CN109350732B - Sugar-free honeyed pill and preparation method and application thereof - Google Patents
Sugar-free honeyed pill and preparation method and application thereof Download PDFInfo
- Publication number
- CN109350732B CN109350732B CN201811230126.2A CN201811230126A CN109350732B CN 109350732 B CN109350732 B CN 109350732B CN 201811230126 A CN201811230126 A CN 201811230126A CN 109350732 B CN109350732 B CN 109350732B
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- parts
- sugar
- free
- honeyed
- honeyed pill
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- 238000002360 preparation method Methods 0.000 title claims abstract description 17
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- 238000001035 drying Methods 0.000 claims abstract description 22
- 244000144927 Aloe barbadensis Species 0.000 claims abstract description 21
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- 235000011399 aloe vera Nutrition 0.000 claims abstract description 21
- 229940069949 propolis Drugs 0.000 claims abstract description 21
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 21
- 229920002752 Konjac Polymers 0.000 claims abstract description 19
- 239000000252 konjac Substances 0.000 claims abstract description 19
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- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims description 12
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 35
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- 230000001070 adhesive effect Effects 0.000 description 2
- HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
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- 238000009835 boiling Methods 0.000 description 1
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- 229910000020 calcium bicarbonate Inorganic materials 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
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- 238000011156 evaluation Methods 0.000 description 1
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- 235000013305 food Nutrition 0.000 description 1
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- -1 fructose and glucose Chemical class 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 230000010030 glucose lowering effect Effects 0.000 description 1
- 238000007446 glucose tolerance test Methods 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
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- 238000000265 homogenisation Methods 0.000 description 1
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- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 1
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Classifications
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Abstract
The invention relates to the technical field of traditional Chinese medicines, in particular to a sugar-free honeyed pill and a preparation method and application thereof. The sugar-free honeyed pill is mainly prepared by mixing raw material powder and concentrated gum; the mass ratio of the raw material powder to the concentrated gel is (1-3) to 1; the raw material powder is mainly prepared from the following components in parts by weight: 15-30 parts of bergamot extract, 15-30 parts of lychee seed, 2-10 parts of rhizoma anemarrhenae, 5-10 parts of rehmannia, 4-12 parts of cinnamon, 1-3 parts of mulberry leaf and 1-3 parts of bitter gourd polypeptide; the concentrated gel comprises one or more of propolis, konjac gum, and aloe vera gel. The invention takes various traditional Chinese medicinal materials with the blood sugar reducing effect, bitter gourd polypeptide and the like as raw materials, adopts the binder with the blood sugar reducing effect to replace auxiliary material honey prepared by the conventional honeyed pills, adopts two-step microwave treatment, reduces the sugar content in the honeyed pills, has excellent sterilization and drying effects, and ensures that the honeyed pills are suitable for diabetics and sugar-limiting crowds.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a sugar-free honeyed pill and a preparation method and application thereof.
Background
The traditional Chinese medicine honeyed pills have a long history in the field of traditional Chinese medicines, and the pills are mostly used for patients who are weak after a major illness and need to be recuperated, or for treating some chronic diseases.
The honey is an important auxiliary material of the honeyed pill, contains various sugars, mainly fructose and glucose, and accounts for about 75-80% of the total components of the honey, and the honey in the honeyed pill accounts for about 55%. The sugar content in honeyed pill is 41-44%. Because the GI of the honey is 73, the honey belongs to high GI components, although a plurality of honey pill products have better curative effect on various diseases, the honey pills prepared by the honey often make a plurality of diabetics and sugar-limiting crowds to be overlooked, thereby greatly limiting the application crowds of the honey pill products.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The first purpose of the invention is to provide a sugar-free honeyed pill which is good in taste, free of sugar, long in shelf life and good in blood sugar reducing effect.
The second purpose of the invention is to provide a preparation method of the sugar-free honeyed pill, which is characterized in that the honeyed pill is sterilized, dried and the like by a two-step microwave method, so that the product stability of the honeyed pill is improved, and the shelf life is prolonged.
The third purpose of the invention is to provide application of the sugar-free honeyed pill in preparing products for reducing blood sugar, including medicines or health-care foods, functional foods and the like.
