CN107266340A - 1,5‑二苯基‑戊‑1,4‑二烯‑3‑酮化合物 - Google Patents
1,5‑二苯基‑戊‑1,4‑二烯‑3‑酮化合物 Download PDFInfo
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- CN107266340A CN107266340A CN201710311576.3A CN201710311576A CN107266340A CN 107266340 A CN107266340 A CN 107266340A CN 201710311576 A CN201710311576 A CN 201710311576A CN 107266340 A CN107266340 A CN 107266340A
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- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
- C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
- C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/121—Ketones acyclic
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
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- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
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- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
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- C07C49/233—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
- C07C49/235—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the aromatic rings
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- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37553410P | 2010-08-20 | 2010-08-20 | |
| US61/375,534 | 2010-08-20 | ||
| CN2011800404067A CN103459361A (zh) | 2010-08-20 | 2011-08-16 | 1,5-二苯基-戊-1,4-二烯-3-酮化合物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011800404067A Division CN103459361A (zh) | 2010-08-20 | 2011-08-16 | 1,5-二苯基-戊-1,4-二烯-3-酮化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107266340A true CN107266340A (zh) | 2017-10-20 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710311576.3A Pending CN107266340A (zh) | 2010-08-20 | 2011-08-16 | 1,5‑二苯基‑戊‑1,4‑二烯‑3‑酮化合物 |
| CN201710311577.8A Pending CN107253915A (zh) | 2010-08-20 | 2011-08-16 | 1,5‑二苯基‑戊‑1,4‑二烯‑3‑酮化合物 |
| CN2011800404067A Pending CN103459361A (zh) | 2010-08-20 | 2011-08-16 | 1,5-二苯基-戊-1,4-二烯-3-酮化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710311577.8A Pending CN107253915A (zh) | 2010-08-20 | 2011-08-16 | 1,5‑二苯基‑戊‑1,4‑二烯‑3‑酮化合物 |
| CN2011800404067A Pending CN103459361A (zh) | 2010-08-20 | 2011-08-16 | 1,5-二苯基-戊-1,4-二烯-3-酮化合物 |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3564204A1 (en) * | 2010-08-20 | 2019-11-06 | The University of Tokyo | 1,5-diphenyl-penta-1,4-dien-3-one compounds |
| US9884825B2 (en) | 2012-08-03 | 2018-02-06 | Georgia State University Research Foundation, Inc. | Curcumin analogs and methods of making and using thereof |
| CN103910616A (zh) * | 2014-03-20 | 2014-07-09 | 浙江工业大学 | 一种姜黄素衍生物及其制备与应用 |
| CN104974038B (zh) * | 2014-04-13 | 2019-04-30 | 江苏康缘药业股份有限公司 | 一种含羧基单羰基姜黄素衍生物及其制备方法和应用 |
| CN103922911A (zh) * | 2014-04-17 | 2014-07-16 | 上海应用技术学院 | 一种(1e,4e)-1,5-二(邻溴间甲氧基苯基)-1,4-戊二烯酮化合物及合成方法 |
| US11708329B2 (en) | 2018-01-30 | 2023-07-25 | The Regents Of The University Of California | Inhibitors of the WNT/beta-catenin pathway |
| AU2019232661A1 (en) * | 2018-03-08 | 2020-10-15 | Pi Therapeutics Ltd. | Compounds for inhibiting protein degradation and methods of use thereof in the treatment of cancer |
| CN108864188B (zh) * | 2018-09-06 | 2020-06-23 | 贵州大学 | 一种含亚磷酸酯的1,4-戊二烯-3-酮类衍生物、其制备方法及应用 |
| CN109970704B (zh) * | 2019-04-22 | 2022-01-28 | 贵州大学 | 一种含噻吩磺酸酯的查耳酮类衍生物、其制备方法及应用 |
| CN109942540B (zh) * | 2019-04-22 | 2021-06-18 | 贵州大学 | 一种含噻吩磺酸酯的1,4-戊二烯-3-酮类衍生物、其制备方法及应用 |
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| JPH08299777A (ja) * | 1995-05-11 | 1996-11-19 | Lion Corp | 分散剤 |
| CN101711231A (zh) * | 2007-01-08 | 2010-05-19 | 安德鲁科技有限公司 | 具有(取代苯基)-丙烯醛部分的化合物、它们的衍生物、生物活性及其用途 |
| US20100152493A1 (en) * | 2005-06-27 | 2010-06-17 | Hiroyuki Shibata | BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, BETA-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER |
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| JPH05509078A (ja) * | 1990-05-17 | 1993-12-16 | ベイラー カレッジ オブ メディシン | 成長抑制因とガンおよび細胞増殖性疾患措置法 |
| JPH0829977A (ja) * | 1994-07-18 | 1996-02-02 | Nippon Zeon Co Ltd | ポジ型レジスト組成物 |
| AU779230C (en) | 1999-12-03 | 2006-05-25 | Emory University | Curcumin analogues for treating cancer |
| US20050069551A1 (en) * | 2002-03-08 | 2005-03-31 | Emory University | Cytotoxic compound-protein conjugates as suppressors of tumor growth and angiogenesis |
| US20060276536A1 (en) | 2004-02-12 | 2006-12-07 | Vander Jagt David L | Cancer treatment using curcumin derivatives |
| JP2008029977A (ja) * | 2006-07-31 | 2008-02-14 | Ntn Corp | エアロゾル吐出ノズルおよび被膜形成装置 |
| WO2010045395A2 (en) * | 2008-10-14 | 2010-04-22 | Danyang Chen | Curcumin analog compositions and related methods |
| CN101475455A (zh) * | 2009-02-10 | 2009-07-08 | 贵州大学 | 1,5-二取代芳基-1,4-戊二烯-3-酮衍生物及制备方法和用途 |
| EP3564204A1 (en) * | 2010-08-20 | 2019-11-06 | The University of Tokyo | 1,5-diphenyl-penta-1,4-dien-3-one compounds |
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| JPH08299777A (ja) * | 1995-05-11 | 1996-11-19 | Lion Corp | 分散剤 |
| US20100152493A1 (en) * | 2005-06-27 | 2010-06-17 | Hiroyuki Shibata | BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, BETA-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER |
| CN101711231A (zh) * | 2007-01-08 | 2010-05-19 | 安德鲁科技有限公司 | 具有(取代苯基)-丙烯醛部分的化合物、它们的衍生物、生物活性及其用途 |
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| EP2606021A2 (en) | 2013-06-26 |
| JP5998139B2 (ja) | 2016-09-28 |
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| CN107253915A (zh) | 2017-10-17 |
| US20140371177A1 (en) | 2014-12-18 |
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| EP3045445A1 (en) | 2016-07-20 |
| KR101907631B1 (ko) | 2018-10-12 |
| EP2606021A4 (en) | 2014-05-07 |
| CA2807776C (en) | 2018-10-09 |
| EP2606021B1 (en) | 2019-07-31 |
| JP2013536227A (ja) | 2013-09-19 |
| US9359279B2 (en) | 2016-06-07 |
| WO2012024282A2 (en) | 2012-02-23 |
| TWI574686B (zh) | 2017-03-21 |
| AR082856A1 (es) | 2013-01-16 |
| EP3045445B1 (en) | 2019-08-07 |
| AU2011292144B2 (en) | 2016-07-14 |
| TW201212905A (en) | 2012-04-01 |
| US8822732B2 (en) | 2014-09-02 |
| AU2011292144A1 (en) | 2013-03-14 |
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