CN107184735A - A kind of Camellia nitidissima antiallergy spray and preparation method thereof - Google Patents
A kind of Camellia nitidissima antiallergy spray and preparation method thereof Download PDFInfo
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- CN107184735A CN107184735A CN201710332815.3A CN201710332815A CN107184735A CN 107184735 A CN107184735 A CN 107184735A CN 201710332815 A CN201710332815 A CN 201710332815A CN 107184735 A CN107184735 A CN 107184735A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
Abstract
The present invention relates to tcm field, more particularly to a kind of Camellia nitidissima antiallergy spray and preparation method thereof.The spray is obtained by the extraction of following Chinese medicine composition：Golden flower tea peels, radix bupleuri, Asian puccoon, dark plum, the fruit of Chinese magnoliavine, radix glycyrrhizae, asarum, cassia twig.Present invention also offers the preparation method of the spray, by above-mentioned raw materials by extraction, filtering, dry acquisition active ingredient, the flavoring agent and preservative of doses are added, Camellia nitidissima antiallergy spray is made after filtering again.The reasonable compatibility that the present invention passes through plurality of Chinese, the effective medicinal effects for having played golden flower tea peels etc., by the active ingredient for extracting Chinese medicine composition, make prepared Camellia nitidissima antiallergy spray not only easy to use, and usage amount is small, be conducive to the absorption of active ingredient, effectively treat anaphylactia.
Description
Technical field
The present invention relates to tcm field, more particularly to a kind of Camellia nitidissima antiallergy spray and preparation method thereof.
Background technology
In recent years anaphylactia with the increment rate in year 20% in drastically ascendant trend, such as allergic asthma, mistake year by year
Quick property rhinitis, early spring pollinosis, contact dermatitis, eczema, hay fever, drug allergy etc..Turn into very noticeable society
Meeting problem, wherein climbing highest is allergic asthma and allergic rhinitis.Not only inconvenience is brought to daily life, make
Into mental suffering, reduction quality of life, and the duration is long, and what is had turns into obstinate disease, and also having causes died.
Camellia nitidissima, is all Theaceae Camellia Plants with tea, South Mountain tea, camellia, oil tea etc., Camellia nitidissima is using its petal as Huang
Color and it is famous, vegetable formal name is Camellia chrysantha (Hu) Tuyama, is Theaceae, Camellia, and evergreen shrubs is to small
Arbor.Clinical research shows that Camellia nitidissima, which has, suppresses tumour, strengthens immunity of organism, anti-aging, the various physiology work(of balanced human
Can, hypotensive strengthens blood vessel elasticity and myocardial contractive power, and enhancing liver is metabolic, and the various enzymes in human activin etc.
Effect.Wang Yong is very waited experiments prove that there is golden flower tea peels antianaphylaxis (to wait Camellia nitidissimas group to plant before Wang Yongqi, Peng Xiao, Tang
The anti-anaphylactoid screening active ingredients of IgE mediating type Is of thing, [J], Central-South pharmacy, 7 (10):721-724.).At present, on golden flower
The document that tea, especially its plant pericarp are used to treat antiallergy disease is less, to the antiallergy research of golden flower tea peels also not
It is deep enough.
Radix bupleuri is conventional diaphoretic medicine.Smoke alias, mountain dish, mushroom grass, faggot, bitter in taste, be slightly cold, Return liver, gallbladder channel.There is reconciliation
In table, the effect of soothing the liver rising Yang.
Asian puccoon, cold in nature, sweet, salty, the thoughts of returning home, Liver Channel.Cure mainly trusted subordinate's perverse trend, five subcutaneous ulcers, tonifying middle-Jiao and Qi, sharp nine orifices, waterway.
Dark plum, it is sour, puckery, it is mild-natured.Return liver, spleen, lung, large intestine channel.With astringing the lung, puckery intestines promote the production of body fluid, the effect of claming ascaris.
