CN109350732A - A kind of sugar-free honeyed bolus and its preparation method and application - Google Patents
A kind of sugar-free honeyed bolus and its preparation method and application Download PDFInfo
- Publication number
- CN109350732A CN109350732A CN201811230126.2A CN201811230126A CN109350732A CN 109350732 A CN109350732 A CN 109350732A CN 201811230126 A CN201811230126 A CN 201811230126A CN 109350732 A CN109350732 A CN 109350732A
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- CN
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- Prior art keywords
- parts
- sugar
- honeyed bolus
- free
- raw material
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- A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts
Abstract
The present invention relates to technical field of traditional Chinese medicines, more particularly, to a kind of sugar-free honeyed bolus and its preparation method and application.Sugar-free honeyed bolus of the invention is mainly mixed to prepare by raw material powder and concentration glue；The mass ratio of the raw material powder and concentration glue is (1-3) ﹕ 1；The raw material powder is mainly made of following component according to parts by weight: 15-30 parts of bergamot extract, 15-30 parts of semen litchi, 2-10 parts of rhizoma anemarrhenae, 5-10 parts of glutinous rehmannia, 4-12 parts of cortex cinnamomi, 1-3 parts of mulberry leaf, 1-3 parts of bitter gourd polypeptide；The concentration glue includes one of propolis, konjac glucomannan, aloe vera gel or a variety of.The present invention is using a variety of Chinese medicines with hypoglycemic effect and bitter gourd polypeptide etc. as raw material, and using the auxiliary material honey that there is the binder of hypoglycemic effect to prepare instead of conventional honeyed bolus, using two step microwave treatments, reduce the sugar in honeyed bolus, with excellent sterilization and drying effect, so that honeyed bolus is applicable to diabetic and candy-limited crowd.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly, to a kind of sugar-free honeyed bolus and its preparation method and application.
Background technique
Traditional Chinese medicine pill has long history in tcm field, and pill is mostly used in the disease for needing to improve physically weak after being ill greatly
People, or some chronic diseases for the treatment of.
Honey is the important auxiliary material of honeyed bolus, wherein accounting for about the total ingredient of honey containing there are many sugar, predominantly fructose and glucose
75%-80%, honey accounts for about 55% or so in honeyed bolus.It is converted into sugar in honeyed bolus finished product and accounts for about 41-44%.Because honey GI is
73, belong to high GI ingredient, although many honeyed bolus products have a better effect various diseases tool, the honeyed bolus made of honey is past
It is past that many diabetics and candy-limited crowd is allowed to hang back, thus greatly limit the application crowd of honeyed bolus product.
In view of this, the present invention is specifically proposed.
Summary of the invention
The first object of the present invention is to provide a kind of sugar-free honeyed bolus, and the sugar-free honeyed bolus is in good taste, without sugar, shelf-life
It is long, have the function of preferable hypoglycemic.
The second object of the present invention is to provide a kind of preparation method of sugar-free honeyed bolus, by two step microwave methods to honeyed bolus into
Row sterilization and drying etc., improve the product stability of honeyed bolus, extend the shelf life.
The third object of the present invention is to provide a kind of application of sugar-free honeyed bolus, the sugar-free honeyed bolus prepare it is hypoglycemic
Application in product, including drug or health food, functional food etc..
In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:
A kind of sugar-free honeyed bolus is mainly mixed to prepare by raw material powder and concentration glue；
The mass ratio of the raw material powder and concentration glue is (1-3) ﹕ 1；
The raw material powder is mainly made of following component according to parts by weight:
15-30 parts of bergamot extract, 15-30 parts of semen litchi, 2-10 parts of rhizoma anemarrhenae, 5-10 parts of glutinous rehmannia, 4-12 parts of cortex cinnamomi, mulberry
1-3 parts of leaf, 1-3 parts of bitter gourd polypeptide；
The concentration glue includes one of propolis, konjac glucomannan, aloe vera gel or a variety of.
The present invention drops blood using a variety of Chinese medicines with hypoglycemic effect and bitter gourd polypeptide etc. as raw material, and using having
The auxiliary material honey that the binder of sugar effect is prepared instead of conventional honeyed bolus, reduces the sugar in honeyed bolus, so that honeyed bolus is applicable
In diabetic and candy-limited crowd.
