CN107427502B - 使用川地匹坦的治疗方法 - Google Patents

使用川地匹坦的治疗方法 Download PDF

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Publication number
CN107427502B
CN107427502B CN201680013797.6A CN201680013797A CN107427502B CN 107427502 B CN107427502 B CN 107427502B CN 201680013797 A CN201680013797 A CN 201680013797A CN 107427502 B CN107427502 B CN 107427502B
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CN107427502A (zh
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M·H·波利梅洛伯罗斯
L·W·利卡梅勒
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Vanda Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Encapsulation Of And Coatings For Semiconductor Or Solid State Devices (AREA)
  • Medicinal Preparation (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Eye Examination Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201680013797.6A 2015-03-04 2016-03-04 使用川地匹坦的治疗方法 Active CN107427502B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110527432.8A CN113262221A (zh) 2015-03-04 2016-03-04 使用川地匹坦的治疗方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562128472P 2015-03-04 2015-03-04
US62/128,472 2015-03-04
US201562232644P 2015-09-25 2015-09-25
US62/232,644 2015-09-25
PCT/US2016/021015 WO2016141341A1 (en) 2015-03-04 2016-03-04 Method of treatment with tradipitant

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202110527432.8A Division CN113262221A (zh) 2015-03-04 2016-03-04 使用川地匹坦的治疗方法

Publications (2)

Publication Number Publication Date
CN107427502A CN107427502A (zh) 2017-12-01
CN107427502B true CN107427502B (zh) 2021-06-04

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CN201680013797.6A Active CN107427502B (zh) 2015-03-04 2016-03-04 使用川地匹坦的治疗方法
CN202110527432.8A Pending CN113262221A (zh) 2015-03-04 2016-03-04 使用川地匹坦的治疗方法

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US (6) US10463655B2 (https=)
EP (2) EP3265087B1 (https=)
JP (4) JP6891385B2 (https=)
KR (3) KR102860817B1 (https=)
CN (2) CN107427502B (https=)
AU (4) AU2016226006B2 (https=)
BR (1) BR112017018620A2 (https=)
CA (2) CA2978736C (https=)
CL (1) CL2017002238A1 (https=)
DK (1) DK3265087T3 (https=)
ES (1) ES2824552T3 (https=)
HR (1) HRP20201627T1 (https=)
HU (1) HUE050944T2 (https=)
IL (1) IL254142B (https=)
MX (2) MX385788B (https=)
PT (1) PT3265087T (https=)
RU (1) RU2770050C2 (https=)
WO (1) WO2016141341A1 (https=)
ZA (1) ZA201706059B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2824552T3 (es) * 2015-03-04 2021-05-12 Vanda Pharmaceuticals Inc Método de tratamiento con tradipitant
AU2018331267B2 (en) * 2017-09-13 2024-03-07 Vanda Pharmaceuticals Inc. Improved treatment of atopic dermatitis with tradipitant
CN119074729A (zh) * 2017-11-17 2024-12-06 万达制药公司 使用川地匹坦治疗胃肠疾病的方法
CA3101210A1 (en) * 2018-06-08 2019-12-12 Vanda Pharmaceuticals Inc. Method of treatment with tradipitant
US10821099B2 (en) 2018-09-28 2020-11-03 Vanda Pharmaceuticals Inc. Use of tradipitant in motion sickness
HUE070000T2 (hu) * 2018-09-28 2025-04-28 Vanda Pharmaceuticals Inc Tradipitant alkalmazása utazási betegségben
WO2020117811A1 (en) 2018-12-03 2020-06-11 Vanda Pharmaceuticals Inc. Method of treatment with tradipitant
WO2020132513A1 (en) 2018-12-21 2020-06-25 Vanda Pharmaceuticals Inc. Improved treatment of atopic dermatitis with tradipitant
KR20220145844A (ko) 2020-02-25 2022-10-31 반다 파마슈티칼즈, 인코퍼레이티드. 트라디피탄트를 이용한 아토피 피부염의 개선된 치료
JP7791832B2 (ja) * 2020-03-26 2025-12-24 バンダ・ファーマシューティカルズ・インコーポレイテッド トラジピタントによる下気道感染症の治療
WO2023019084A1 (en) 2021-08-12 2023-02-16 Vanda Pharmaceuticals Inc. Treatment of gastric accommodation with tradipitant
US20240350469A1 (en) 2021-08-31 2024-10-24 Vanda Pharmaceuticals Inc. Treatment of lower respiratory tract infection with tradipitant
AU2023413130A1 (en) 2022-12-21 2025-06-05 Vanda Pharmaceuticals Inc. Methods of treatment with tradipitant
EP4599831A1 (en) 2024-02-09 2025-08-13 Vanda Pharmaceuticals Inc. Treatment of gastroparesis with tradipitant

