CN107496903A - A kind of melbine and preparation method thereof - Google Patents
A kind of melbine and preparation method thereof Download PDFInfo
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- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
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Abstract
The invention discloses a kind of melbine and preparation method thereof, belongs to health medicine field, and the melbine includes the component of following mass fraction：35~45 parts of aloe vera gel powder, 35~45 parts of bitter gourd polypeptide, 6~10 parts of resistant dextrin, 3~6 parts of deep-sea fish oil-bound distemper, 1~2 part of xylitol, 1~2 part of D-sorbite, 1~2 part of Sucralose, 2~3 parts of microcrystalline cellulose, 0.1~0.2 part of magnesium stearate；Its preparation method includes weighing, and major ingredient mixing, dries, crushes, total mixed, manufactures particle, the step of tabletting, sterilization.The present invention is cooperateed with by each active ingredient, strengthens hypoglycemic effect, and it is short to solve action time present in existing most of hypoglycemic medicines, easily repeatedly the problem of；Simultaneously, moreover it is possible to strengthen body immunity, reducing blood lipid, solve the problems such as user's immunity and other body injuries are reduced present in existing hypoglycemic medicine；And materials safety, have no side effect, can trust and take.
Description
Technical field
The present invention relates to health medicine field, is specifically related to a kind of safe, lasting melbine and preparation method thereof.
Background technology
Diabetes are to cause metabolic disease characterized by chronic hyperglycemia by Different types of etiopathogenises, due to insulin secretion or
The defects of effect, or both exist simultaneously, cause a series of metabolic disorders such as sugar, albumen, fat, water and electrolyte.Prolonged illness can
Multisystem damage can be caused, be in a bad way or stress when the acute metablize confusion may occur.Diabetes turn into after cardiovascular disease
With the third-largest uninfection after tumour, be serious threat human health worldwide problem.In China, reported according to correlation
Road, recognize that diabetes morbidity is up to 11.6%, new data further illustrates diabetes and has become the great doctor in China
Treatment problem.At present, OHA（OAD）Appearance has had more than 50 years, develops the new of a variety of different mechanism of action again in recent years
Medicine, diabetic there are more selections in drug therapy, while add them again and pondered over when selecting medicine
Content.It is preferred that should be that blood sugar reducing function is strong, and not impaired isle function, blood glucose can be controlled for a long time, and mortality is low, user
Just, affordable, few side effects, moreover it is possible to prevent and treat chronic complicating diseases of diabetes.Above-mentioned requirements will be taken into account actually very tired completely
Difficulty, there is presently no Related product can meet above-mentioned desirable.
At present, the blood sugar reducing function of existing melbine is not lasting enough, and easily repeatedly；Also often along with to diabetic with
A series of the problems such as carrying out body and mind infringements.
The content of the invention
1. technical problems to be solved
The technical problem to be solved in the present invention is to provide a kind of melbine and preparation method thereof, and it is assisted by each active ingredient
Together, hypoglycemic effect is strengthened, and blood sugar reducing function is more lasting, solves and is acted on present in existing most of hypoglycemic medicines
Time is short, easily repeatedly the problem of；Body immunity can also be strengthened hypoglycemic while, reducing blood lipid, hyperglycemia population can be achieved
The purpose expressed according to the human normal physiology natural law, moreover it is possible to reduce the generation of related complication, solve existing hypoglycemic
The problems such as user's immunity and other body injuries are reduced present in medicine；, will not be to taking and materials are free from side effects
Person causes body and mind to injure, and can trust and take.
2. technical scheme
To solve the above problems, the present invention adopts the following technical scheme that：
A kind of melbine, include the component of following mass fraction：
35~45 parts of aloe vera gel powder；
35~45 parts of bitter gourd polypeptide；
6~10 parts of resistant dextrin；
3~6 parts of deep-sea fish oil-bound distemper；
1~2 part of xylitol；
1~2 part of D-sorbite；
1~2 part of Sucralose；
2~3 parts of microcrystalline cellulose；
0.1~0.2 part of magnesium stearate.
Further, the melbine includes the component of following mass fraction：
42 parts of aloe vera gel powder；
35 parts of bitter gourd polypeptide；
8 parts of resistant dextrin；
6 parts of deep-sea fish oil-bound distemper；
2 parts of xylitol；
2 parts of D-sorbite；
2 parts of Sucralose；
2.8 parts of microcrystalline cellulose；
0.2 part of magnesium stearate.
