CN107441391A - 一种治疗慢性阻塞性肺疾病的汤剂药物及其制备方法 - Google Patents
一种治疗慢性阻塞性肺疾病的汤剂药物及其制备方法 Download PDFInfo
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- CN107441391A CN107441391A CN201710596977.8A CN201710596977A CN107441391A CN 107441391 A CN107441391 A CN 107441391A CN 201710596977 A CN201710596977 A CN 201710596977A CN 107441391 A CN107441391 A CN 107441391A
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- Medicines Containing Plant Substances (AREA)
Abstract
本发明属于中药制剂领域,目的是根据中医治疗慢性阻塞性肺疾病的认识机理而提供的一种治疗慢性阻塞性肺疾病的汤剂药物,所述药物的各个组分及其质量份比如下:麻黄10g、红丝线360g、川芎10g、独活8g、丹参12g、羌活20g、防己12g、甘草10g、陈皮12g、杏仁8g、肉桂4g、附子12g、五味子10g、茯苓20g、升麻8g、细辛3g、麦冬10g、人参12g、防风8g、生石膏48g、白术12g、当归12g、赤芍10g、天麻12g、僵蚕8g、全蝎4g、半夏7g、橘红8g、紫菀10g、柴胡10g、丹皮12g、天花粉12g、薏苡仁42g、白芥子6g、前胡10g、白前10g、天竺黄10g、鸡屎藤12g、红景天12g、银杏叶10g、补骨脂12g、黄芪28g、海风藤10g;本发明提供的药物是一个标本兼治的中药组方。
Description
技术领域
本发明属于中药制剂领域,具体涉及一种治疗慢性阻塞性肺疾病的汤剂药物,特别是供慢性阻塞性肺疾病患者使用的汤剂药物及其制备方法的领域。
背景技术
慢性阻塞性肺疾病是一种具有气流阻塞特征的慢性支气管炎和(或)肺气肿,可进一步发展为肺心病和呼吸衰竭的常见慢性疾病。与有害气体及有害颗粒的异常炎症反应有关,致残率和病死率很高,全球40岁以上发病率已高达9%~10%。
慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是一种常见的以持续气流受限为特征的可以预防和治疗的疾病,气流受限进行性发展,与气道和肺脏对有毒颗粒或气体的慢性炎性反应增强有关。
那么,就如何找到一种可有效治疗慢性阻塞性肺疾病的药物,是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗慢性阻塞性肺疾病上,人们逐渐意识到了中医治疗慢性阻塞性肺疾病的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西医治疗慢性阻塞性肺疾病的现状,本发明的目的是在于提供一种治疗慢性阻塞性肺疾病的汤剂药物,以解决慢性阻塞性肺疾病患者早日恢复健康的问题。该药物是以常见的中药为原料,通过选择合理的药物及质量份比,可有效治疗上述慢性阻塞性肺疾病。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种治疗慢性阻塞性肺疾病的汤剂药物及其制备方法,其特征在于,所述药物的各个组分及其质量份比如下所示:
麻黄2.5~12g、红丝线25~500g、川芎5~12g、独活3~10g、丹参5~16g、羌活10~26g、防己8~16g、甘草3~12g、陈皮3~15g、杏仁5~10g、肉桂2~6g、附子3~15g、五味子3~12g、茯苓15~25g、升麻3~10g、细辛1~4g、麦冬6~12g、人参3~16g、防风5~10g、生石膏15~65g、 白术8~16g、当归8~16g、赤芍6~12g、天麻8~16g、僵蚕5~10g、全蝎2~5g、半夏3~9g、橘红3~10g、紫菀5~12g、 柴胡3~12g、丹皮8~16g、天花粉10~16g、薏苡仁15~55g、白芥子3~8g、前胡3~12g、白前3~12g、天竺黄3~12g、鸡屎藤10~16g、红景天5~16g、银杏叶9~12g、补骨脂6~15g、黄芪9~35g、海风藤6~12g。
一种治疗慢性阻塞性肺疾病的汤剂药物及其制备方法,其特征在于,所述药物的各个组分及其质量份比如下所示:
麻黄3~11g、红丝线30~420g、川芎6~11g、独活5~9g、丹参6~14g、羌活11~23g、防己9~14g、甘草5~11g、陈皮5~13g、杏仁6~9g、肉桂3~5g、附子5~13g、五味子5~11g、茯苓17~22g、升麻5~9g、细辛2~3.5g、麦冬7~11g、人参6~14g、防风6~9g、生石膏18~56g、 白术10~14g、当归10~14g、赤芍7~11g、天麻9~14g、僵蚕6~9g、全蝎3~4.5g、半夏5~8g、橘红4~9g、紫菀6~11g、 柴胡5~11g、丹皮9~14g、天花粉11~14g、薏苡仁17~50g、白芥子5~7g、前胡5~11g、白前5~11g、天竺黄5~11g、鸡屎藤11~14g、红景天6~14g、银杏叶9.5~11g、补骨脂7~13g、黄芪10~31g、海风藤7~11g。
一种治疗慢性阻塞性肺疾病的汤剂药物及其制备方法,其特征在于,所述“最佳方案”的药物的各个组分及其质量份比如下所示:
麻黄10g、红丝线360g、川芎10g、独活8g、丹参12g、羌活20g、防己12g、甘草10g、陈皮12g、杏仁8g、肉桂4g、附子12g、五味子10g、茯苓20g、升麻8g、细辛3g、麦冬10g、人参12g、防风8g、生石膏48g、白术12g、当归12g、赤芍10g、天麻12g、僵蚕8g、全蝎4g、半夏7g、橘红8g、紫菀10g、 柴胡10g、丹皮12g、天花粉12g、薏苡仁42g、白芥子6g、前胡10g、白前10g、天竺黄10g、鸡屎藤12g、红景天12g、银杏叶10g、补骨脂12g、黄芪28g、海风藤10g。
一种治疗慢性阻塞性肺疾病的汤剂药物及其制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、将上述原料中药拣去杂质和粉尘后,按照质量份比分别粉碎成粗粒状包煎;
B、将包好的原料中药放入冷开水中浸泡半小时,然后再将浸泡好的药物和浸泡药物的澄清液一并放入砂锅内,注入过药60mm的冷开水进行第一次煎煮56分钟,滤取药液后,再次注入过药56mm的微温开水进行第二次煎煮45分钟,二次混合浓缩成50%的中药液1620毫升备用。
一种治疗慢性阻塞性肺疾病的汤剂药物及其制备方法,其特征在于,所述服用方法为:将制备好的中药液以一天服用,早中晚各服一次,给药量180毫升/次,趁温服。30天为一个疗程,服药1~2.5个疗程,症状明显减轻或痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
