CN107007693A - A kind of Camellia nitidissima antiallergy buccal tablet and preparation method thereof - Google Patents
A kind of Camellia nitidissima antiallergy buccal tablet and preparation method thereof Download PDFInfo
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- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The present invention relates to tcm field, more particularly to a kind of Camellia nitidissima antiallergy buccal tablet and preparation method thereof.The buccal tablet is obtained by the extraction of following Chinese medicine composition：Golden flower tea peels, radix bupleuri, windproof, dark plum, the fruit of Chinese magnoliavine, radix glycyrrhizae, periostracum cicada, balloonflower root.Present invention also offers the preparation method of Camellia nitidissima antiallergy buccal tablet, above-mentioned raw materials are obtained into active ingredient by extraction, filtering, concentration, the filler and sweetener of doses are added, adds after lubricant and Camellia nitidissima antiallergy buccal tablet is made using direct power compressing method.The present invention has effectively played the medicinal effects of golden flower tea peels etc., has effectively treated various anaphylactias by the reasonable compatibility of plurality of Chinese.
Description
Technical field
The present invention relates to tcm field, more particularly to a kind of Camellia nitidissima antiallergy buccal tablet and preparation method thereof.
Background technology
In recent years anaphylactia with the increment rate in year 20% in drastically ascendant trend, such as allergic asthma, mistake year by year
Quick property rhinitis, early spring pollinosis, contact dermatitis, eczema, hay fever, drug allergy etc..Turn into very noticeable society
Meeting problem, wherein climbing highest is allergic asthma and allergic rhinitis.Not only inconvenience is brought to daily life, make
Into mental suffering, reduction quality of life, and the duration is long, and what is had turns into obstinate disease, and also having causes died.
Camellia nitidissima, is all Theaceae Camellia Plants with tea, South Mountain tea, camellia, oil tea etc., Camellia nitidissima is using its petal as Huang
Color and it is famous, vegetable formal name is Camellia chrysantha (Hu) Tuyama, is Theaceae, Camellia, and evergreen shrubs is to small
Arbor.Clinical research shows that Camellia nitidissima, which has, suppresses tumour, strengthens immunity of organism, anti-aging, the various physiology work(of balanced human
Can, hypotensive strengthens blood vessel elasticity and myocardial contractive power, and enhancing liver is metabolic, and the various enzymes in human activin etc.
Effect.In addition, Camellia nitidissima seed can also extract oil, eat, industry is used as lubricating oil etc., the raw material of other solvents is alternatively arranged as.
Wang Yong is very waited experiments prove that there is golden flower tea peels antianaphylaxis (to wait Camellia Section Chrysanthas to resist before Wang Yongqi, Peng Xiao, Tang
The anaphylactoid screening active ingredients of IgE mediating type Is, [J], Central-South pharmacy, 7 (10):721-724.).At present, on Camellia nitidissima, especially
It is that its plant pericarp is less for the document for treating antiallergy disease, and the antiallergy research to golden flower tea peels is deep not enough
Enter.
Radix bupleuri is conventional diaphoretic medicine.Smoke alias, mountain dish, mushroom grass, faggot, bitter in taste, be slightly cold, Return liver, gallbladder channel.There is reconciliation
In table, the effect of soothing the liver rising Yang.
It is windproof, alias copper rue, Hui Yun, return grass, hundred, hundred kinds.It is pungent, sweet, slightly warm in nature.Expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion,
Only effect of convulsion.
Dark plum, it is sour, puckery, it is mild-natured.Return liver, spleen, lung, large intestine channel.With astringing the lung, puckery intestines promote the production of body fluid, the effect of claming ascaris.
The fruit of Chinese magnoliavine, with astringing the lung, nourshing kidney is promoted the production of body fluid, and sweat is received, the effect of puckery smart.
Radix glycyrrhizae, gas is micro-, taste sweet tea and it is special.Major function is clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen etc..