Preferably, the concentration glue includes propolis, konjac glucomannan and aloe vera gel.It is furthermore preferred that the propolis, evil spirit
Taro glue and the mass ratio of aloe vera gel are 4 ﹕ (1 ﹕ 1 of 1-3) ﹕ (1-3), preferably 2 ﹕.
The concentration glue is to mix propolis, konjac glucomannan and aloe vera gel with water, and homogeneous is endured glue and obtained.It is described
Be concentrated glue density be 1.3-1.4, preferably 1.35.The mass concentration of propolis, konjac glucomannan and aloe vera gel in water
For 8-15%, homogenization is then carried out.
The preparation method of the concentration glue, preferably includes: propolis, konjac glucomannan and aloe vera gel is mixed with water,
100 ± 5 DEG C of homogeneous are heated to, enduring glue to density is 1.3-1.4, obtains the concentration glue.It is preferred that the material obtained after glue will be endured
It is used after filtering.Wherein, propolis, konjac glucomannan and aloe vera gel are mixed with water, so that propolis, konjac glucomannan and Curacao reed
The total mass concentration of luxuriant growth gel is 8-15%.
The present invention substitutes auxiliary material honey using three kinds of composite adhesives with hypoglycemic effect, is guaranteeing that honeyed bolus storage is steady
While qualitative, improve honeyed bolus hypoglycemic effect, honeyed bolus is made to be suitable for diabetic and candy-limited crowd's use.
Preferably, the raw material powder is mainly made of following component according to parts by weight:
18-25 parts of bergamot extract, 18-25 parts of semen litchi, 4-9 parts of rhizoma anemarrhenae, 6-9 parts of glutinous rehmannia, 6-9 parts of cortex cinnamomi, mulberry leaf
1-3 parts, 1-3 parts of bitter gourd polypeptide.
As in different embodiments, the dosage of bergamot extract can be 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23
Part, 24 parts, 25 parts etc.；The dosage of semen litchi can be 8 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts etc.
Deng；The dosage of rhizoma anemarrhenae can be 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts etc.；The dosage of glutinous rehmannia can be 6 parts, 7 parts, 8 parts, 9
Part etc.；The dosage of cortex cinnamomi can be 6 parts, 7 parts, 8 parts, 9 parts etc.；The dosage of mulberry leaf can be 1 part, 2 parts, 3 parts etc.；It is bitter
The dosage of melon polypeptide can be 1 part, 2 parts, 3 parts etc..
To advanced optimize raw material powder proportion, to improve the hypoglycemic effect of honeyed bolus, while guaranteeing the stay in grade of honeyed bolus
Property, the raw material powder are mainly made of following component according to parts by weight:
20 parts of bergamot extract, 22 parts of semen litchi, 5 parts of rhizoma anemarrhenae, 8 parts of glutinous rehmannia, 8 parts of cortex cinnamomi, 2 parts of mulberry leaf, bitter gourd polypeptide 2
Part.
Preferably, the partial size of the raw material powder is 300-500 mesh, preferably 350-450 mesh, more preferably 400 mesh.
The present invention also provides a kind of preparation methods of sugar-free honeyed bolus, include the following steps:
Raw material powder is mixed into pill with concentration glue in proportion, carries out microwave disinfection, microwave drying treatment.
Preparation method of the invention has excellent sterilization and drying effect using two step microwave treatments, reduces microorganism
Content inhibits the growth of microorganism, while drying efficiency is high, and appearance character keeps effect good, has good bactericidal effect
Stability is kept with quality.
Preferably, it is 800-1000MHz, sterilizing time 30-200s that the condition of microwave disinfection, which includes: frequency,.More preferably
, the frequency of the microwave disinfection is 850-950MHz.
Preferably, it is 2000-2700MHz, sterilizing time 30-150s that the condition of microwave drying, which includes: frequency,.More preferably
, the frequency of the microwave drying is 2100-2500MHz.