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1107476A (zh) * 1993-11-10 1995-08-30 武田药品工业株式会社 杂环化合物及其制备和应用
CN1646502A (zh) * 2002-04-26 2005-07-27 伊莱利利公司 用作速激肽受体拮抗剂的三唑衍生物
CN1863791A (zh) * 2003-10-24 2006-11-15 伊莱利利公司 {2－[1－(3,5－双－三氟甲基－苄基)－5－吡啶－4－基－1h－[1,2,3]三唑－4－基]－吡啶－3－基}－(2－氯苯基)－甲酮的新晶形
WO2014209962A1 (en) * 2013-06-24 2014-12-31 Tigercat Pharma, Inc. Use of nk-1 receptor antagonist serlopitant in pruritus

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9305718D0 (en) 1993-03-19 1993-05-05 Glaxo Group Ltd Medicaments
GB9513972D0 (en) 1995-07-08 1995-09-06 Merck Sharp & Dohme Pharmaceutical compositions
PT1035115E (pt) 1999-02-24 2005-01-31 Hoffmann La Roche Derivados de 4-fenilpiridina e a sua utilizacao como antagonistas do receptor nk-1
US6849624B2 (en) * 2001-07-31 2005-02-01 Hoffmann-La Roche Inc. Aromatic and heteroaromatic substituted amides
ES2307925T3 (es) * 2002-04-26 2008-12-01 Eli Lilly And Company Antagonistas de los receptores de la taquiquinina.
JP2004250329A (ja) 2002-12-26 2004-09-09 Dainippon Pharmaceut Co Ltd イサチン誘導体
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
JP4673068B2 (ja) 2005-01-19 2011-04-20 独立行政法人科学技術振興機構 Ｔｈ１型アレルギー疾患治療用組成物
DE102005006217B4 (de) 2005-02-07 2007-08-16 Universitätsklinikum Hamburg-Eppendorf Diagnose von allergischen Erkrankungen und/oder atopischen Erkrankungen durch Nachweis von Autoantikörpern gegen CD28 in humanem Serum
EP1996179A2 (en) 2006-02-22 2008-12-03 Valorisation-Recherche, Limited Partnership Compositions for disorders associated with metachromatic cell activation
BRPI0721069A2 (pt) 2006-12-20 2014-02-04 Lilly Co Eli Intermediários e processo útil na preparação de {2-[1-(3,5-bis-trifluorometil-benzil)-5-piridin-4-il-1h[1,2, 3]triazol-4-il]-piridin-3-il}-2-clorofenil)-metanona
CN102573475B (zh) 2009-08-14 2016-01-20 欧科生医股份有限公司 神经激肽-1拮抗剂的静脉内制剂
ES2623503T3 (es) 2009-11-18 2017-07-11 Helsinn Healthcare Sa Composiciones para tratar náuseas y vómitos mediados centralmente
EP2722045B1 (en) 2009-11-18 2016-07-06 Helsinn Healthcare SA Compositions for treating centrally mediated nausea and vomiting
WO2014093907A1 (en) 2012-12-13 2014-06-19 A.P. Pharma, Inc. Pharmaceutical composition comprising antiemetic compounds and polyorthoester
JP6644328B2 (ja) 2013-02-28 2020-02-12 ロート製薬株式会社 アトピー性疾患の発症又は重症化リスクの評価法
US8906951B1 (en) * 2013-06-24 2014-12-09 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
ES2824552T3 (es) * 2015-03-04 2021-05-12 Vanda Pharmaceuticals Inc Método de tratamiento con tradipitant
WO2016195723A1 (en) 2015-06-03 2016-12-08 Beller Pharmaceuticals LLC Methods of treatment for conditions mediated by substance p
WO2017060488A1 (en) 2015-10-09 2017-04-13 Almirall, S.A. New trpa1 antagonists
SG10202112628UA (en) 2015-11-30 2021-12-30 Anacor Pharmaceuticals Inc Topical pharmaceutical formulations for treating inflammatory-related conditions
CN115531553A (zh) 2015-12-22 2022-12-30 武田药品工业株式会社 内体g蛋白-偶联的受体的三部分调节剂
AU2018331267B2 (en) 2017-09-13 2024-03-07 Vanda Pharmaceuticals Inc. Improved treatment of atopic dermatitis with tradipitant
CN119074729A (zh) * 2017-11-17 2024-12-06 万达制药公司 使用川地匹坦治疗胃肠疾病的方法
CA3101210A1 (en) * 2018-06-08 2019-12-12 Vanda Pharmaceuticals Inc. Method of treatment with tradipitant
US10821099B2 (en) 2018-09-28 2020-11-03 Vanda Pharmaceuticals Inc. Use of tradipitant in motion sickness
HUE070000T2 (hu) * 2018-09-28 2025-04-28 Vanda Pharmaceuticals Inc Tradipitant alkalmazása utazási betegségben
WO2020117811A1 (en) * 2018-12-03 2020-06-11 Vanda Pharmaceuticals Inc. Method of treatment with tradipitant