In order to achieve the above purpose of the present invention, the following technical solutions are adopted:
a sugar-free honeyed pill is prepared by mixing raw material powder with concentrated gum;
the mass ratio of the raw material powder to the concentrated gel is (1-3) to 1;
the raw material powder is mainly prepared from the following components in parts by weight:
15-30 parts of bergamot extract, 15-30 parts of lychee seed, 2-10 parts of rhizoma anemarrhenae, 5-10 parts of rehmannia, 4-12 parts of cinnamon, 1-3 parts of mulberry leaf and 1-3 parts of bitter gourd polypeptide;
the concentrated gel comprises one or more of propolis, konjac gum, and aloe vera gel.
The invention takes various traditional Chinese medicinal materials with the blood sugar reducing effect, bitter gourd polypeptide and the like as raw materials, adopts the binder with the blood sugar reducing effect to replace auxiliary material honey prepared by the conventional honeyed pills, reduces the sugar content in the honeyed pills, and ensures that the honeyed pills are suitable for diabetics and people with sugar limitation.
Preferably, the concentrated gel comprises propolis, konjac gum, and aloe vera gel. More preferably, the mass ratio of propolis, konjac glucomannan and aloe vera gel is 4: 1: 3 (1-3), preferably 2: 1.
The concentrated gel is prepared by mixing propolis, konjac glucomannan and aloe vera gel with water, homogenizing, and decocting. The density of the concentrated gum is 1.3-1.4, preferably 1.35. The mass concentration of propolis, konjac glucomannan and aloe vera gel in water is 8-15%, and then homogenization treatment is carried out.
The preparation method of the concentrated gum preferably comprises the following steps: mixing propolis, konjac glucomannan and Aloe barbadensis gel with water, heating to 100 + -5 deg.C, homogenizing, and decocting until the density is 1.3-1.4 to obtain the concentrated gel. Preferably, the material obtained after the gum boiling is filtered for use. Wherein the propolis, konjac glucomannan and aloe vera gel are mixed with water such that the total mass concentration of propolis, konjac glucomannan and aloe vera gel is 8-15%.
The invention adopts three composite adhesives with the blood sugar reducing effect to replace auxiliary material honey, and improves the blood sugar reducing effect of the honeyed pills while ensuring the storage stability of the honeyed pills, so that the honeyed pills are suitable for diabetics and people with sugar limitation.
Preferably, the raw material powder is mainly prepared from the following components in parts by weight:
18-25 parts of bergamot extract, 18-25 parts of lychee seed, 4-9 parts of rhizoma anemarrhenae, 6-9 parts of rehmannia, 6-9 parts of cinnamon, 1-3 parts of mulberry leaf and 1-3 parts of bitter gourd polypeptide.
As in the various embodiments, bergamot extract may be used in amounts of 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, and the like; the dosage of the lychee seeds can be 8 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts and the like; the amount of the rhizoma anemarrhenae can be 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts and the like; the rehmannia can be used in 6 parts, 7 parts, 8 parts, 9 parts and the like; cinnamon may be used in amounts of 6 parts, 7 parts, 8 parts, 9 parts, etc.; the dosage of the mulberry leaves can be 1 part, 2 parts, 3 parts and the like; the amount of momordica charantia polypeptide may be 1 part, 2 parts, 3 parts, etc.
In order to further optimize the mixture ratio of the raw material powder, improve the blood sugar reducing effect of the honeyed pills and ensure the quality stability of the honeyed pills, the raw material powder is mainly prepared from the following components in parts by weight:
20 parts of bergamot extract, 22 parts of lychee seed, 5 parts of rhizoma anemarrhenae, 8 parts of rehmannia, 8 parts of cinnamon, 2 parts of mulberry leaf and 2 parts of balsam pear polypeptide.
Preferably, the particle size of the raw material powder is 300-500 meshes, preferably 350-450 meshes, and more preferably 400 meshes.
The invention also provides a preparation method of the sugar-free honeyed pill, which comprises the following steps:
mixing the raw material powder and concentrated gum at a certain proportion, making into pill, performing microwave sterilization, and microwave drying.
The preparation method provided by the invention adopts two-step microwave treatment, has excellent sterilization and drying effects, reduces the content of microorganisms, inhibits the growth of the microorganisms, has high drying efficiency and good appearance property maintaining effect, and has good sterilization effect and quality maintaining stability.
Preferably, the microwave sterilization conditions include: the frequency is 800-1000MHz, and the sterilization time is 30-200 s. More preferably, the frequency of the microwave sterilization is 850-950 MHz.