Present invention also offers the preparation method of above-mentioned melbine, comprise the following steps：
A. weigh：Each component is weighed respectively according to the mass fraction, it is standby；
B. major ingredient mixes：Aloe vera gel powder is first tuned into pasty state with boiling water, adds bitter gourd polypeptide and deep-sea fish oil-bound distemper,
Softwood is made；
C. dry, crush：Above-mentioned softwood is placed in drying machine and dried, it is 80 targeted fine powders to be then comminuted into fineness；
D. it is total mixed：Resistant dextrin, xylitol, D-sorbite and Sucralose are added in above-mentioned fine powder, is well mixed, must mix
Powder；
E. particle is manufactured：Microcrystalline cellulose is added in above-mentioned mixed powder, after being well mixed, is granulated in comminutor, then through dry
Dry, whole grain, obtains hypoglycemic granule；
F. tabletting, sterilization：Magnesium stearate is added in above-mentioned hypoglycemic granule, after being well mixed, the tabletting in tablet press machine, after sterilization
Packaging, then sterilize, produce melbine.
Further, the temperature of boiling water used is 60~70 DEG C in the step b.
Further, first bitter gourd polypeptide and deep-sea fish oil-bound distemper are well mixed in the step b, are then added to Curacao reed
In the pasty mass that luxuriant growth gel powder is adjusted.Adjusted if bitter gourd polypeptide and deep-sea fish oil-bound distemper are added separately to aloe vera gel powder
Pasty mass in, then need stir pasty mass twice；And additive is first mixed, it is then added to aloe vera gel powder and is adjusted
Pasty mass in, the stirring to pasty mass only needs once, the more convenient operation of the method, is advantageous to the efficiency that speeds operations.
Further, in the step d resistant dextrin, xylitol, D-sorbite and Sucralose before combination, respectively
Cross 80 mesh sieves.The fineness degree of auxiliary material is examined, the fineness degree of unified auxiliary material and major ingredient is smaller in 80 mesh or fineness degree, is beneficial to mix
Uniformly.
Further, first xylitol, D-sorbite and Sucralose are well mixed in the step d, then added anti-
Property dextrin and be well mixed, be finally well mixed again with gained fine powder in step c, mixed powder be made.According to different Function Class,
First similar mixing and then different types of mixing is completed one by one, may advantageously facilitate well mixed, and mix orderly.
Further, employ powder mixer when being mixed in the step d, the powder mixer include support frame and
The mixing chamber and splicing support plate being fixed on support frame, and mixing chamber upper end is provided with No.1 on its axis is symmetrical
Feed hopper and No. two feed hoppers, the mixing chamber lower end are provided with discharging opening, and the splicing support plate is located at below mixing chamber simultaneously
Face discharging opening；
The structure of the No.1 feed hopper and No. two feed hoppers is consistent, the funnel body that includes being sequentially connected from top to bottom, vertical
To connecting leg and bulk cargo pipe, the equal lateral inclination of bulk cargo pipe of the No.1 feed hopper and No. two feed hoppers is fixed on mixing chamber
End, and the phase near-end of two bulk cargo pipes is mutually proximally located in mixing chamber less than its phase distal end, described two bulk cargo pipes, two
The phase distal end of bulk cargo pipe is equipped with hair-dryer；Longitudinal connecting leg connects with upper side in the middle part of bulk cargo pipe, on longitudinal connecting leg
End is connected to funnel body lower port, and the funnel body and the junction of longitudinal connecting leg are provided with baffle plate, and described baffle plate one end is consolidated
It is scheduled in a rotary shaft being installed on funnel body lower end inner wall；
The rotary shaft is driven by micro servo motor, and the micro servo motor and hair-dryer are connected with controller respectively；Institute
State support frame to be provided with the data display screen be connected with controller, input keyboard, release the button and SR, the control
PLC and angular encoder are provided with device；After the triggering of releasing the button, hair-dryer starts, and controller is according to by inputting keyboard
The proportionate relationship of input, the angle of rotation of the motor shaft of No.1 feed hopper and the micro servo motor in No. two feed hoppers is controlled respectively
Degree, and then make rotary shaft drive baffle plate to be rotated down corresponding angle, the ratio and the ratio of input of two rotary shaft institute rotational angles
Example is consistent；After the SR triggering, hair-dryer is closed, and micro servo motor drives the related baffle plate of rotary shaft to reset.
