CN102145060A - Dual-cordis effect of Xin Keshu - Google Patents
Dual-cordis effect of Xin Keshu Download PDFInfo
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Abstract
The invention relates to a new curative application of a traditional Chinese medicine, in particular to the dual-cordis effect treatment of Xin Keshu as a traditional Chinese medicine. The traditional Chinese medicine has new curative application to patients accompanied with adverse moods, such as worry, depression, and the like.
Description
Technical field:
The new treatment that the present invention relates to a kind of Chinese medicine is used, particularly the treatment of the diplocardia effect that can relax of the Chinese medicine heart.
Background technology:
The heart can relax and be the Chinese medicine preparation of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, and its prescription consists of: Fructus Crataegi, Radix Puerariae, Radix Salviae Miltiorrhizae, Radix Notoginseng, the Radix Aucklandiae.Uncomfortable in chest, dizzy, the headache that is used for that qi stagnation and blood stasis type coronary heart disease causes, neck pain and arrhythmia, hyperlipidemia etc.Domestic have tablet, capsule, the launch of dosage forms such as granule at present.
XINKESHU PIAN agent [prescription] Radix Puerariae 600g, Fructus Crataegi 600g, Radix Salviae Miltiorrhizae 600g, Radix Notoginseng 40g, Radix Aucklandiae 40g
The preparation of XINKESHU PIAN agent may further comprise the steps,
1) Fructus Crataegi of 1/3 amount, Radix Notoginseng, the Radix Aucklandiae are pulverized,
2) Fructus Crataegi, the Radix Puerariae ethanol extraction of 2/3 amount;
3) Radix Salviae Miltiorrhizae decocting in water,
4) extract is mixed with ground product,
5) make tablet.
Concrete processing step is as follows:
[method for making] 1/3 Fructus Crataegi, Radix Notoginseng, Radix Aucklandiae powder are broken into fine powder, and all the other Fructus Crataegis, Radix Puerariae added 60% ethanol warm macerating after 30 minutes, the heating and refluxing extraction secondary, and 2.5 hours for the first time, 2 hours for the second time, merge alcohol extract, decompression recycling ethanol filters filtrate for later use; Radix Salviae Miltiorrhizae decocts with water secondary, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filter, with above-mentioned filtrate and decoction liquor mix homogeneously, be concentrated into relative density 1.24～1.26 (75 ℃～80 ℃ surveys).With extractum and fine powder mixing, make granule, drying, tabletting, coating, promptly.
Unhealthy emotions such as the anxiety that coronary heart disease is followed, depression mainly contain three classes: (1) patient's work ethos pressure is big, has that some are uncomfortable in chest, the chest pain symptom, and suspection has a heart disease, and is worried, but does not have the evidence of organic heart disease after inspection at all.(2) patient has symptom uncomfortable in chest, cardiopalmus, and the electrocardiogram performance only for premature beat or slight ST-T change, there is no serious organic heart disease, the prognosis bona, but because doctor's incorrect explanation causes the patient's heart disease heavy, stress is very heavy.(3) suffers from the patient of organic heart disease, the patient of experience coronary artery intervene operation, coronary artery bypass surgery, cardiac pacemaker implantation surgery, operative treatment is extremely successful, but the first aid of being experienced in hospital, operation, ward mate's strikes such as death, and the multiple incompatibility in ill back are added not the understanding of disease prognosis, ignorant, thereby the wound that causes soul, produce spiritual mental maladjustment such as depression, anxiety, cause increasing the weight of prognosis, worsen quality of life etc.
Fertile magnificent XINKESHU PIAN confirms that through clinical practice in 30 years treatment coronary heart disease effect stability is reliable, discovery beyond the present invention, fertile magnificent XINKESHU PIAN is evident in efficacy to coronary heart disease incessantly, simultaneously unhealthy emotions such as patient's anxiety, depression are improved significantly, meet " diplocardia effect " when promptly treating coronary heart disease, patient's psychology (emotion) is also had certain regulating action.
Summary of the invention:
The invention provides a kind of heart new therapeutic use of preparation that can relax, described new therapeutic use is unhealthy emotions such as the anxiety followed of patients with coronary heart disease, depression.
