CN107207559B - 作为制备类固醇fxr调节剂的中间体的6-烷基-7-羟基-4-烯-3-酮类固醇 - Google Patents

作为制备类固醇fxr调节剂的中间体的6-烷基-7-羟基-4-烯-3-酮类固醇 Download PDF

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Publication number
CN107207559B
CN107207559B CN201580062904.XA CN201580062904A CN107207559B CN 107207559 B CN107207559 B CN 107207559B CN 201580062904 A CN201580062904 A CN 201580062904A CN 107207559 B CN107207559 B CN 107207559B
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CN107207559A (zh
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A·韦茅斯-威尔逊
Z·科姆斯塔
J·博伊德尔
C·奥特
L·沃利斯
R·巴彻勒
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Nzp Uk Ltd
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Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1505670.8A external-priority patent/GB201505670D0/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201580062904.XA 2014-11-19 2015-11-19 作为制备类固醇fxr调节剂的中间体的6-烷基-7-羟基-4-烯-3-酮类固醇 Active CN107207559B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GB1420593.4 2014-11-19
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GB1420594.2 2014-11-19
GBGB1505670.8A GB201505670D0 (en) 2015-04-01 2015-04-01 Compounds
GB1505670.8 2015-04-01
PCT/GB2015/053516 WO2016079517A1 (en) 2014-11-19 2015-11-19 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators

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CN107207559A CN107207559A (zh) 2017-09-26
CN107207559B true CN107207559B (zh) 2019-10-25

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US (1) US10301350B2 (https=)
EP (1) EP3221331B1 (https=)
JP (1) JP6700274B2 (https=)
KR (1) KR102526631B1 (https=)
CN (1) CN107207559B (https=)
BR (1) BR112017010319B1 (https=)
CA (1) CA2968309A1 (https=)
DK (1) DK3221331T3 (https=)
EA (1) EA033427B1 (https=)
ES (1) ES2759725T3 (https=)
MX (1) MX375863B (https=)
PL (1) PL3221331T3 (https=)
PT (1) PT3221331T (https=)
TW (1) TWI690536B (https=)
WO (1) WO2016079517A1 (https=)

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CN111138509B (zh) * 2018-11-02 2022-12-06 东莞东阳光药物研发有限公司 奥贝胆酸的制备方法
CN112521438B (zh) * 2020-12-08 2021-11-23 苏利制药科技江阴有限公司 一种β-谷甾醇的合成工艺
WO2023288123A1 (en) * 2021-07-16 2023-01-19 Interecept Pharmaceuticals, Inc. Methods and intermediates for the preparation of 3.alpha.,7.alpha.,11.beta.-trihydroxy-6.alpha.-ethyl-5.beta.-cholan-24-oic acid
CN113912661B (zh) * 2021-11-11 2023-04-21 湖南科瑞生物制药股份有限公司 一种7-羟基甾体化合物的合成方法

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MX375863B (es) 2025-03-07
EP3221331A1 (en) 2017-09-27
DK3221331T3 (da) 2019-12-02
PL3221331T3 (pl) 2020-03-31
NZ731924A (en) 2020-12-18
PT3221331T (pt) 2019-12-23
KR20170086604A (ko) 2017-07-26
EA201790884A8 (ru) 2019-07-31
EP3221331B1 (en) 2019-09-18
ES2759725T3 (es) 2020-05-12
EA033427B1 (ru) 2019-10-31
TW201632537A (zh) 2016-09-16
TWI690536B (zh) 2020-04-11
WO2016079517A1 (en) 2016-05-26
HK1246801A1 (en) 2018-09-14
KR102526631B1 (ko) 2023-04-27
JP2017534670A (ja) 2017-11-24
CA2968309A1 (en) 2016-05-26
BR112017010319B1 (pt) 2023-04-11
BR112017010319A2 (pt) 2017-12-26
CN107207559A (zh) 2017-09-26
JP6700274B2 (ja) 2020-05-27
MX2017006563A (es) 2018-01-26
US20170327528A1 (en) 2017-11-16
US10301350B2 (en) 2019-05-28
EA201790884A1 (ru) 2017-11-30

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