CA2968309A1 - 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators - Google Patents

6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators Download PDF

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Publication number
CA2968309A1
CA2968309A1 CA2968309A CA2968309A CA2968309A1 CA 2968309 A1 CA2968309 A1 CA 2968309A1 CA 2968309 A CA2968309 A CA 2968309A CA 2968309 A CA2968309 A CA 2968309A CA 2968309 A1 CA2968309 A1 CA 2968309A1
Authority
CA
Canada
Prior art keywords
general formula
compound
alkyl
halo
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2968309A
Other languages
English (en)
French (fr)
Inventor
Alexander Weymouth-Wilson
Zofia KOMSTA
James Boydell
Carl OTTER
Laura WALLIS
Rhys BATCHELOR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nzp Uk Ltd
Original Assignee
Nzp Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1505670.8A external-priority patent/GB201505670D0/en
Application filed by Nzp Uk Ltd filed Critical Nzp Uk Ltd
Publication of CA2968309A1 publication Critical patent/CA2968309A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2968309A 2014-11-19 2015-11-19 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators Abandoned CA2968309A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GB1420593.4 2014-11-19
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GB1420594.2 2014-11-19
GBGB1505670.8A GB201505670D0 (en) 2015-04-01 2015-04-01 Compounds
GB1505670.8 2015-04-01
PCT/GB2015/053516 WO2016079517A1 (en) 2014-11-19 2015-11-19 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators

Publications (1)

Publication Number Publication Date
CA2968309A1 true CA2968309A1 (en) 2016-05-26

Family

ID=54704019

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2968309A Abandoned CA2968309A1 (en) 2014-11-19 2015-11-19 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators

Country Status (15)

Country Link
US (1) US10301350B2 (https=)
EP (1) EP3221331B1 (https=)
JP (1) JP6700274B2 (https=)
KR (1) KR102526631B1 (https=)
CN (1) CN107207559B (https=)
BR (1) BR112017010319B1 (https=)
CA (1) CA2968309A1 (https=)
DK (1) DK3221331T3 (https=)
EA (1) EA033427B1 (https=)
ES (1) ES2759725T3 (https=)
MX (1) MX375863B (https=)
PL (1) PL3221331T3 (https=)
PT (1) PT3221331T (https=)
TW (1) TWI690536B (https=)
WO (1) WO2016079517A1 (https=)

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US10131688B2 (en) 2014-11-19 2018-11-20 NZP UK Limited 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal FXR modulators
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GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
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CN112521438B (zh) * 2020-12-08 2021-11-23 苏利制药科技江阴有限公司 一种β-谷甾醇的合成工艺
WO2023288123A1 (en) * 2021-07-16 2023-01-19 Interecept Pharmaceuticals, Inc. Methods and intermediates for the preparation of 3.alpha.,7.alpha.,11.beta.-trihydroxy-6.alpha.-ethyl-5.beta.-cholan-24-oic acid
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US10538550B2 (en) 2014-11-19 2020-01-21 NZP UK Limited 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal FXR modulators
US10131688B2 (en) 2014-11-19 2018-11-20 NZP UK Limited 5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal FXR modulators
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Also Published As

Publication number Publication date
MX375863B (es) 2025-03-07
EP3221331A1 (en) 2017-09-27
DK3221331T3 (da) 2019-12-02
PL3221331T3 (pl) 2020-03-31
NZ731924A (en) 2020-12-18
PT3221331T (pt) 2019-12-23
KR20170086604A (ko) 2017-07-26
CN107207559B (zh) 2019-10-25
EA201790884A8 (ru) 2019-07-31
EP3221331B1 (en) 2019-09-18
ES2759725T3 (es) 2020-05-12
EA033427B1 (ru) 2019-10-31
TW201632537A (zh) 2016-09-16
TWI690536B (zh) 2020-04-11
WO2016079517A1 (en) 2016-05-26
HK1246801A1 (en) 2018-09-14
KR102526631B1 (ko) 2023-04-27
JP2017534670A (ja) 2017-11-24
BR112017010319B1 (pt) 2023-04-11
BR112017010319A2 (pt) 2017-12-26
CN107207559A (zh) 2017-09-26
JP6700274B2 (ja) 2020-05-27
MX2017006563A (es) 2018-01-26
US20170327528A1 (en) 2017-11-16
US10301350B2 (en) 2019-05-28
EA201790884A1 (ru) 2017-11-30

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20210831