In terms of the sterilization of honeyed bolus and preservation, since honeyed bolus is using Chinese medicine as raw material, and Chinese medicine is from a wealth of sources, such as dynamic
The different parts of object, the different parts of plant, natural minerals, processed goods etc., therefore honeyed bolus is caused to be very easy to microbiological contamination, mouldy change
Matter, for the sanitary index for controlling honeyed bolus, process for sterilizing commonly used in the prior art is the side such as Co 60, hot air sterilization, pressure sterilizing
The microorganism of formula control raw material sources.The modes such as honey high sugar content and sealing wax isolation air in product are relied primarily in terms of preservation
Inhibit the growth of microorganism, to achieve the purpose that extend period of storage.It is most of in the prior art in terms of the drying of honeyed bolus
Equal traditional approach are dried using Indoor Natural, drying time is long, and occupancy production area is big, and the drawbacks such as easy microbiological contamination such as use hot wind
Dry honeyed bolus can then generate phenomena such as deformation of feeling like jelly, cracking.
In the present invention, not using honey as raw material, so that sugar-free honeyed bolus is suitable for diabetic and candy-limited crowd
It uses.By specifically sterilizing and drying process, two step microwave methods make content of reducing sugar≤0.5g/ in the honeyed bolus being prepared
100g, moisture≤10%, total plate count≤10cfu/g prove that product indices are stable by 90 days Acceleration studies, solution
The certainly sterilization of sugar-free honeyed bolus and the problem of preservation.
Preferably, after drying process, sterile dress shell and sealing wax are carried out to dry pill, obtain the sugar-free honeyed bolus at
Product.
The present invention also provides a kind of sugar-free honeyed bolus to prepare the application in hypoglycemic product.
Sugar-free honeyed bolus of the invention is through hypoglycemic zoopery, the results showed that sugar-free honeyed bolus function of blood sugar reduction zoopery knot
Fruit is positive, has preferable hypoglycemic effect.
Compared with prior art, the invention has the benefit that
(1) present invention is using a variety of Chinese medicines with hypoglycemic effect and bitter gourd polypeptide etc. as raw material, and use has
The auxiliary material honey that the binder of hypoglycemic effect is prepared instead of honeyed bolus reduces the sugar in honeyed bolus, and product is by hypoglycemic
Zoopery, the results showed that sugar-free honeyed bolus function of blood sugar reduction results of animal is positive, is applicable to diabetic；
(2) present invention substitutes auxiliary material honey using three kinds of composite adhesives with hypoglycemic effect, is guaranteeing honeyed bolus storage
While depositing stability, improve honeyed bolus hypoglycemic effect；
(3) preparation method of the invention has excellent sterilization and drying effect using two step microwave treatments, reduces micro-
Biological content inhibits the growth of microorganism, while drying efficiency is high, and appearance character keeps effect good, has good sterilization
Effect and quality keep stability.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with specific embodiment, but ability
Field technique personnel will be understood that following described embodiments are some of the embodiments of the present invention, instead of all the embodiments,
It is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.Based on the embodiments of the present invention, the common skill in this field
Art personnel every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.The person that is not specified actual conditions in embodiment, carries out according to conventional conditions or manufacturer's recommended conditions.Agents useful for same or instrument
Production firm person is not specified, is the conventional products that can be obtained by commercially available purchase.
In the primary raw material used in the specific embodiment of the invention, propolis quality meets the requirement of GB/T24283-2018,
One of belong to for poplar category, Baccharis, eucalyptus category, blood paulownia；In embodiment by taking poplar category propolis as an example；Konjaku adhesiveness is big
In 10000mPa.s, quality meets the requirement of GB/T18104-2000；Aloe vera gel meets the Ministry of Public Health and announces 2008
The quality requirement of aloe vera gel in No. 12 bulletin.
Embodiment 1
The preparation method of the sugar-free honeyed bolus of the present embodiment, includes the following steps:
(1) 20 parts of bergamot extract, 22 parts of semen litchi, 5 parts of rhizoma anemarrhenae, 8 parts of glutinous rehmannia, cortex cinnamomi 8 are weighed according to parts by weight
Part, 2 parts of mulberry leaf, 2 parts of bitter gourd polypeptide after coarse crushing, are 400 mesh with super-micro wall-broken grinder micro mist to partial size, obtain raw material powder；
(2) propolis, konjac glucomannan, aloe vera gel are weighed for 2 ﹕, 1 ﹕ 1 in mass ratio, be added in purified water, propolis, evil spirit
Taro glue, aloe vera gel total mass concentration be 12%, by continuing at 100 after homogenizer homogeneous after being heated to 100 DEG C
DEG C heating endure glue to density be 1.35, after filtering collect concentration glue it is spare；
It (3) is in mass ratio that 2 ﹕ 1 carry out mixing pill with concentration glue by raw material powder, then using the polishing of water chestnut pot and choosing
Ball, satisfactory honeyed bolus use the microwave disinfection 100s of 920MHz, the microwave drying 80s of 2400MHz are then used, after dry
Honeyed bolus carries out sterile dress shell and sealing wax, obtains sugar-free honeyed bolus finished product.