3. beneficial effect
（1）The each component of melbine provided by the present invention has following effect：
1. aloe vera gel powder, it is using aloe barbadensis Miller blade as raw material, through dripping the step such as quinone cleaning, peeling, blanching, sterilization
Suddenly it is made.Essence, alcohol, pigment are not added, does not add deionized water, belongs to pure natural fresh aloe juice, natural safety, are easily absorbed,
Long-term use has no side effect.It is a kind of new resource food.Aloe barbadensis Miller, also known as Ji Lasuo aloes, aloe barbadensis Miller or U.S. reed
Luxuriant growth, medicinal aloe is commonly called as, its main component has Anthraquinones synthesis, carbohydrate, amino acid, trace element, organic acid, enzyme, gleditsia sinensis
Glycosides, lignin and plant hormone etc..A Er Poland plain A, B in aloe have notable hypoglycemic effect, and and can promotes new old
Metabolism, body immunity is improved, show that aloe barbadensis Miller has the effect of mystery, stable to diabetes through scientific experimentation.Aloe
Possessed significant hypoglycemic effect, can prevent and improve diabetes, improve nerve, the kidney trouble of diabetic complication
Become, moreover it is possible to enhance metabolism, improve body immunity.
2. balsam pear fruity sweetness and bitterness, main to make vegetables, mature sarcocarp and aril also edible.There are good health care and medicinal valency
Value.Bitter gourd polypeptide is the bioactive ingredients being extract from fresh special balsam pear, is made up of 17 kinds of 166 amino acid,
It can be combined with insulin antibody, several scientists, which study, shows that it is known as similar structure and physical and chemical index to pancreas islet, by swashing
Work insulin, activation insulin receptor, improve insulin effective rate of utilization to adjust blood glucose, so as to realize blood glucose according to people
The purpose of body normal physiological natural law expression, and be free from side effects.
3. resistant dextrin is process by starch, be indigestibility composition industrial technology extraction process by dextrin is baked simultaneously
A kind of Low Caloric Polydextrose formed is refined, belongs to low molecule water-soluble dietary fiber, is that a kind of soluble food low in calories is former
Material, it is safe and non-toxic.Resistant dextrin can significantly improve diabetes and recognize sugar tolerance, reduce the speed sum that body absorbs glucose
Amount.Simultaneously from the point of view of anti-digestive ferment characteristic possessed by resistant dextrin, it will not be digested absorption in alimentary canal, water miscible
Resistant dextrin absorbs water in intestines and stomach and forms gel, can thus adsorb glucose and slow down the diffusion of carbohydrate, postpone sugar
The absorption of class in the intestine, so as to inhibit carbohydrate absorb after blood glucose rising.Meanwhile the solubility and gelation of resistant dextrin have
Relatively stable effect for reducing fat, its mechanism be resistant dextrin by disturbing the absorption of cholesterol or the reabsorption of bile in enteron aisle, from
And the blood fat that can be effectively promoted diabetes patient recovers, promote the benign cycle of glycometabolism and lipid metaboli.
4. hyperglycaemia is easiest to cause blood fat high, many diabetes patients are with hyperlipemia, therefore people are generally sugar
Urine disease is referred to as sister's disease with hyperlipidemia, and thinks that high fat of blood is the secondary disease of diabetes.According to statistics, about 40% diabetes
Patient has disorders of lipid metabolism symptom, and be characterized in that triglycerides increases reduces with HDL.Have to arteriosclerosis pre-
The deep sea fish oil of anti-effect, although little to hyperglycemia, it can soften the rubbish in blood vessel removing blood vessel, to reducing blood lipid
There is good effect.Illustrate that a small amount of deep sea fish oil is also good to diabetes.
5. the sweetener of xylitol, D-sorbite and Sucralose as melbine, wherein, xylitol is a kind of day
So, healthy sweetener, D-sorbite are a kind of nutritive sweeteners with preferable moisture retention and fragrance protectiveness, and Sucralose is
The uniquely functional sweetener using sucrose as raw material, it has absolute security, without the query in terms of any toxicological study.
