CN107412109B - Allergy-relieving scalp care solution - Google Patents
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Abstract
The invention belongs to the field of daily chemicals, and particularly relates to a care solution with a scalp allergy-relieving effect. The allergy-relieving scalp care solution comprises the following components besides acceptable components of the scalp care solution: (A) 1.2-11% of the composition weight of the extract of the rhizome of Zingiber zerumbet Smith, wherein the extract of the rhizome of Zingiber zerumbet Smith is water extract of rhizome of Zingiber zerumbet Smith and ethanol extract of rhizome of Zingiber zerumbet Smith; (B) the scalp allergy-relieving conditioner accounts for 0.9-15% of the weight of the composition, and the scalp allergy-relieving conditioner is prepared from 0.5-8% of PEG-8 caprylic capric glyceride water-soluble oil, 0.3-10% of pentanediol humectant and 0.1-1.5% of peppermint oil; (C) denatured ethanol in an amount of 5-30% by weight of the composition; (D) and the balance of deionized water. The scalp care solution can effectively clean and refresh hairy roots and scalp, and reduce the symptoms of dandruff, scalp itch, scalp pimples and the like.
Description
Technical Field
The invention belongs to the field of daily chemicals, and particularly relates to a scalp care solution, in particular to a care solution with a scalp allergy-relieving effect.
Background
People pay less attention to the scalp in daily life than to hair, but have fewer problems not representing the scalp. The scalp, which is a specific extension of the skin, has six differences from the skin (1) the scalp secretes more oil and therefore needs oil control, (2) the stratum corneum of the scalp has a lower moisture content, (3) the scalp has a poorer barrier function, (4) the newcastle metabolism of the stratum corneum of the scalp requires a cleaner scalp, (5) the scalp is more prone to problems such as dandruff, itchiness, seborrheic dermatitis, acne or pimples, and (6) the scalp tastes heavier than the skin. The above analysis shows that the scalp is a susceptible part relative to the facial skin, and the susceptibility of the scalp relative to the skin causes the scalp to have more or less abnormal feelings such as scalp discomfort, scalp tightness, scalp swelling, dandruff and scalp itching, scalp pimples, scalp prickling, scalp redness, and other scalp abnormal feelings to the skin caused by temperature difference, humidity difference, microbial environment of the scalp (including bacteria and fungi on the scalp), and self barrier function loss of the scalp.
Allergy relief means relieving or repairing allergic symptoms. Particularly, the scalp can reduce the phenomena of scalp itching, dandruff and pimple on the scalp.
Therefore, the inventor needs to develop a hair-root-cleansing and scalp-refreshing composition which can reduce the occurrence of symptoms such as dandruff, scalp itching and scalp pimples. The scalp is recovered to a healthy micro-ecological environment through various ways such as scalp barrier repair, scalp antibiosis, scalp antianaphylaxis and the like.
Disclosure of Invention
The invention aims to provide a scalp care solution, and particularly provides a scalp soothing care solution.
The purpose of the invention is realized as follows: the allergy-relieving scalp care solution comprises the following components besides acceptable components of the scalp care solution:
(A) the rhizomes of the red ball ginger extract accounts for 1.2-11% of the weight of the care solution, and the rhizomes of the red ball ginger extract is a rhizomes of the red ball ginger water extract and a rhizomes of the red ball ginger ethanol extract, wherein the rhizomes of the red ball ginger water extract accounts for 1.0-8% of the weight of the care solution, and the rhizomes of the red ball ginger ethanol extract accounts for 0.2-3% of the weight of the care solution;
(B) the scalp allergy-relieving conditioner accounts for 0.9-15% of the weight of the care solution, the scalp allergy-relieving conditioner is a PEG-8 caprylic capric glyceride water-soluble oil accounting for 0.5-8% of the weight of the scalp allergy-relieving conditioner, and a pentanediol humectant accounting for 0.3-10% of the weight of the care solution, wherein the pentanediol humectant is 1,2 pentanediol or isoprene glycol, and the weight ratio of the two is 1,2 pentanediol: 1:10 of isoamyl glycol and peppermint oil accounting for 0.1 to 1.5 percent of the weight of the care solution;
(C) denatured ethanol in an amount of 5-30% by weight of the composition;
(D) and the balance of deionized water.