The fruit of Chinese magnoliavine, with astringing the lung, nourshing kidney is promoted the production of body fluid, and sweat is received, the effect of puckery smart.
Radix glycyrrhizae, gas is micro-, taste sweet tea and it is special.Major function is clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen etc..
Asarum, with expelling wind and clearing away cold, sensible analgesic, effect of Wenfei of drink.
Cassia twig, property acrid, sweet, warm.The thoughts of returning home, lung, bladder warp.There are sweating expelling pathogenic factors from muscles and skin, warming meridians and promoting circulation of qi, helps yang transforming qi, eliminating cold to stop pain
Effect.
At present, the product using Camellia nitidissima as raw material is mostly common with drink, it is impossible to meets the demand of people, wastes golden flower
The medicine resource of tea, and Chinese medicine odor is poor, and mouthfeel is not good, and many people are unwilling to take.
The content of the invention
It is used to treat allergic asthma, anaphylaxis there is provided one kind it is an object of the invention to the defect for overcoming problem above
The Camellia nitidissima antiallergy spray of rhinitis and other disease.
The purpose of the present invention can be achieved through the following technical solutions：
A kind of Camellia nitidissima antiallergy spray, includes the raw material of following parts by weight：15~20 parts of golden flower tea peels, radix bupleuri 15
~20 parts, 10~20 parts of Asian puccoon, 10~15 parts of dark plum, 10~15 parts of the fruit of Chinese magnoliavine, 5~8 parts of radix glycyrrhizae, 10~15 parts of asarum, cassia twig
10~15 parts.
The preparation method of above-mentioned Camellia nitidissima antiallergy spray, comprises the following steps：
(1) extract
Radix bupleuri, Asian puccoon, dark plum, the fruit of Chinese magnoliavine, radix glycyrrhizae, asarum, cassia twig are cleaned by raw material proportioning, crushes, obtains raw material powder,
Raw material powder is soaked into 12h with 80% ethanol of 5 times of quality, then adds 80% ethanol percolation 4h of 10 times of quality, ethanol is reclaimed, obtains
Composition extract solution；
Golden flower tea peels are cleaned and crushed, percolator are put into, 90% ethanol for being continuously added to its 10 times of quality from top oozes
Filter, collect leachate, obtain Camellia nitidissima Fruit peel extract；
(2) filter, dry
The composition extract solution and Camellia nitidissima Fruit peel extract that are obtained in step (1) is well mixed, add 4 times of matter of raw material
The 2%NaOH solution of amount is sufficiently stirred for, and is precipitated, and filtering, filtrate adds slightly excessive hydrochloric acid to be sufficiently stirred for, control filtrate pH value 3~4,
Refilter, precipitation is washed at neutrality, 60 DEG C and is dried in vacuo, and obtains medicinal powder；
(3) prepare
The medicinal powder that will be obtained in step (2), adds 2 times of ethanol of quality 80% and 5 times of quality propane diols are used as double solvents
Dissolving, adds solubilizer, flavoring agent and preservative, is filtered after stirring and evenly mixing, produces Camellia nitidissima antiallergy spray.
Solubilizer is added in the preparation method of above-mentioned Camellia nitidissima antiallergy spray, step (3) for Tween 80, addition
Measure as 5% of double solvents quality used in step (3).
Flavoring agent is added in the preparation method of above-mentioned Camellia nitidissima antiallergy spray, step (3) for borneol, the amount of addition
For 5% of gained medicinal powder quality in step (2).
Preservative is added in the preparation method of above-mentioned Camellia nitidissima antiallergy spray, step (3) for P-hydroxybenzoic acid
Ethyl ester, the amount of addition is 3% of gained medicinal powder quality in step (2).
