CN107209934B - 用于定量分析异质生物标志物分布的方法、系统和装置 - Google Patents

用于定量分析异质生物标志物分布的方法、系统和装置 Download PDF

Info

Publication number
CN107209934B
CN107209934B CN201580065794.2A CN201580065794A CN107209934B CN 107209934 B CN107209934 B CN 107209934B CN 201580065794 A CN201580065794 A CN 201580065794A CN 107209934 B CN107209934 B CN 107209934B
Authority
CN
China
Prior art keywords
image
data
tumor
fov
cluster
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580065794.2A
Other languages
English (en)
Chinese (zh)
Other versions
CN107209934A (zh
Inventor
M.巴恩斯
D.查芬
K.加沙
T.M.格罗根
E.罗伯茨
B.史蒂芬斯
F.文图拉
C.谢夫’奥泰尔
K.尚穆加姆
J.格雷
D.拉姆诺-约翰逊
武 T.(T.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oregon Health and Science University
Ventana Medical Systems Inc
Original Assignee
Oregon Health and Science University
Ventana Medical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oregon Health and Science University, Ventana Medical Systems Inc filed Critical Oregon Health and Science University
Publication of CN107209934A publication Critical patent/CN107209934A/zh
Application granted granted Critical
Publication of CN107209934B publication Critical patent/CN107209934B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/21—Design or setup of recognition systems or techniques; Extraction of features in feature space; Blind source separation
    • G06F18/213—Feature extraction, e.g. by transforming the feature space; Summarisation; Mappings, e.g. subspace methods
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/10—Segmentation; Edge detection
    • G06T7/11—Region-based segmentation
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/90—Determination of colour characteristics
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/23—Clustering techniques
    • G06F18/232—Non-hierarchical techniques
    • G06F18/2321—Non-hierarchical techniques using statistics or function optimisation, e.g. modelling of probability density functions
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/23—Clustering techniques
    • G06F18/232—Non-hierarchical techniques
    • G06F18/2321—Non-hierarchical techniques using statistics or function optimisation, e.g. modelling of probability density functions
    • G06F18/23211—Non-hierarchical techniques using statistics or function optimisation, e.g. modelling of probability density functions with adaptive number of clusters
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10032—Satellite or aerial image; Remote sensing
    • G06T2207/10036—Multispectral image; Hyperspectral image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10064—Fluorescence image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20024—Filtering details
    • G06T2207/20032—Median filtering
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20092—Interactive image processing based on input by user
    • G06T2207/20104—Interactive definition of region of interest [ROI]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/20—Special algorithmic details
    • G06T2207/20112—Image segmentation details
    • G06T2207/20152—Watershed segmentation
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30096—Tumor; Lesion
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/20—Image preprocessing
    • G06V10/25—Determination of region of interest [ROI] or a volume of interest [VOI]
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/40—Extraction of image or video features
    • G06V10/56—Extraction of image or video features relating to colour

Landscapes

  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Multimedia (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Quality & Reliability (AREA)
  • Radiology & Medical Imaging (AREA)
  • Data Mining & Analysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Artificial Intelligence (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Evolutionary Computation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
CN201580065794.2A 2014-12-03 2015-12-03 用于定量分析异质生物标志物分布的方法、系统和装置 Active CN107209934B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462086840P 2014-12-03 2014-12-03
US62/086840 2014-12-03
PCT/EP2015/078532 WO2016087589A1 (en) 2014-12-03 2015-12-03 Methods, systems, and apparatuses for quantitative analysis of heterogeneous biomarker distribution

Publications (2)

Publication Number Publication Date
CN107209934A CN107209934A (zh) 2017-09-26
CN107209934B true CN107209934B (zh) 2021-03-30

Family

ID=54979630

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580065794.2A Active CN107209934B (zh) 2014-12-03 2015-12-03 用于定量分析异质生物标志物分布的方法、系统和装置

Country Status (7)