According to the nursing liquid, the rhizomes of the zingiber zerumbet turcz contain flavonoids and terpenoids, wherein the terpenoids are 2,6,9, 9-tetramethyl-2, 6, 10-cycloundecatrien-1-one, and the structural formula is shown as a formula I; the flavonoid is 5, 7-dihydroxy-2- (4-hydroxy-phenyl) -3-methoxy-benzopyran-4-ketone, and the structural formula is II:
2,6,9, 9-tetramethyl-2, 6, 10-cycloundecatrien-1-one of the formula I
The structural formula II is 5, 7-dihydroxy-2- (4-hydroxy-phenyl) -3-methoxy-benzopyran-4-ketone.
The scalp care solution of the present invention comprises: the water extract of the rhizomes of the red ball ginger accounts for 1.0 to 4 percent of the weight of the invention, and the ethanol extract of the rhizomes of the red ball ginger accounts for 0.2 to 1.2 percent of the weight of the invention; the water-soluble grease accounts for 3-6% of the weight of the invention; the weight of the pentanediol humectant is further optimized to be 3-6.6 percent, and the weight of the peppermint oil is further optimized to be 0.4-1 percent; the denatured ethanol accounts for 5-20% of the weight of the composition.
The scalp care solution of the present invention comprises: the pentanediol humectant is 1,2 pentanediol or isoprene glycol, and the weight ratio of the 1,2 pentanediol to the isoprene glycol is as follows: 1:5 of isopentyl glycol.
A allergy-relieving scalp care solution comprises the following components in percentage by weight of the composition:
the scalp soothing care solution comprises essence, an acid-base regulator, an antioxidant and a chelating agent which are accepted by the care solution.
Compared with the prior art, the invention has the following advantages:
the soothing scalp care solution is developed on the basis of physiological differentiation characteristics of head skin and face skin, and the formula composition has the technical characteristics of three aspects, namely, a root and stem extract of zingiber zerumbet is particularly adopted, a scalp soothing conditioner is adopted, and a solvent is adopted; wherein flavonoids and terpenes contained in the extract have antiinflammatory and antiallergic effects, and have scalp allergy relieving effect; the water-soluble grease, the pentanediol humectant and the peppermint oil contained in the scalp soothing conditioner respectively have the functions of rebuilding a scalp barrier, moisturizing the scalp and resisting bacteria, and have the functions of cleaning and refreshing the scalp and soothing the scalp; the solvent such as denatured ethanol plays a role in refreshing (cleaning) hair roots and synergistically soothing the scalp in the present invention. Clinical market adjustment shows that the technical characteristics of the scalp care solution have the effects of improving scalp health (improving scalp microenvironment balance), effectively cleaning and refreshing hair roots, refreshing scalp, and reducing symptoms such as dandruff, scalp itch, scalp pimples and the like.
Detailed Description
The present invention will be described in further detail with reference to examples.
The rhizomes extract of the zingiber zerumbet miq plays a role in diminishing inflammation and resisting allergy in the invention, and consists of a water extract of rhizomes of the zingiber zerumbet miq and an ethanol extract of rhizomes of the zingiber zerumbet miq, wherein active ingredients contained in the rhizomes extract of the zingiber zerumbet miq are flavonoids and terpenoids, wherein the flavonoids are 5, 7-dihydroxy-2- (4-hydroxy-phenyl) -3-methoxy-benzopyran-4-one, and the terpenoids are 2,6,9, 9-tetramethyl-2, 6, 10-cycloundecatriene-1-one;
the scalp allergy-relieving conditioner plays a role in repairing a scalp barrier, helping to reduce dandruff, and relieving scalp discomfort phenomena such as scalp itching and scalp pimples, and is composed of water-soluble grease, a pentanediol humectant and peppermint oil.
Rhizome extract of Zingiber zerumbet Mill: the Zingiber zerumbet (Hemsl.) Rosc is a perennial herb of Zingiberaceae with a plant height of 0.6-2 m; the total length of the pedicel is 10-30 cm; the inflorescence is spherical, the length is 6-15 cm, the width is 3.5-5 cm, the flowering period is 7-10 months, the bract is light green in 7-8 months, and the inflorescence gradually becomes red and spherical in 9-10 months. It is similar to red fire ball, so it is named as red ball ginger. Produced in provinces such as Guangdong, Guangxi and Yunnan provinces in China; it is in the shade and wet place. The tropical region of Asia is widespread. The rhizome can dispel wind and remove toxicity, treat stomachache and diarrhea, and can extract aromatic oil as a raw material of the blending essence.