The present invention has the advantages that compared with prior art：
1. the present invention has effectively been played the medicinal effects of golden flower tea peels etc., had by the reasonable compatibility of plurality of Chinese
The diseases such as effect treatment allergic rhinitis, allergic asthma；
2. by extracting the active ingredient of Chinese medicine composition, make prepared Camellia nitidissima antiallergy spray not only user
Just, and usage amount is small, be conducive to the absorption of active ingredient, effectively treat anaphylactia.
Embodiment
Below in conjunction with specific embodiment, the present invention will be further described.
Embodiment 1：
A kind of Camellia nitidissima antiallergy spray, includes the raw material of following parts by weight：18 parts of golden flower tea peels, 15 parts of radix bupleuri,
10 parts of Asian puccoon, 10 parts of dark plum, 10 parts of the fruit of Chinese magnoliavine, 6 parts of radix glycyrrhizae, 10 parts of asarum, 10 parts of cassia twig.
The preparation method of above-mentioned Camellia nitidissima antiallergy spray, comprises the following steps：
(1) extract
Radix bupleuri 15g, Asian puccoon 10g, dark plum 10g, fruit of Chinese magnoliavine 10g, radix glycyrrhizae 6g, asarum 10g, cassia twig 10g compositions are cleaned,
Crush, obtain raw material powder, raw material powder is soaked into 12h with 5 times of 80% ethanol of amount, then add the ethanol percolation 4h of 10 times of amounts 80%, return
Ethanol is received, composition extract solution is obtained；
Golden flower tea peels 18g is cleaned and crushed, percolator is put into, 10 times of 90% ethanol percolations of amount are continuously added to from top,
Leachate is collected, Camellia nitidissima Fruit peel extract is obtained；
(2) filter, dry
The composition extract solution and Camellia nitidissima Fruit peel extract that are obtained in step (1) is well mixed, add 4 times of amounts of medicine
2% NaOH solution is sufficiently stirred for, and is precipitated, filtering, and filtrate adds slightly excessive hydrochloric acid to be sufficiently stirred for making pH value be 3, refilters, and precipitates
It is washed at neutrality, 60 DEG C and is dried in vacuo, obtains medicinal powder；
(3) prepare
The medicinal powder that will be obtained in step (2), adds 2 times of 80% ethanol of amount and 5 times of amount propane diols dissolve as double solvents,
30ml Tween 80s, 5g borneols and 3g ethyl-para-hydroxybenzoates are added, is stirred and evenly mixed, then is filtered, Camellia nitidissima is produced and resists
Allergic spray.
Embodiment 2：
A kind of Camellia nitidissima antiallergy spray, includes the raw material of following parts by weight：15 parts of golden flower tea peels, 15 parts of radix bupleuri,
10 parts of Asian puccoon, 15 parts of dark plum, 15 parts of the fruit of Chinese magnoliavine, 6 parts of radix glycyrrhizae, 10 parts of asarum, 10 parts of cassia twig.
The preparation method of above-mentioned Camellia nitidissima antiallergy spray, comprises the following steps：
(1) extract
Radix bupleuri 15g, Asian puccoon 10g, dark plum 15g, fruit of Chinese magnoliavine 15g, radix glycyrrhizae 6g, asarum 10g, cassia twig 10g compositions are cleaned,
Crush, obtain raw material powder, raw material powder is soaked into 12h with 5 times of 80% ethanol of amount, then add the ethanol percolation 4h of 10 times of amounts 80%, return
Ethanol is received, composition extract solution is obtained；
Golden flower tea peels 15g is cleaned and crushed, percolator is put into, 10 times of 90% ethanol percolations of amount are continuously added to from top,
Leachate is collected, Camellia nitidissima Fruit peel extract is obtained；
(2) filter, dry
The composition extract solution and Camellia nitidissima Fruit peel extract that are obtained in step (1) is well mixed, add 4 times of amounts of medicine
2% NaOH solution is sufficiently stirred for, and is precipitated, filtering, and filtrate adds slightly excessive hydrochloric acid to be sufficiently stirred for making pH value be 4, refilters, and precipitates
It is washed at neutrality, 60 DEG C and is dried in vacuo, obtains medicinal powder；
(3) prepare
The medicinal powder that will be obtained in step (2), adds 2 times of 80% ethanol of amount and 5 times of amount propane diols dissolve as double solvents,
35ml Tween 80s, 5g borneols and 3g ethyl-para-hydroxybenzoates are added, is stirred and evenly mixed, then is filtered, Camellia nitidissima is produced and resists
Allergic spray.
