CN107281166A - A kind of medicinal plant enteric-coated sustained release capsule and preparation method thereof - Google Patents
A kind of medicinal plant enteric-coated sustained release capsule and preparation method thereof Download PDFInfo
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- CN107281166A CN107281166A CN201710454329.9A CN201710454329A CN107281166A CN 107281166 A CN107281166 A CN 107281166A CN 201710454329 A CN201710454329 A CN 201710454329A CN 107281166 A CN107281166 A CN 107281166A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
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Abstract
In order to improve effect of active components of plants, the present invention proposes a kind of medicinal plant enteric-coated sustained release capsule formulation and preparation method thereof, and described method is plant tissue or vegetable products after drying and crushing, is fitted into capsulae enterosolubilis and realizes intestinal mucosa sustained-release administration.The formulation is pharmaceutical carrier directly using original plant tissue, allows intestinal mucosa to adsorb plant tissue powder, stimulation of the string to intestinal mucosa is played, to promote fully absorbing for medicinal active ingredient.The formulation can improve active component effect more than 5 times, so as to reduce dosage, and have the advantages that to prepare simple, Small side effects.
Description
Technical field
The present invention relates to a kind of medicinal plant form of administration and preparation method thereof.More specifically, it is related to a kind of medicinal plant
Enteric-soluble controlled-release capsule of tissue or vegetable products and preparation method thereof.
Background technology
Medicinal plant containing active component is Chinese medicine and the main raw material sources of health products.For a long time, efficacy of drugs
Problem be perplex Development of Chinese Medicine main reason, on the one hand, the autonomic drug of artificial growth due to the factors such as growing environment its
Effect has declined, and is eaten as common food.On the other hand, the chemical drugs of synthesis are most with more or less side effect,
Long-term use may have undesirable effect to human body, have potentially hazardous property for chronic disease treatment and health care.Cause
This, effect tool for improving medicinal plant is of great significance.
Research of the people in terms of medicinal plant effect is improved in recent years never has stopping.Conventional oral Chinese medicine is with decoction
Based on pellet forms.Decoction is that water boils the decoction that Chinese medicine is obtained, and the formulation is due to fractions of active ingredient poorly water-soluble and medicine
Liquid is short by the time of intestines and stomach, can cause the loss of active component；Pill is to be glued after Chinese medicine active compound is crushed using adhesive
System is formed, and the use of adhesive can be impacted to the diffusion of active component, so as to influence drug effect.Also have in addition to conventional method and borrow
The preparation method of mirror Western medicine, the active component of Chinese medicine is extracted, Chinese patent drug is prepared into, and mainly includes tablet and capsule
Type, the dosage of both formulations has dropped really, but equally exists recovery rate is not high, stomach is to active component influence and lead to
The factor such as the time is short of enteron aisle is crossed, effect of Chinese patent drug is not significantly improved.
The active component of many medicines can fail because of being influenceed by hydrochloric acid in gastric juice, and for example running into strong acid can be neutralized
Alkali, the ester that can be hydrolyzed or the enzyme that can be failed.Therefore the people method that is administered using enteric shields the influence of stomach, protection activity
Effect of composition, such as《Food research and development》9th phase in 2009 delivered one it is entitled《The preparation of onion enteric coated preparations and its
Quality evaluation》Article, this article loads hollow capsulae enterosolubilis after the onion powder dried is mixed with appropriate magnesium stearate
Onion capsulae enterosolubilis preparation is obtained, influence of the shielding hydrochloric acid in gastric juice to allinase is administered by enteric, effect of its active component is improved.But
It is that the way of enteric administration is the influence to shield stomach.
Chinese patent【Application Number (patent)】2015800003049.5 disclose a kind of drug regimen of autonomic control
Thing and preparation, product and application, the combination medicine of the disclosure of the invention be by carrier of montmorillonite, calcium hydroxide or hydrochloric acid be activity into
The slow releasing pharmaceutical divided, product therein includes enteric-coated sustained release formulation.Medicine is made after enteric formulation, can not only eliminate gastric mucosa
With the influence of hydrochloric acid in gastric juice, and sustained-release administration can also be realized, but the patent do not relate to medicinal plant enteric-coated sustained release capsule and its
Preparation method.
The content of the invention
It is an object of the invention to provide a kind of medicinal plant enteric-coated sustained release capsule and preparation method thereof, to solve plant at present
The problem of thing medicine effect is not high.