The rhizome of Zingiber zerumbet Smith contains flavonoids and terpenes, which have anti-inflammatory and antiallergic effects. The extraction method of the red ball ginger rhizome can comprise a steam distillation method and an ethanol extraction method.
Water extract of red ball ginger rhizome
Steam distillation method: adding 500 ml of distilled water (weight ratio is 1:10) into 50 g of dry powder of the rhizome of the red ball ginger, refluxing for 4 hours at the temperature of 100 ℃, cooking, filtering, concentrating to 100 ml, and performing freeze drying treatment to obtain a water extract (dry powder) of the rhizome of the red ball ginger. HPLC test, recrystallization separation, proton nuclear magnetic resonance and mass spectrum experiment confirm that the terpene substance is 2,6,9, 9-tetramethyl-2, 6, 10-cycloundecatrien-1-one (shown in structural formula I) with molecular formula of C15H22O, melting point 67-69 deg.C, density 0.887g/cm3, refractive index 1.468 molecular weight 218.34. The content of 2,6,9, 9-tetramethyl-2, 6, 10-cycloundecatrien-1-one in the water extract of the rhizome of Zingiber zerumbet Smith obtained by water extraction method is 0.5-8 wt%, and is further optimized to 3-4 wt%.
The water extract of the red ball ginger rhizome accounts for 0.1 to 8 percent of the weight of the invention, and is further optimized to be 0.5 to 4 percent.
Structural formula I2, 6,9, 9-tetramethyl-2, 6, 10-cycloundecatrien-1-one molecular structural formula
Ethanol extract of red ball ginger rhizome
An ethanol method: or diluting the dry powder of the rhizomes of Zingiber zerumbet Smith with 10 times of ethanol (10 ml of ethanol per gram of dry powder of Zingiber zerumbet Smith), placing into a rotary evaporator, refluxing at 60 deg.C for 4 hr, filtering and concentrating the extract to 1/10 volume, filtering the extract, and lyophilizing to obtain the alcoholic extract (dry powder) of the rhizomes of Zingiber zerumbet Smith. The ethanol extract of the rhizomes of the zingiber zerumbet hance contains flavonoids, a crude flavonoid product is obtained by separation, purification and recrystallization through a silica gel column chromatography, and finally the flavonoid is determined to be 5, 7-dihydroxy-2- (4-hydroxy-phenyl) -3-methoxy-benzopyran-4-ketone (shown as a structural formula II) through a proton nuclear magnetic resonance and liquid-mass spectrometry combined instrument, the ethanol extract of the rhizomes of the zingiber zerumbet hance contains the flavonoid 5, 7-dihydroxy-2- (4-hydroxy-phenyl) -3-methoxy-benzopyran-4-ketone, and the molecular formula is as follows: C16H12O6, the content of 5, 7-dihydroxy-2- (4-hydroxy-phenyl) -3-methoxy-benzopyran-4-one in the ethanol extract of the rhizomes of Zingiber zerumbet Hance is 0.005-0.50 wt%, and further optimized to be 0.01-0.25 wt%.
The weight percentage of the ethanol extract of the red ball ginger rhizome accounts for 0.05 to 3 percent of the invention, and the ethanol extract is further optimized to be 0.1 to 1.2 percent.
The structural formula II is 5, 7-dihydroxy-2- (4-hydroxy-phenyl) -3-methoxy-benzopyran-4-ketone.
The red ball ginger rhizome extract is a red ball ginger rhizome water extract and a red ball ginger rhizome ethanol extract, and has anti-inflammatory and anti-allergic effects.
Scalp allergy-relieving conditioner: the scalp soothing conditioner disclosed by the invention is composed of water-soluble grease, a pentanediol humectant and peppermint oil.