And the characteristics of D-sorbite and Sucralose are respectively provided with noenergy, sugariness is high, after human body intake, blood glucose value will not increase, and can press down
The glycemic index of blood glucose processed.
6. microcrystalline cellulose and magnesium stearate, which are conventional pharmaceutical tablet, makes auxiliary material, safe and non-toxic.
（2）From the foregoing, first, resistant dextrin absorbs water in intestines and stomach and forms gel, adsorb glucose and slow down
The diffusion of carbohydrate, postponed the absorption of carbohydrate in the intestine, so as to inhibit carbohydrate absorb after blood glucose rising；Then, Curacao
Aloe gel powder is reduced to existing elevated blood glucose levels in diabetic's body as foreign substance, meanwhile, balsam pear is more
Peptide improves insulin effective rate of utilization to reduce diabetic by activating internal body insulin, activation insulin receptor
Existing hyperglycaemia in body.Inside and outside common cooperation, realizes significant blood sugar decreasing effect；Finally, aloe vera gel powder comes
Improve nerve, the renal lesions of diabetic complication, the solubility and gelation of resistant dextrin have relatively stable effect for reducing fat, deep
Ocean fish oil-bound distemper softening blood vessel removes the rubbish in blood vessel, alleviates secondary disease --- the high fat of blood of diabetes.Aloe vera gel
Powder, bitter gourd polypeptide, resistant dextrin and deep-sea fish oil-bound distemper synergy, can significantly increase this product to the hypoglycemic of diabetic
Effect, and blood sugar reducing function is more lasting.Solve that action time present in existing most of hypoglycemic medicines is short, easily repeatedly
Problem.
（3）From the foregoing, in addition to above-mentioned hypoglycemic effect, aloe vera gel powder, which also has, adjusts Human Physiology machine
Can, enhance metabolism, the effect of strengthen immunity；Resistant dextrin and fish oil can adjust the blood fat of human body, and hyperglycaemia is caused
Blood fat height have good effect for reducing blood fat, recover so as to be effectively promoted the blood fat of diabetes patient, promote glycometabolism and fat
The benign cycle of metabolism, the protein metabolism system of human body, lipid metaboli system is set also progressively to be adjusted to normal condition by disturbance state.
Solve reduction user's immunity present in existing hypoglycemic medicine and other bring asking for the side effects such as damage to body
Topic.
（4）In addition, aloe vera gel powder belongs to crude, bitter gourd polypeptide, resistant dextrin and its auxiliary material are
Safe and non-toxic material, deep sea fish oil is a kind of unsaturated fat composition, and dosage is relatively fewer.So this product does not have substantially
Side effect, body and mind will not be caused to injure user, can trust and take.
（5）In the preparation method of melbine provided by the present invention, first by aloe vera gel powder, bitter gourd polypeptide and and
The big key component material of deep-sea fish oil-bound distemper three is mixed and made into softwood, is then dried, crushes pulverulent material is made；Then again with
Resistant dextrin and each sweetener are mixed.So that the first largely mutually fusion of three big key component materials, then again with
Auxiliary material mixes, and mixed process orderliness is clear, in good order, and mix it is reasonable, be advantageous to keep melbine blood sugar reducing function and its
His effect.
（6）The present invention employs powder mixer when total mixed in the preparation process of melbine, and it designs thing to be mixed
The outlet of material rotates on same circle, the scope of being scattered of control material；Meanwhile pass through the feeding rate control to material corresponding proportion
System, realizes the uniform mixing of material in proportion.Without stirring for device, avoid agitator to material attach and other effects,
The loss of material is advantageously reduced, ensures the stability of material.
Cooperateed with melbine provided by the present invention by each active ingredient, strengthen hypoglycemic effect, and blood sugar reducing function
More persistently, to solve action time present in existing most of hypoglycemic medicines short, easily repeatedly the problem of；Hypoglycemic
Body immunity can also be strengthened simultaneously, reducing blood lipid, can be achieved what hyperglycemia population was expressed according to the human normal physiology natural law
Purpose, moreover it is possible to reduce the generation of related complication, solve present in existing hypoglycemic medicine reduce user's immunity and
The problems such as other body injuries；And materials are free from side effects, body and mind will not be caused to injure user, can trust and take.