Preferably, the conditions of microwave drying include: the frequency is 2000 + 2700MHz, and the sterilization time is 30-150 s. More preferably, the frequency of the microwave drying is 2100-2500 MHz.
In the aspect of sterilization and preservation of the honeyed pills, the honeyed pills are prepared from traditional Chinese medicinal materials which are wide in source, such as different parts of animals, different parts of plants, natural minerals, processed products and the like, so that the honeyed pills are very easy to be infected with bacteria, mildewed and deteriorated, and in order to control the sanitation indexes of the honeyed pills, the common sterilization process in the prior art is to control microorganisms of the source of the raw materials in the modes of cobalt 60, dry heat sterilization, hot press sterilization and the like. In the aspect of preservation, the growth of microorganisms is inhibited mainly by means of high honey sugar in the product, wax sealing and air isolation and the like, so that the aim of prolonging the storage time is fulfilled. In the aspect of honeyed bolus drying, most adopt traditional modes such as indoor natural drying among the prior art, drying time is long, and it is big to occupy production area, drawback such as easy microbiological contamination, if adopt hot-blast drying honeyed bolus then can produce phenomenons such as going soft and warping, fracture.
In the invention, honey is not adopted as a raw material, so that the sugar-free honeyed pill is suitable for diabetics and sugar-limited people. Through a specific sterilization and drying process and a two-step microwave method, the content of reducing sugar in the prepared honeyed pills is less than or equal to 0.5g/100g, the water content is less than or equal to 10%, and the total number of colonies is less than or equal to 10cfu/g, and 90-day acceleration experiments prove that all indexes of the product are stable, and the problems of sterilization and storage of the sugar-free honeyed pills are solved.
Preferably, after drying, the dried pills are aseptically shelled and wax-sealed to obtain the finished sugar-free honeyed pills.
The invention also provides application of the sugar-free honeyed pill in preparation of a product for reducing blood sugar.
The results of animal experiments on blood sugar reduction of the sugar-free honeyed pills show that the animal experiments on blood sugar reduction function of the sugar-free honeyed pills have positive results and have better blood sugar reduction effect.
Compared with the prior art, the invention has the beneficial effects that:
(1) according to the invention, a plurality of traditional Chinese medicinal materials with the blood sugar reducing effect, bitter gourd polypeptide and the like are used as raw materials, and the binder with the blood sugar reducing effect is adopted to replace auxiliary material honey for preparing the honeyed pills, so that the sugar content in the honeyed pills is reduced, and the results of the blood sugar reducing animal experiments of the product show that the blood sugar reducing function of the sugar-free honeyed pills have positive animal experiment results and can be suitable for diabetics;
(2) according to the invention, three composite adhesives with the blood sugar reducing effect are adopted to replace auxiliary material honey, so that the blood sugar reducing effect of the honeyed pills is improved while the storage stability of the honeyed pills is ensured;
(3) the preparation method provided by the invention adopts two-step microwave treatment, has excellent sterilization and drying effects, reduces the content of microorganisms, inhibits the growth of the microorganisms, has high drying efficiency and good appearance property maintaining effect, and has good sterilization effect and quality maintaining stability.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following detailed description, but those skilled in the art will understand that the following described examples are some, not all, of the examples of the present invention, and are only used for illustrating the present invention, and should not be construed as limiting the scope of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
In the main raw materials adopted in the specific embodiment of the invention, the quality of the propolis meets the requirements of GB/T24283-2018 and is one of populus, brevifolius, eucalyptus and erythrina; in the embodiment, propolis of genus Populus is taken as an example; the konjac gum has the viscosity of more than 10000mPa.s, and the quality meets the requirement of GB/T18104-2000; the aloe vera gel meets the quality requirements of aloe vera gel in the 2008 th bulletin of the ministry of health.
Example 1
The preparation method of the sugar-free honeyed pill comprises the following steps:
(1) weighing 20 parts of bergamot extract, 22 parts of lychee seed, 5 parts of rhizoma anemarrhenae, 8 parts of rehmannia root, 8 parts of cinnamon, 2 parts of mulberry leaf and 2 parts of balsam pear polypeptide according to parts by weight, coarsely crushing, and micronizing by using an ultramicro wall-breaking pulverizer until the particle size is 400 meshes to obtain raw material powder;
(2) weighing propolis, konjac glucomannan and aloe vera gel according to a mass ratio of 2: 1, adding into purified water, heating to 100 ℃, homogenizing by a homogenizer, continuously heating at 100 ℃ for gel decocting to density of 1.35, filtering, and collecting concentrated gel for later use;
(3) mixing the raw material powder and the concentrated gum according to a mass ratio of 2: 1, pelleting, polishing and selecting pills by using a water chestnut pot, sterilizing the honeyed pills meeting the requirements for 100s by using 920MHz microwave, drying for 80s by using 2400MHz microwave, and performing aseptic shell filling and wax sealing on the dried honeyed pills to obtain the finished sugar-free honeyed pills.
