CN107223960A - 一种具有改善前列腺症状的组合物及其制备方法 - Google Patents
一种具有改善前列腺症状的组合物及其制备方法 Download PDFInfo
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Classifications
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- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
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- Medicinal Preparation (AREA)
Abstract
本发明公开了一种具有改善前列腺症状的组合物及其制备方法,该组合物主要是由松花粉、雨生红球藻粉按一定重量配比制备而成。它可以被制备成任何一种常用剂型,优选口服制剂。
Description
技术领域
本发明涉及一种具有改善前列腺症状的组合物及其制备方法,属于食品的技术领域。
背景技术
良性前列腺增生症是发生在老年男性的一种常见病,患者具有尿频、尿急,严重时排尿困难的症状,十分痛苦,而在现有技术中,至今尚未有一种有效而又安全的治疗药物,通常是采用手术治疗的办法。因此,针对现有技术所存在的不足,研发一种可改善前列腺症状的食品或保健食品尤为重要。
食疗是中国人的传统习惯,通过饮食达到调理身体,强壮体魄的目的。食疗文化源远流长,食疗是一种长远的养生行为,是一种健康的健体之道。因此,有必要根据中医的药食同源理论和食疗养生理论,研制出一种适合人们需要的食用方便的新型功能性可改善前列腺症状的食疗产品。
发明内容
本发明主要解决的技术问题是提供一种具有改善前列腺症状的组合物;本发明还提供了该组合物的制备方法。
本发明是通过以下技术方案实现的:
本发明是由下述重量份的组分制成的:
松花粉100-200份、雨生红球藻粉10-80份。
优选为:
松花粉130-170份、雨生红球藻粉20-45份。
进一步优选为:
松花粉140-160份、雨生红球藻粉25-40份。
最佳优选为:
松花粉150份、雨生红球藻粉30份。
本发明涉及一种组合物,它是在现有中医理论的基础上,进行科学配伍,发挥组分之间相互协同的作用,从而筛选出可有效改善前列腺症状的组方。其中,松花粉为松科植物马尾松Pinus massoniana Lamb.、油松Pinus tabuli formis Carr.或同属数种植物的干燥花粉。其含有多种营养物质,包括22种氨基酸、14种维生素和30多种微量元素以及大量的活性蛋白酶、核、黄酮类化合物及其它活性物质。服用松花粉,会减轻疲劳、增强体力;便秘消失、消化转好;皮肤细腻、面色红润;睡眠踏实、心情愉悦;精力充沛、记忆力提高等。松花粉所含微量元素、黄酮类、精氨酸、维生素C、E、胡萝卜素及硒等,均有清除体内自由基作用,可提高机体抗氧化酶类(如铜锌超氧化物歧化酶等)的活性,抑制脂质过氧化反应,消除老年斑,延缓细胞衰老。
