CN107397974B - 一种治疗慢性创伤的创贴 - Google Patents
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Abstract
本发明公开了属于医疗用敷料制备技术领域的一种治疗慢性创伤的创贴。由基质布层，海藻绵层和纺丝治疗层组成；纺丝治疗层由三层共轴的纺丝构成；第一层纺丝内设有黄柏提取物；第二层纺丝内设有成纤维细胞生长因子；第三层纺丝内设有冰片。本发明的慢创贴符合6864医用卫生材料及敷料、6866医用高分子材料及制品，参照二类医疗器械产品标准，具有治疗性功能，能够为创伤皮肤消炎、生肌、恢复组织生长，适合于一般性创伤、慢性创伤的治疗。
Description
技术领域
本发明属于医疗用敷料制备技术领域，具体涉及一种适用于一般性创伤、慢性创伤的创贴。
背景技术
创伤可以根据发生地点、受伤部位、受伤组织、致伤因素及皮肤完整程度进行分类。按发生地点分为战争伤、工业伤、农业伤、交通伤、体育伤、生活伤等；按受伤部位分为颅脑创伤、胸部创伤、腹部创伤、各部位的骨折和关节脱位、手部伤等；按受伤类型分为骨折、脱位、脑震荡、器官破裂等；相邻部位同时受伤者称为联合伤；按受伤的组织或器官分类时，又可按受伤组织的深浅分为软组织创伤、骨关节创伤和内脏创伤。软组织创伤指皮肤、皮下组织和肌肉的损伤，也包括行于其中的血管和神经。单纯的软组织创伤一般较轻，但广泛的挤压伤可致挤压综合征。血管破裂大出血亦可致命。骨关节创伤包括骨折和脱位，并按受伤的骨或关节进一步分类并命名。如股骨骨折、肩关节脱位等。内脏创伤又可按受伤的具体内脏进行分类和命名。如脑挫裂伤、肺挫伤、肝破裂等。同一致伤原因引起两个以上部位或器官的创伤，称为多处伤或多发伤。按致伤因素，分为火器伤、切伤、刺伤、撕裂伤、挤压伤、扭伤、挫伤等。按皮肤完整程度，分为闭合性创伤、开放性创伤等。
目前，治疗创伤主要采用创口贴，口服药物等治疗，容易感染细菌，愈合后留下伤疤等，对于一些慢性创伤，尤其难以治愈。专利200310124306.X公开了一种生物性创伤敷料，其获自经处理的选自皮肤、小肠粘膜和羊膜的动物性材料，其保持表皮的生物学结构和成分，在真皮部分下层接触创面层中具有无细胞基质，并保留了细胞外基质原始形状，不含可引起宿主生物排斥的细胞性成分。该敷料使用后，容易感染细菌，不容易生肌，创伤修复后产生较大的疤痕。
发明内容
本发明的目的在于提供一种适用于一般性创伤、慢性创伤的创贴。
一种治疗慢性创伤的创贴，由基质布层1，海藻绵层2和纺丝治疗层3组成；
所述纺丝治疗层3由三层共轴的纺丝4构成；所述第一层纺丝内设有黄柏提取物；所述第二层纺丝内设有成纤维细胞生长因子；所述第三层纺丝内设有冰片。
所述基质布层1上开设有透气孔5。
所述三层共轴的纺丝4的材质为丝素、壳聚糖、蚕丝、竹纤维中的一种或一种以上。
所述黄柏提取物采用如下方法提取：将黄柏晒干，磨成粉末，加3-5倍重量份数的水回流提取3次，合并滤液，蒸干制成。
所述第一层纺丝内还设有青木香提取物，所述青木香提取物采用如下方法提取：将青木香晒干，磨成粉末，加3-5倍重量份数的水回流提取3次，合并滤液，蒸干制成。
所述成纤维细胞生长因子为FGF1、FGF2、FGF3、FGF4中的一种或一种以上。
所述第二层纺丝内设有青金石粉末。
上述治疗慢性创伤的创贴在消炎、生肌、恢复组织生长中的应用。
本发明的有益效果：本发明的治疗慢性创伤的创贴符合6864医用卫生材料及敷料、6866医用高分子材料及制品，参照二类医疗器械产品标准，具有治疗性功能，能够为创伤皮肤消炎、生肌、恢复组织生长，适合于一般性创伤、慢性创伤的治疗。
附图说明
图1为本发明治疗慢性创伤的创贴结构示意图；
图2为基质布层上的透气孔结构；
图3为三层共轴的纺丝结构示意图；
图中，1-基质布层、2-海藻绵层、3-纺丝治疗层、4-三层共轴的纺丝、5-透气孔。
具体实施方式
下面结合附图和具体实施例对本发明做进一步说明。
实施例1