The preparation method of the bergamot extract comprises the following steps: extracting fructus Citri Limoniae at a ratio of 1: 15 at 100 deg.C for 2 hr, filtering, collecting filtrate, concentrating, and vacuum drying under microwave to obtain fructus Citri Limoniae extract.
Example 2
The preparation method of the sugar-free honeyed pill comprises the following steps:
(1) weighing 25 parts of bergamot extract, 15 parts of lychee seed, 3 parts of rhizoma anemarrhenae, 5 parts of rehmannia root, 10 parts of cinnamon, 3 parts of mulberry leaf and 1 part of balsam pear polypeptide in parts by weight, coarsely crushing, and micronizing by using an ultramicro wall-breaking pulverizer until the particle size is 400 meshes to obtain raw material powder;
(2) weighing propolis, konjac glucomannan and aloe vera gel according to a mass ratio of 2: 1, adding into purified water, heating to 100 ℃, homogenizing by a homogenizer, continuously heating at 100 ℃ for gel decocting to density of 1.35, filtering, and collecting concentrated gel for later use;
(3) mixing the raw material powder and the concentrated gel according to a mass ratio of 3: 1, pelleting, polishing and selecting pills by using a water chestnut pot, sterilizing the honeyed pills meeting the requirements by using 850MHz microwave for 30s, drying the sterilized honeyed pills by using 2100MHz microwave for 30s, and performing aseptic shell filling and wax sealing on the dried honeyed pills to obtain the finished sugar-free honeyed pills.
Example 3
The preparation method of the sugar-free honeyed pill comprises the following steps:
(1) weighing 30 parts of bergamot extract, 25 parts of lychee seed, 9 parts of rhizoma anemarrhenae, 8 parts of rehmannia root, 10 parts of cinnamon, 1 part of mulberry leaf and 3 parts of balsam pear polypeptide according to parts by weight, coarsely crushing, and micronizing by using an ultramicro wall-breaking pulverizer until the particle size is 400 meshes to obtain raw material powder;
(2) weighing propolis, konjac glucomannan and aloe vera gel according to a mass ratio of 2: 1, adding into purified water, heating to 100 ℃, homogenizing by a homogenizer, continuously heating at 100 ℃ for gel decocting to density of 1.35, filtering, and collecting concentrated gel for later use;
(3) mixing the raw material powder and the concentrated gum according to a mass ratio of 1: 1, pelleting, polishing and selecting the water chestnut pot, sterilizing the honeyed pill meeting the requirement by 890MHz microwave for 200s, drying by 2450MHz microwave for 150s, and performing aseptic shell filling and wax sealing on the dried honeyed pill to obtain the finished sugar-free honeyed pill.
Example 4
The preparation method of the sugar-free honeyed pill comprises the following steps:
(1) weighing 15 parts of bergamot extract, 15 parts of lychee seed, 2 parts of rhizoma anemarrhenae, 5 parts of rehmannia root, 5 parts of cinnamon, 1 part of mulberry leaf and 2 parts of balsam pear polypeptide in parts by weight, coarsely crushing, and micronizing by using an ultramicro wall-breaking pulverizer until the particle size is 400 meshes to obtain raw material powder;
(2) weighing propolis, konjac glucomannan and aloe vera gel according to a mass ratio of 2: 1, adding into purified water, heating to 100 ℃, homogenizing by a homogenizer, continuously heating at 100 ℃ for gel decocting to density of 1.35, filtering, and collecting concentrated gel for later use;
(3) mixing the raw material powder and the concentrated gum according to a mass ratio of 1.5: 1, pelleting, polishing and selecting pills by using a water chestnut pot, sterilizing the honeyed pills meeting the requirements by using 1000MHz microwave for 150 seconds, drying the honeyed pills by using 2700MHz microwave for 100 seconds, and performing aseptic shell filling and wax sealing on the dried honeyed pills to obtain the finished sugar-free honeyed pills.