A large amount of clinicians feeds back the patient after taking fertile magnificent XINKESHU PIAN, feels that generally coronary heart disease symptom obviously alleviates, and feels and be in a cheerful frame of mind.The doctor also sends out in return visit and thinks that the patient is emotionally stable, and unhealthy emotions such as anxiety, depression significantly improve.
Below be clinical research data:
XINKESHU PIAN treatment angina pectoris merges anxiety-depression obstacle 132 routine observation of curative effect
1 clinical data
In JIUYUE, 2008～2010 year April, internal medicine is in hospital, the outpatient service angina pectoris merges anxiety-depression disease patient 132 examples.
Inclusion criteria: meet intentionally angor medical history, inspections such as underwent coronary radiography, color Doppler echocardiography, electrocardiogram are diagnosed as the angina pectoris patient; Use the Zung anxiety neurosis and carry out psychometry from meter (SAS) and Zung depression from meter (SDS), Zung scale total points＞40 fens persons.
By the prescription on individual diagnosis sequencing patient is divided into treatment group and matched group at random, 87 examples are organized in treatment, wherein male 51 examples, women 36 examples, 35～78 years old age, 61.4 years old mean age, matched group 45 examples, wherein male 33 examples, women 12 examples, 37～79 years old age, 59.7 years old mean age.2 groups of no significant differences on age, the course of disease have comparability.
2 Therapeutic Method
Oral XINKESHU PIAN (Shandong China Wo Medicine Co provides) every day 3 times is organized in treatment, each 4.The oral persantin of matched group, each 50mg, every day 3 times; Oral enteric aspirin 25mg every day, oral happiness too happy every day of 20mg.
Be for 10 weeks 2 groups of courses of treatment, and the periodic review electrocardiogram.
3 observation index and method
3.1 myocardial ischemia total load
Using dynamic cardiograph detects, standard is that ST-T section level or declivity type move down, amplitude 〉=1mm, persistent period 〉=1min, next time, ischemic episode needed to recover baseline 1min at least in the ST section of last time showing effect, and the amplitude peak of forcing down with the ST section (mm) reaches the summation of persistent period (min) product that forces down continuously as myocardial ischemia total load (TIB).
3.2 anxiety state is improved
Use the Zung anxiety neurosis from meter (SAS) evaluation curative effect.Judge the anxiety neurosis and the order of severity thereof according to scoring index (total points/80).Be no anxiety below 0.5 as index; 0.5～0.59 is LA; 0.6～0.69 be in to severe anxiety;＞0.7 is severe anxiety.After the treatment, Zung scale total points＜40 fens persons is recovery from illness; Total points＞40 minute but＞10 fens persons that descend are for effectively;＜10 fens persons that descend are for invalid.
3.3 depressive state improves
Use the Zung depression from meter (SDS) evaluation curative effect.Judge the depression and the order of severity thereof according to scoring index (total points/80).Be the nothing depression below 0.5 as index; 0.5～0.59 is slight depressed; 0.6～0.69 be in to severe depression;＞0.7 is severe depression.After the treatment, Zung scale total points＜40 fens persons is recovery from illness; Total points＞40 minute but＞10 fens persons that descend are for effectively;＜10 fens persons that descend are for invalid.
3.4 statistical method:
All statistical test all adopt the SPSS13.0 statistical software, and the P value is less than or equal to 0.05 and will be recognized
For the difference of being checked has statistical significance.Different batch total amount data will adopt mean ± standard deviation to carry out descriptive statistics.
4 results
4.1 TIB, resting heart rate change (seeing Table 1) before and after 2 groups of treatments
TIB, resting heart rate change relatively before and after 2 groups of treatments of table 1
Two groups of curative effects compare, and there is significant difference P＜0.05.
4.2 anxiety state improvement degree is (seeing Table 2,3) relatively
Anxiety state changes relatively before and after 2 groups of treatments of table 2
Anxiety state improvement degree changes relatively before and after 2 groups of treatments of table 3
| Group | n | Recovery from illness | Effectively | Invalid | Effective percentage (%) |
| The treatment group | 87 | 52 | 17 | 18 | 79.31 |
| Matched group | 45 | 21 | 10 | 14 | 68.89 |
Two groups of curative effects compare, and there is significant difference P＜0.05.