Brief description of the drawings
Fig. 1 is the structural representation of powder mixer；
Wherein, 1- support frames, 2- mixing chambers, 3- splicing support plates, 4- discharging openings, 5- splicing containers, 6- input keyboards, 7- data
Display screen, 8- release the button, 9- SRs, 10- No.1 feed hoppers, 11- funnel bodies, 12- longitudinal directions connecting leg, 13- bulk cargo pipes,
14- rotary shafts, 15- baffle plates, 16- hair-dryers, No. bis- feed hoppers of 20-.
Embodiment
The present invention is further detailed explanation with reference to the accompanying drawings and examples.
Embodiment 1
A kind of melbine, include the component of following mass fraction：
45 parts of aloe vera gel powder；
39 parts of bitter gourd polypeptide；
6 parts of resistant dextrin；
3 parts of deep-sea fish oil-bound distemper；
1.5 parts of xylitol；
1.5 parts of D-sorbite；
1.5 parts of Sucralose；
2.3 parts of microcrystalline cellulose；
0.2 part of magnesium stearate.
The preparation method of above-mentioned melbine is：
A. weigh：Each component is weighed respectively according to the mass fraction, it is standby；
B. major ingredient mixes：Aloe vera gel powder is first tuned into pasty state with boiling water, adds bitter gourd polypeptide and deep-sea fish oil-bound distemper,
Softwood is made；
C. dry, crush：Above-mentioned softwood is placed in drying machine and dried, it is 80 targeted fine powders to be then comminuted into fineness；
D. it is total mixed：Resistant dextrin, xylitol, D-sorbite and Sucralose are added in above-mentioned fine powder, is well mixed, must mix
Powder；
E. particle is manufactured：Microcrystalline cellulose is added in above-mentioned mixed powder, after being well mixed, is granulated in comminutor, then through dry
Dry, whole grain, obtains hypoglycemic granule；
F. tabletting, sterilization：Magnesium stearate is added in above-mentioned hypoglycemic granule, after being well mixed, the tabletting in tablet press machine, after sterilization
Packaging, then sterilize, produce melbine.
In the present embodiment, the temperature of boiling water used is 70 DEG C in the step b.
Specifically,
First bitter gourd polypeptide and deep-sea fish oil-bound distemper are well mixed in the step b, aloe vera gel powder is then added to and is adjusted
Pasty mass in.If bitter gourd polypeptide and deep-sea fish oil-bound distemper are added separately to the pasty mass that aloe vera gel powder is adjusted
In, then need to stir pasty mass twice；And additive is first mixed, it is then added to the pasty mass that aloe vera gel powder is adjusted
In, the stirring to pasty mass only needs once, the more convenient operation of the method, is advantageous to the efficiency that speeds operations.
Resistant dextrin, xylitol, D-sorbite and Sucralose before combination, respectively cross 80 mesh sieves in the step d.
The fineness degree of auxiliary material is examined, the fineness degree of unified auxiliary material and major ingredient is smaller in 80 mesh or fineness degree, is beneficial to well mixed.
First xylitol, D-sorbite and Sucralose are well mixed in the step d, resistant dextrin is then added and mixes
Close uniformly, be finally well mixed again with gained fine powder in step c, mixed powder is made.According to different Function Class, first similar mixing
Then different types of mixing is completed one by one, may advantageously facilitate well mixed, and is mixed orderly.