Periostracum cicada, it is sweet, salty, it is cool in nature.Return lung, Liver Channel.There is dispelling wind and heat from the body, relieving sore-throat opens sound, and promoting eruption, removing nebula, ceases wind is stopped
The effect of convulsion.
Balloonflower root, facilitaing lung, relieving sore-throat, eliminating the phlegm, apocenosis.For coughing with a lot of sputum, uncomfortable in chest not smooth, pharyngalgia, sound is mute, lung carbuncle pyemesis, sore
Ulcer purulence is not into bursting.
At present, the product using Camellia nitidissima as raw material is mostly common with drink, it is impossible to meets the demand of people, wastes golden flower
The medicine resource of tea especially golden flower tea peels.
The content of the invention
It is used to treat allergic asthma, anaphylaxis there is provided one kind it is an object of the invention to the defect for overcoming problem above
The Camellia nitidissima antiallergy buccal tablet of the diseases such as rhinitis, early spring pollinosis, contact dermatitis, eczema, hay fever, drug allergy.
The purpose of the present invention can be reached by following measure：
A kind of Camellia nitidissima antiallergy buccal tablet, includes the raw material of following parts by weight：20~30 parts of golden flower tea peels, radix bupleuri 10
~15 parts, windproof 10~15 parts, 10~15 parts of dark plum, 10~15 parts of the fruit of Chinese magnoliavine, 5~10 parts of radix glycyrrhizae, 10~12 parts of periostracum cicada, balloonflower root
12~15.
A kind of preparation method of above-mentioned Camellia nitidissima antiallergy buccal tablet, comprises the following steps：
(1) extract
Radix bupleuri, windproof, dark plum, the fruit of Chinese magnoliavine, radix glycyrrhizae, periostracum cicada, balloonflower root composition are cleaned by the amount of raw material proportioning, crushed,
Raw material powder is obtained, raw material powder is boiled into 1.5h with 20 times of decocting, takes juice to stay slag, then is decocted, is so decocted three times repeatedly, is merged
Juice, produces Chinese medicine composition juice；
Golden flower tea peels are cleaned, crushes, is put into percolator, ethanol percolation is continuously added to from top, leachate is collected, plus
Heat makes ethanol evaporation, obtains Camellia nitidissima Fruit peel extract；
(2) filter, concentrate
By the Chinese medicine composition juice obtained in step (1) filtering after-purification processing, the precipitation in extract solution is reduced, to net
Extract solution after change is concentrated again, is concentrated into clear cream shape, obtains clear cream 1；Camellia nitidissima Fruit peel extract mistake in the same way
Filter is concentrated to give clear cream 2；
(3) dry, sieve
By the clear cream 1 obtained in step (2) in 60 DEG C~80 DEG C vacuum drying, dry cream 1 is obtained；Clear cream 2 is 35 DEG C~45
DEG C low temperature drying, obtains dry cream 2；Dry cream 1 is mixed with dry cream 2, crushed, 30 mesh sieves is crossed, obtains medicinal powder；Take sweetener, filling
Agent and lubricant sieve for subsequent use respectively；
(4) tabletting
By medicinal powder and filler and sweetener in mass ratio 40:59:1 is well mixed, and buccal tablet mixed powder is obtained, by lubricant
Directly it is applied to by 1%~2% amount of buccal tablet mixed powder quality on the drift of tablet press machine, using direct power compressing method pressure
Piece, produces buccal tablet.
Vacuum drying temperature is 70 DEG C in a kind of preparation method of above-mentioned Camellia nitidissima antiallergy buccal tablet, step (3)；Low temperature
Dry temperature is 40 DEG C.
Sweetener used is honey element in the preparation method of above-mentioned Camellia nitidissima antiallergy buccal tablet, step (3)；It is used to fill out
It is protein sugar and mannitol in mass ratio 1.5 to fill agent:1 mixture；It is with lubricator magnesium stearate.