4.3 depressive state improvement degree is (seeing Table 4,5) relatively
Depressive state changes relatively before and after 2 groups of treatments of table 4
Depressive state improvement degree changes relatively before and after 2 groups of treatments of table 5
Two groups of curative effects compare, and there is significant difference P＜0.05.
Discuss
Data shows that it is very high that many cardiovascular diseasess merge anxiety-depression obstacle rate.The domestic and foreign literature report, depression incidence 41% among the unstable angina patient, and the serious symptom depression accounts for 15%; In the patients with coronary heart disease, the common sick incidence rate 6.5%～53% of panic disorder; In be in hospital coronary heart disease, patients of acute myocardial infarction, 69% merges various anxiety symptoms; Anxiety that hypertension and arrhythmia merge and depressive disorder are also up to 30%～50%.Intracardiac section of General Hospital of Beijing Military Command is since carrying out " diplocardia outpatient service ", and anxiety disorder comprises that generalized anxiety disorder and iatrogenic anxiety account for 20%～30% among the statistics out-patient, and depressive disorder accounts for 15%～20%.
XINKESHU PIAN mainly is made up of Radix Salviae Miltiorrhizae, Radix Puerariae, Radix Notoginseng, Fructus Crataegi, the Radix Aucklandiae as the Chinese patent medicine of clinical treatment angina pectoris commonly used, and all medicines share and do corresponding plus-minus according to concrete card feelings, obtain better clinical effectiveness.Compare untoward reaction with the anxiety Western medicine and obviously reduce, patient's compliance is higher, and the cure rate height is easy for patients to accept, can obviously improve patients ' life quality.Originally studies show that, XINKESHU PIAN treatment coronary heart disease is evident in efficacy, simultaneously unhealthy emotions such as patient's anxiety, depression are improved significantly, meet " diplocardia effect " when promptly treating coronary heart disease, patient's psychology (emotion) is also had certain regulating action.
For this reason, the invention provides a kind of Chinese medicine composition for the treatment of unhealthy emotions such as anxiety that patients with coronary heart disease follows, depression, said composition is made up of pharmaceutically active substance and medicine acceptable carrier, and wherein said pharmaceutically active substance is made by following Chinese medicine raw materials by weight proportion:
[prescription] Radix Puerariae 300-900g, Fructus Crataegi 300-900g, Radix Salviae Miltiorrhizae 300-900g, Radix Notoginseng 20-60g, Radix Aucklandiae 20-60g
Most preferred consisting of:
[prescription] Radix Puerariae 600g, Fructus Crataegi 600g, Radix Salviae Miltiorrhizae 600g, Radix Notoginseng 40g, Radix Aucklandiae 40g
In more than forming, the weight of each medicine of distinguishing the flavor of is calculated with crude drug, and above-mentioned prescription composition can be made into 1000 doses of pharmaceutical preparatioies.The described dose of final drug preparation that finger is made refers to 1000 of capsule preparations for 1000 doses as capsule, and tablet refers to 1000 in tablet for 1000 doses, is granule 1000 grams for granule, and oral liquid is meant oral liquid 1000ml etc.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.
Raw material of Chinese medicine, especially adjuvant drug in more than forming can be replaced with the suitable Chinese medicine with identical property of medicine with messenger drug, and its drug effect of the Chinese medicine preparation after the replacement is constant.
Chinese medicine composition of the present invention is to process through extraction or other modes by the raw material of Chinese medicine that above-mentioned prescription is formed, and makes pharmaceutically active substance, subsequently, with this material is raw material, adds the medicine acceptable carrier when needing, and makes according to the routine techniques of galenic pharmacy.Described active substance can obtain by extracting raw material of Chinese medicine respectively, also can obtain by the co-extracted raw material of Chinese medicine, also can obtain by other modes, as: by pulverize, squeeze, calcine, grind, sieve, percolation, extraction, water are carried, alcohol extraction, ester are carried, methods such as ketone is carried, chromatography obtain, these active substances can be the material of extractum form, can be that dry extract also can be a fluid extract, make different concentration according to the different needs decision of preparation.
