CN107405348B - Raf抑制剂与紫杉烷的组合 - Google Patents

Raf抑制剂与紫杉烷的组合 Download PDF

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Publication number
CN107405348B
CN107405348B CN201580073526.5A CN201580073526A CN107405348B CN 107405348 B CN107405348 B CN 107405348B CN 201580073526 A CN201580073526 A CN 201580073526A CN 107405348 B CN107405348 B CN 107405348B
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China
Prior art keywords
cancer
raf
compound
pharmaceutically acceptable
ras
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CN201580073526.5A
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English (en)
Chinese (zh)
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CN107405348A (zh
Inventor
V·博泽恩
K·M·加尔文
R·L·布雷克
Q·徐
K·卡纳安
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Point Therapy 1 Co
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Point Therapy 1 Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580073526.5A 2014-12-23 2015-12-22 Raf抑制剂与紫杉烷的组合 Active CN107405348B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462096020P 2014-12-23 2014-12-23
US62/096,020 2014-12-23
US201562242629P 2015-10-16 2015-10-16
US62/242,629 2015-10-16
PCT/US2015/067462 WO2016106359A1 (en) 2014-12-23 2015-12-22 Combination of raf inhibitors and taxanes

Publications (2)

Publication Number Publication Date
CN107405348A CN107405348A (zh) 2017-11-28
CN107405348B true CN107405348B (zh) 2021-06-11

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Family Applications (1)

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CN201580073526.5A Active CN107405348B (zh) 2014-12-23 2015-12-22 Raf抑制剂与紫杉烷的组合

Country Status (7)

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US (2) US20190117652A1 (cg-RX-API-DMAC7.html)
EP (1) EP3236966B1 (cg-RX-API-DMAC7.html)
JP (2) JP2018502087A (cg-RX-API-DMAC7.html)
CN (1) CN107405348B (cg-RX-API-DMAC7.html)
CA (1) CA2972189A1 (cg-RX-API-DMAC7.html)
ES (1) ES2827024T3 (cg-RX-API-DMAC7.html)
WO (1) WO2016106359A1 (cg-RX-API-DMAC7.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4065122A4 (en) * 2019-11-27 2023-12-27 Day One Biopharmaceuticals, Inc. Solid dispersion of pan-raf kinase inhibitor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102300854A (zh) * 2008-12-02 2011-12-28 武田药品工业株式会社 作为抗癌剂的苯并噻唑衍生物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2008001933A1 (es) * 2007-06-29 2009-09-25 Millennium Pharm Inc Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros.
CA2924418A1 (en) * 2007-07-30 2009-02-05 Jean-Michel Vernier Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same
JP2012511021A (ja) * 2008-12-05 2012-05-17 アークル インコーポレイテッド Ｒａｆの阻害剤およびその使用
US20120214828A1 (en) * 2009-08-24 2012-08-23 Georgia Hatzivassiliou Determining sensitivity of cells to b-raf inhibitor treatment by detecting kras mutation and rtk expression levels
CN104428001A (zh) * 2012-03-30 2015-03-18 武田药品工业有限公司 Raf抑制剂和mek抑制剂在黑素瘤治疗中的投与
RU2708247C2 (ru) * 2013-03-05 2019-12-05 Юниверсити Оф Теннесси Рисерч Фаундейшн Соединение для лечения рака
UY36046A (es) * 2014-03-26 2015-10-30 Millennium Pharm Inc Formulaciones farmacéuticas, procesos para la preparación y métodos de uso

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102300854A (zh) * 2008-12-02 2011-12-28 武田药品工业株式会社 作为抗癌剂的苯并噻唑衍生物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A Phase 1B Study of MLN2480 in Combination With MLN0128 or Alisertib, or Paclitaxel, or Cetuximab, or Irinotecan in Adult Participants With Advanced Nonhematologic Malignancies;U.S.National Library of Medicine;《http://clinicaltrials.gov/ct2/show/nct02327169》;20141230;第1-13页 *

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Publication number Publication date
CA2972189A1 (en) 2016-06-30
US20200316067A1 (en) 2020-10-08
WO2016106359A1 (en) 2016-06-30
EP3236966A1 (en) 2017-11-01
JP2020114857A (ja) 2020-07-30
JP2018502087A (ja) 2018-01-25
CN107405348A (zh) 2017-11-28
ES2827024T3 (es) 2021-05-19
US20190117652A1 (en) 2019-04-25
EP3236966B1 (en) 2020-08-12
EP3236966A4 (en) 2018-10-03

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