The present invention has the advantages that：
1. there is provided a kind of simple, the applied widely Camellia nitidissima antiallergy buccal tablet of good in taste, technique and its preparation
Method；
2. the present invention has effectively been played the medicinal effects of golden flower tea peels etc., had by the reasonable compatibility of plurality of Chinese
The various anaphylactias of effect treatment；
3. by extracting the active ingredient of Chinese medicine composition, make the prepared Camellia nitidissima antiallergy buccal tablet not only side of taking
Just, and dose is small, be conducive to the absorption of effective medicinal components, effectively treat anaphylactia.
Embodiment：
Below in conjunction with specific embodiment, the present invention will be further described.
Embodiment 1：
A kind of Camellia nitidissima antiallergy buccal tablet, includes the raw material of following parts by weight：It is golden flower tea peels 20g, radix bupleuri 12g, anti-
Wind 12g, dark plum 12g, fruit of Chinese magnoliavine 10g, radix glycyrrhizae 5g, periostracum cicada 10g, balloonflower root 12g.
A kind of preparation method of above-mentioned Camellia nitidissima antiallergy buccal tablet, comprises the following steps：
(1) extract
Radix bupleuri 12g, windproof 12g, dark plum 12g, fruit of Chinese magnoliavine 10g, radix glycyrrhizae 5g, periostracum cicada 10g, balloonflower root 12g compositions are cleaned,
Crush, obtained raw material powder is boiled into 1.5h with 20 times of decocting, takes juice to stay slag, then decocted, so decocted three times repeatedly, closed
And juice；
Golden flower tea peels 20g is cleaned and crushed, percolator is put into, ethanol percolation is continuously added to from top, leachate is collected,
Heating makes ethanol evaporation, obtains extract solution；
(2) filter, concentrate
By the Chinese medicine composition juice obtained in step (1) filtering after-purification processing, the precipitation in extract solution is reduced, to net
Extract solution after change is concentrated again, is concentrated into clear cream shape, obtains clear cream 1；Camellia nitidissima Fruit peel extract mistake in the same way
Filter is concentrated to give clear cream 2；
(3) dry, sieve
It will be dried in vacuo at 1,70 DEG C of the clear cream obtained in step (2), obtain dry cream 1；Clear cream 2 carries out low temperature at 40 DEG C and done
It is dry, obtain dry cream 2.Dry cream 1 is mixed with dry cream 2, crushed, 30 mesh sieves is crossed, obtains medicinal powder, take 2.3g honey elements, 82.2g albumen
Sugared 54.8 mannitol and 3g magnesium stearates sieve respectively；
(4) tabletting
Gained medicinal powder in step (3) is well mixed with honey element, protein sugar and mannitol, magnesium stearate is directly smeared
On the drift of tablet press machine, using direct power compressing method tabletting, buccal tablet is produced.
Embodiment 2：
A kind of Camellia nitidissima antiallergy buccal tablet, includes the raw material of following parts by weight：It is golden flower tea peels 20g, radix bupleuri 12g, anti-
Wind 15g, dark plum 12g, fruit of Chinese magnoliavine 10g, radix glycyrrhizae 8g, periostracum cicada 10g, balloonflower root 13g.
The preparation method of above-mentioned Camellia nitidissima antiallergy buccal tablet, comprises the following steps：
(1) extract
Radix bupleuri 12g, windproof 15g, dark plum 12g, fruit of Chinese magnoliavine 10g, radix glycyrrhizae 8g, periostracum cicada 10g, balloonflower root 13g compositions are cleaned,
Crush, obtained raw material powder is boiled into 1.5h with 20 times of decocting, takes juice to stay slag, then decocted, so decocted three times repeatedly, closed
And juice；
Golden flower tea peels 20g is cleaned and crushed, percolator is put into, ethanol percolation is continuously added to from top, leachate is collected,
Heating makes ethanol evaporation, obtains extract solution；
(2) filter, concentrate
By the Chinese medicine composition juice obtained in step (1) filtering after-purification processing, the precipitation in extract solution is reduced, to net
Extract solution after change is concentrated again, is concentrated into clear cream shape, obtains clear cream 1；Camellia nitidissima Fruit peel extract mistake in the same way
Filter is concentrated to give clear cream 2；
(3) dry, sieve
It will be dried in vacuo at 1,70 DEG C of the clear cream obtained in step (2), obtain dry cream 1；Clear cream 2 carries out low temperature at 40 DEG C and done
It is dry, obtain dry cream 2.Dry cream 1 is mixed with dry cream 2, crushed, 30 mesh sieves is crossed, obtains medicinal powder, take 2.6g honey elements, 93g albumen
Sugar, 62g mannitol and 3g magnesium stearates sieve respectively；；
(4) tabletting
Gained medicinal powder in step (3) is well mixed with honey element, protein sugar and mannitol, magnesium stearate is directly smeared
On the drift of tablet press machine, using direct power compressing method tabletting, buccal tablet is produced.