Pharmaceutical composition of the present invention, preferably the pharmaceutical dosage forms of unit dose can be made any pharmaceutically useful dosage form when making pharmaceutical preparation, and these dosage forms are selected from: tablet is as conventional tablet, sugar coated tablet, film coated tablet, enteric coated tablet; Capsule is as hard capsule, soft capsule; And oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.
Chinese medicine composition of the present invention is the oral formulations form preferably, most preferably tablet.
Chinese medicine composition of the present invention can add some medicine acceptable carriers as required, can adopt the galenic pharmacy routine techniques to prepare this Chinese medicine preparation, as pharmaceutically active substance is mixed with the medicine acceptable carrier.Described medicine acceptable carrier is selected from: mannitol, sorbitol, sorbic acid or potassium salt, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin A, vitamin C, vitamin E, vitamin D, azone, the EDTA disodium, EDTA calcium sodium, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, propylene glycol, ethanol, soil temperature 60-80, span-80, Cera Flava, lanoline, liquid paraffin, hexadecanol, gallate ester, agar, triethanolamine, basic amino acid, carbamide, allantoin, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, the phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese medicine preparation compositions of the present invention, when making medicament, the medicament of unit dose can contain pharmaceutically active substance 0.1-1000mg of the present invention, and all the other are pharmaceutically acceptable carrier.Pharmaceutically acceptable carrier can be the 0.1-99.9% of total formulation weight amount by weight.
Compositions of the present invention is determined usage and dosage according to patient's situation in use, as 1-3 time on the one.A 1-10 sheet/grain etc.
The specific embodiment:
Further specify the present invention by the following examples, but not as limitation of the present invention.
The preparation of embodiment 1 tablet
[prescription] Radix Puerariae 600g, Fructus Crataegi 600g, Radix Salviae Miltiorrhizae 600g, Radix Notoginseng 40g, Radix Aucklandiae 40g
[method for making] 1/3 Fructus Crataegi, Radix Notoginseng, Radix Aucklandiae powder are broken into fine powder, and all the other Fructus Crataegis, Radix Puerariae added 60% ethanol warm macerating after 30 minutes, the heating and refluxing extraction secondary, and 2.5 hours for the first time, 2 hours for the second time, merge alcohol extract, decompression recycling ethanol filters filtrate for later use; Radix Salviae Miltiorrhizae decocts with water secondary, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filter, with above-mentioned filtrate and decoction liquor mix homogeneously, be concentrated into relative density 1.24～1.26 (75 ℃～80 ℃ surveys).With extractum and fine powder mixing, make granule, drying, tabletting, coating, promptly.
Embodiment 2 capsular preparations
[prescription] Radix Puerariae 600g, Fructus Crataegi 600g, Radix Salviae Miltiorrhizae 600g, Radix Notoginseng 40g, Radix Aucklandiae 40g
[method for making] 1/3 Fructus Crataegi, Radix Notoginseng, Radix Aucklandiae powder are broken into fine powder, and all the other Fructus Crataegis, Radix Puerariae added 60% ethanol warm macerating after 30 minutes, the heating and refluxing extraction secondary, and 2.5 hours for the first time, 2 hours for the second time, merge alcohol extract, decompression recycling ethanol filters filtrate for later use; Radix Salviae Miltiorrhizae decocts with water secondary, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filter, with above-mentioned filtrate and decoction liquor mix homogeneously, be concentrated into relative density 1.24～1.26 (75 ℃～80 ℃ surveys).With extractum and fine powder mixing, make granule, promptly encapsulated.
The preparation of embodiment 3 dispersible tablets
[prescription] Radix Puerariae 300g, Fructus Crataegi 300g, Radix Salviae Miltiorrhizae 300g, Radix Notoginseng 20g, Radix Aucklandiae 20g
[method for making] 1/3 Fructus Crataegi, Radix Notoginseng, Radix Aucklandiae powder are broken into fine powder, and all the other Fructus Crataegis, Radix Puerariae added 60% ethanol warm macerating after 30 minutes, the heating and refluxing extraction secondary, and 2.5 hours for the first time, 2 hours for the second time, merge alcohol extract, decompression recycling ethanol filters filtrate for later use; Radix Salviae Miltiorrhizae decocts with water secondary, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filter, with above-mentioned filtrate and decoction liquor mix homogeneously, be concentrated into relative density 1.24～1.26 (75 ℃～80 ℃ surveys).With extractum and fine powder mixing, make granule, drying, tabletting, coating, promptly.