The present inventor in order to achieve the above object, " a kind of pharmaceutical composition of autonomic control and preparation, product and
Using " on the basis of, the mechanism that enteric-coated sustained release is administered is studied repeatedly, the present invention is completed.
The present invention a kind of medicinal plant enteric-coated sustained release capsule preparation method, it is characterized in that using intestinal mucosa be sustained to
Medicine, concrete implementation method is as follows：
1st, plant tissue or vegetable products are dried at 60-150 DEG C, is then crushed to 100-700 mesh, obtains gluing
It is attached to the drug powder of intestinal mucosa；
2nd, drug powder is packaged in capsulae enterosolubilis, obtains plant enteric-coated sustained release capsule.
Above-described sustained release is that the carrier of active components of plants is the institutional framework of plant in itself.
Above-described plant tissue can be leaf, root, skin, stem, flower or the fruit one of which of plant, or more than one
Mixture.
Above-described vegetable products can be the plant tissue one of which that the prepared slices of Chinese crude drugs or process working process are crossed, or
More than one mixture.
Above-described drug powder, it is necessary to be the powder do not reunited, if reuniting, it is necessary to another or
More than one plant tissues do not reunited or vegetable products are mixed crushing.
A kind of preparation method of medicinal plant enteric-coated sustained release capsule of the present invention, its principle is that drug powder adhesion intestinal mucosa delays
Release administration.So-called adhesion intestinal mucosa is that organization structure of the plant includes plant cell and string etc., and plant cell glues with intestines
Theca cell has good biocompatibility, can be adsorbed by intestinal mucosa；And the plant sticked to by crushing on intestinal mucosa is fine
Dimension can produce mechanical stimulus to intestinal mucosa, accelerate the wriggling of intestines, the digestion and absorption function of intestinal mucosa be improved, so as to greatly speed up
The infiltration rate of active component in plant tissue.On the other hand, the active component being embedded in plant tissue is due to extending out
Dissipate speed unhappy, add medicament powder and stick to for a long time on intestinal mucosa, it is achieved thereby that sustained-release administration.Active component is in plant
Diffused out in tissue slowly, diffusing out infiltration rate after particle surface, soon, both combinations can greatly improve active component
Utilization rate.
Compared with the prior art, its novelty is the present invention：
1st, effect that active component is administered using intestinal mucosa improves more than 5 times, and the taking dose of active compound drops to 150-
350mg, the dose degradation of active component has reached the level of synthetic drug to 3-50mg.The raising of active component effect so that plant
The demand of thing medicine is decreased obviously, and can be greatly reduced wild medicinal plant and be used.
2nd, the total amount and intensity that the chemical composition in the reduction due to dosage and slow releasing function, medicinal plants enters blood are equal
Substantially reduce, side effect is decreased obviously.
3rd, autonomic drug enormously simplify preparation technology without extracting and purifying.
4th, due to the raising of effect, many original vegetables and fruit for being used as food can also pass through enteric-coated sustained release preparation
Medicine or health products are made, the source of medicine, and Small side effects are not only enriched.
Embodiment
Embodiment 1
The preparation of balsam pear enteric-coated sustained release capsule
Balsam pear slice is dried at 90 DEG C, 200 mesh is then crushed to, obtains that the drug powder of intestinal mucosa can be adhered to；
Drug powder is packaged in capsulae enterosolubilis, just obtains balsam pear enteric-coated sustained release capsule.The capsule has the reduction work(such as blood glucose and fat-reducing
Effect, the dosage of every is 300mg, and directly oral balsam pear slice at least needs more than 3g just to have health-care effect.
Embodiment 2
The preparation of soya bean enteric-coated sustained release capsule
Soya bean is dried at 140 DEG C, 200 mesh is then crushed to, obtains that the drug powder of intestinal mucosa can be adhered to；Medicine
Thing powder is packaged in capsulae enterosolubilis, just obtains soya bean enteric-coated sustained release capsule.The capsule, which has, improves the work(such as immune, extra-nutrition
Effect, the dosage of every is 230mg, and directly oral soya bean at least needs more than 2g just to have health-care effect.
