CN107281328A - One kind treats dermopathic herbal composite and its manufacture method - Google Patents

One kind treats dermopathic herbal composite and its manufacture method Download PDF

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Publication number
CN107281328A
CN107281328A CN201710425583.6A CN201710425583A CN107281328A CN 107281328 A CN107281328 A CN 107281328A CN 201710425583 A CN201710425583 A CN 201710425583A CN 107281328 A CN107281328 A CN 107281328A
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CN
China
Prior art keywords
parts
herbal composite
pigeonpea
manufacture method
dermopathic
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Pending
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CN201710425583.6A
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Chinese (zh)
Inventor
王安
王一安
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Individual
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Individual
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Priority to CN201710425583.6A priority Critical patent/CN107281328A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/85Verbenaceae (Verbena family)
    • A61K36/855Clerodendrum, e.g. glorybower
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234Cnidium (snowparsley)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/37Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention provides one kind and treats dermopathic herbal composite and its manufacture method, and wherein herbal composite is made up of following parts by weight raw material:35 parts of picria fel tarrae, 6 10 parts of pigeonpea, 6 10 parts of frutus cnidii, 25 parts of rose glorybower root, 10 15 parts of Celastrus angulatus, 10 15 parts of Chinese alangium leaf.Said composition further comprises the ethanol used in the fabrication process, AEO, alkylglycoside, dodecyl benzyl dimethyl ammonium chloride, OIT.The composition being made is having good effect to treating for skin disease, to no skin irritation.

