CN107207532A - 抗肺结核病的硝基咪唑衍生物 - Google Patents

抗肺结核病的硝基咪唑衍生物 Download PDF

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Publication number
CN107207532A
CN107207532A CN201680006991.1A CN201680006991A CN107207532A CN 107207532 A CN107207532 A CN 107207532A CN 201680006991 A CN201680006991 A CN 201680006991A CN 107207532 A CN107207532 A CN 107207532A
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methyl
milliliters
milligrams
equivalents
dihydro
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CN201680006991.1A
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CN107207532B (zh
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罗微
丁照中
黄志刚
陈曙辉
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Chengdu Jiabao Pharmaceutical Silver Pharmaceutical Technology Co ltd
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Medshine Discovery Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

本发明公开了一种取代硝基咪唑类衍生物，其主要用于治疗由分支杆菌感染引起的相关疾病，如结核分枝杆菌，尤其适用于耐药性结核分支杆菌引起的疾病。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201680006991.1A 2015-01-29 2016-01-28 抗肺结核病的硝基咪唑衍生物 Active CN107207532B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2015100480408 2015-01-29
CN201510048040 2015-01-29
CN201610006632.8A CN106946909A (zh) 2016-01-06 2016-01-06 抗肺结核病的硝基咪唑衍生物
CN2016100066328 2016-01-06
PCT/CN2016/072447 WO2016119706A1 (zh) 2015-01-29 2016-01-28 抗肺结核病的硝基咪唑衍生物

Publications (2)

Publication Number Publication Date
CN107207532A true CN107207532A (zh) 2017-09-26
CN107207532B CN107207532B (zh) 2019-07-30

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CN201680006991.1A Active CN107207532B (zh) 2015-01-29 2016-01-28 抗肺结核病的硝基咪唑衍生物

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US (1) US10227362B2 (zh)
EP (1) EP3252059A4 (zh)
JP (1) JP6542900B2 (zh)
CN (1) CN107207532B (zh)
BR (1) BR112017015744A2 (zh)
MX (1) MX2017009810A (zh)
RU (1) RU2675622C1 (zh)
TW (1) TW201632533A (zh)
WO (1) WO2016119706A1 (zh)
ZA (1) ZA201705362B (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109496214A (zh) * 2016-07-22 2019-03-19 南京明德新药研发股份有限公司 一种硝基咪唑类化合物的晶型、盐型及其制备方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10971760B2 (en) 2018-01-31 2021-04-06 Keracel, Inc. Hybrid solid-state cell with a sealed anode structure
JP7530384B2 (ja) 2019-05-01 2024-08-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング （ｒ）－（２－メチルオキシラン－２－イル）メチル ４－ブロモベンゼンスルホネート
CN113603706A (zh) * 2021-08-04 2021-11-05 深圳市泰力生物医药有限公司 德拉马尼的晶型、含有该晶型的活性药物和药物组合物
WO2023237580A1 (en) * 2022-06-07 2023-12-14 Institut National De La Sante Et De La Recherche Medicale Tricyclic spirolactam compounds with antimycobacterial activity

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1705670A (zh) * 2002-10-11 2005-12-07 大塚制药株式会社 2,3－二氢－6－硝基咪唑并[2,1－b]噁唑化合物
CN1878777A (zh) * 2003-10-31 2006-12-13 大塚制药株式会社 治疗结核病的2,3－二氢－6－硝基咪唑并[2,1－b]噁唑化合物
CN103596960A (zh) * 2011-04-15 2014-02-19 大塚制药株式会社 6,7-二氢咪唑并[2,1-b][1,3]噁嗪杀菌剂