Experimental example 1
In order to illustrate the physicochemical properties of the sugar-free honeyed pills prepared in the embodiments of the present invention, the physicochemical properties of the sugar-free honeyed pills prepared in the embodiments were tested, and the test results are shown in table 1.
TABLE 1 results of physicochemical Properties test of different sugar-free honeyed pills
Numbering | Reducing sugar content | Water content | Total number of colonies |
Example 1 | 0.08% | 7.2% | <10cfu/g |
Example 2 | 0.12% | 8.5% | <10cfu/g |
Example 3 | 0.15% | 8.0% | <10cfu/g |
Example 4 | 0.08% | 7.5% | <10cfu/g |
Experimental example 2
In order to investigate the stability of the sugar-free honeyed pills according to the embodiments of the present invention, stability experiments were performed on the sugar-free honeyed pills according to "handbook for implementation of test and evaluation of health food" in examples 1 to 4. The storage conditions of the test samples are 38 +/-1 ℃ and 75% of humidity, and the test samples are respectively checked and analyzed on 0 day, 30 days, 60 days and 90 days after the storage is started. The results are shown in tables 2 to 4.
TABLE 2 test results of samples tested after 0-day and 30-day storage
TABLE 3 test results of samples tested for 60 days and 90 days
TABLE 4 sensory test results of the test samples
From the above table, the sugar-free honeyed pills have no obvious change in the whole accelerated stability test in 90 days, no change in the sense, ash content, reducing sugar content, mold, yeast, coliform group bacteria and pathogenic bacteria, the moisture of each example is slightly increased only in the 90 th day, and the total number of colonies of examples 2 and 4 is slightly increased in the 90 th day, but is in the qualified range.
Experimental example 3
In order to verify the blood sugar reducing effect of the sugar-free honeyed pill, the sugar-free honeyed pill of each embodiment of the invention is subjected to a blood sugar reducing animal experiment, and the experimental method is as follows.
Experimental animals:
adult rats (180. + -.20 g) and males were selected, and 100 animals were used in total.
High-heat energy feed:
10% of lard, 15% of sucrose, 15% of yolk powder, 5% of casein, 1.2% of cholesterol, 0.2% of sodium cholate, 0.6% of calcium bicarbonate, 0.4% of stone powder and 52.6% of mouse maintaining material.
Blood sugar reduction test for normal animals
Adult rats (180. + -.20 g) were selected as 50, and were divided into groups of fasting blood glucose levels for 3 to 5 hours, and 1 control group and 4 example groups were randomly selected. The control group is given solvent, the experimental group is given 1mL of 500mg/kg dose for 30 consecutive days, fasting blood glucose values are measured (fasting is the same as before the experiment), and blood glucose values of five groups of animals are compared.
Hyperglycemia model hypoglycemic experiment:
molding method
50 adult rats (180 +/-20 g) are selected, after 1 day of adaptation, 15 animals are randomly selected to be fasted for 3-5 hours, and fasting blood glucose is measured to serve as the basic blood glucose value of the batch of animals. Then the animals are fasted for 24h (free drinking water), the animals are injected with 50-80mg/kg BW.iv dose alloxan (prepared by using fresh water before) for molding, the animals are fasted for 3-5h after 5-7 days, the blood sugar is measured, and the blood sugar value is 10-25mmol/L, which is the successful animal of the hyperglycemic model.
Blood sugar reduction experiment of hyperglycemia model animal
45 successfully modeled rats were selected, and grouped by fasting blood glucose levels for 3-5h, and 1 model control group and 4 examples (difference between groups is not more than 1.1mmol/L) were randomly selected. In each example, 1mL of a 500mg/kg dose was administered to each group, and in each model control group, a solvent was administered for 30 consecutive days, and fasting blood glucose values (fasting before the experiment) were measured, and blood glucose values and percent blood glucose reductions were compared in each group.
The blood glucose decrease rate%
Hyperglycemia model animal glucose tolerance test
Dose grouping and administration time of the test samples are the same as those of the blood sugar reduction experiment. After fasting for 3-5h, the blood glucose level was measured for each group of animals (i.e., 0h), 1mL of the dose of 500mg/kg was administered to each example group, 1mL of the dose of 1 mg/kg was administered to the model control group, 2.0g/kg of BW was orally administered to each group after 15-20min, the blood glucose level was measured for each group 0.5, 2h after administration of glucose or the blood glucose level was measured for 1, 2h after administration of medical starch, and the change in the blood glucose level and the area under the blood glucose curve at each time point (0, 0.5, 2h) after administration of glucose was observed for the model control group and each example group.