麻黄,性味:辛苦、温,具有发汗、平喘、利水之功效,用于治疗伤寒表实、发热恶寒无汗、头痛鼻塞、骨节疼痛、咳嗽气喘、风水浮肿、小便不利、风邪顽痹、皮肤不仁、风疹瘙痒;
红丝线,性味:甘、淡、凉,具有清肺止咳,散瘀止血之功效,用于治疗肺结核咯血、肺炎、糖尿病,外用治跌打损伤肿痛;
川芎,性味:辛、温,具有行气开郁、法风燥湿、活血止痛之功效,用于治疗风冷头痛旋晕、胁痛腹疼、寒痹筋挛、经闭、难产、产后瘀阻块痛、痈疽疮疡、月经不调、瘕腹痛、胸胁刺痛、跌扑肿痛、风湿痹痛;
独活,性味:辛、苦、微温,具有祛风除湿、通痹止痛之功效,用于治疗风寒湿痹、腰膝疼痛、少阴伏风头痛;
丹参,性味:味苦、性微寒,具有活血祛瘀、调经止痛、养血安神、凉血消痈之功效,用于治疗妇女月经不调、痛经、经闭、产后瘀滞腹痛、心腹疼痛、癥瘕积聚、热痹肿痛、跌打损伤、热入营血、烦躁不安、心烦失眠、痈疮肿毒;
羌活,性味:辛苦、温,具有散表寒、祛风湿、利关节之功效,用于治疗感冒风寒、头痛无汗、风寒湿痹、项强筋急、骨节酸疼、风水浮肿、痈疽疮毒;
防己,性味:苦、寒,具有利水消肿、祛风止痛之功效,用于治疗水肿脚气、小便不利、湿疹疮毒、风湿痹痛、高血压等症;
甘草,性味:甘、平,具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药之功效,用于治疗倦怠食少、肌瘦面黄、心悸气短、腹痛便溏、四肢挛急疼痛、脏躁、咳嗽气喘、咽喉肿痛、痈疮肿痛、小儿胎毒及药物、食物中毒;
陈皮,性味:味辛、苦、性温,具有理气和中,燥湿化痰,利水通便之功效,用于治疗脾胃不和、脘腹胀痛、不思饮食、呕吐哕逆、痰湿阻肺、咳嗽痰多、胸膈满闷、头目眩晕、水肿、小便不利、大便秘结、乳痈疥癣、中鱼蟹毒、酒毒;
杏仁,性味:苦、微温,有小毒,具有降气止咳平喘、润肠通便之功效,用于治疗咳嗽气喘、胸满痰多、血虚津枯、肠燥便秘;
肉桂,性味:性大热、味辛、甘,具有补火助阳、引火归源、散寒止痛、活血通经之功效,用于治疗阳痿、宫冷、心腹冷痛、虚寒吐泻、经闭、痛经;
附子,性味:辛、甘、大热,有毒,具有回阳救逆、补火助阳、逐风寒湿邪之功效,用于治疗亡阳虚脱、肢冷脉微、阳萎、宫冷、心腹冷痛、虚寒吐泻、阴寒水肿、阳虚外感、寒湿痹痛;
五味子,性味:酸、甘、温,具有收敛固涩、益气生津、补肾宁心之功效,用于治疗久泻不止、久咳虚喘、心悸、失眠、多梦、自汗、盗汗、津伤口渴、消渴、遗精、滑精;
茯苓,性味:甘、淡、平,具有渗湿利水、健脾和胃、宁心安神之功效,用于治疗小便不利、水肿胀满、痰饮咳逆、呕吐、脾虚食少、泄泻、心悸不安、失眠健忘、遗精白浊;
升麻,性味:辛、微甘、微寒,具有发表透疹、清热解毒、升举阳气之功效,用于治疗风热头痛、齿痛、口疮、咽喉肿痛、麻疹不透、阳毒发斑、脱肛、子宫脱垂;
细辛,性味:辛、温,具有祛风散寒、通窍止痛、温肺化饮之功效,用于治疗风寒感冒、头痛、牙痛、鼻塞鼻渊、风湿痹痛、痰饮喘咳;
麦冬,性味:甘、微苦、微寒,具有养阴生津、润肺清心之功效,用于治疗肺燥干咳、虚痨咳嗽、津伤口渴、心烦失眠、内热消渴、肠燥便秘、咽白喉等症;
人参,性味:甘微苦、温,具有大补元气、固脱生津、安神之功效,用于治疗劳伤虚损、食少、倦怠、反胃吐食、大便滑泄、虚咳喘促、自汗暴脱、惊悸、健忘、眩晕头痛、阳痿、尿频、消渴、妇女崩漏、小儿慢惊、及久虚不复、一切气血津液不足;