The preparation of embodiment 4 coated tablets
[prescription] Radix Puerariae 900g, Fructus Crataegi 900g, Radix Salviae Miltiorrhizae 900g, Radix Notoginseng 60g, Radix Aucklandiae 60g
[method for making] 1/3 Fructus Crataegi, Radix Notoginseng, Radix Aucklandiae powder are broken into fine powder, and all the other Fructus Crataegis, Radix Puerariae added 60% ethanol warm macerating after 30 minutes, the heating and refluxing extraction secondary, and 2.5 hours for the first time, 2 hours for the second time, merge alcohol extract, decompression recycling ethanol filters filtrate for later use; Radix Salviae Miltiorrhizae decocts with water secondary, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filter, with above-mentioned filtrate and decoction liquor mix homogeneously, be concentrated into relative density 1.24～1.26 (75 ℃～80 ℃ surveys).With extractum and fine powder mixing, make granule, drying, tabletting, coating, promptly.
Claims (10)
1. the Chinese medicine heart application of compositions in anxiety that preparation treatment coronary heart disease is followed, depressed medicine of can relaxing, the described heart compositions of can relaxing, its Chinese medicine preparation is Radix Puerariae 300-900g, Fructus Crataegi 300-900g, Radix Salviae Miltiorrhizae 300-900g, Radix Notoginseng 20-60g, Radix Aucklandiae 20-60g.
2. according to the application of claim 1, it is characterized in that it is evident in efficacy to coronary heart disease incessantly that described application comprises that the heart can relax, simultaneously unhealthy emotions such as patient's anxiety, depression are improved significantly, meet " diplocardia effect ".
3. according to the application of claim 1, it is characterized in that, the described heart compositions of can relaxing, its Chinese medicine preparation is Radix Puerariae 600g, Fructus Crataegi 600g, Radix Salviae Miltiorrhizae 600g, Radix Notoginseng 40g, Radix Aucklandiae 40g.
4. according to the application of claim 1, it is characterized in that the described heart compositions of can relaxing is an XINKESHU PIAN.
5. according to the application of claim 1, it is characterized in that the described heart compositions of can relaxing is an XINKESHU JIAONANG.
6. according to the application of claim 1, it is characterized in that the described heart compositions of can relaxing is the heart coated tablet that can relax.
7. according to the application of claim 1, it is characterized in that the described heart compositions of can relaxing is the heart Film coated tablets that can relax.
8. according to the application of claim 1, it is characterized in that described application comprises takes the heart compositions of can relaxing, 1-3 time on the one, a 1-10 sheet/grain.
9. according to the application of claim 1, it is characterized in that the described heart compositions method for preparing tablet thereof wherein that can relax is as follows:
[prescription] Radix Puerariae 600g, Fructus Crataegi 600g, Radix Salviae Miltiorrhizae 600g, Radix Notoginseng 40g, Radix Aucklandiae 40g
[method for making] 1/3 Fructus Crataegi, Radix Notoginseng, Radix Aucklandiae powder are broken into fine powder, and all the other Fructus Crataegis, Radix Puerariae added 60% ethanol warm macerating after 30 minutes, the heating and refluxing extraction secondary, and 2.5 hours for the first time, 2 hours for the second time, merge alcohol extract, decompression recycling ethanol filters filtrate for later use; Radix Salviae Miltiorrhizae decocts with water secondary, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filter, with above-mentioned filtrate and decoction liquor mix homogeneously, be concentrated into relative density 1.24～1.26, with extractum and fine powder mixing, make granule, drying, tabletting, coating, promptly.