The scalp allergy-relieving conditioner accounts for 0.1-15% of the weight of the care solution, wherein the water-soluble grease accounts for 1-8% of the weight of the scalp allergy-relieving conditioner, and the water-soluble grease is further optimized to be 2-6%.
The water-soluble oil of the present invention is a water-soluble vegetable oil such as oil obtained from fruit, seed, or embryo of a plant. Such as water-soluble oil obtained by esterifying polyglycerin such as peanut oil, soybean oil, linseed oil, castor oil, rapeseed oil, etc., the main component of the vegetable oil is ester generated from straight chain higher fatty acid and glycerin, and fatty glyceride contained in the vegetable oil can relieve skin and moisten skin with luster; and water-soluble oils and fats obtained by ethoxylation such as polyethylene glycol caprylic capric acid glyceride are water-soluble synthetic oils and fats obtained by ethoxylation. Caprylic capric acid glyceride is high-purity oil prepared by esterifying caprylic acid/capric acid and glycerol, is excellent moisturizing oil, has good spreadability, and can make skin feel smooth but not greasy, and be easily absorbed by skin. Has good effect on the uniformity and the fineness of cosmetics and can ensure that the skin is smooth and glossy. The caprylic/capric glyceride is formed by adding ethylene oxide to monocaprylic capric glyceride, and is PEG-6 caprylic/capric glyceride and PEG-8 caprylic/capric glyceride respectively. The water-soluble grease PEG-6 caprylic capric acid glyceride or PEG-8 caprylic capric acid glyceride can lubricate the scalp and has the function of repairing the scalp barrier. The water-soluble grease is preferably PEG-8 caprylic capric acid glyceride, and the PEG-8 caprylic capric acid glyceride accounts for 1-8% of the weight of the grease, and is further optimized to be 2-6%.
And (3) pentanediol: the invention contains 0.3-10% of the humectant of pentanediol based on the weight of the composition, and is further optimized to 1.8-7%, the pentanediol is 1,2 pentanediol or isoprene glycol, and the analysis of the structural formula shows that the antibacterial property of 1,2 pentanediol is better than that of isoprene glycol (the position of hydroxyl group is determined), and the fat-rich property of isoprene glycol is better than that of 1,2 pentanediol (the position of methyl group is determined), so when designing the formula, 1,2 pentanediol is preferred only from the antibacterial property consideration, and isoprene glycol is preferred from the skin touch and other aspects.
According to the invention, by combining the advantages of 1, 2-pentanediol and isoprene glycol according to a certain weight ratio, the optimal antibacterial and moisturizing properties can be exerted. The weight ratio of 1,2 pentanediol to isoprene glycol of the invention is 1,2 pentanediol: the isoprene glycol is 1:10, further optimized to 1: 5.
Peppermint oil: the mint oil accounts for 0.1-1.5% of the weight of the care solution, and is further optimized to be 0.2-1%.
The peppermint oil in the invention has the functions of relieving and calming the scalp, has an antibacterial effect, and has the functions of cleaning and refreshing the scalp and relieving the scalp.
Denatured ethanol; the modified ethanol accounts for 1-30% of the weight of the care solution, and is further optimized to be 5-20%.
The denatured ethanol used in the present invention is dealdehydized ethanol. The denatured ethanol plays a role in system stabilization, and has the effects of synergistic solubilization, hair root cleaning (cleaning) and scalp synergistic relief on active substances in the care solution.
The scalp care solutions of the present invention also comprise cosmetically acceptable carriers such as: glycerin, propylene glycol, polyethylene glycol-400, essence, an acid-base regulator, an antioxidant and a chelating agent, wherein the antioxidant is a grease antioxidant commonly used in the field, such as: 2, 6-di-tert-butyl-4-methylphenol. The chelating agent is a chelating agent commonly used in the art, preferably sodium EDTA-2, and the pH regulator is a pH regulator commonly used in the art, preferably sodium citrate. The addition of these substances is not limited and can be determined at the discretion of the person skilled in the art. For example, an antioxidant may be added in an amount of 0.04 to 0.14% by weight, or polyethylene glycol-400 (PEG-400) may be added in an amount of 1 to 10% by weight, based on the weight of the care solution of the present invention.