防风,性味:辛、甘、温,具有解表祛风、胜湿、止痉之功效,用于治疗感冒头痛、风湿痹痛、风疹瘙痒、破伤风;
生石膏,性味:味甘、辛、性大寒,具有清热泻火、除烦止渴的功效,煅用:具有敛疮生肌、收湿、止血之功效,常用于外感热病、高热烦渴、肺热喘咳、胃火亢盛、头痛、牙痛等症;
白术,性味:味苦、甘、性温,具有健脾益气、燥湿利水、止汗、安胎之功效,用于治疗脾气虚弱、神疲乏力、食少少腹胀、大便溏薄、水饮内停、小便不利、水肿、痰饮眩晕、温痹酸痛、气虚自汗、胎动不安等症;
当归,性味:性温、味甘辛,具有补血和血、调经止痛、润燥滑肠之功效,用于治疗血虚、面色萎黄、眩晕心悸、血虚、或兼有瘀滞的月经不调、经闭、痛经、虚寒性腹痛、冠心病心绞痛、风湿痹痛、跌打损伤;
赤芍,性味:苦、微寒,具有清热凉血、活血祛瘀之功效,用于治疗温毒发斑、吐血衄血、肠风下血、目赤肿痛、痈肿疮疡、闭经、痛经、崩带淋浊、瘀滞胁痛、疝瘕积聚、跌扑损伤;
天麻,性味:甘、平,具有息风、定惊之功效,用于治疗眩晕眼黑、头风头痛、肢体麻木、半身不遂、语言蹇涩、小儿惊痫动风;
僵蚕,性味:咸、辛、平,具有祛风定惊、化痰散结之功效,用于治疗惊风抽搐、咽喉肿痛、皮肤瘙痒、颌下淋巴结炎、面神经麻痹等症;
全蝎,性味:味辛、性平,有毒,具有祛风止痉、通络止痛、玫毒散结之功效,用于治疗小儿惊风、抽搐痉挛、中风口、半身不遂、破伤风、风湿顽痹、偏正头痛、牙痛、耳聋、痈肿疮毒、瘰疬痰核、蛇咬、烧伤、风疹、顽癣等症;
半夏,性味:辛、温,有毒,具有燥湿化痰、降逆止呕、消痞散结之功效,用于治疗痰多咳喘、痰饮眩悸、风痰眩晕、痰厥头痛、呕吐反胃、胸脘痞闷、梅核气,生用外治痈肿痰核,姜半夏多用于降逆止呕;
橘红,性味:辛、苦、温,具有散寒、燥湿、利气、消痰之功效,用于治疗风寒咳嗽、喉痒痰多、食积伤酒、呕恶痞闷;
紫菀,性味:味苦、辛、性温,具有润肺下气、化痰止咳之功效,用于治疗咳嗽、肺虚劳嗽、肺痿肺痈、咳吐脓血、小便不利;
柴胡,性味:味苦、辛、性微寒,具有解表退热、疏肝解郁、升举阳气之功效,用于治疗外感发热、寒热往来、疟疾、肝郁胁痛乳胀、头痛头眩、月经不调、气虚下陷之脱肛、子宫脱垂、胃下垂;
丹皮,性味:辛苦、凉、微寒,具有清热、活血散瘀之功效,用于治疗温热病热入血分、发斑、吐衄、热泪盈眶病菌后期热伏阴分发热、阴虚骨蒸潮热、血滞经闭、痛经、痈肿疮毒、跌扑伤痛、风湿热痹等症;
天花粉,性味:甘、微苦、微寒,具有清热生津,消肿排脓之功效,用于治疗热病烦渴、肺热燥咳、内热消渴、疮疡肿毒;
薏苡仁,性味:甘淡,具有健脾、补肺、清热、利湿之功效,用于治疗泄泻、湿痹、筋脉拘挛、屈伸不利、水肿、脚气、肺痿、肺痈、肠痈、淋浊、白带等病症;
白芥子,性味:无臭、味辛、辣,具有温肺豁痰利气、乳腺散结通络止痛之功效,用于治疗寒痰喘咳、胸胁胀痛、痰滞经络、关节麻木、疼痛、痰湿流注、阴疽肿毒;
前胡,性味:苦、辛、微寒,具有散风清热,降气化痰之功效,用于治疗风热咳嗽痰多、痰热喘满、咯痰黄稠;
白前,性味:辛、苦、微温,具有降气、消痰、止咳之功效,用于治疗肺气壅实、咳嗽痰多、胸满喘急;
天竺黄,性味:甘、寒,具有清热豁痰,凉心定惊之功效,用于治疗热病神昏、中风痰迷、小儿痰热惊痫、抽搐、夜啼等症;
鸡屎藤,性味:甘酸、平,具有祛风除湿、消食化积、解毒消肿、活血止痛之功效,用于治疗风湿痹痛、食积腹胀、小儿疳积、腹泻、痢疾、中暑、黄疸、肝炎、肝脾肿大、咳嗽、瘰疬、肠痈、无名肿毒、脚湿肿烂、烫火伤、湿疹、皮炎、跌打损伤、蛇蛟蝎螫;
