CN107205922A - 水凝胶药物递送植入物 - Google Patents

水凝胶药物递送植入物 Download PDF

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Publication number
CN107205922A
CN107205922A CN201580075658.1A CN201580075658A CN107205922A CN 107205922 A CN107205922 A CN 107205922A CN 201580075658 A CN201580075658 A CN 201580075658A CN 107205922 A CN107205922 A CN 107205922A
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CN
China
Prior art keywords
hydrogel
particles
release
precursor
precursors
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Pending
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CN201580075658.1A
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English (en)
Chinese (zh)
Inventor
P.贾勒特
R.埃尔-海克
A.S.索内
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Incept LLC
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Incept LLC
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Priority to CN202510552462.2A priority Critical patent/CN120501693A/zh
Publication of CN107205922A publication Critical patent/CN107205922A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201580075658.1A 2014-12-10 2015-12-10 水凝胶药物递送植入物 Pending CN107205922A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202510552462.2A CN120501693A (zh) 2014-12-10 2015-12-10 水凝胶药物递送植入物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462089994P 2014-12-10 2014-12-10
US62/089,994 2014-12-10
PCT/US2015/064975 WO2016094646A1 (en) 2014-12-10 2015-12-10 Hydrogel drug delivery implants

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202510552462.2A Division CN120501693A (zh) 2014-12-10 2015-12-10 水凝胶药物递送植入物

Publications (1)

Publication Number Publication Date
CN107205922A true CN107205922A (zh) 2017-09-26

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201580075658.1A Pending CN107205922A (zh) 2014-12-10 2015-12-10 水凝胶药物递送植入物
CN202510552462.2A Pending CN120501693A (zh) 2014-12-10 2015-12-10 水凝胶药物递送植入物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202510552462.2A Pending CN120501693A (zh) 2014-12-10 2015-12-10 水凝胶药物递送植入物

Country Status (8)

Country Link
US (2) US20160166504A1 (https=)
EP (2) EP3229779B1 (https=)
JP (2) JP7092502B2 (https=)
KR (1) KR20170117384A (https=)
CN (2) CN107205922A (https=)
AU (1) AU2015360469B2 (https=)
CA (1) CA2969716C (https=)
WO (1) WO2016094646A1 (https=)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110392584A (zh) * 2018-02-20 2019-10-29 先进美学科技公司 高浓度水凝胶及相关方法
CN110772376A (zh) * 2019-11-20 2020-02-11 韩熠 一种用于婴幼儿及儿童的医用眼贴及其制备方法
CN112752568A (zh) * 2018-08-15 2021-05-04 微思有限公司 具有用于流动路径修饰的可生物降解材料的持续释出部件及相应的药物输送装置
CN113230019A (zh) * 2021-04-16 2021-08-10 南京佑羲医药科技有限公司 一种用于眼球玻璃体内植入的长效缓释给药装置
CN114980937A (zh) * 2020-01-14 2022-08-30 持田制药株式会社 用于使用了褐藻酸盐的对象的处置的组合和方法
CN115209926A (zh) * 2020-03-25 2022-10-18 学校法人福冈大学 用于眼内膜剥离术的制剂
CN115461040A (zh) * 2020-03-25 2022-12-09 视觉治疗股份有限公司 含有酪氨酸激酶抑制剂的眼用植入物
CN115671036A (zh) * 2022-11-15 2023-02-03 上海交通大学医学院附属第九人民医院 用于治疗眼底和眼内疾病的凝胶药物
CN115768385A (zh) * 2020-04-27 2023-03-07 视觉治疗股份有限公司 治疗过敏性结膜炎的方法
CN116687840A (zh) * 2023-08-03 2023-09-05 四川省医学科学院·四川省人民医院 一种用于治疗眼部病状的凝胶制剂及其制备方法
US12453724B2 (en) 2023-04-11 2025-10-28 Ocular Therapeutix, Inc. Ocular implant containing a tyrosine kinase inhibitor