Powder mixer is employed when being mixed in the step d, as shown in figure 1, the powder mixer includes support frame 1
And mixing chamber 2 and splicing support plate 3 on support frame 1 are fixed on, and the upper end of mixing chamber 2 is set on its axis is symmetrical
There are No.1 feed hopper 10 and No. two feed hoppers 20, the lower end of mixing chamber 2 is provided with discharging opening 4, and the splicing support plate 3 is positioned at mixed
Close the lower section of cavity 2 and face discharging opening 4；
The No.1 feed hopper 10 is consistent with the structure of No. two feed hoppers 20, includes the funnel body being sequentially connected from top to bottom
11st, the 13 equal lateral inclination of bulk cargo pipe of longitudinal connecting leg 12 and bulk cargo pipe 13, the No.1 feed hopper 10 and No. two feed hoppers 20 is consolidated
The upper end of mixing chamber 2 is scheduled on, and the phase near-end of two bulk cargo pipes 13 is less than its phase distal end, the phase near-end of described two bulk cargo pipes 13
In mixing chamber 2, the phase distal end of two bulk cargo pipes 13 is equipped with hair-dryer 16；In longitudinal connecting leg 12 and bulk cargo pipe 13
Portion's upper side connection, longitudinal upper end of connecting leg 12 are connected to the lower port of funnel body 11, and the funnel body 11 connects with longitudinal direction
The junction of pipe 12 is provided with baffle plate 15, and described one end of baffle plate 15, which is fixed on one and is installed on the lower end inner wall of funnel body 11, to be turned
On moving axis 14；
The rotary shaft 14 is driven by micro servo motor, and the micro servo motor and hair-dryer 16 connect with controller respectively
Connect；Support frame as described above 1 is provided with the data display screen 7 being connected with controller, input keyboard 6, release the button 8 and SR
9, the controller is interior to be provided with PLC and angular encoder；After 8 triggerings of releasing the button, hair-dryer 16 starts, controller according to
The proportionate relationship inputted by inputting keyboard 6, the miniature servo electricity in No.1 feed hopper 10 and No. two feed hoppers 20 is controlled respectively
The rotational angle of the motor shaft of machine, and then make rotary shaft 14 drive baffle plate 15 to be rotated down corresponding angle（The scope of angle is
0 °~90 °）, the ratio of two rotary shafts, 14 rotational angles is consistent with the ratio inputted；After the SR 9 triggers, blowing
Machine 16 is closed, and micro servo motor drives the related baffle plate 15 of rotary shaft 14 to reset.
Above-mentioned powder mixer be applied to preparation method in step d when detailed process be：
（1）Any two kinds in xylitol, D-sorbite and Sucralose are added separately to No.1 feed hopper 10 and No. two are entered
In hopper 20, splicing container 5 is put on splicing support plate 3, then inputs two identical data by inputting keyboard 6（According to
Quality parts ratio input data；When material content to be mixed is fewer, the data of its corresponding input are smaller）, then start and open
Open button 8, according to the proportionate relationship of input, control respectively in No.1 feed hopper 10 and No. two feed hoppers 20 miniature watches controller
The rotational angle of motor shaft in motor is taken, and then makes rotary shaft 14 drive baffle plate 15 to be rotated down corresponding angle（Two rotations
The ratio of 14 rotational angles of axle is consistent with the ratio inputted）, meanwhile, open hair-dryer 16；
（2）Material to be mixed is dropped down onto in bulk cargo pipe 13 under the opening between baffle plate 15 and longitudinal connecting leg 12, and is being dried
Under the wind action that machine 16 is blown out, two kinds of materials to be mixed are scattered in mixing chamber 2 simultaneously, in mixing chamber 2 fully
Mixing, it is final to fall and fallen into from discharging opening 4 in splicing container 5；Treat that material is fallen completely within splicing container 5, that is, complete two kinds
The mixing of material, SR 9 is pressed, hair-dryer 16 decommissions, and micro servo motor drives the related baffle plate 15 of rotary shaft 14
Reset；
（3）Then the mixture of above two sweetener and a kind of remaining sweetener are respectively placed in No.1 feed hopper 10 and No. two
In feed hopper 20, operate as described above and be well mixed both, this time the ratio of the data of input is 2：1；
（4）Then the mixture of above-mentioned three kinds of sweeteners and resistant dextrin are respectively placed in No.1 feed hopper 10 and No. two feed hoppers
In 20, operate as described above and be well mixed both, this time the mass fraction summation of ratio and the three kinds of sweeteners of the data of input and
The ratio of the mass fraction of resistant dextrin is consistent；
（5）Finally gained fine powder in said mixture and step c is respectively placed in No.1 feed hopper 10 and No. two feed hoppers 20,
Operate as described above and be well mixed both, this time the ratio of the data of input is total with the mass fraction of three kinds of sweeteners and resistant dextrin
It is consistent with the ratio of the mass fraction of gained fine powder in step c；After well mixed, mixed powder is produced.