红景天,性味:甘、涩、寒,具有清肺止咳、止血、止带之功效,用于治疗肺热咳嗽、咯血、白带,外用治跌打损伤、烧烫伤;
银杏叶,性味:甘、苦、涩、平,具有敛肺、平喘、活血化瘀,止痛之功效,用于治疗肺虚咳喘、冠心病、心绞痛、高血脂;
补骨脂,性味:味辛、苦、性温,具有补肾助阳、纳气平喘、温脾止泻之功效,用于治疗肾阳不足、下元虚冷、腰膝冷痛、阳痿精、尿频、遗尿、肾不纳气、虚喘不止、脾肾两虚、大便久泻、白癜风、斑秃、银屑病;
黄芪,性味:甘、微温,具有补气固表、利尿托毒、排脓、敛疮生肌之功效,用于治疗气虚乏力、食少便溏、中气下陷、久泻脱肛、便血崩漏、表虚自汗、气虚水肿、痈疽难溃、久溃不敛、血虚痿黄、内热消渴、慢性肾炎蛋白尿、糖尿病等症;
海风藤,性味:辛、苦、微温,具有祛风湿、通经络、止痹痛之功效,用于治疗风寒湿痹、肢节疼痛、筋脉拘挛、屈伸不利。
本发明药物是基于中医治疗慢性阻塞性肺疾病的原则,从依据慢性阻塞性肺疾病的病理机制及药理作用认为:就慢性阻塞性肺疾病,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述慢性阻塞性肺疾病的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个标本兼治的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种治疗慢性阻塞性肺疾病的汤剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
麻黄10g、红丝线360g、川芎10g、独活8g、丹参12g、羌活20g、防己12g、甘草10g、陈皮12g、杏仁8g、肉桂4g、附子12g、五味子10g、茯苓20g、升麻8g、细辛3g、麦冬10g、人参12g、防风8g、生石膏48g、 白术12g、当归12g、赤芍10g、天麻12g、僵蚕8g、全蝎4g、半夏7g、橘红8g、紫菀10g、 柴胡10g、丹皮12g、天花粉12g、薏苡仁42g、白芥子6g、前胡10g、白前10g、天竺黄10g、鸡屎藤12g、红景天12g、银杏叶10g、补骨脂12g、黄芪28g、海风藤10g。
实施例2:
一种治疗慢性阻塞性肺疾病的汤剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
麻黄11g、红丝线420g、川芎11g、独活9g、丹参14g、羌活23g、防己14g、甘草11g、陈皮13g、杏仁9g、肉桂5g、附子13g、五味子11g、茯苓22g、升麻9g、细辛3.5g、麦冬11g、人参14g、防风9g、生石膏56g、白术14g、当归14g、赤芍11g、天麻14g、僵蚕9g、全蝎4.5g、半夏8g、橘红9g、紫菀11g、 柴胡11g、丹皮14g、天花粉14g、薏苡仁50g、白芥子7g、前胡11g、白前11g、天竺黄11g、鸡屎藤14g、红景天14g、银杏叶11g、补骨脂13g、黄芪31g、海风藤11g。
实施例3:
一种治疗慢性阻塞性肺疾病的汤剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
麻黄12g、红丝线500g、川芎12g、独活10g、丹参16g、羌活26g、防己16g、甘草12g、陈皮15g、杏仁10g、肉桂6g、附子15g、五味子12g、茯苓25g、升麻10g、细辛4g、麦冬12g、人参16g、防风10g、生石膏65g、白术16g、当归16g、赤芍12g、天麻16g、僵蚕10g、全蝎5g、半夏9g、橘红10g、紫菀12g、 柴胡12g、丹皮16g、天花粉16g、薏苡仁55g、白芥子8g、前胡12g、白前12g、天竺黄12g、鸡屎藤16g、红景天16g、银杏叶12g、补骨脂15g、黄芪35g、海风藤12g。