Wherein, bergamot extract the preparation method comprises the following steps: by bergamot according to 1 ﹕, 15 material-water ratio, mentioned under the conditions of 100 DEG C
2h is taken, filtrate is collected by filtration, is dried in vacuo under microwave condition after concentration, bergamot extract is obtained.
Embodiment 2
The preparation method of the sugar-free honeyed bolus of the present embodiment, includes the following steps:
(1) 25 parts of bergamot extract, 15 parts of semen litchi, 3 parts of rhizoma anemarrhenae, 5 parts of glutinous rehmannia, cortex cinnamomi 10 are weighed according to parts by weight
Part, 3 parts of mulberry leaf, 1 part of bitter gourd polypeptide after coarse crushing, are 400 mesh with super-micro wall-broken grinder micro mist to partial size, obtain raw material powder；
(2) propolis, konjac glucomannan, aloe vera gel are weighed for 2 ﹕, 1 ﹕ 1 in mass ratio, be added in purified water, propolis, evil spirit
Taro glue, aloe vera gel total mass concentration be 9%, by continuing at 100 after homogenizer homogeneous after being heated to 100 DEG C
DEG C heating endure glue to density be 1.35, after filtering collect concentration glue it is spare；
It (3) is in mass ratio that 3 ﹕ 1 carry out mixing pill with concentration glue by raw material powder, then using the polishing of water chestnut pot and choosing
Ball, satisfactory honeyed bolus use the microwave disinfection 30s of 850MHz, the microwave drying 30s of 2100MHz are then used, after dry
Honeyed bolus carries out sterile dress shell and sealing wax, obtains sugar-free honeyed bolus finished product.
Embodiment 3
The preparation method of the sugar-free honeyed bolus of the present embodiment, includes the following steps:
(1) 30 parts of bergamot extract, 25 parts of semen litchi, 9 parts of rhizoma anemarrhenae, 8 parts of glutinous rehmannia, cortex cinnamomi 10 are weighed according to parts by weight
Part, 1 part of mulberry leaf, 3 parts of bitter gourd polypeptide after coarse crushing, are 400 mesh with super-micro wall-broken grinder micro mist to partial size, obtain raw material powder；
(2) propolis, konjac glucomannan, aloe vera gel are weighed for 2 ﹕, 1 ﹕ 1 in mass ratio, be added in purified water, propolis, evil spirit
Taro glue, aloe vera gel total mass concentration be 15%, by continuing at 100 after homogenizer homogeneous after being heated to 100 DEG C
DEG C heating endure glue to density be 1.35, after filtering collect concentration glue it is spare；
It (3) is in mass ratio that 1 ﹕ 1 carries out mixing pill with concentration glue by raw material powder, then using the polishing of water chestnut pot and choosing
Ball, satisfactory honeyed bolus use the microwave disinfection 200s of 890MHz, the microwave drying 150s of 2450MHz are then used, after dry
Honeyed bolus carry out sterile dress shell and sealing wax, obtain sugar-free honeyed bolus finished product.
Embodiment 4
The preparation method of the sugar-free honeyed bolus of the present embodiment, includes the following steps:
(1) 15 parts of bergamot extract, 15 parts of semen litchi, 2 parts of rhizoma anemarrhenae, 5 parts of glutinous rehmannia, cortex cinnamomi 5 are weighed according to parts by weight
Part, 1 part of mulberry leaf, 2 parts of bitter gourd polypeptide after coarse crushing, are 400 mesh with super-micro wall-broken grinder micro mist to partial size, obtain raw material powder；
(2) propolis, konjac glucomannan, aloe vera gel are weighed for 2 ﹕, 1 ﹕ 1 in mass ratio, be added in purified water, propolis, evil spirit
Taro glue, aloe vera gel total mass concentration be 8%, by continuing at 100 after homogenizer homogeneous after being heated to 100 DEG C
DEG C heating endure glue to density be 1.35, after filtering collect concentration glue it is spare；
It (3) is in mass ratio that 1.5 ﹕ 1 carry out mixing pill with concentration glue by raw material powder, then using the polishing of water chestnut pot and choosing
Ball, satisfactory honeyed bolus use the microwave disinfection 150s of 1000MHz, the microwave drying 100s of 2700MHz are then used, after dry
Honeyed bolus carry out sterile dress shell and sealing wax, obtain sugar-free honeyed bolus finished product.