Area under the blood glucose curve ═ [ (0h blood glucose +0.5h blood glucose) × 0.5]/2+ [ (2h blood glucose +0.5h blood glucose) × 1.5]/2
The results are shown in tables 5-9.
Group of | Initial body weight/g | Body weight/g in the end stage | Weight gain/g |
Control group of normal animals | 182.25±10.51 | 245.37±18.25 | 63.12±7.42 |
Normal animals example 1 group | 178.39±9.75 | 240.23±17.39 | 61.84±6.68 |
Normal animals example 2 group | 184.61±10.08 | 248.86±15.67 | 64.25±5.15 |
Normal animals example 3 group | 180.86±8.27 | 241.44±16.92 | 60.58±6.71 |
Normal animals example 4 group | 179.24±11.50 | 240.69±17.64 | 61.45±8.24 |
As can be seen from Table 5, the weight and weight gain of the 4 examples of the blood glucose reducing experiment of the normal animals are compared with those of the control group, and the differences are not significant (P is more than 0.05), which indicates that the test object has no obvious influence on the weight and weight gain of the normal animals.
As can be seen from Table 6, the change of fasting plasma glucose was not significantly different (P > 0.05) in the blood glucose lowering test of normal animals, compared with the control group, indicating that the test substance had no significant effect on the blood glucose of normal animals.
Group of | Initial body weight/g | Body weight/g in the end stage | Weight gain/g |
Model control group | 197.63±12.14 | 238.21±28.95 | 40.58±15.27 |
EXAMPLE 1 group | 204.15±15.28 | 254.72±30.36 | 50.57±20.29 |
EXAMPLE 2 group | 206.97±14.84 | 255.22±26.74 | 48.25±18.61 |
EXAMPLE 3 group | 198.45±17.13 | 250.37±25.42 | 51.92±24.68 |
EXAMPLE 4 group | 202.41±16.85 | 255.08±29.15 | 52.67±26.14 |
As can be seen from Table 7, the body weight and the weight gain of the test object on the hyperglycemia model animal are compared with those of the control group in the 4 examples of the blood glucose reduction experiment, and the differences are not significant (P is more than 0.05), which indicates that the test object has no significant influence on the body weight and the weight gain of the normal animal.
Note: p < 0.05, compared to model control
As can be seen from Table 8, the height of percent fasting glucose and percent glucose drop were significantly different (P < 0.05) in each example group of the test subjects compared to the control group of the model under the premise that the hyperglycemic animal model was established.
Note: p < 0.05, compared to model control
As can be seen from table 9, on the premise that the hyperglycemic animal model was established, the group of each example of the test substance showed significant differences (P < 0.05) in the decrease in blood glucose 2h, the increase in the percentage of decrease in blood glucose 2h, and the decrease in area under the blood glucose curve, compared with the model control.
The product of each embodiment is used for carrying out auxiliary blood sugar reducing animal experiments, and the experimental results show that the fasting blood sugar and the sugar tolerance of the animal experiments of the products of each embodiment are positive, and the fasting blood sugar of normal animals is not influenced, so that the animal experiments with the auxiliary blood sugar reducing function of the products of each embodiment can be judged to be positive.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (16)
1. A sugar-free honeyed pill is characterized in that the sugar-free honeyed pill is prepared by mixing raw material powder and concentrated gum;
the mass ratio of the raw material powder to the concentrated gel is (1-3) to 1;
the raw material powder is prepared from the following components in parts by weight:
15-30 parts of bergamot extract, 15-30 parts of lychee seed, 2-10 parts of rhizoma anemarrhenae, 5-10 parts of rehmannia, 4-12 parts of cinnamon, 1-3 parts of mulberry leaf and 1-3 parts of bitter gourd polypeptide;
the concentrated gel is prepared from propolis, konjac glucomannan and aloe vera gel;
the mass ratio of propolis to konjac glucomannan to aloe vera gel is 4: 1-3.
2. The sugar-free honeyed pill according to claim 1, wherein the mass ratio of propolis, konjac gum and aloe vera gel is 2: 1.