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US9855317B2 (en) 2015-04-27 2018-01-02 Reflex Medical, Inc. Systems and methods for sympathetic cardiopulmonary neuromodulation
EP4279064A3 (en) * 2015-05-12 2024-02-28 Incept, LLC Drug delivery from hydrogels
US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
HK1257499A1 (zh) 2015-11-12 2019-10-25 Graybug Vision, Inc. 用於治疗的聚集性微粒
AU2016361579B2 (en) 2015-11-25 2022-08-04 Incept, Llc Shape changing drug delivery devices and methods
WO2017139487A1 (en) 2016-02-09 2017-08-17 Northwind Medical, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
US20190099365A1 (en) * 2016-03-22 2019-04-04 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Thermoresponsive hydrogel containing polymer microparticles for noninvasive ocular biologic delivery
EP3478287A4 (en) 2016-06-29 2020-04-08 Tulavi Therapeutics, Inc. TREATMENT OF SEPTICEMIA AND ASSOCIATED INFLAMMATORY CONDITIONS BY LOCAL NEUROMODULATION OF THE AUTONOMOUS NERVOUS SYSTEM
EP3487586A4 (en) * 2016-07-20 2020-03-04 Emory University FORMULAS FOR THE SUPRACHOROIDAL SPACE OF AN EYE AND METHOD
EP3515406B1 (en) * 2016-09-23 2024-07-24 Incept, LLC Intracameral drug delivery depots
AU2018265415A1 (en) 2017-05-10 2019-10-31 Graybug Vision, Inc. Extended release microparticles and suspensions thereof for medical therapy
WO2019043699A1 (en) * 2017-08-30 2019-03-07 Hadasit Medical Research Services And Development Ltd. DEVICES, KITS AND METHODS FOR REDUCING AND / OR PREVENTING INTRA-ABDOMINAL ADHESIONS
EP3708605A4 (en) * 2017-11-06 2020-12-16 Konica Minolta, Inc. HYDROGEL PARTICLE AND ITS PRODUCTION PROCESS, CELL OR CELLULAR STRUCTURE EACH CONTAINING A HYDROGEL PARTICLE, PROCESS FOR EVALUATING THE ACTIVITY OF A CELL USING A HYDROGEL PARTICLE, AND USE OF A PARTICLE OF HYDROGEL AS A LONG-RELEASE PREPARATION
US20210315587A1 (en) 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
AU2019299519B2 (en) 2018-07-02 2025-03-06 Incept Llc Methods and devices for in situ formed nerve cap
US12599577B2 (en) 2018-11-16 2026-04-14 University of Pittsburgh—of the Commonwealth System of Higher Education Thermoresponsive gel eye drop for ocular delivery of cysteamine
PT3861985T (pt) 2020-02-06 2023-08-03 Ocular Therapeutix Inc Composições e métodos para tratar doenças oculares
EP4149400B1 (en) * 2020-05-15 2026-04-22 Georgia Tech Research Corporation Methods and compositions for reducing intraocular pressure
EP3973952B1 (en) 2020-09-24 2024-02-14 Ocular Therapeutix, Inc. Sustained release biodegradable intracanalicular inserts comprising a hydrogel and cyclosporine
EP4216929A1 (en) 2020-09-24 2023-08-02 Ocular Therapeutix, Inc. Sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent
US12343454B2 (en) 2020-11-12 2025-07-01 Pramand LLC Hydrogels formed in situ and composition design for intrauterine use
US12605311B2 (en) 2021-02-05 2026-04-21 Kao Corporation Hydrogel structure
US12582767B2 (en) 2021-12-30 2026-03-24 Taiyo Weber Compressible, minimally invasive implants and related systems and methods
KR20240135062A (ko) * 2022-02-01 2024-09-10 오큘라 테라퓨틱스, 인코포레이티드 생물 제제용 제어 방출 임플란트 및 상응하는 치료 방법
US12251466B2 (en) 2022-04-20 2025-03-18 Pramand LLC Single solution hydrogels with covalent bonding formed in situ, composition design and medical procedures using the hydrogels

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110392584A (zh) * 2018-02-20 2019-10-29 先进美学科技公司 高浓度水凝胶及相关方法
CN112752568A (zh) * 2018-08-15 2021-05-04 微思有限公司 具有用于流动路径修饰的可生物降解材料的持续释出部件及相应的药物输送装置
CN110772376A (zh) * 2019-11-20 2020-02-11 韩熠 一种用于婴幼儿及儿童的医用眼贴及其制备方法
CN114980937A (zh) * 2020-01-14 2022-08-30 持田制药株式会社 用于使用了褐藻酸盐的对象的处置的组合和方法
CN115209926B (zh) * 2020-03-25 2024-05-14 学校法人福冈大学 用于眼内膜剥离术的制剂
CN115209926A (zh) * 2020-03-25 2022-10-18 学校法人福冈大学 用于眼内膜剥离术的制剂
CN115461040A (zh) * 2020-03-25 2022-12-09 视觉治疗股份有限公司 含有酪氨酸激酶抑制剂的眼用植入物
US12357565B2 (en) 2020-03-25 2025-07-15 Ocular Therapeutix, Inc. Ocular implant containing a tyrosine kinase inhibitor
CN115768385A (zh) * 2020-04-27 2023-03-07 视觉治疗股份有限公司 治疗过敏性结膜炎的方法
CN113230019A (zh) * 2021-04-16 2021-08-10 南京佑羲医药科技有限公司 一种用于眼球玻璃体内植入的长效缓释给药装置
CN115671036A (zh) * 2022-11-15 2023-02-03 上海交通大学医学院附属第九人民医院 用于治疗眼底和眼内疾病的凝胶药物
US12453724B2 (en) 2023-04-11 2025-10-28 Ocular Therapeutix, Inc. Ocular implant containing a tyrosine kinase inhibitor
CN116687840B (zh) * 2023-08-03 2023-10-20 四川省医学科学院·四川省人民医院 一种用于治疗眼部病状的凝胶制剂及其制备方法
CN116687840A (zh) * 2023-08-03 2023-09-05 四川省医学科学院·四川省人民医院 一种用于治疗眼部病状的凝胶制剂及其制备方法

Also Published As

Publication number Publication date
JP2021046429A (ja) 2021-03-25
CA2969716A1 (en) 2016-06-16
US20260060921A1 (en) 2026-03-05
EP3858329A1 (en) 2021-08-04
CN120501693A (zh) 2025-08-19
CA2969716C (en) 2023-12-19
EP3229779A1 (en) 2017-10-18
JP2017537130A (ja) 2017-12-14
WO2016094646A1 (en) 2016-06-16
EP3229779B1 (en) 2021-02-03
JP7092502B2 (ja) 2022-06-28
US20160166504A1 (en) 2016-06-16
KR20170117384A (ko) 2017-10-23
AU2015360469B2 (en) 2021-03-25
AU2015360469A1 (en) 2017-06-22

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Application publication date: 20170926