The method for preparing the allergy-relieving scalp care solution comprises the following steps:
1. weighing the components according to the formula;
2. adding essence, rhizoma Zingiberis recens rhizome extract, and scalp allergy-relieving conditioner into denatured ethanol, mixing, and stirring to obtain ethanol solution;
3. adding chelating agent, adding deionized water to 100 wt%, stirring, and regulating pH to 4-6.
The following table 1 is a non-limiting example of the scalp care solution of the present invention and these examples are given for illustrative purposes only and are not intended to limit the scope of the present invention as many variations of the present invention are possible without departing from the spirit and scope of the present invention. Unless otherwise indicated.
The technical means used in the examples are conventional means well known to those skilled in the art, and the raw materials used are all commercially available products.
Examples I to V (where examples I and II are comparative examples of the invention)
Examples VI to X (where example VI is a comparative example of the invention)
The best embodiment of the invention is as follows:
| components | The content is% |
| Water extract of red ball ginger rhizome | 3.0 |
| Ethanol extract of red ball ginger rhizome | 1.0 |
| PEG-8 caprylic capric acid glyceride | 5.5 |
| 1,2 pentanediol | 1.0 |
| Isoprenyl glycols | 5.0 |
| Mint oil | 0.9 |
| Denatured ethanol | 18 |
| PEG-400 | 9 |
| 2, 6-di-tert-butyl-4-methylphenol | 0.12 |
| Ethylenediaminetetraacetic acid disodium salt | 1.0 |
| Sodium citrate, colorant, perfume | Proper amount of |
| Water (W) | Adding to 100 percent |
Evaluation of scalp allergy-relieving Effect
The subject of the invention is scalp allergy relief, so the efficacy of the volunteers corresponding to the embodiment of the invention in dandruff, scalp itch, hair pimples and the like is mainly evaluated in the efficacy evaluation aspect of the invention.
Evaluation of dandruff, scalp itching, and scalp pimple formation
Using objects
200 volunteers with more dandruff, itchy scalp and pimples on the scalp are selected, and the age of the volunteers is 25-45 years, and 100 men and women are selected. Groups were randomized into 10 groups of 20 people each (half the proportion of men and women).
Application method
The volunteers who select the pimples with much scurf, itchy hair and pimples on the scalp respectively use the product of the embodiment of the invention once a day (used at night) and continuously use for 10 days, and the symptoms of much scurf, itchy hair and pimples on the scalp are compared before and after use, and the effect is shown in table 1
TABLE 1
As shown in Table 1, the effective percentages of the examples III, IV, V, VII, VIII, IX and X of the present invention in three aspects of dandruff, scalp itch and scalp keloid increase in a gradient manner, which shows that the effective percentages of the examples III to X (except for the comparison of example VI) in 7 examples exhibit an enhanced trend of scalp allergy-relieving effects (such as the effective rates of dandruff, scalp itch and scalp keloid) with the increase of the weight percentage of the active ingredients in the scalp care solution, such as the extract of the rhizome of Zingiber zerumbet Smith and the scalp allergy-relieving conditioning agent, and the comprehensive effect of example IX is the best.
In addition, the scalp soothing effects (e.g., effective rate of dandruff, itchy head and pimples on the scalp) of the remaining 3 comparative examples, such as example i (comparative), example ii (comparative) and example vi (comparative) were much lower than those of the remaining 7 examples; meanwhile, the example I (comparison) does not contain the active ingredients such as the rhizomes extract of Zingiber zerumbet Smith and the scalp allergy-relieving conditioner described in the description of the invention, compared with the example II (comparison) and the example VI (comparison) which only contain the active ingredients of the scalp allergy-relieving conditioner, the scalp allergy-relieving effect (such as the effective rate of dandruff, scalp itch and scalp pimple) of the example I (comparison) is the lowest, and compared with the example II (comparison) and the example VI (comparison), the scalp allergy-relieving effect (such as the effective rate of dandruff, scalp itch and scalp pimple) of the example VI (comparison) is the best in 3 comparison examples, which shows that the scalp allergy-relieving effect of the example is increased along with the increase of the addition amount of the scalp allergy-relieving conditioner.