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1107476A (zh) * 1993-11-10 1995-08-30 武田药品工业株式会社 杂环化合物及其制备和应用
CN1646502A (zh) * 2002-04-26 2005-07-27 伊莱利利公司 用作速激肽受体拮抗剂的三唑衍生物
CN1863791A (zh) * 2003-10-24 2006-11-15 伊莱利利公司 {2－[1－(3,5－双－三氟甲基－苄基)－5－吡啶－4－基－1h－[1,2,3]三唑－4－基]－吡啶－3－基}－(2－氯苯基)－甲酮的新晶形
WO2014209962A1 (en) * 2013-06-24 2014-12-31 Tigercat Pharma, Inc. Use of nk-1 receptor antagonist serlopitant in pruritus

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Development of the 2nd generation neurokinin-1 receptor antagonist LY686017 for social anxiety disorder;Johannes Tauscher et al;《European Neuropsychopharmacology》;20100201;第20卷(第2期);第80-87页 *
Neurokinin 1 Receptor Antagonism as a Possible Therapy for Alcoholism;David T. George et al;《SCIENCE》;20080314;第319卷(第5869期);第1536-1539页 *
Targeting the Neurokinin Receptor 1 with Aprepitant: A Novel Antipruritic Strategy;Sonja Stander et al;《PLoS ONE》;20100101;第5卷(第6期);第e10968-e10968页 *

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AU2023233141B2 (en) 2025-05-22
DK3265087T3 (da) 2020-10-19
JP2024074963A (ja) 2024-05-31
HK1248552A1 (zh) 2018-10-19
US20180110761A1 (en) 2018-04-26
RU2770050C2 (ru) 2022-04-14
KR102860817B1 (ko) 2025-09-16
CN107427502A (zh) 2017-12-01
JP2023052486A (ja) 2023-04-11
AU2021202956B2 (en) 2023-06-29
NZ735121A (en) 2024-07-26
CA2978736A1 (en) 2016-09-09
ES2824552T3 (es) 2021-05-12
CN113262221A (zh) 2021-08-17
AU2016226006B2 (en) 2021-03-04
EP3730140B1 (en) 2026-05-06
KR20250136946A (ko) 2025-09-16
HRP20201627T1 (hr) 2021-02-19
KR20230173743A (ko) 2023-12-27
US20220226295A1 (en) 2022-07-21
CL2017002238A1 (es) 2018-04-20
JP2021073258A (ja) 2021-05-13
EP3730140A1 (en) 2020-10-28
EP3265087B1 (en) 2020-07-22
HUE050944T2 (hu) 2021-01-28
PT3265087T (pt) 2020-10-15
MX385788B (es) 2025-03-18
MX2021010460A (es) 2021-09-21
US20190290626A1 (en) 2019-09-26
CA3213864A1 (en) 2016-09-09
US20250205213A1 (en) 2025-06-26
WO2016141341A1 (en) 2016-09-09
AU2021202956A1 (en) 2021-06-03
CA2978736C (en) 2023-11-07
EP3265087A1 (en) 2018-01-10
US10772880B2 (en) 2020-09-15
AU2025210905A1 (en) 2025-08-21
US10463655B2 (en) 2019-11-05
IL254142A0 (en) 2017-10-31
RU2017134443A3 (https=) 2019-09-05
RU2017134443A (ru) 2019-04-04
IL254142B (en) 2022-05-01
US20190290625A1 (en) 2019-09-26
ZA201706059B (en) 2023-08-30
MX2017011279A (es) 2018-01-25
AU2016226006A1 (en) 2017-09-21
US11324735B2 (en) 2022-05-10
KR20170122777A (ko) 2017-11-06
BR112017018620A2 (pt) 2018-04-17
JP6891385B2 (ja) 2021-06-18
US12318375B2 (en) 2025-06-03
US20200360358A1 (en) 2020-11-19
JP2018507243A (ja) 2018-03-15
AU2023233141A1 (en) 2023-10-12
CA3213864C (en) 2026-02-03

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