Embodiment 3
The preparation of mushroom enteric-coated sustained release capsule
The mushroom crossed with alcohol pre-treatment is dried at 95 DEG C, 300 mesh is then crushed to, obtains that intestinal mucosa can be adhered to
Drug powder；Drug powder is packaged in capsulae enterosolubilis, mushroom enteric-coated sustained release capsule is just obtained.The capsule is exempted from raising
Effect of epidemic disease, the dosage of every is 250mg, and directly oral mushroom at least needs more than 2.5g just effective.
Embodiment 4
The preparation of ganoderma lucidum enteric-coated sustained release capsule
The ganoderma lucidum crossed with alcohol pre-treatment is dried at 95 DEG C, 200 mesh is then crushed to, obtains that intestinal mucosa can be adhered to
Drug powder；Drug powder is packaged in capsulae enterosolubilis, ganoderma lucidum enteric-coated sustained release capsule is just obtained.The capsule is exempted from raising
Epidemic disease and the effect promoted longevity, the dosage of every is 150mg, and directly oral ganoderma lucidum at least needs more than 1.5g just effective.
Embodiment 5
The preparation of pyrus nivalis enteric-coated sustained release capsule
70 parts of (butt) pyrus nivaliss and 30 portions of (butt) wheats are dried at 75 DEG C, 100 mesh are then crushed to together, are obtained
The drug powder of intestinal mucosa can be adhered to；Drug powder is packaged in capsulae enterosolubilis, pyrus nivalis enteric-coated sustained release capsule is just obtained.By
Higher containing sugar in pyrus nivalis, its powder is easily reunited, so adding wheat mainly plays peptizaiton.The capsule has moistening lung and alleviation
Effect of cough, the dosage of every is 300mg, and directly oral pyrus nivalis at least needs more than 3g just effective.
Embodiment 6
The preparation of guava enteric-coated sustained release capsule
Guava is dried at 100 DEG C, is then crushed to 200 mesh, obtains that the drug powder of intestinal mucosa can be adhered to；Medicine
Thing powder is packaged in capsulae enterosolubilis, just obtains guava enteric-coated sustained release capsule.Guava capsule has the work(such as antidiarrheal, fat-reducing
Can, the dosage of the capsule every is 300mg, and directly oral guava at least needs more than 2g just effective.
Embodiment 7
The preparation of American Ginseng capsulae enterosolubilis
American Ginseng is dried at 100 DEG C, is then crushed to 300 mesh, is obtained that the drug powder of intestinal mucosa can be adhered to；Medicine
Thing powder is packaged in capsulae enterosolubilis, just obtains American Ginseng enteric-coated sustained release capsule.There is American ginseng capsule enhancing to be immunized, it is tired to alleviate
The effect of labor, the dosage of every is 280mg, and directly oral American Ginseng at least needs more than 2g just effective.
Embodiment 8
The preparation of coffee capsulae enterosolubilis
Coffee is dried at 120 DEG C, is then crushed to 300 mesh, is obtained that the drug powder of intestinal mucosa can be adhered to；Medicine
Powder is packaged in capsulae enterosolubilis, just obtains coffee enteric-coated sustained release capsule.The dosage of the capsule every is 250mg, and directly mouth
Taking coffee at least needs more than 2g just effective.Coffee capsule has anti-brain fag, the effect of enhancing heart vigor.
Embodiment 9
The preparation of honeysuckle capsulae enterosolubilis
The honeysuckle handled by petroleum ether degreasing is dried at 110 DEG C, is then crushed to 200 mesh, obtains gluing
The drug powder of attached intestinal mucosa；Drug powder is packaged in capsulae enterosolubilis, honeysuckle enteric-coated sustained release capsule is just obtained.The capsule
Effect with antibacterial, the dosage of every is 250mg, and directly oral honeysuckle at least needs more than 2g just effective.
Embodiment 10
The preparation of red sage root capsulae enterosolubilis
Salvia piece is dried at 100 DEG C, is then crushed to 200 mesh, is obtained that the drug powder of intestinal mucosa can be adhered to；
Drug powder is packaged in capsulae enterosolubilis, just obtains Salvia Miltiorrhiza delayed-release capsulae enterosolubilis.Capsule of red sage root has promoting blood circulation and removing blood stasis, enhancing heart
The effect of vigor, the dosage of every is 300mg, and directly oral American Ginseng at least needs more than 2g just effective.