Embodiment 2
A kind of melbine, include the component of following mass fraction：
41 parts of aloe vera gel powder；
42 parts of bitter gourd polypeptide；
7 parts of resistant dextrin；
4 parts of deep-sea fish oil-bound distemper；
1.3 parts of xylitol；
1.3 parts of D-sorbite；
1.3 parts of Sucralose；
2 parts of microcrystalline cellulose；
0.1 part of magnesium stearate.
The difference of the preparation method of melbine described in the present embodiment and preparation method in embodiment 1 is：In step b
The temperature of boiling water used is 65 DEG C.
Other are the same as embodiment 1.
The powder mixer used in step d is also the same as embodiment 1.
Embodiment 3
A kind of melbine, include the component of following mass fraction：
42 parts of aloe vera gel powder；
35 parts of bitter gourd polypeptide；
8 parts of resistant dextrin；
6 parts of deep-sea fish oil-bound distemper；
2 parts of xylitol；
2 parts of D-sorbite；
2 parts of Sucralose；
2.8 parts of microcrystalline cellulose；
0.2 part of magnesium stearate.
The difference of the preparation method of melbine described in the present embodiment and preparation method in embodiment 1 is：In step b
The temperature of boiling water used is 60 DEG C.
Other are the same as embodiment 1.
The powder mixer used in step d is also the same as embodiment 1.
Embodiment 4
A kind of melbine, include the component of following mass fraction：
36 parts of aloe vera gel powder；
45 parts of bitter gourd polypeptide；
9 parts of resistant dextrin；
3.8 parts of deep-sea fish oil-bound distemper；
1 part of xylitol；
1 part of D-sorbite；
1 part of Sucralose；
3 parts of microcrystalline cellulose；
0.2 part of magnesium stearate.
The difference of the preparation method of melbine described in the present embodiment and preparation method in embodiment 1 is：In step b
The temperature of boiling water used is 70 DEG C.
Other are the same as embodiment 1.
The powder mixer used in step d is also the same as embodiment 1.
Embodiment 5
A kind of melbine, include the component of following mass fraction：
35 parts of aloe vera gel powder；
43 parts of bitter gourd polypeptide；
10 parts of resistant dextrin；
5 parts of deep-sea fish oil-bound distemper；
1.4 parts of xylitol；
1.4 parts of D-sorbite；
1.4 parts of Sucralose；
2.7 parts of microcrystalline cellulose；
0.1 part of magnesium stearate.
The difference of the preparation method of melbine described in the present embodiment and preparation method in embodiment 1 is：In step b
The temperature of boiling water used is 60 DEG C.
Other are the same as embodiment 1.
The powder mixer used in step d is also the same as embodiment 1.
Those of ordinary skill in the art it should be appreciated that the embodiment of the above be intended merely to explanation the present invention,
And be not used as limitation of the invention, as long as in the spirit of the present invention, the change to embodiment described above
Change, modification will all fall in scope of the presently claimed invention.
Claims (8)
1. a kind of melbine, it is characterised in that include the component of following mass fraction：
35~45 parts of aloe vera gel powder；
35~45 parts of bitter gourd polypeptide；
6~10 parts of resistant dextrin；
3~6 parts of deep-sea fish oil-bound distemper；
1~2 part of xylitol；
1~2 part of D-sorbite；
1~2 part of Sucralose；
2~3 parts of microcrystalline cellulose；
0.1~0.2 part of magnesium stearate.
2. a kind of melbine according to claim 1, it is characterised in that include the component of following mass fraction：
42 parts of aloe vera gel powder；
35 parts of bitter gourd polypeptide；
8 parts of resistant dextrin；
6 parts of deep-sea fish oil-bound distemper；
2 parts of xylitol；
2 parts of D-sorbite；
2 parts of Sucralose；
2.8 parts of microcrystalline cellulose；
0.2 part of magnesium stearate.
3. the preparation method of melbine according to claim 1 or claim 2, it is characterised in that comprise the following steps：
Weigh：Each component is weighed respectively according to the mass fraction, it is standby；
Major ingredient mixes：Aloe vera gel powder is first tuned into pasty state with boiling water, adds bitter gourd polypeptide and deep-sea fish oil-bound distemper, is made
Into softwood；
Dry, crush：Above-mentioned softwood is placed in drying machine and dried, it is 80 targeted fine powders to be then comminuted into fineness；
It is total mixed：Resistant dextrin, xylitol, D-sorbite and Sucralose are added in above-mentioned fine powder, is well mixed, must mix
Powder；
Manufacture particle：Add microcrystalline cellulose in above-mentioned mixed powder, be well mixed after, be granulated in comminutor, then through drying,
Whole grain, obtain hypoglycemic granule；
Tabletting, sterilization：Magnesium stearate is added in above-mentioned hypoglycemic granule, after being well mixed, the tabletting in tablet press machine, is wrapped after sterilization
Dress, then sterilize, produce melbine.