雨生红球藻被公认为自然界中生产天然虾青素的最好生物,大量研究表明雨生红球藻对虾青素的积累速率和生产总量较其它绿藻高。雨生红球藻中虾青素含量为1.5%~10.0%,被看作是天然虾青素的“浓缩品”。虾青素是一种类油菜花粉,也是类油菜花粉合成的最高级别产物,呈深粉红色,化学结构类似于β-油菜花粉。研究表明,虾青素能显著影响动物的免疫功能,在有抗原存在时,能明显促进脾细胞产生抗体的能力,增强T细胞的作用,刺激体内免疫球蛋白的产生。虾青素还能够部分恢复年老小鼠的体液免疫系统,其中可使小鼠体内的IgM、IgA和IgG分别都增加至10mol/L,表明在抗原入侵初期,它能增强特异性体液免疫反应。另外,虾青素还可以增强小鼠释放白细胞介素-Iα和肿瘤坏死因子α的能力,其作用比β-油菜花粉和角黄素强得多。由此认为,虾青素有很强的诱导细胞分裂的活性,具有重要的免疫调节作用。
为了使本发明组合物的功效能发挥到最大化,在组合物中还可以加入油菜花粉、番茄红素、锌、硒中的一种或几种。
本发明组合物的制备方法如下:
取松花粉、雨生红球藻粉混合,不加或者加入适量辅料,按常规工艺制成制剂。
如可以制成常用的片剂(分散片、泡腾片、口腔崩解片、含片、咀嚼片、泡腾片)、胶囊剂(硬胶囊、软胶囊)、颗粒剂、丸剂(滴丸剂)、散剂等固体制剂形式的口服药物,也可以制成糖浆、酒剂、酊剂、口服液等液体制剂形式的口服药物;还可以制成膏剂、凝胶剂、软膏剂、巴布剂、贴膏剂、搽剂、洗剂、涂膜剂等外用制剂形式的外用药物。因此,该药物组合物中除有效成分外,还可以含有药学上可以接受的辅料。
这里所述的辅料,可以根据不同的制剂有所不同,如在片剂、胶囊剂、颗粒剂等固体制剂中常用的稀释剂、崩解剂、赋形剂、粘合剂、润滑剂、表面活性剂、填充剂等;在糖浆、口服液等液体制剂形式中常用的表面活性剂、稀释剂、防腐剂、稳定剂、矫味剂、增稠剂、助流剂等;在凝胶剂、软膏剂等外用制剂形式中常用的药用油性基质、水性基质、防腐剂、抗氧剂、保湿剂、透皮吸收促进剂、表面活性剂等。
其常用辅料如淀粉、乳糖、蔗糖、糊精、糖粉、微晶纤维素、甘露醇、木糖醇、聚乙二醇、硫酸钙、磷酸氢钙、碳酸钙、改良淀粉、山梨醇、聚乙烯吡咯烷酮、重质碳酸镁、羧甲基纤维素钠、羟丙甲基纤维素、甲基纤维素、乙基纤维素、羧甲淀粉钠、羟丙基纤维素、聚维酮K30、白陶土、预胶化淀粉、硬脂酸镁、滑石粉、微粉硅胶、二氧化硅、甜叶菊苷、甜菜碱、阿司帕坦、甘草甜素、糖精钠、冰糖、蜂蜜、蜂蜡、大豆油、麻油、玉米油、花生油、蓖麻油、鱼油、枸橼酸、碳酸氢钠、碳酸钠、卡拉胶、琼脂、明胶、海藻酸钠、甲壳素、黄原胶、瓜耳豆胶、西黄耆胶、阿拉伯胶、槐豆胶、刺梧桐胶、硬脂酸、单硬脂酸甘油酯、聚丙烯酰胺、交联型聚丙烯酸钠、聚乙烯醇、卡波姆、山梨酸、山梨酸钾、羟苯乙酯、苯甲醇、尼泊金、硫柳汞、二甲基亚砜、氮酮、三乙醇胺、氢氧化钠、甘油、丙二醇、BHT、BHA、十二烷基硫酸钠、吐温类、司盘类、焦糖色、番茄红素、赤藓红、柠檬黄、胭脂虫红等。
本发明组合物优先被制成片剂,制备方法为:
取松花粉、雨生红球藻粉混合,加入适量填充剂,混匀,制粒,干燥,整粒,加入适量润滑剂,混匀,压片,包衣或不包衣,即得片剂。
或,取松花粉加入适量填充剂,混匀,制粒,干燥,整粒,得颗粒,备用;取雨生红球藻粉加入适量润滑剂与上述颗粒,混匀,压片,包衣或不包衣,即得片剂。
其中,填充剂是指淀粉、甘露醇、木糖醇、预胶化淀粉、糊精、乳糖、麦芽糊精、微晶纤维素中的一种或一种以上,优选麦芽糊精、微晶纤维素;润滑剂是指硬脂酸镁、微粉硅胶、滑石粉中的一种或一种以上,优选硬脂酸镁。