Experimental example 1
For the physicochemical property of the sugar-free honeyed bolus of comparative illustration various embodiments of the present invention, the nothing that each embodiment is prepared
The physicochemical property of molasses ball is tested, and test result is shown in Table 1.
The physicochemical property test result of the different sugar-free honeyed bolus of table 1
| Number | Content of reducing sugar | Moisture content | Total plate count |
| Embodiment 1 | 0.08% | 7.2% | < 10cfu/g |
| Embodiment 2 | 0.12% | 8.5% | < 10cfu/g |
| Embodiment 3 | 0.15% | 8.0% | < 10cfu/g |
| Embodiment 4 | 0.08% | 7.5% | < 10cfu/g |
Experimental example 2
In order to probe into various embodiments of the present invention sugar-free honeyed bolus stability, according to " health food examine and assessment technique
Enforcement of regulations handbook " stability experiment is carried out to the sugar-free honeyed bolus of embodiment 1-4.Given the test agent preservation condition is temperature 38 ± 1
DEG C, humidity 75%, and respectively the 0th day after starting to save, test analysis to given the test agent within 30 days, 60 days, 90 days.As a result
As shown in Table 2-4.
Table 2 saves the testing result of 0 day, 30 days given the test agent
Table 3 saves the testing result of 60 days, 90 days given the test agent
4 given the test agent organoleptic indicator's testing result of table
It is found that sugar-free honeyed bolus product totally had no significant change in acceleration for stabilization experiment in 90 days from upper table, sense organ, ash
Point, content of reducing sugar, yeast and mold, coliform, pathogenic bacteria it is unchanged, only the 90th day when each embodiment moisture omit
There is increase, the total plate count of embodiment 2 and 4 was increased slightly at the 90th day, but in acceptability limit.
Experimental example 3
In order to verify the hypoglycemic effect of sugar-free honeyed bolus of the invention, the sugar-free honeyed bolus of various embodiments of the present invention is dropped
Blood glucose zoopery, experimental method are as follows.
Experimental animal:
It selects adult rat (180 ± 20g), male amounts to 100.
High thermal energy fodder:
Lard 10%, sucrose 15%, yolk powder 15%, casein 5%, cholesterol 1.2%, sodium taurocholate 0.2%, bicarbonate
Calcium 0.6%, mountain flour 0.4%, mouse maintain material 52.6%.
The experiment of intact animal hypoglycemic
Adult rat (180 ± 20g) 50 is selected, is grouped by the blood glucose level of fasting 3-5h, selects 1 control group and 4 at random
A embodiment group.Control group gives solvent, and experimental group gives 500mg/kg dosage 1mL, continuous 30 days, surveys fasting blood sugar and (prohibit
Before food is with experiment), compare five groups of animal blood glucose values.
The experiment of hyperglycemia model hypoglycemic:
Modeling method
Adult rat (180 ± 20g) 50 is selected, after adapting to 1 day, 15 animal fasting 3-5h is taken at random, surveys fasting blood-glucose,
As the batch animal basal plasma glucose value.Subsequent animal fasting for 24 hours (free water), injects 50-80mg/kg BW.iv dosage four
Oxygen pyrimidine (with preceding Fresh) modeling, animal fasting 3-5h after 5-7 days survey blood glucose, and blood glucose value 10-25mmol/L is hyperglycemia
Model success animal.
The experiment of hyperglycemia model animal hypoglycemic
The successful rat of modeling 45 is selected, is grouped by the blood glucose level of fasting 3-5h, selects 1 model control group and 4 at random
A embodiment (difference is not more than 1.1mmol/L between group).Each embodiment group gives 500mg/kg dosage 1mL, and model control group is given
Solvent continuous 30 days, surveys fasting blood sugar (before fasting is with experiment), compares groups of animals blood glucose value and blood glucose decline percentage.