4. preparation method according to claim 3, it is characterised in that in the step b temperature of boiling water used be 60~
70℃。
5. preparation method according to claim 4, it is characterised in that first by bitter gourd polypeptide and deep-sea fish in the step b
Oil-bound distemper is well mixed, and is then added in the pasty mass that aloe vera gel powder is adjusted.
6. preparation method according to claim 3, it is characterised in that resistant dextrin, xylitol, sorb in the step d
Sugar alcohol and Sucralose before combination, respectively cross 80 mesh sieves.
7. preparation method according to claim 6, it is characterised in that in the step d first by xylitol, D-sorbite and
Sucralose is well mixed, and is then added resistant dextrin and is well mixed, and is finally well mixed again with gained fine powder in step c,
Mixed powder is made.
8. preparation method according to claim 7, it is characterised in that powder mixing is employed when being mixed in the step d
Machine, the powder mixer include support frame（1）And it is fixed on support frame（1）On mixing chamber（2）With splicing support plate（3）,
And mixing chamber（2）Upper end is provided with No.1 feed hopper on its axis is symmetrical（10）With No. two feed hoppers（20）, it is described
Mixing chamber（2）Lower end is provided with discharging opening（4）, the splicing support plate（3）Positioned at mixing chamber（2）Lower section and face discharging opening
（4）；
The No.1 feed hopper（10）With No. two feed hoppers（20）Structure it is consistent, include the funnel that is sequentially connected from top to bottom
Main body（11）, longitudinal connecting leg（12）And bulk cargo pipe（13）, the No.1 feed hopper（10）With No. two feed hoppers（20）Bulk cargo pipe
（13）Equal lateral inclination is fixed on mixing chamber（2）Upper end, and two bulk cargo pipes（13）Phase near-end less than its phase distal end, it is described
Two bulk cargo pipes（13）Be mutually proximally located at mixing chamber（2）It is interior, two bulk cargo pipes（13）Phase distal end be equipped with hair-dryer
（16）；Longitudinal connecting leg（12）With bulk cargo pipe（13）Middle part upper side connection, longitudinal connecting leg（12）Upper end is connected to Lou
Struggle against main body（11）Lower port, the funnel body（11）With longitudinal connecting leg（12）Junction be provided with baffle plate（15）, the baffle plate
（15）One end is fixed on one and is installed on funnel body（11）Rotary shaft on lower end inner wall（14）On；
The rotary shaft（14）Driven by micro servo motor, the micro servo motor and hair-dryer（16）Respectively with controller
Connection；Support frame as described above（1）It is provided with the data display screen being connected with controller（7）, input keyboard（6）, release the button（8）
And SR（9）, the controller is interior to be provided with PLC and angular encoder；It is described to release the button（8）After triggering, hair-dryer
（16）Start, controller is according to by inputting keyboard（6）The proportionate relationship of input, No.1 feed hopper is controlled respectively（10）With No. two
Feed hopper（20）The rotational angle of the motor shaft of interior micro servo motor, and then make rotary shaft（14）Drive baffle plate（15）Downwards
Rotate corresponding angle, two rotary shafts（14）The ratio of institute's rotational angle is consistent with the ratio inputted；The SR（9）Touch
After hair, hair-dryer（16）Close, micro servo motor drives rotary shaft（14）Related baffle plate（15）Reset.
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Effective date of registration: 20180109 Address after: 412000 Changjiang South Road, acorn garden, Zhuzhou high tech Zone, Hunan Province, No. 8 Applicant after: HUNAN KANGQI100 BIOTECHNOLOGY CO., LTD. Address before: No. 3, Wangjia Ping Community, Tai Po, Tianyuan District, Zhuzhou, Hunan Applicant before: Wang Haijun |
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Application publication date: 20171222 |