Description

One kind treats dermopathic herbal composite and its manufacture method
Technical field
The present invention relates to field of traditional Chinese medicine technology, more particularly to one kind treats dermopathic herbal composite and its system Make method.
Background technology
Skin disease be skin (including hair and first) by after the influence of internal and external factor, its form, 26S Proteasome Structure and Function are sent out Changing, produces pathologic process.The dermopathic incidence of disease is high, and most of illnesss are light, not unhealthful.But minority is heavier or even can With threat to life.
At present, treat above-mentioned skin disease and be broadly divided into western medical treatment and Chinese traditional treatment.Treating skin disease is typically adopted at present With the external application of ointment of Western medicine, effect is general.Doctor trained in Western medicine is more with calm, stable, hypnosis and antihistamine, hormone medicine, or using general Shandong cacaine vein closing or calcium agent intravenous injection, not only effect is not good, and side effect is big, is often accompanied by allergic etc. bad anti- Should, injected organism tissue and skin injury, and easily recurrence are easily caused, patient is more, and bitter its tires out.The traditional Chinese medical science is then more with dispelling wind dampness removing, clearly It is heat, dampness removing, antipruritic;Or clearing liver-fire, nourishing the blood to expel wind is moisturized, for the purpose of enriching the blood to restore normal menstruation, though it is with strong points, it is small using scope, With larger limitation, easily recurrence.
The content of the invention
Dermopathic herbal composite and manufacture method are treated it is an object of the present invention to provide one kind, therapeutic effect is good, with Solve the undesirable effect that currently used doctor trained in Western medicine technology treatment is produced.
The present invention treats dermopathic herbal composite by providing one kind, and it includes the raw material of following parts by weight: 3-5 parts of picria fel tarrae, 6-10 parts of pigeonpea, 6-10 parts of frutus cnidii, 2-5 parts of rose glorybower root, 10-15 parts of Celastrus angulatus, Chinese alangium leaf 10-15 Part.
The above-mentioned dermopathic herbal composite for the treatment of, including following parts by weight raw material:5 parts of picria fel tarrae, 10 parts of pigeonpea, 7 parts of frutus cnidii, 3 parts of rose glorybower root, 15 parts of Celastrus angulatus, 15 parts of Chinese alangium leaf.
The preparation method of the herbal composite is:Total medicinal material is obtained after ethanol solution second extraction concentration Chinese herbal medicine to contain Amount 8% medicinal extract, by 1kg AEOs, 1.5kg alkylglycosides, 0.5kg dodecyl benzyl dimethyl ammonium chlorides, 2kg OITs are dissolved in 10kg deionized water, add the medicinal extract that 8kg is concentrated to give.Mixture heating stirring 4hr, 20 DEG C of elimination insoluble matters are cooled to get product.
The formula of the present invention has the following effects that:
Picria fel tarrae, clearing heat and detoxicating, swelling and pain relieving.
Pigeonpea, clearing heat and detoxicating, tonifying middle-Jiao and Qi, inducing diuresis and reducing edema, blood stasis removing analgesic, blood stasis and swelling pain.
Frutus cnidii, warming kidney and enhancing yang, dispelling wind and arresting itching.
Rose glorybower root, invigorating the spleen tonifying Qi, promoting blood circulation, subdhing swelling and detoxicating, dizzy for controlling uterine bleeding, void is coughed, hypertension, rheumatalgia.
Celastrus angulatus, heat-clearing and damp-drying drug, detoxify desinsection.
Chinese alangium leaf, stagnation resolvation synthetism effect.
AEO, is with relatively low excitant and biology with wetting, emulsification, hard water resistance characteristic The nonionic surfactant of degradation function.
Alkylglycoside, it is weak to skin irritation, with broad spectrum antibiotic activity.
Dodecyl benzyl dimethyl ammonium chloride, the sterilization algae removal ability with broad-spectrum high efficacy.
OIT, a kind of wide spectrum, efficient, low toxicity, non-oxidative bactericide.
The dermopathic herbal composite raw material for the treatment of that the present invention is provided is natural Chinese medicinal herb, and human skin is acted on Gently, with preferable therapeutic effect.The compound added in the processing procedure of Chinese herbal medicine can increase finished product curative effect and Store duration.The present invention can solve the present situation that western medicines in treatment limitation of the prior art is big, therapeutic effect is not good.
Embodiment
This specification will be further illustrated by following examples.
Embodiment 1
One kind treats dermopathic herbal composite, including following parts by weight raw material:3 parts of picria fel tarrae, 7 parts of pigeonpea, 7 parts of frutus cnidii, 3 parts of rose glorybower root, 10 parts of Celastrus angulatus, 10 parts of Chinese alangium leaf.
Embodiment 2
One kind treats dermopathic herbal composite, including following parts by weight raw material:4 parts of picria fel tarrae, 7 parts of pigeonpea, 8 parts of frutus cnidii.
Embodiment 3
One kind treats dermopathic herbal composite, including following parts by weight raw material:3 parts of picria fel tarrae, 9 parts of pigeonpea, 6 parts of frutus cnidii, 4 parts of rose glorybower root, 13 parts of Celastrus angulatus, 15 parts of Chinese alangium leaf.
Embodiment 4
One kind treats dermopathic herbal composite, including following parts by weight raw material:4 parts of picria fel tarrae, 8 parts of pigeonpea, 6 parts of frutus cnidii, 3 parts of rose glorybower root, 12 parts of Celastrus angulatus, 14 parts of Chinese alangium leaf.
Embodiment 5
One kind treats dermopathic herbal composite, including following parts by weight raw material:5 parts of picria fel tarrae, 9 parts of pigeonpea, 6 parts of frutus cnidii.
Embodiment 6
One kind treats dermopathic herbal composite, including following parts by weight raw material:4 parts of picria fel tarrae, 8 parts of pigeonpea, 6 parts of frutus cnidii, 3 parts of rose glorybower root, 10 parts of Celastrus angulatus, 15 parts of Chinese alangium leaf.
Clinical test
Experimental group:Using the herbal composite product of embodiment 1 through manufacturing obtained medicament, using external application affected part Mode, it is continuous to use 14 days daily using twice.
Control group 1:The medicament of skin disease containing plant component sold using pharmacy, is smeared affected part, continuously used twice daily 21 days.
Control group 2:The antifungal activity skin disease medicament sold using pharmacy, is smeared affected part, continuously used twice daily 21 days.
Patient numbers:Every group each 80, M-F is close, and eczema, psoriasis, epifolliculitis, erythema Proportion of patients are identical.
Judgement of medicine curative effect standard:
Work well:Had clear improvement, or fully recovered after use using rear illing skin.
Effect is not notable:It is not improved using rear illing skin, or situation is aggravated.
Clinical trial statistical form
Group Work well/people Effect not significantly/people Work well percentage/%
Experimental group 75 5 93.75
Control group 1 52 28 65.00
Control group 2 46 34 57.50
Experiment conclusion:
From experiment statisticses table data can with it is concluded that, the herbal composite medicament that experimental group is used has to skin disease Preferable curative effect.The generation of allergic reaction or any adverse reaction is found no in experimental group, the medium-height grass is further demonstrated The security of drug composition composition.
The patient of part control group 1 is after medicament is used for multiple times in the rear phenomenon for just observing part recovery from illness, the work of medicine It is slow with speed.
The few patients of control group 2 generate of short duration red swelling of the skin, pruritis after using medicament, and in the short time Interior symptom is died away.A portion patient, which occurs in that, uses the inapparent situation of rear effect.
Chinese herbal medicine combination medicament contained by the embodiment 1 that experimental group is used is helpful for treating for skin disease.Due to reality Apply example 2,3,4,5,6 close with the formula composition of embodiment 1, other Example formulations also have close clinical effectiveness.
Contained drug preparation of the present invention can reach therapeutic effect by lotion, with various forms of externally applied formulations, contain There are this treatment skin disease herbal composite and manufacture method all should be in the scope of the present invention.
The formula that the present invention is illustrated does not constitute the restriction to invention protection domain.Formula and manufacture method base more than Improvement on plinth should be comprising within the scope of the present invention with replacement.