典型病例
经临床诊断治疗慢性阻塞性肺疾病患者共1990例,年龄为58岁以上的1070例,只有920例为58岁以下。1990例患者中痊愈的1920例,有效的70例,总有效率达100%。
Claims (3)
1.一种治疗慢性阻塞性肺疾病的汤剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
麻黄2.5~12g、红丝线25~500g、川芎5~12g、独活3~10g、丹参5~16g、羌活10~26g、防己8~16g、甘草3~12g、陈皮3~15g、杏仁5~10g、肉桂2~6g、附子3~15g、五味子3~12g、茯苓15~25g、升麻3~10g、细辛1~4g、麦冬6~12g、人参3~16g、防风5~10g、生石膏15~65g、 白术8~16g、当归8~16g、赤芍6~12g、天麻8~16g、僵蚕5~10g、全蝎2~5g、半夏3~9g、橘红3~10g、紫菀5~12g、 柴胡3~12g、丹皮8~16g、天花粉10~16g、薏苡仁15~55g、白芥子3~8g、前胡3~12g、白前3~12g、天竺黄3~12g、鸡屎藤10~16g、红景天5~16g、银杏叶9~12g、补骨脂6~15g、黄芪9~35g、海风藤6~12g。
2.根据权利要求1所述的治疗慢性阻塞性肺疾病的汤剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
麻黄3~11g、红丝线30~420g、川芎6~11g、独活5~9g、丹参6~14g、羌活11~23g、防己9~14g、甘草5~11g、陈皮5~13g、杏仁6~9g、肉桂3~5g、附子5~13g、五味子5~11g、茯苓17~22g、升麻5~9g、细辛2~3.5g、麦冬7~11g、人参6~14g、防风6~9g、生石膏18~56g、 白术10~14g、当归10~14g、赤芍7~11g、天麻9~14g、僵蚕6~9g、全蝎3~4.5g、半夏5~8g、橘红4~9g、紫菀6~11g、 柴胡5~11g、丹皮9~14g、天花粉11~14g、薏苡仁17~50g、白芥子5~7g、前胡5~11g、白前5~11g、天竺黄5~11g、鸡屎藤11~14g、红景天6~14g、银杏叶9.5~11g、补骨脂7~13g、黄芪10~31g、海风藤7~11g。
3.根据权利要求1至2所述的治疗慢性阻塞性肺疾病的汤剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
麻黄10g、红丝线360g、川芎10g、独活8g、丹参12g、羌活20g、防己12g、甘草10g、陈皮12g、杏仁8g、肉桂4g、附子12g、五味子10g、茯苓20g、升麻8g、细辛3g、麦冬10g、人参12g、防风8g、生石膏48g、白术12g、当归12g、赤芍10g、天麻12g、僵蚕8g、全蝎4g、半夏7g、橘红8g、紫菀10g、 柴胡10g、丹皮12g、天花粉12g、薏苡仁42g、白芥子6g、前胡10g、白前10g、天竺黄10g、鸡屎藤12g、红景天12g、银杏叶10g、补骨脂12g、黄芪28g、海风藤10g。
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