Country Link
US (4) US10664967B2 (enExample)
EP (1) EP3227830B8 (enExample)
JP (1) JP6654634B2 (enExample)
CN (1) CN107209934B (enExample)
AU (1) AU2015357088A1 (enExample)
CA (1) CA2969038C (enExample)
WO (1) WO2016087589A1 (enExample)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014531908A (ja) 2011-10-14 2014-12-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 構造アッセンブリによる配列決定
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
US10138509B2 (en) 2013-03-12 2018-11-27 President And Fellows Of Harvard College Method for generating a three-dimensional nucleic acid containing matrix
WO2015069827A2 (en) * 2013-11-06 2015-05-14 H. Lee Moffitt Cancer Center And Research Institute, Inc. Pathology case review, analysis and prediction
WO2016007839A1 (en) 2014-07-11 2016-01-14 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
JP6893877B2 (ja) 2014-10-29 2021-06-23 スペクトラル エムディー, インコーポレイテッドSpectral Md, Inc. 組織を分類するための反射モードマルチスペクトル時間分解型光学イメージングの方法および装置
US20180040120A1 (en) * 2014-12-29 2018-02-08 Flagship Biosciences, Inc. Methods for quantitative assessment of mononuclear cells in muscle tissue sections
JP7092503B2 (ja) * 2014-12-30 2022-06-28 ベンタナ メディカル システムズ， インコーポレイテッド 共発現解析のためのシステム及び方法
HK1248112A1 (zh) 2015-02-02 2018-10-12 Novadaq Technologies ULC 用於表徵受试者的组织的方法和系统
KR20240116531A (ko) 2015-02-09 2024-07-29 슬링샷 바이오사이언시즈 인코포레이티드 튜닝가능한 광 특성을 갖는 하이드로겔 입자 및 이를 사용하기 위한 방법
EP3352697A4 (en) 2015-09-23 2019-06-19 Novadaq Technologies ULC METHOD AND SYSTEMS FOR ADMINISTERING DATA FROM MEDICAL IMAGING
JP6882282B2 (ja) 2015-11-03 2021-06-02 プレジデント アンド フェローズ オブ ハーバード カレッジ 三次元核酸含有マトリックスの立体撮像のための方法と装置
US9524205B1 (en) * 2016-01-04 2016-12-20 International Business Machines Corporation Code fingerprint-based processor malfunction detection
EP3203413A1 (en) * 2016-02-08 2017-08-09 Ecole Polytechnique Federale De Lausanne (Epfl) Method for quantitative measurement of a biomarker by in situ immunofluorescence and uses thereof
EP4613756A3 (en) 2016-04-25 2025-11-12 President And Fellows Of Harvard College Hybridization chain reaction methods for in situ molecular detection
CN109564617B (zh) * 2016-06-13 2023-09-26 纳诺利弗股份有限公司 表征和成像微观物体的方法
WO2017221592A1 (ja) * 2016-06-23 2017-12-28 コニカミノルタ株式会社 画像処理装置、画像処理方法及び画像処理プログラム
US10572996B2 (en) * 2016-06-28 2020-02-25 Contextvision Ab Method and system for detecting pathological anomalies in a digital pathology image and method for annotating a tissue slide
EP3275361B1 (en) * 2016-07-29 2024-06-05 Leica Instruments (Singapore) Pte. Ltd. Medical imaging apparatus and method for the imaging of a light-sensitive object, such as biological tissue
CN109843176A (zh) * 2016-07-29 2019-06-04 诺瓦达克技术有限公司 用于利用机器学习来表征受验者的组织的方法和系统
CN109923216B (zh) 2016-08-31 2024-08-02 哈佛学院董事及会员团体 将生物分子的检测组合到使用荧光原位测序的单个试验的方法
WO2018052912A1 (en) * 2016-09-13 2018-03-22 Oregon Health & Science University Pathogen quantification using labeled probes
TR201619702A1 (tr) * 2016-12-27 2018-07-23 Univ Yeditepe Hücresel otomatlar i̇le kümeleme problemi̇ni̇n isi yayilimi tabanli çözülmesi̇ne yöneli̇k bi̇r yöntem