一种治疗慢性创伤的创贴，如图1-3所示，由基质布层1，海藻绵层2和纺丝治疗层3组成；所述纺丝治疗层3由三层共轴的纺丝4构成；所述第一层纺丝内设有黄柏提取物；所述第二层纺丝内设有成纤维细胞生长因子FGF2；所述第三层纺丝内设有冰片。所述基质布层1上开设有透气孔5。
所述三层共轴的纺丝4的材质为丝素和壳聚糖按照质量比1:1混合纺成。
所述黄柏提取物采用如下方法提取：将黄柏晒干，磨成粉末，加4倍重量份数的水回流提取3次，合并滤液，蒸干制成。
实施例2
一种治疗慢性创伤的创贴，如图1-3所示，由基质布层1，海藻绵层2和纺丝治疗层3组成；所述纺丝治疗层3由三层共轴的纺丝4构成；所述第一层纺丝内设有黄柏提取物；所述第二层纺丝内设有成纤维细胞生长因子FGF3；所述第三层纺丝内设有冰片。所述基质布层1上开设有透气孔5。
所述三层共轴的纺丝4的材质为蚕丝。
所述黄柏提取物采用如下方法提取：将黄柏晒干，磨成粉末，加5倍重量份数的水回流提取3次，合并滤液，蒸干制成。
所述第一层纺丝内还设有青木香提取物，所述青木香提取物采用如下方法提取：将青木香晒干，磨成粉末，加4倍重量份数的水回流提取3次，合并滤液，蒸干制成。
实施例3
一种治疗慢性创伤的创贴，如图1-3所示，由基质布层1，海藻绵层2和纺丝治疗层3组成；所述纺丝治疗层3由三层共轴的纺丝4构成；所述第一层纺丝内设有黄柏提取物；所述第二层纺丝内设有成纤维细胞生长因子FGF4和青金石粉末，所述第三层纺丝内设有冰片。所述基质布层1上开设有透气孔5。
所述三层共轴的纺丝4的材质为竹纤维。
所述黄柏提取物采用如下方法提取：将黄柏晒干，磨成粉末，加5倍重量份数的水回流提取3次，合并滤液，蒸干制成。
实施例4
一种治疗慢性创伤的创贴，如图1-3所示，由基质布层1，海藻绵层2和纺丝治疗层3组成；所述纺丝治疗层3由三层共轴的纺丝4构成；所述第一层纺丝内设有黄柏提取物；所述第二层纺丝内设有成纤维细胞生长因子FGF2；所述第三层纺丝内设有冰片。所述基质布层1上开设有透气孔5。
所述三层共轴的纺丝4的材质为丝素和壳聚糖按照质量比1:1混合纺成。
提取物采用如下方法提取：将黄柏晒干，磨成粉末，加4倍重量份数的水回流提取3次，合并滤液，蒸干制成。
所述第三层纺丝内还设有洋椿提取物，所述洋椿提取物采用如下方法提取：将洋椿晒干，磨成粉末，加5倍重量份数的水回流提取3次，合并滤液，蒸干制成。
对比例1
一种治疗慢性创伤的创贴，如图1-3所示，由基质布层1，海藻绵层2和纺丝治疗层3组成；所述纺丝治疗层3由三层共轴的纺丝4构成；所述第二层纺丝内设有成纤维细胞生长因子FGF2；所述第三层纺丝内设有冰片。所述基质布层1上开设有透气孔5。
所述三层共轴的纺丝4的材质为丝素和壳聚糖按照质量比1:1混合纺成。
实验例：
选取创伤病人500名，均为皮外伤，伤口大小深浅基本一致，分为5组，每组100人，分别使用实施例1-4的慢创贴及对比例1的创口贴，每天1贴，使用60天，治愈率分别为：实施例1为75％，实施例2为85％，实施例3为85％，实施例4为95％，对比例1为60％；治疗过程中感染病菌导致发炎的概率：实施例1为12％，实施例2为13％，实施例3为2％，实施例4为2％，对比例1为25％。
Claims (1)
1.一种治疗慢性创伤的创贴，其特征在于，由基质布层1，海藻绵层2和纺丝治疗层3组成；所述纺丝治疗层3由三层共轴的纺丝4构成；所述第一层纺丝内设有黄柏提取物；所述第二层纺丝内设有成纤维细胞生长因子FGF2；所述第三层纺丝内设有冰片；所述基质布层1上开设有透气孔5；
所述三层共轴的纺丝4的材质为丝素和壳聚糖按照质量比1:1混合纺成；黄柏提取物采用如下方法提取：将黄柏晒干，磨成粉末，加4倍重量份数的水回流提取3次，合并滤液，蒸干制成；
所述第三层纺丝内还设有洋椿提取物，所述洋椿提取物采用如下方法提取：将洋椿晒干，磨成粉末，加5倍重量份数的水回流提取3次，合并滤液，蒸干制成。
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