Embodiment 3：
A kind of Camellia nitidissima antiallergy spray, includes the raw material of following parts by weight：20 parts of golden flower tea peels, 15 parts of radix bupleuri,
10 parts of Asian puccoon, 10 parts of dark plum, 15 parts of the fruit of Chinese magnoliavine, 8 parts of radix glycyrrhizae, 10 parts of asarum, 15 parts of cassia twig.
The preparation method of above-mentioned Camellia nitidissima antiallergy spray, comprises the following steps：
(1) extract
Radix bupleuri 15g, Asian puccoon 10g, dark plum 10g, fruit of Chinese magnoliavine 15g, radix glycyrrhizae 8g, asarum 10g, cassia twig 15g compositions are cleaned,
Crush, obtain raw material powder, raw material powder is soaked into 12h with 5 times of 80% ethanol of amount, then add the ethanol percolation 4h of 10 times of amounts 80%, return
Ethanol is received, composition extract solution is obtained；
Golden flower tea peels 20g is cleaned and crushed, percolator is put into, 10 times of 90% ethanol percolations of amount are continuously added to from top,
Leachate is collected, Camellia nitidissima Fruit peel extract is obtained；
(2) filter, dry
The composition extract solution and Camellia nitidissima Fruit peel extract that are obtained in step (1) is well mixed, add 4 times of amounts of medicine
2% NaOH solution is sufficiently stirred for, and is precipitated, filtering, and filtrate adds slightly excessive hydrochloric acid to be sufficiently stirred for making pH value be 4, and filtering precipitates water
It is washed till at neutrality, 60 DEG C and is dried in vacuo, obtains medicinal powder；
(3) prepare
The medicinal powder that will be obtained in step (2), adds 2 times of 80% ethanol of amount and 5 times of amount propane diols dissolve as double solvents,
35ml Tween 80s, 5g borneols and 3g ethyl-para-hydroxybenzoates are added, is stirred and evenly mixed, then is filtered, Camellia nitidissima is produced and resists
Allergic spray.
Animal toxicity test：
1st, experiment mice 90 is taken, male and female half and half, 140~180g of body weight is respectively divided into three group 1~3, every group each 30,
Every group of mouse sign is good, and the physiological performance such as body weight is without exception, with comparativity.
2nd, filled after the Camellia nitidissima antiallergy spray dissolving prepared respectively using the embodiment of the present invention 1~3 to three groups of mouse
Stomach is administered, and three times a day, continuously takes one month, the sign situation of all mouse is observed and recorded during testing.
3rd, the sign performance of all mouse is without exception in experimentation, and experiment does not occur dead mouse situation after terminating, right
5 progress dissection inspections are randomly selected in every group of mouse, major organs are no abnormal, from experimental result, the present invention
Camellia nitidissima antiallergy spray without overt toxicity, can safe medication.
Conditioning for anaphylactia state improves clinical observation statistics：
1st, case is chosen：Clinically choose the anaphylactia patient 90 made a definite diagnosis, 20~60 years old age, male 60,
Women 30, is divided into three groups of experimental groups 1~3, every group 30.
2nd, experimental method：The spray prepared respectively using the embodiment of the present invention 1~3 to experimental group 1~3, three times a day,
Continuous use one month, observes and records the recovery situation of patient.