CN110573066A (zh) 2017-03-02 2019-12-13 光谱Md公司 用于多光谱截肢部位分析的机器学习系统和技术
US9738937B1 (en) * 2017-03-31 2017-08-22 Cellmax, Ltd. Identifying candidate cells using image analysis
WO2019002281A1 (en) * 2017-06-28 2019-01-03 Ventana Medical Systems, Inc. CALIBRATION OF SYSTEM LEVEL
CN107818341A (zh) * 2017-10-25 2018-03-20 天津大学 一种基于改进K‑means算法的颜色提取方法
CN111448584B (zh) * 2017-12-05 2023-09-26 文塔纳医疗系统公司 计算肿瘤空间和标记间异质性的方法
US11568657B2 (en) 2017-12-06 2023-01-31 Ventana Medical Systems, Inc. Method of storing and retrieving digital pathology analysis results
JP7197584B2 (ja) * 2017-12-06 2022-12-27 ベンタナ メディカル システムズ， インコーポレイテッド デジタル病理学分析結果の格納および読み出し方法
CN108228900B (zh) * 2018-02-06 2021-12-24 国网山西省电力公司电力科学研究院 基于分层结构的电力设备多光谱数据中心模型建立方法
CN108427657B (zh) * 2018-02-28 2021-05-25 东北大学 一种地下水封油库水幕系统有效性分析与调控方法
CN108537785B (zh) * 2018-04-04 2021-04-30 北京大学人民医院 一种子宫超声微蠕动视频处理方法
GB201806002D0 (en) * 2018-04-11 2018-05-23 Univ Liverpool Methods of spectroscopic analysis
EP3776458B1 (en) * 2018-04-12 2022-05-04 Google LLC Augmented reality microscope for pathology with overlay of quantitative biomarker data
CN108664937A (zh) * 2018-05-14 2018-10-16 宁波江丰生物信息技术有限公司 一种基于数字病理切片扫描仪的多区域扫描方法
EP3794548B1 (en) * 2018-05-15 2024-06-26 Ventana Medical Systems, Inc. Quantitation of signal in stain aggregates
CN108648199B (zh) * 2018-05-21 2022-07-19 上海工程技术大学 基于分水岭和cv模型的超声相控阵ndt图像分割方法
WO2019231298A1 (ko) * 2018-05-31 2019-12-05 (주) 솔 영상 기반의 대면적 시료 분석 장치, 매질 특성 차이를 이용한 영상 기반의 시료 분석 장치 및 이를 이용하여 시료를 측정하고 분석하는 방법
CN108562750A (zh) * 2018-06-01 2018-09-21 安图实验仪器(郑州)有限公司 印迹膜条结果判读方法
KR102162895B1 (ko) * 2018-06-04 2020-10-07 주식회사 딥바이오 듀얼 클래스를 지원하는 질병 진단 시스템 및 그 방법
EP3591574A3 (en) * 2018-07-06 2020-01-15 Universität Zürich Method and computer program for clustering large multiplexed spatially resolved data of a biological sample
US12020493B2 (en) 2018-07-27 2024-06-25 Ventana Medical Systems, Inc. Systems for automated in situ hybridization analysis
KR102215269B1 (ko) * 2018-08-07 2021-02-15 주식회사 딥바이오 진단 결과 생성 시스템 및 방법
EP3608701A1 (de) * 2018-08-09 2020-02-12 Olympus Soft Imaging Solutions GmbH Verfahren zur bereitstellung wenigstens einer auswertemethode für proben
WO2020066041A1 (ja) 2018-09-28 2020-04-02 オリンパス株式会社 顕微鏡システム
JPWO2020066043A1 (ja) * 2018-09-28 2021-08-30 オリンパス株式会社 顕微鏡システム、投影ユニット、及び、画像投影方法
EP3988988A4 (en) 2018-09-28 2023-09-13 Evident Corporation Microscope system, projection unit, and image projection method
CN112714886B (zh) 2018-09-28 2023-03-21 仪景通株式会社 显微镜系统、投影单元以及图像投影方法
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
US12288323B2 (en) 2018-10-17 2025-04-29 Koninklijke Philips N.V. Mapping image signatures of cancer cells to genetic signatures
BR112021011132A2 (pt) 2018-12-14 2021-08-31 Spectral Md, Inc. Sistemas de aprendizado por máquina e métodos para avaliação, predição de cicatrização e tratamento de feridas
WO2020123722A1 (en) * 2018-12-14 2020-06-18 Spectral Md, Inc. System and method for high precision multi-aperture spectral imaging
US10740884B2 (en) * 2018-12-14 2020-08-11 Spectral Md, Inc. System and method for high precision multi-aperture spectral imaging