10. according to the application of claim 1, it is characterized in that the described heart compositions capsule preparation method thereof wherein that can relax is as follows:
[prescription] Radix Puerariae 600g, Fructus Crataegi 600g, Radix Salviae Miltiorrhizae 600g, Radix Notoginseng 40g, Radix Aucklandiae 40g
[method for making] above five tastes are got Radix Notoginseng, Radix Aucklandiae powder is broken into fine powder, and Fructus Crataegi, Radix Puerariae added 60% ethanol warm macerating after 30 minutes, the heating and refluxing extraction secondary, 2.5 hours for the first time, 2 hours for the second time, merge alcohol extract, decompression recycling ethanol is concentrated into relative density 1.35 (20 ℃); Radix Salviae Miltiorrhizae decocts with water secondary, and 2 hours for the first time, 1.5 hours for the second time, merge decoction liquor, filter, be concentrated into relative density 1.35 (20 ℃); Above-mentioned two kinds of thick pastes are dry under 80 ℃, be ground into fine powder and Radix Notoginseng, Radix Aucklandiae fine powder mixing, make granule, drying is distributed into 1000, promptly.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610786A (en) * | 2013-12-13 | 2014-03-05 | 山东沃华医药科技股份有限公司 | Chinese medicinal composition for treating coronary heart disease and preparation method thereof |
| CN104161840A (en) * | 2014-09-02 | 2014-11-26 | 山东沃华医药科技股份有限公司 | Application of Xinkeshu preparation in preparation of medicine for treating coronary heart disease combined arrhythmia with psychological problems of anxiety and depression and preparation method of Xinkeshu preparation |
| CN104173496A (en) * | 2014-09-02 | 2014-12-03 | 山东沃华医药科技股份有限公司 | Application of Xinkeshu preparation in preparing medicine for treating hypertension with coronary heart disease with accompany of anxiety and mental depression problems and preparation method of Xinkeshu preparation |
| CN104189144A (en) * | 2014-09-02 | 2014-12-10 | 山东沃华医药科技股份有限公司 | Application of Xinkeshu preparation to preparation of medicine for treating hypertension and psychological problems of anxiety and depression and preparation method of Xinkeshu preparation |
| CN106309612A (en) * | 2015-06-24 | 2017-01-11 | 山东沃华医药科技股份有限公司 | Traditional Chinese medicinal composition for treating mental and psychological problems accompanying arrhythmia |
| CN108279272A (en) * | 2017-01-06 | 2018-07-13 | 山东沃华医药科技股份有限公司 | Method that is a kind of while measuring the content of Multiple components in Xin Ke Shu ' tablet for treating coronary heart disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103610786A (en) * | 2013-12-13 | 2014-03-05 | 山东沃华医药科技股份有限公司 | Chinese medicinal composition for treating coronary heart disease and preparation method thereof |
| CN104161840A (en) * | 2014-09-02 | 2014-11-26 | 山东沃华医药科技股份有限公司 | Application of Xinkeshu preparation in preparation of medicine for treating coronary heart disease combined arrhythmia with psychological problems of anxiety and depression and preparation method of Xinkeshu preparation |
| CN104173496A (en) * | 2014-09-02 | 2014-12-03 | 山东沃华医药科技股份有限公司 | Application of Xinkeshu preparation in preparing medicine for treating hypertension with coronary heart disease with accompany of anxiety and mental depression problems and preparation method of Xinkeshu preparation |
| CN104189144A (en) * | 2014-09-02 | 2014-12-10 | 山东沃华医药科技股份有限公司 | Application of Xinkeshu preparation to preparation of medicine for treating hypertension and psychological problems of anxiety and depression and preparation method of Xinkeshu preparation |
| CN106309612A (en) * | 2015-06-24 | 2017-01-11 | 山东沃华医药科技股份有限公司 | Traditional Chinese medicinal composition for treating mental and psychological problems accompanying arrhythmia |
| CN108279272A (en) * | 2017-01-06 | 2018-07-13 | 山东沃华医药科技股份有限公司 | Method that is a kind of while measuring the content of Multiple components in Xin Ke Shu ' tablet for treating coronary heart disease |
| CN108279272B (en) * | 2017-01-06 | 2020-11-27 | 山东沃华医药科技股份有限公司 | Method for simultaneously determining contents of multiple components in Xinkeshu tablet |
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