Embodiment 11
The preparation of balsam pear guava capsulae enterosolubilis
80 portions of (butt) balsam pears and 20 parts of (butt) guavas are dried at 85 DEG C, 200 mesh are then crushed to together, are obtained
To the drug powder of intestinal mucosa can be adhered to；Drug powder is packaged in capsulae enterosolubilis, balsam pear guava sustained release intestines are just obtained
Colloidal sol capsule.The capsule has effects that fat-reducing, and the dosage of every is 300mg, and directly oral pyrus nivalis at least needs more than 3g
It is effective.
Embodiment 12
The preparation of pomelo peel capsulae enterosolubilis
Pomelo peel by washing process is dried at 100 DEG C, is then crushed to 200 mesh, is obtained that intestinal mucosa can be adhered to
Drug powder；Drug powder is packaged in capsulae enterosolubilis, pomelo peel enteric-coated sustained release capsule is just obtained.Pomelo peel capsule has
Promote digestion, the effect of fat-reducing, the dosage of every is 300mg, and directly oral pomelo peel at least needs more than 2g just effective.
Claims (5)
1. a kind of preparation method of medicinal plant enteric-coated sustained release capsule, it is characterized in that using intestinal mucosa sustained-release administration, it is specific real
Existing method is as follows：
(1) plant tissue or vegetable products are dried at 60-150 DEG C, is then crushed to 100-700 mesh, obtains adhering to
The drug powder of intestinal mucosa；
(2) drug powder is packaged in capsulae enterosolubilis, just obtains plant enteric-coated sustained release capsule.
2. the carrier that sustained release according to claim 1 is active components of plants is plant tissue.
3. plant tissue according to claim 1 can be leaf, root, skin, stem, flower or the fruit one of which of plant, or
More than one mixture.
4. vegetable products according to claim 1 can be the prepared slices of Chinese crude drugs or pass through pretreated plant tissue wherein one
Kind, or more than one mixture.
5. drug powder according to claim 1, it is necessary to be the powder do not reunited, if reuniting, it is necessary to it is another
The plant tissue or vegetable products that outer one or more are not reunited are mixed crushing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710454329.9A CN107281166A (en) | 2017-06-15 | 2017-06-15 | A kind of medicinal plant enteric-coated sustained release capsule and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710454329.9A CN107281166A (en) | 2017-06-15 | 2017-06-15 | A kind of medicinal plant enteric-coated sustained release capsule and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108785390A (en) * | 2018-06-13 | 2018-11-13 | 中南大学湘雅二医院 | A kind of preparation method of Guava Leaf hypoglycemic extract slow-release tablet |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526772A (en) * | 2012-02-02 | 2012-07-04 | 董涛 | Chinese medicinal enteric capsule capable of indicating early-phase small intestinal exogenous tumor |
| CN102614530A (en) * | 2012-04-10 | 2012-08-01 | 吴淑站 | Traditional Chinese medical capsule for auxiliary examination of early tumor on inner wall of small intestine |
| US20150328182A1 (en) * | 2012-12-26 | 2015-11-19 | Morinaga Milk Industry Co., Ltd. | Igf-1 production-promoting agent |
| CN105079061A (en) * | 2015-07-22 | 2015-11-25 | 苏保洲 | Pseudo-ginseng active medicine prepared by adopting ultramicro wall-breaking grinding technology as well as health product and preparation method thereof |
-
2017
- 2017-06-15 CN CN201710454329.9A patent/CN107281166A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526772A (en) * | 2012-02-02 | 2012-07-04 | 董涛 | Chinese medicinal enteric capsule capable of indicating early-phase small intestinal exogenous tumor |
| CN102614530A (en) * | 2012-04-10 | 2012-08-01 | 吴淑站 | Traditional Chinese medical capsule for auxiliary examination of early tumor on inner wall of small intestine |
| US20150328182A1 (en) * | 2012-12-26 | 2015-11-19 | Morinaga Milk Industry Co., Ltd. | Igf-1 production-promoting agent |
| CN105079061A (en) * | 2015-07-22 | 2015-11-25 | 苏保洲 | Pseudo-ginseng active medicine prepared by adopting ultramicro wall-breaking grinding technology as well as health product and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108785390A (en) * | 2018-06-13 | 2018-11-13 | 中南大学湘雅二医院 | A kind of preparation method of Guava Leaf hypoglycemic extract slow-release tablet |
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