WO2020142461A1 (en) * 2018-12-31 2020-07-09 Oregon Health & Science University Translation of images of stained biological material
CN109712142B (zh) * 2019-01-11 2023-03-28 山东省计算中心（国家超级计算济南中心） 基于染色分离的乳腺癌Ki67/ER/PR核染色细胞计数方法
KR102805539B1 (ko) * 2019-02-01 2025-05-12 한국전자통신연구원 인물 영역 추출 방법, 이를 이용하는 영상 처리 장치 및 인물 영역 추출 시스템
CN110163250B (zh) * 2019-04-10 2023-10-24 创新先进技术有限公司 基于分布式调度的图像脱敏处理系统、方法以及装置
CN109961448A (zh) * 2019-04-10 2019-07-02 杭州智团信息技术有限公司 组织病变区域勾勒方法及系统
EP3953898A4 (en) * 2019-04-12 2023-01-11 Invenio Imaging Inc. IMAGING SYSTEM FOR DETECTING INTRAOPERATIVE CONTRAST AGENT IN TISSUE
JP7092952B2 (ja) * 2019-04-25 2022-06-28 ドルビー ラボラトリーズ ライセンシング コーポレイション ライブフィードにおけるコンテンツアウェアｐｑレンジアナライザとトーンマッピング
US12152969B2 (en) * 2019-06-04 2024-11-26 JelloX Biotech Inc. Method for preparation of tissue sections
US20200388032A1 (en) * 2019-06-04 2020-12-10 JelloX Biotech Inc. Three dimensional histopathology imaging method and system thereof
CN110208244B (zh) * 2019-06-18 2020-07-28 华南理工大学 一种基于拉曼光谱测试果蔬组织中细胞水平水分含量和分布的方法
US20210027890A1 (en) * 2019-07-24 2021-01-28 ConnSante BioTech, Inc. Detecting, evaluating and predicting system for cancer risk
CN110504029B (zh) * 2019-08-29 2022-08-19 腾讯医疗健康(深圳)有限公司 一种医学图像处理方法、医学图像识别方法及装置
CN114902342A (zh) * 2019-10-18 2022-08-12 纳米线科技公司 用于表达谱分析的空间映射的系统和方法
AU2020388047A1 (en) * 2019-11-18 2022-06-23 10X Genomics, Inc. Systems and methods for tissue classification
JP2021081342A (ja) * 2019-11-20 2021-05-27 ソニーグループ株式会社 情報処理システムおよび情報処理装置
WO2021102039A1 (en) * 2019-11-21 2021-05-27 10X Genomics, Inc, Spatial analysis of analytes
WO2021102005A1 (en) * 2019-11-22 2021-05-27 10X Genomics, Inc. Systems and methods for spatial analysis of analytes using fiducial alignment
WO2021127019A1 (en) * 2019-12-17 2021-06-24 Applied Materials, Inc. System and method for acquisition and processing of multiplexed fluorescence in-situ hybridization images
US11977723B2 (en) * 2019-12-17 2024-05-07 Palantir Technologies Inc. Image tiling and distributive modification
KR102512332B1 (ko) * 2019-12-24 2023-03-22 광운대학교 산학협력단 신경세포의 신호전달 학습이 가능한 바이오닉 뉴럴 인공지능 프로세서
US11908130B2 (en) * 2020-01-03 2024-02-20 Protein Metrics Llc Apparatuses and methods for digital pathology
EP4088288B1 (en) * 2020-01-06 2025-10-29 PAIGE.AI, Inc. Systems and methods for processing electronic images for computational assessment of disease
EP4094064A4 (en) 2020-01-24 2024-02-28 Slingshot Biosciences, Inc. Compositions and methods for cell-like calibration particles
US11250568B2 (en) * 2020-03-06 2022-02-15 Bostongene Corporation Techniques for determining tissue characteristics using multiplexed immunofluorescence imaging
CZ308990B6 (cs) * 2020-03-20 2021-11-10 Univerzita Hradec Králové Způsob zpracování předzpracovaného obrazu a zařízení k provádění tohoto způsobu
WO2021221985A1 (en) * 2020-04-27 2021-11-04 Ventana Medical Systems, Inc. Methods for efficiently determining density and spatial relationship of multiple cell types in regions of tissue