3. The sugar-free honeyed pill according to claim 1, wherein the preparation method of the concentrated gum comprises: mixing propolis, rhizoma Amorphophalli gel and Aloe Barbadensis Miller gel with water, heating to 100 + -5 deg.C, homogenizing, and decocting until the density is 1.3-1.4.
4. The sugar-free honeyed pill according to claim 3, wherein the propolis, konjac gum and aloe vera gel are mixed with water such that the total mass concentration of propolis, konjac gum and aloe vera gel is 8-15%.
5. The sugar-free honeyed pill according to claim 1, wherein the raw material powder is prepared from the following components in parts by weight:
18-25 parts of bergamot extract, 18-25 parts of lychee seed, 4-9 parts of rhizoma anemarrhenae, 6-9 parts of rehmannia, 6-9 parts of cinnamon, 1-3 parts of mulberry leaf and 1-3 parts of bitter gourd polypeptide.
6. The sugar-free honeyed pill according to claim 1, wherein the raw material powder is prepared from the following components in parts by weight: 20 parts of bergamot extract, 22 parts of lychee seed, 5 parts of rhizoma anemarrhenae, 8 parts of rehmannia, 8 parts of cinnamon, 2 parts of mulberry leaf and 2 parts of balsam pear polypeptide.
7. The sugar-free honeyed pill according to any one of claims 1 to 6, wherein the sugar-free honeyed pill has a reducing sugar content of 0.5g/100g or less, a water content of 10% or less, and a total number of colonies of 10cfu/g or less.
8. The sugar-free honeyed pill according to any one of claims 1 to 6, wherein the particle size of the raw material powder is 300-500 mesh.
9. The sugar-free honeyed pill according to any one of claims 1 to 6, wherein the particle size of the raw material powder is 350-450 mesh.
10. The method for preparing sugar-free honeyed pills according to any one of claims 1 to 9, comprising the steps of:
mixing the raw material powder and concentrated gum at a certain proportion, making into pill, performing microwave sterilization, and microwave drying.
11. The method for preparing sugar-free honeyed pills according to claim 10, wherein the microwave sterilization conditions comprise: the frequency is 800-1000MHz, and the sterilization time is 30-200 s.
12. The method for preparing sugar-free honeyed pill according to claim 10, wherein the microwave sterilization frequency is 850-950 MHz.
13. The method for preparing sugar-free honeyed pills according to claim 10, wherein the conditions of microwave drying comprise: the frequency is 2000 + 2700MHz, and the sterilization time is 30-150 s.
14. The method for preparing sugar-free honeyed pill according to claim 10, wherein the frequency of microwave drying is 2100-2500 MHz.
15. The method for preparing sugar-free honeyed pills according to claim 10, wherein after drying, the dried pills are aseptically shelled and wax-sealed to obtain the finished sugar-free honeyed pills.
16. Use of a sugar-free honeyed pill according to any one of claims 1 to 9 for the preparation of a hypoglycemic product.
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1394623A (en) * | 2001-07-10 | 2003-02-05 | 北京双鹤现代医药技术有限责任公司 | Health-care food capable of regulating blood sugar and preparing method thereof |
CN102144781A (en) * | 2010-12-28 | 2011-08-10 | 北京同仁堂健康药业股份有限公司 | Composite for assisting to lower blood sugar and preparation method thereof |
CN102727586A (en) * | 2011-04-02 | 2012-10-17 | 苏州润新生物科技有限公司 | Composition for preventing and treating diabetes |
CN107496903A (en) * | 2017-08-25 | 2017-12-22 | 王海军 | A kind of melbine and preparation method thereof |
-
2018
- 2018-10-22 CN CN201811230126.2A patent/CN109350732B/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1394623A (en) * | 2001-07-10 | 2003-02-05 | 北京双鹤现代医药技术有限责任公司 | Health-care food capable of regulating blood sugar and preparing method thereof |
CN102144781A (en) * | 2010-12-28 | 2011-08-10 | 北京同仁堂健康药业股份有限公司 | Composite for assisting to lower blood sugar and preparation method thereof |
CN102727586A (en) * | 2011-04-02 | 2012-10-17 | 苏州润新生物科技有限公司 | Composition for preventing and treating diabetes |
CN107496903A (en) * | 2017-08-25 | 2017-12-22 | 王海军 | A kind of melbine and preparation method thereof |
Non-Patent Citations (1)
Title |
---|
香柠檬的功效与作用;lsp;《http://z.xiziwang.net/ninmeng/18711/》;20150124;第1页 * |
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