1 (en) 2016-08-25

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