KR20230029612A (ko) 2020-05-04 2023-03-03 슬링샷 바이오사이언시즈 인코포레이티드 다중 검정을 위한 수동 광학 바코딩용 조성물 및 방법
KR102512331B1 (ko) * 2020-05-06 2023-03-22 광운대학교 산학협력단 신경세포의 신호 전달 체계를 이용하여 비정형적 연산의 출력이 가능한 바이오닉 뉴럴 인공지능 프로세서
GB2594939B (en) 2020-05-11 2022-05-11 Forsite Diagnostics Ltd Assay reading method
FR3112010B1 (fr) * 2020-06-26 2022-07-08 Institut National De Rech En Informatique Et En Automatique Dispositif d’imagerie tumorale
US11422355B2 (en) * 2020-07-22 2022-08-23 Sartorius Bioanalytical Instruments, Inc. Method and system for acquisition of fluorescence images of live-cell biological samples
WO2022031616A1 (en) 2020-08-04 2022-02-10 PAIGE.AI, Inc. Systems and methods to process electronic images to provide image-based cell group targeting
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
CN111982638B (zh) * 2020-08-20 2023-11-10 诒福生物科技南通有限公司 生物组织染色方法、装置、计算机设备和存储介质
GB2601057B (en) * 2020-10-21 2024-01-17 Green Vision Systems Ltd Method and system for detecting a biological substance by hyperspectral imaging
WO2022125558A1 (en) * 2020-12-11 2022-06-16 Progenity, Inc. Methods and systems for image processing
CN112911105B (zh) * 2021-01-19 2022-03-29 中国计量科学研究院 一种数字pcr结果读取装置及读取方法
US11734242B1 (en) * 2021-03-31 2023-08-22 Amazon Technologies, Inc. Architecture for resolution of inconsistent item identifiers in a global catalog
CN113297723B (zh) * 2021-04-22 2022-11-08 哈尔滨理工大学 基于均值漂移-灰色关联分析的电主轴温度测点优化方法
US11995810B2 (en) * 2021-04-27 2024-05-28 City University Of Hong Kong System and method for generating a stained image
CN113240685B (zh) * 2021-04-29 2023-06-13 平安科技（深圳）有限公司 图像层次化超像素分割方法、系统、电子设备及存储介质
CN113450877B (zh) * 2021-06-28 2022-04-08 深圳裕泰抗原科技有限公司 一种基于多重免疫组化技术的生物标志物分析方法及其应用
CN113593640B (zh) * 2021-08-03 2023-07-28 哈尔滨市米杰生物科技有限公司 一种鳞癌组织功能状态与细胞组分评估方法及系统
US20240428939A1 (en) * 2021-09-22 2024-12-26 Volastra Therapeutics, Inc. Systems and methods for evaluation of mitotic events using machine-learning
US12327625B2 (en) 2021-09-24 2025-06-10 PAIGE.AI, Inc. Systems and methods to process electronic images to identify tumor subclones and relationships among subclones
CN113762416B (zh) * 2021-10-15 2023-05-30 南京澄实生物科技有限公司 基于多模态深度编码的抗原免疫原性预测方法和系统
CA3235582A1 (en) 2021-10-29 2023-05-04 Anh Tuan Nguyen Hydrogel particles as feeder cells and as synthetic antigen presenting cells
TWI813145B (zh) * 2022-01-25 2023-08-21 佛教慈濟醫療財團法人 多重螢光組織影像分析方法及其系統
EP4519690A1 (en) 2022-05-05 2025-03-12 Slingshot Biosciences, Inc. Engineered particles as red blood cell mimics and compositions containing same for hematology
KR20250025383A (ko) 2022-06-02 2025-02-21 슬링샷 바이오사이언시즈 인코포레이티드 아폽토시스 세포 모방체
CN115099287B (zh) * 2022-08-24 2022-11-11 山东大学 基于图傅里叶变换的空间可变基因识别与分析系统
CN120712108A (zh) 2022-10-26 2025-09-26 弹弓生物科学公司 具有可调整光学性质的大小可调整合成颗粒和用于使用其进行免疫细胞激活的方法
CN120239886A (zh) * 2022-12-30 2025-07-01 深圳华大生命科学研究院 一种组织切片数据异质性的评估方法以及相关设备
WO2024185434A1 (ja) * 2023-03-03 2024-09-12 ソニーグループ株式会社 情報処理装置、生体試料解析システム及び生体試料解析方法
WO2025049609A1 (en) 2023-08-29 2025-03-06 Slingshot Biosciences, Inc. Cd34 stem cell mimics
CN120927952B (zh) * 2025-09-30 2025-12-05 南通大学附属医院 一种基于空间重构的多重免疫荧光检测方法、设备及介质