Claims (3)

1. one kind treats dermopathic herbal composite and its manufacture method, it is characterised in that former by following parts by weight Material is made:3-5 parts of picria fel tarrae, 6-10 parts of pigeonpea, 6-10 parts of frutus cnidii, 2-5 parts of rose glorybower root, 10-15 parts of Celastrus angulatus, alangium 10-15 parts of leaf.
2. dermopathic Chinese herbal medicine combination is treated according to claim 1, it is characterised in that former including following parts by weight Material:5 parts of picria fel tarrae, 10 parts of pigeonpea, 7 parts of frutus cnidii, 3 parts of rose glorybower root, 15 parts of Celastrus angulatus, 15 parts of Chinese alangium leaf.
3. dermopathic Chinese herbal medicine combination is treated according to claim 1, it is characterised in that the system of the herbal composite Preparation Method is:The medicinal extract of total medicinal material content 8% is obtained after ethanol solution second extraction concentration Chinese herbal medicine, by 1kg fatty alcohol polyoxies Vinethene, 1.5kg alkylglycosides, 0.5kg dodecyl benzyl dimethyl ammonium chlorides, 2kg OITs are dissolved in going for 10kg In ionized water, the medicinal extract that 8kg is concentrated to give is added, mixture heating stirring 4hr is cooled to 20 DEG C of elimination insoluble matters and produced into Product.
CN201710425583.6A 2017-06-02 2017-06-02 One kind treats dermopathic herbal composite and its manufacture method Pending CN107281328A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710425583.6A CN107281328A (en) 2017-06-02 2017-06-02 One kind treats dermopathic herbal composite and its manufacture method

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Application Number Priority Date Filing Date Title
CN201710425583.6A CN107281328A (en) 2017-06-02 2017-06-02 One kind treats dermopathic herbal composite and its manufacture method

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CN107281328A true CN107281328A (en) 2017-10-24

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CN201710425583.6A Pending CN107281328A (en) 2017-06-02 2017-06-02 One kind treats dermopathic herbal composite and its manufacture method

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104474148A (en) * 2015-01-16 2015-04-01 杜卫兵 Traditional Chinese medicine composition used for treating dermatomycosis and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104474148A (en) * 2015-01-16 2015-04-01 杜卫兵 Traditional Chinese medicine composition used for treating dermatomycosis and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
欧阳卫权: "《皮肤病中医外治特色疗法精选》", 31 October 2015, 广东科技出版社 *

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Application publication date: 20171024