The preparation method of the allergy-relieving scalp care solution comprises the following steps:
1. weighing the components according to the formula;
2. adding essence, rhizoma Zingiberis recens rhizome extract, and scalp allergy-relieving conditioner into denatured ethanol, mixing, and stirring to obtain ethanol solution;
3. adding 2, 6-di-tert-butyl-4-methylphenol, PEG-400, chelating agent, sodium citrate and colorant, supplementing to 100% by weight with deionized water, stirring well, and adjusting pH to 4-6.
Claims (5)
1. The allergy-relieving scalp care solution comprises the following components besides acceptable components of the scalp care solution:
(A) the rhizomes of the red ball ginger extract accounts for 1.2-11% of the weight of the care solution, and the rhizomes of the red ball ginger extract is a rhizomes of the red ball ginger water extract and a rhizomes of the red ball ginger ethanol extract, wherein the rhizomes of the red ball ginger water extract accounts for 1.0-8% of the weight of the care solution, and the rhizomes of the red ball ginger ethanol extract accounts for 0.2-3% of the weight of the care solution;
(B) the scalp allergy-relieving conditioner accounts for 0.9-15% of the weight of the care solution, the scalp allergy-relieving conditioner is prepared from PEG-8 caprylic capric glyceride water-soluble oil accounting for 0.5-8% of the weight of the care solution, and a pentanediol humectant accounting for 0.3-10% of the weight of the care solution, wherein the pentanediol humectant is 1,2 pentanediol or isoprene glycol, and the weight ratio of the two is 1,2 pentanediol: 1:10 of isoamyl glycol and peppermint oil accounting for 0.1 to 1.5 percent of the weight of the care solution;
(C) denatured ethanol in an amount of 5-30% by weight of the composition;
(D) and the balance of deionized water.
2. The scalp care solution according to claim 1, wherein the rhizome of zingiber zerumbet sm contains flavonoids and terpenes, wherein the terpenes are 2,6,9, 9-tetramethyl-2, 6, 10-cycloundecatrien-1-one, and have the structural formula of formula i; the flavonoid is 5, 7-dihydroxy-2- (4-hydroxy-phenyl) -3-methoxy-benzopyran-4-ketone, and the structural formula is II:
3. a scalp care solution according to claim 1 wherein: the water extract of the rhizomes of the red ball ginger accounts for 1 to 4 percent of the weight of the care solution, and the ethanol extract of the rhizomes of the red ball ginger accounts for 0.2 to 1.2 percent of the weight of the care solution; the water-soluble grease accounts for 3-6% of the weight of the care solution; the pentanediol humectant accounts for 3-6.6% of the weight of the care solution, and the peppermint oil accounts for 0.4-1% of the weight of the care solution; the denatured ethanol accounts for 5-20% of the weight of the care solution.
4. A scalp care solution according to claim 3 wherein: the pentanediol humectant is 1,2 pentanediol or isoprene glycol, and the weight ratio of the 1,2 pentanediol to the isoprene glycol is as follows: 1:5 of isopentyl glycol.
5. The allergy-relieving scalp care solution comprises the following components in percentage by weight:
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| CN201710780074.5A CN107412109B (en) | 2017-09-01 | 2017-09-01 | Allergy-relieving scalp care solution |
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| FR3107185B1 (en) * | 2018-12-06 | 2024-01-12 | Fabre Pierre Dermo Cosmetique | Zingiber zerumbet extract to fight dandruff |
| FR3089414B1 (en) * | 2018-12-06 | 2021-05-07 | Fabre Pierre Dermo Cosmetique | Zingiber zerumbet extract to fight dandruff |
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| US5925615A (en) * | 1998-03-06 | 1999-07-20 | Nu Skin International, Inc. | Awapuhi (Zingiber zerumbet) -containing hair cleansing and conditioning compositions |
| AU2005274765B2 (en) * | 2004-07-23 | 2012-08-30 | Arjil Pharmaceuticals Llc | Anti-hypersensitive inflammation and anti-allergy activities of Zingiber zerumbet (L.) Smith |
| CN104000749B (en) * | 2014-05-30 | 2016-09-07 | 纳爱斯集团有限公司 | A kind of scalp nursing solution |
| CN104887578B (en) * | 2015-06-05 | 2018-07-31 | 广州环亚化妆品科技有限公司 | A kind of composition and hair conditioner with scalp care function of not silicate-containing oil |
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