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102308212A (zh) * 2008-12-04 2012-01-04 加利福尼亚大学董事会 用于确定前列腺癌诊断和预后的材料和方法
WO2014031997A1 (en) * 2012-08-24 2014-02-27 Yale University System, device and method for high-throughput multi-plexed detection

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2237189B1 (en) * 2005-01-27 2018-08-01 Cambridge Research & Instrumentation, Inc. Classifying image features
EP1882237A2 (en) * 2005-05-13 2008-01-30 Tripath Imaging, Inc. Methods of chromogen separation-based image analysis
CN101553579B (zh) 2006-10-06 2016-01-20 赛里根有限公司 用于定向生物标志物信号放大的荧光方法和材料
WO2008073187A2 (en) 2006-10-30 2008-06-19 George Mason Intellectual Properties, Inc. Tissue preservation and fixation method
DK2078197T3 (en) 2006-11-01 2016-05-23 Ventana Med Syst Inc Haptenes, hapten conjugates, compositions thereof and processes for their preparation and use
US8244021B2 (en) 2006-12-20 2012-08-14 Ventana Medical Systems, Inc. Quantitative, multispectral image analysis of tissue specimens stained with quantum dots
EP2335221B8 (en) 2008-09-16 2016-05-25 Novartis AG Reproducible quantification of biomarker expression
US10126216B2 (en) 2011-02-17 2018-11-13 Ventana Medical Systems, Inc. Method for tissue sample fixation
JP2014110592A (ja) * 2012-12-04 2014-06-12 Toshiba Corp 画像処理装置
US8995740B2 (en) * 2013-04-17 2015-03-31 General Electric Company System and method for multiplexed biomarker quantitation using single cell segmentation on sequentially stained tissue