Blood glucose rate of descent %=[(blood glucose value after blood glucose value-experiment before testing)/test preceding blood glucose value] × 100%
The experiment of hyperglycemia model animal sugar tolerance
Dosage grouping and given the test agent are given the time and are tested with hypoglycemic.Groups of animals fasting 3-5h is measured to glucose (i.e.
0h) blood glucose value, each embodiment group give 500mg/kg dosage 1mL, and model control group gives same volume solvent, each after 15-20min
Group oral administration of glucose 2.0g/kg BW is measured to each group 0.5, the blood glucose value of 2h after glucose or to 1,2h after medical starch
Blood glucose value, observing and nursing control group and each embodiment group are bent to time point each after glucose (0,0.5,2h) blood glucose value and blood glucose
The variation of area under line.
Area under the curve of blood glucose=[(0h blood glucose+0.5h blood glucose) × 0.5]/2+ [(2h blood glucose+0.5h blood glucose) × 1.5]/2
Experimental result is shown in Table 5-9.
Influence of 5 tested material of table to intact animal weight
| Group | Original body mass/g | Final weight/g | Weight gain/g |
| Intact animal control group | 182.25±10.51 | 245.37±18.25 | 63.12±7.42 |
| Intact animal example 1 group | 178.39±9.75 | 240.23±17.39 | 61.84±6.68 |
| 2 groups of intact animal embodiment | 184.61±10.08 | 248.86±15.67 | 64.25±5.15 |
| 3 groups of intact animal embodiment | 180.86±8.27 | 241.44±16.92 | 60.58±6.71 |
| 4 groups of intact animal embodiment | 179.24±11.50 | 240.69±17.64 | 61.45±8.24 |
As shown in Table 5,4 embodiment group weight of the hypoglycemic experiment of intact animal, weight gain compared with the control group, the equal nothing of difference
Significant difference (P > 0.05) shows that tested material has no significant effect intact animal weight, weight gain.
Influence of 6 tested material of table to intact animal blood glucose
As shown in Table 6, compared with the control group, fasting blood-glucose variation is without significant for the hypoglycemic each embodiment group of experiment of intact animal
Sex differernce (P > 0.05), shows that tested material has no significant effect intact animal blood glucose.
Influence of 7 tested material of table to hyperglycemia model the weight of animals
| Group | Original body mass/g | Final weight/g | Weight gain/g |
| Model control group | 197.63±12.14 | 238.21±28.95 | 40.58±15.27 |
| Example 1 group | 204.15±15.28 | 254.72±30.36 | 50.57±20.29 |
| 2 groups of embodiment | 206.97±14.84 | 255.22±26.74 | 48.25±18.61 |
| 3 groups of embodiment | 198.45±17.13 | 250.37±25.42 | 51.92±24.68 |
| 4 groups of embodiment | 202.41±16.85 | 255.08±29.15 | 52.67±26.14 |
As shown in Table 7, tested material to 4 embodiment group weight of hyperglycemia model animal hypoglycemic test, weight gain and compares
Group compares, difference there are no significant difference (P > 0.05), shows that tested material has no significant effect intact animal weight, weight gain.
Influence of 8 tested material of table to zoic model with hyperglycemia fasting blood-glucose
Note: * is indicated, compared with model control group, P < 0.05
As shown in Table 8, under the premise of zoic model with hyperglycemia is set up, each embodiment group of tested material and model control group ratio
Compared with fasting blood-glucose decline and blood glucose decline percentage height have significant difference (P < 0.05).
Influence of 9 tested material of table to zoic model with hyperglycemia sugar tolerance
Note: * is indicated, compared with model control group, P < 0.05
As shown in Table 9, under the premise of zoic model with hyperglycemia is set up, each embodiment group of tested material and model comparison ratio
Compared with the decline of 2h blood glucose, the decline percentage raising of 2h blood glucose and Area under the curve of blood glucose reduction have significant after glucose administration
Sex differernce (P < 0.05).
Auxiliary hyperglycemic zoopery is carried out according to each embodiment product, the experimental results showed that each embodiment set product is dynamic
Object experiment fasting blood-glucose and sugar tolerance are positive, and on intact animal fasting blood-glucose without influence, so can determine that each implementation
The product auxiliary hyperglycemic function results of animal of example is positive.
Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Pipe present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. a kind of sugar-free honeyed bolus, which is characterized in that be mainly mixed to prepare by raw material powder and concentration glue；
The mass ratio of the raw material powder and concentration glue is (1-3) ﹕ 1；
The raw material powder is mainly made of following component according to parts by weight:
15-30 parts of bergamot extract, 15-30 parts of semen litchi, 2-10 parts of rhizoma anemarrhenae, 5-10 parts of glutinous rehmannia, 4-12 parts of cortex cinnamomi, mulberry leaf 1-
3 parts, 1-3 parts of bitter gourd polypeptide；
The concentration glue includes one of propolis, konjac glucomannan, aloe vera gel or a variety of.
2. sugar-free honeyed bolus according to claim 1, which is characterized in that the concentration glue includes propolis, konjac glucomannan and Ku La
Rope aloe gel；
Preferably, the mass ratio of the propolis, konjac glucomannan and aloe vera gel is 4 ﹕ (1-3) ﹕ (1-3)；
It is furthermore preferred that the mass ratio of the propolis, konjac glucomannan and aloe vera gel is 2 ﹕, 1 ﹕ 1.
3. sugar-free honeyed bolus according to claim 2, which is characterized in that it is described concentration glue preparation method include: by propolis,
Konjac glucomannan and aloe vera gel are mixed with water, are heated to 100 ± 5 DEG C of homogeneous, and enduring glue to density is 1.3-1.4；
Preferably, propolis, konjac glucomannan and aloe vera gel are mixed with water, so that propolis, konjac glucomannan and aloe barbadensis Miller are solidifying
The total mass concentration of glue is 8-15%.
4. sugar-free honeyed bolus according to claim 1, which is characterized in that the raw material powder mainly by according to parts by weight as
Lower component is made:
18-25 parts of bergamot extract, 18-25 parts of semen litchi, 4-9 parts of rhizoma anemarrhenae, 6-9 parts of glutinous rehmannia, 6-9 parts of cortex cinnamomi, mulberry leaf 1-3
Part, 1-3 parts of bitter gourd polypeptide；
Preferably, the raw material powder is mainly made of following component according to parts by weight: 20 parts of bergamot extract, semen litchi
22 parts, 5 parts of rhizoma anemarrhenae, 8 parts of glutinous rehmannia, 8 parts of cortex cinnamomi, 2 parts of mulberry leaf, 2 parts of bitter gourd polypeptide.
5. sugar-free honeyed bolus according to claim 1-4, which is characterized in that in the sugar-free honeyed bolus, reduced sugar contains
Amount≤0.5g/100g, moisture content≤10%, total plate count≤10cfu/g；
Preferably, the partial size of the raw material powder is 300-500 mesh；
It is furthermore preferred that the partial size of the raw material powder is 350-450 mesh.
6. the preparation method of the described in any item sugar-free honeyed bolus of claim 1-5, which comprises the steps of:
Raw material powder is mixed into pill with concentration glue in proportion, carries out microwave disinfection, microwave drying treatment.
7. the preparation method of sugar-free honeyed bolus according to claim 6, which is characterized in that the condition packet of the microwave disinfection
It includes: frequency 800-1000MHz, sterilizing time 30-200s；
Preferably, the frequency of the microwave disinfection is 850-950MHz.
8. the preparation method of sugar-free honeyed bolus according to claim 6, which is characterized in that the condition packet of the microwave drying
It includes: frequency 2000-2700MHz, sterilizing time 30-150s；
Preferably, the frequency of the microwave drying is 2100-2500MHz.
9. the preparation method of sugar-free honeyed bolus according to claim 6, which is characterized in that after drying process, to dry ball
Agent carries out sterile dress shell and sealing wax, obtains the sugar-free honeyed bolus finished product.
10. the described in any item sugar-free honeyed bolus of claim 1-5 are preparing the application in hypoglycemic product.
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| CN201811230126.2A CN109350732B (en) | 2018-10-22 | 2018-10-22 | Sugar-free honeyed pill and preparation method and application thereof |
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| CN201811230126.2A CN109350732B (en) | 2018-10-22 | 2018-10-22 | Sugar-free honeyed pill and preparation method and application thereof |
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