CN107405321A - 短链脂肪酸在癌症预防中的应用 - Google Patents

短链脂肪酸在癌症预防中的应用 Download PDF

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Publication number
CN107405321A
CN107405321A CN201680017250.3A CN201680017250A CN107405321A CN 107405321 A CN107405321 A CN 107405321A CN 201680017250 A CN201680017250 A CN 201680017250A CN 107405321 A CN107405321 A CN 107405321A
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Prior art keywords
acid
composition
mice
cancer
hbx
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CN201680017250.3A
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Chinese (zh)
Inventor
H·M·G·P·V·雷斯
M·A·斐特尔森
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Temple Univ School of Medicine
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Temple Univ School of Medicine
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Priority to CN202210967776.5A priority Critical patent/CN115350171A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Non-Alcoholic Beverages (AREA)
CN201680017250.3A 2015-01-23 2016-01-21 短链脂肪酸在癌症预防中的应用 Pending CN107405321A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210967776.5A CN115350171A (zh) 2015-01-23 2016-01-21 短链脂肪酸在癌症预防中的应用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562106778P 2015-01-23 2015-01-23
US62/106,778 2015-01-23
PCT/US2016/014292 WO2016118730A1 (en) 2015-01-23 2016-01-21 Use of short chain fatty acids in cancer prevention

Related Child Applications (1)

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CN202210967776.5A Division CN115350171A (zh) 2015-01-23 2016-01-21 短链脂肪酸在癌症预防中的应用

Publications (1)

Publication Number Publication Date
CN107405321A true CN107405321A (zh) 2017-11-28

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CN201680017250.3A Pending CN107405321A (zh) 2015-01-23 2016-01-21 短链脂肪酸在癌症预防中的应用
CN202210967776.5A Pending CN115350171A (zh) 2015-01-23 2016-01-21 短链脂肪酸在癌症预防中的应用

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US (6) US10231941B2 (https=)
EP (1) EP3247342B1 (https=)
JP (4) JP6783247B2 (https=)
KR (1) KR102735818B1 (https=)
CN (2) CN107405321A (https=)
AU (3) AU2016209244A1 (https=)
IL (1) IL253581A0 (https=)
MX (1) MX387817B (https=)
RU (1) RU2017127597A (https=)
SG (2) SG11201705953XA (https=)
WO (1) WO2016118730A1 (https=)
ZA (1) ZA201704977B (https=)

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CN110090230A (zh) * 2018-01-30 2019-08-06 青岛东海药业有限公司 凝结芽孢杆菌在制备预防或治疗胆管癌制剂中的应用
CN113116940A (zh) * 2020-01-14 2021-07-16 景岳生物科技股份有限公司 一种副干酪乳杆菌gmnl-346用于抗口腔癌之用途
CN115210364A (zh) * 2019-09-25 2022-10-18 马尔堡菲利普大学 短链脂肪酸戊酸作为细胞疗法和抗肿瘤疗法的增强剂
CN116212027A (zh) * 2023-02-28 2023-06-06 西湖大学 一种调控Treg细胞内铁水平的试剂的用途
CN116782949A (zh) * 2020-11-12 2023-09-19 英联邦高等教育系统天普大学 短链脂肪酸在癌症预防中的用途
CN119258047A (zh) * 2024-11-26 2025-01-07 哈尔滨医科大学 琥珀酸在制备防治肝癌药物中的新用途
WO2025176152A1 (en) * 2024-02-19 2025-08-28 The University Of Hong Kong Probiotics mixtures and methods of use thereof for treating cancers

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JP2023517869A (ja) * 2020-03-05 2023-04-27 リスキュア・バイオサイエンシーズ・カンパニー・リミテッド ロイコノストック属株を有効成分として含む癌の予防又は治療用医薬組成物
US20240009154A1 (en) * 2020-08-04 2024-01-11 Temple University-Of The Commonwealth System Of Higher Education Methods and compositions for treating cytokine release syndrome
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WO2022177409A1 (ko) * 2021-02-22 2022-08-25 주식회사 리스큐어바이오사이언시스 류코노스톡 메센테로이데스 균주 유래 나노소포체를 유효성분으로 포함하는 암의 예방 또는 치료용 약학 조성물
WO2023141202A1 (en) * 2022-01-19 2023-07-27 Hodgdon Ian Short-chain fatty acids for cancer treatment
CN117925434B (zh) * 2022-10-26 2025-02-14 慕恩（广州）生物科技有限公司 粪肠球菌mnh 22871及其应用
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CN110090230A (zh) * 2018-01-30 2019-08-06 青岛东海药业有限公司 凝结芽孢杆菌在制备预防或治疗胆管癌制剂中的应用
CN110090230B (zh) * 2018-01-30 2022-07-12 青岛东海药业有限公司 凝结芽孢杆菌在制备预防或治疗胆管癌制剂中的应用
CN115210364A (zh) * 2019-09-25 2022-10-18 马尔堡菲利普大学 短链脂肪酸戊酸作为细胞疗法和抗肿瘤疗法的增强剂
CN113116940A (zh) * 2020-01-14 2021-07-16 景岳生物科技股份有限公司 一种副干酪乳杆菌gmnl-346用于抗口腔癌之用途
CN113116940B (zh) * 2020-01-14 2023-09-29 景岳生物科技股份有限公司 一种副干酪乳杆菌gmnl-346用于抗口腔癌之用途
CN116782949A (zh) * 2020-11-12 2023-09-19 英联邦高等教育系统天普大学 短链脂肪酸在癌症预防中的用途
CN116212027A (zh) * 2023-02-28 2023-06-06 西湖大学 一种调控Treg细胞内铁水平的试剂的用途
WO2025176152A1 (en) * 2024-02-19 2025-08-28 The University Of Hong Kong Probiotics mixtures and methods of use thereof for treating cancers
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