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102308212A (zh) * 2008-12-04 2012-01-04 加利福尼亚大学董事会 用于确定前列腺癌诊断和预后的材料和方法
WO2014031997A1 (en) * 2012-08-24 2014-02-27 Yale University System, device and method for high-throughput multi-plexed detection

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Spectral imaging in preclinical research and clinical pathology;Levenson;《Analytical Cellular Pathology》;20121230;摘要以及第342-350页 *

Also Published As

Publication number Publication date
JP6654634B2 (ja) 2020-02-26
US20170262984A1 (en) 2017-09-14
US20200219256A1 (en) 2020-07-09
CA2969038A1 (en) 2016-06-09
US20230260116A1 (en) 2023-08-17
EP3227830B8 (en) 2020-07-01
CA2969038C (en) 2023-07-04
EP3227830A1 (en) 2017-10-11
US10664967B2 (en) 2020-05-26
EP3227830B1 (en) 2020-05-20
AU2015357088A1 (en) 2017-05-18
JP2018509591A (ja) 2018-04-05
US11049247B2 (en) 2021-06-29
CN107209934A (zh) 2017-09-26
WO2016087589A1 (en) 2016-06-09
US11663717B2 (en) 2023-05-30
US20210279870A1 (en) 2021-09-09

Similar Documents

Publication Publication Date Title
US20230260116A1 (en) Methods, Systems, and Apparatuses for Quantitative Analysis of Heterogeneous Biomarker Distribution
JP7273215B2 (ja) 画像処理のための自動アッセイ評価および正規化
Ptacek et al. Multiplexed ion beam imaging (MIBI) for characterization of the tumor microenvironment across tumor types
US12367692B2 (en) Systems for automated in situ hybridization analysis
Blom et al. Systems pathology by multiplexed immunohistochemistry and whole-slide digital image analysis
JP6800152B2 (ja) 組織学画像中の核の分類
Mori et al. Characterizing the tumor immune microenvironment with tyramide-based multiplex immunofluorescence
JP2021506003A (ja) デジタル病理学分析結果の格納および読み出し方法
JP7214756B2 (ja) ステイン集合体における信号の定量
Maiques et al. Recent advances in tissue imaging for cancer research
JP2023022233A (ja) 散乱補正を用いた色分離
Doyle et al. Whole-Slide Imaging, Mutual Information Registration for Multiplex Immunohistochemistry and Immunofluorescence
Dolled-Filhart et al. Automated analysis of tissue microarrays
Moeder et al. Quantitative, fluorescence-based in-situ assessment of protein expression
GROGAN et al. C ZIT) źd d': http:% pic. gc. ca-Ottawa-Hull K1A 0C9-http://cipo. gc. ca () PI
Grote et al. Exploring the spatial dimension of estrogen and progesterone signaling: detection of nuclear labeling in lobular epithelial cells in normal mammary glands adjacent to breast cancer
Roberts et al. Mapping cancer signaling networks by an integrated multiplexed tissue imaging platform
Kung Assessing a Hyperspectral Image Analysis System to Study Tumor and Immune Cell Spatial Organizations Within Lung Tumor Microenvironments
Stokes et al. Quality Control and Analysis Algorithms for Tissue Microarrays as Biomarker Validation Tools

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CB03 Change of inventor or designer information

Inventor after: M. Barnes

Inventor after: J. Gray

Inventor after: D. Lamunuo - Johnson

Inventor after: T.(T.)Wu

Inventor after: B J Drucker

Inventor after: T. James

Inventor after: D .chafen

Inventor after: Garsha Karl

Inventor after: T.M. Grogan

Inventor after: E. Roberts

Inventor after: B. Stephen

Inventor after: F. Ventura

Inventor after: C. Xie Fu, Altair

Inventor after: K. Shammugam

Inventor before: M. Barnes

Inventor before: J. Gray

Inventor before: D. Lamunuo - Johnson

Inventor before: T.(T.)Wu

Inventor before: D .chafen

Inventor before: Garsha Karl

Inventor before: T.M. Grogan

Inventor before: E. Roberts

Inventor before: B. Stephen

Inventor before: F. Ventura

Inventor before: C. Xie Fu, Altair

Inventor before: K. Shammugam

CB03 Change of inventor or designer information