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087358A (en) 1995-06-26 2000-07-11 Pathogenesis Corporation Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof
US5668127A (en) 1995-06-26 1997-09-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
ES2314460T3 (es) * 2003-10-31 2009-03-16 Otsuka Pharmaceutical Co., Ltd. Compuestos de 2,3-dihidro-6-nitroimidazo (2,1-b)oxazol para el tratamiento de la tuberculosis.
JP4761756B2 (ja) 2003-10-31 2011-08-31 大塚製薬株式会社 ２，３−ジヒドロイミダゾ［２，１−ｂ］オキサゾ−ル化合物
JP4787529B2 (ja) * 2004-04-09 2011-10-05 大塚製薬株式会社 医薬組成物
CA2631661A1 (en) 2005-12-23 2007-07-05 Novartis Ag Nitroimidazole compounds
WO2008008480A2 (en) 2006-07-12 2008-01-17 Cumbre Pharmaceuticals Inc. Nitroheteroaryl-containing rifamycin derivatives
AR070301A1 (es) 2007-05-08 2010-03-31 Otsuka Pharma Co Ltd Compuesto epoxi y metodo para producir el mismo
EP2254892B1 (en) 2008-03-26 2014-04-23 Global Alliance For Tb Drug Development Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones
AU2010278777B2 (en) 2009-07-31 2015-05-07 Global Alliance For Tb Drug Development Nitroimidazooxazines and their uses in anti-tubercular therapy
NZ598165A (en) 2009-07-31 2013-05-31 Global Alliance For Tb Drug Dev Nitroimidazooxazine and nitroimidazooxazole analogues and their uses
WO2011087995A2 (en) 2010-01-13 2011-07-21 Clifton Barry Organic compounds
TW201200523A (en) 2010-01-29 2012-01-01 Otsuka Pharma Co Ltd Synthetic intermediate of oxazole compound and method for producing the same
GB201012209D0 (en) 2010-05-31 2010-09-08 Ge Healthcare Ltd In vivo imaging agent
WO2013072903A1 (en) 2011-11-17 2013-05-23 Ithemba Pharmaceuticals (Proprietary) Limited Nitroimidazoxadiazocine compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1705670A (zh) * 2002-10-11 2005-12-07 大塚制药株式会社 2,3－二氢－6－硝基咪唑并[2,1－b]噁唑化合物
CN1878777A (zh) * 2003-10-31 2006-12-13 大塚制药株式会社 治疗结核病的2,3－二氢－6－硝基咪唑并[2,1－b]噁唑化合物
CN103596960A (zh) * 2011-04-15 2014-02-19 大塚制药株式会社 6,7-二氢咪唑并[2,1-b][1,3]噁嗪杀菌剂

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109496214A (zh) * 2016-07-22 2019-03-19 南京明德新药研发股份有限公司 一种硝基咪唑类化合物的晶型、盐型及其制备方法
CN109496214B (zh) * 2016-07-22 2024-09-10 成都嘉葆药银医药科技有限公司 一种硝基咪唑类化合物的晶型、盐型及其制备方法

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Publication number Publication date
RU2675622C1 (ru) 2018-12-21
BR112017015744A2 (pt) 2018-03-13
US10227362B2 (en) 2019-03-12
EP3252059A4 (en) 2018-07-11
JP6542900B2 (ja) 2019-07-10
MX2017009810A (es) 2018-11-09
JP2018503658A (ja) 2018-02-08
TW201632533A (zh) 2016-09-16
CN107207532B (zh) 2019-07-30
ZA201705362B (en) 2019-06-26
WO2016119706A1 (zh) 2016-08-04
US20180162878A1 (en) 2018-06-14
EP3252059A1 (en) 2017-12-06

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Address after: Room 218, No. 9 Commercial Office Building, Gaoxin Road, Nanjing High-tech Development Zone, Jiangsu Province

Patentee after: Nanjing Mingde New Drug Development Co.,Ltd.

Address before: Room 218, No. 9 Commercial Office Building, Gaoxin Road, Nanjing High-tech Development Zone, Jiangsu Province

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Address after: 518053 2201-6, building a, wisdom Plaza, Nanshan District, Shenzhen City, Guangdong Province

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Address before: 518053 2201-6, building a, wisdom Plaza, Nanshan District, Shenzhen City, Guangdong Province

Patentee before: Shenzhen Huayi Biotechnology Group Co.,Ltd.