本发明组合物颗粒剂的制备方法为:
取松花粉、雨生红球藻粉混合,加入适量填充剂、矫味剂混匀,制粒,干燥,整粒,即得颗粒剂。
以下通过实施例形式的具体实施方式,对本发明的上述内容作进一步的详细说明。但不应将此理解为本发明上述主题的范围仅限于以下的实施例。凡基于本发明上述内容所实现的技术均属于本发明的范围。
具体实施方式
实施例1
松花粉150g、雨生红球藻粉 30g
取处方量的松花粉加入适量麦芽糊精、微晶纤维素,混匀,制粒,干燥,整粒,得颗粒,备用;取处方量的雨生红球藻粉加入适量硬脂酸镁与上述颗粒混匀,压片,包衣,即得片剂。
实施例2
松花粉140g、雨生红球藻粉 40g
取处方量的松花粉加入适量麦芽糊精、微晶纤维素,混匀,制粒,干燥,整粒,得颗粒,备用;取处方量的雨生红球藻粉加入适量硬脂酸镁与上述颗粒混匀,压片,包衣,即得片剂。
实施例3
松花粉160g、雨生红球藻粉 20g
取处方量的松花粉加入适量麦芽糊精、微晶纤维素,混匀,制粒,干燥,整粒,得颗粒,备用;取处方量的雨生红球藻粉加入适量硬脂酸镁与上述颗粒混匀,压片,包衣,即得片剂。
实施例4
松花粉130g、雨生红球藻粉 45g
取处方量的松花粉加入适量麦芽糊精、微晶纤维素,混匀,制粒,干燥,整粒,得颗粒,备用;取处方量的雨生红球藻粉加入适量硬脂酸镁与上述颗粒混匀,压片,即得片剂。
实施例5
松花粉170g、雨生红球藻粉 25g
取处方量的松花粉、雨生红球藻粉混合,加入适量麦芽糊精、微晶纤维素,混匀,制粒,干燥,整粒,加入适量硬脂酸镁,混匀,压片,即得片剂。
实施例6
松花粉100g、雨生红球藻粉 80g
取处方量的松花粉、雨生红球藻粉混合,加入适量乳糖、麦芽糊精,混匀,制粒,干燥,整粒,即得颗粒剂。
实施例7
松花粉200g、雨生红球藻粉10g
取处方量的松花粉、雨生红球藻粉,过筛,加入乳糖,混匀,制粒,干燥,装胶囊,即得胶囊剂。
实施例8
松花粉155g、雨生红球藻粉 37g
取处方量的松花粉、雨生红球藻粉,过筛,加入适量辅料,常规方法制成丸剂。
实施例9
松花粉145g、雨生红球藻粉 35g
取处方量的松花粉、雨生红球藻粉,过筛,加入适量辅料,常规方法制成袋装茶剂。
实施例10
松花粉120g、雨生红球藻粉 70g
取处方量的松花粉、雨生红球藻粉,过筛,加入适量辅料,常规方法制成口服液体制剂。
实施例11
松花粉150g、雨生红球藻粉 37g
将纯化水加热至70-80℃,再加入甘油、焦糖色,搅拌均匀,加入明胶,继续搅拌,抽真空脱尽气泡,过滤,保温,得明胶溶液,待用;将松花粉、雨生红球藻粉混合均匀,得药粉;将玉米油加热至70-80℃,加入蜂蜡熔融,降温至40℃,加入药粉,搅拌均匀,胶体磨研磨,过筛,抽真空脱尽气泡,得药液,待用;将配好的药液和明胶溶液置于制丸机中,压丸,定型,洗丸,干燥,选丸,包装,即得软胶囊。
实施例12
松花粉150g、雨生红球藻粉 38g
取处方量的松花粉、雨生红球藻粉混合,加入适量乳糖、微晶纤维素、糊精,混匀,制粒,干燥,整粒,加入适量硬脂酸镁,混匀,压片,包衣,即得片剂。
实施例13
松花粉140g、雨生红球藻粉 50g