3rd, curative effect determinate standard：Effectively：Anaphylactia clinical symptom disappearance, every sign recovers normal, in half a year not
See recurrence；It is effective：Anaphylactia clinical symptoms improve, and the performance of each sign is clearly better before patient compares medication；It is invalid：Disease
Feelings are without any improvement or aggravate.
4th, experimental data is counted：
| Classification | Case load | Effectively | It is effective | It is invalid | Adverse reaction | It is efficient |
| Embodiment 1 | 30 | 10 | 20 | 0 | 0 | 100.0 |
| Embodiment 2 | 30 | 12 | 18 | 0 | 0 | 100.0 |
| Embodiment 3 | 30 | 10 | 17 | 3 | 0 | 90.0 |
5th, experimental result：As can be seen from the above experimental data, the Camellia nitidissima antiallergy spray for preparing of the present invention for
The total effective rate of the treatment of anaphylactia is 96.7%, and 90 patients have no any adverse reaction, therefore explanation, the present invention
Camellia nitidissima antiallergy spray be treat anaphylactia safe and effective medicine, with good clinical expansion meaning.
Claims (5)
1. a kind of Camellia nitidissima antiallergy spray, it is characterised in that include the raw material of following parts by weight：Golden flower tea peels 15~20
Part, 15~20 parts of radix bupleuri, 10~20 parts of Asian puccoon, 10~15 parts of dark plum, 10~15 parts of the fruit of Chinese magnoliavine, 5~8 parts of radix glycyrrhizae, asarum 10~
15 parts, 10~15 parts of cassia twig.
2. the preparation method of Camellia nitidissima antiallergy spray as claimed in claim 1, it is characterised in that comprise the following steps：
(1) extract
Radix bupleuri, Asian puccoon, dark plum, the fruit of Chinese magnoliavine, radix glycyrrhizae, asarum, cassia twig are cleaned by raw material proportioning, crushes, raw material powder is obtained, by original
Feed powder 80% ethanol of 5 times of quality soaks 12h, then adds 80% ethanol percolation 4h of 10 times of quality, reclaims ethanol, is combined
Thing extract solution；
Golden flower tea peels are cleaned and crushed, percolator is put into, 90% ethanol percolation of its 10 times of quality is continuously added to from top, are received
Collect leachate, obtain Camellia nitidissima Fruit peel extract；
(2) filter, dry
The composition extract solution and Camellia nitidissima Fruit peel extract that are obtained in step (1) is well mixed, add 4 times of quality of raw material
2%NaOH solution is sufficiently stirred for, and is precipitated, and filtering, filtrate adds slightly excessive hydrochloric acid to be sufficiently stirred for, control filtrate pH value 3~4, after
Filter, precipitation is washed at neutrality, 60 DEG C and is dried in vacuo, and obtains medicinal powder；
(3) prepare
The medicinal powder that will be obtained in step (2), adds 2 times of ethanol of quality 80% and 5 times of quality propane diols dissolve as double solvents,
Solubilizer, flavoring agent and preservative are added, is filtered after stirring and evenly mixing, produces Camellia nitidissima antiallergy spray.
3. the preparation method of Camellia nitidissima antiallergy spray as claimed in claim 2, it is characterised in that added in step (3)
Plus solubilizer is Tween 80, the amount of addition is 5% of double solvents quality used in step (3).
4. the preparation method of Camellia nitidissima antiallergy spray as claimed in claim 2, it is characterised in that added in step (3)
Plus flavoring agent is borneol, the amount of addition is 5% of gained medicinal powder quality in step (2).
5. the preparation method of Camellia nitidissima antiallergy spray as claimed in claim 2, it is characterised in that added in step (3)
Adding preservative agent is ethyl-para-hydroxybenzoate, and the amount of addition is 3% of gained medicinal powder quality in step (2).
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110917289A (en) * | 2019-10-30 | 2020-03-27 | 无锡济民可信山禾药业股份有限公司 | Preparation method of sprain angelica spray |
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