取处方量的松花粉加入适量糊精、乳糖、微晶纤维素,混匀,制粒,干燥,整粒,得颗粒,备用;取处方量的雨生红球藻粉加入适量硬脂酸镁与上述颗粒混匀,压片,包衣,即得片剂。
实施例14
松花粉180g、雨生红球藻粉 25g
取处方量的松花粉、雨生红球藻粉混合,加入适量预胶化淀粉、羧甲基纤维素钠、羟丙基纤维素,混匀,制粒,干燥,整粒,加入适量滑石粉、微粉硅胶,混匀,压片,包衣,即得片剂。
实施例15
松花粉190g、雨生红球藻粉 55g
取处方量的松花粉加入适量淀粉、木糖醇、微晶纤维素,混匀,制粒,干燥,整粒,得颗粒,备用;取处方量的雨生红球藻粉加入适量硬脂酸镁与上述颗粒混匀,压片,包衣,即得片剂。
以上均为本发明较佳的实现方案,除此之外,本发明还可以其他实现方式,需要说明的是,在没有脱离本发明发明构思的前提下,任何显而易见的替换均在本发明保护范围之内。
以下通过临床试用结果来阐述本发明组合物的有益效果:
通过对45例良性前列腺增生症患者,服用本发明组合物30天的跟踪观察,在45例患者中排尿困难的均有明显改善,其中10例急性尿潴留患者中有9例恢复自立排尿;20例在服用前经过B超检测前列腺体积,服用本发明组合物后再行检测对比,前列腺体积显著缩小,服用前平均为45.28ml,服用后平均为34.19ml;15例患者接受尿流率检测,服用本发明组合物后,平均尿流率和最大尿流率均有显著升高,残余尿量显著减少,由服用前的平均160.2ml到服用后的平均61.7ml,因此,由临床观察的结果表明,本发明对缩小前列腺增生体积和改善良性前列腺增生症状都是有明显效果的。因此,提示本发明组合物具有改善前列腺症状的功效。
Claims (9)
1.一种具有改善前列腺症状的组合物,其特征在于,它是由下列重量份的组分组成:松花粉100-200份、雨生红球藻粉10-80份。
2.根据权利要求1所述的组合物,其特征在于,它是由下列重量份的组分组成:松花粉130-170份、雨生红球藻粉20-45份。
3.权利要求1或2所述组合物的制备方法,其特征在于,它是这样制备的:
取松花粉、雨生红球藻粉混合,不加或者加入适量辅料,按常规工艺制成制剂。
4.根据权利要求3所述的制备方法,其特征在于,所述的制剂是指片剂、颗粒剂、胶囊剂、丸剂、散剂、口服液体制剂。
5.根据权利要求4所述的制备方法,其特征在于,片剂是这样制备的:
取松花粉、雨生红球藻粉,加入适量填充剂,混匀,制粒,干燥,整粒,加入适量润滑剂,混匀,压片,包衣或不包衣,即得片剂。
6.根据权利要求4所述的制备方法,其特征在于,片剂是这样制备的:
取松花粉加入适量填充剂,混匀,制粒,干燥,整粒,得颗粒,备用;取雨生红球藻粉加入适量润滑剂与上述颗粒,混匀,压片,包衣或不包衣,即得片剂。
7.根据权利要求5或6所述的制备方法,其特征在于,所述的填充剂是指淀粉、甘露醇、木糖醇、预胶化淀粉、糊精、乳糖、麦芽糊精、微晶纤维素中的一种或一种以上;润滑剂是指硬脂酸镁、微粉硅胶、滑石粉中的一种或一种以上。
8.根据权利要求7所述的制备方法,其特征在于,所述的填充剂是指麦芽糊精、微晶纤维素;润滑剂是指硬脂酸镁。
9.权利要求1或2所述组合物用于制备具有改善前列腺症状的食品或保健食品中的应用。
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