Embodiment 3：
A kind of Camellia nitidissima antiallergy buccal tablet, includes the raw material of following parts by weight：Golden flower tea peels 30g, radix bupleuri 15g,
Windproof 15g, dark plum 12g, fruit of Chinese magnoliavine 10g, radix glycyrrhizae 6g, periostracum cicada 12g, balloonflower root 10g.
The preparation method of above-mentioned Camellia nitidissima antiallergy buccal tablet, comprises the following steps：
(1) extract
Radix bupleuri 15g, windproof 15g, dark plum 12g, fruit of Chinese magnoliavine 10g, radix glycyrrhizae 6g, periostracum cicada 12g, balloonflower root 10g compositions are cleaned,
Crush, obtained raw material powder is boiled into 1.5h with 20 times of decocting, takes juice to stay slag, then decocted, so decocted three times repeatedly, closed
And juice；
Golden flower tea peels 30g is cleaned and crushed, percolator is put into, ethanol percolation is continuously added to from top, leachate is collected,
Heating makes ethanol evaporation, obtains extract solution；
(2) filter, concentrate
By the Chinese medicine composition juice obtained in step (1) filtering after-purification processing, the precipitation in extract solution is reduced, to net
Extract solution after change is concentrated again, is concentrated into clear cream shape, obtains clear cream 1；Camellia nitidissima Fruit peel extract mistake in the same way
Filter is concentrated to give clear cream 2；
(3) dry, sieve
It will be dried in vacuo at 1,70 DEG C of the clear cream obtained in step (2), obtain dry cream 1；Clear cream 2 carries out low temperature at 40 DEG C and done
It is dry, obtain dry cream 2.Dry cream 1 is mixed with dry cream 2, crushed, 30 mesh sieves is crossed, obtains medicinal powder, take 2.6g honey elements, 97.2g albumen
Sugar, 64.8g mannitol and 3g magnesium stearates sieve respectively；
(4) tabletting
Gained medicinal powder in step (3) is well mixed with honey element, protein sugar and mannitol, magnesium stearate is directly smeared
On the drift of tablet press machine, using direct power compressing method tabletting, buccal tablet is produced.
Animal toxicity test：
1st, experiment mice 90 is taken, male and female half and half, 140~180g of body weight is respectively divided into three group 1~3, every group each 30,
Every group of mouse sign is good, and the physiological performance such as body weight is without exception, with comparativity.
2nd, filled after the Camellia nitidissima antiallergy buccal tablet dissolving prepared respectively using the embodiment of the present invention 1~3 to three groups of mouse
Stomach is administered, and three times a day, continuously takes one month, the sign situation of all mouse is observed and recorded during testing.
3rd, the sign performance of all mouse is without exception in experimentation, and experiment does not occur dead mouse situation after terminating, right
5 progress dissection inspections are randomly selected in every group of mouse, major organs are no abnormal, from experimental result, the present invention
Camellia nitidissima antiallergy buccal tablet without overt toxicity, can safety of medication.
Conditioning for anaphylactia state improves clinical observation statistics：
1st, case is chosen：Clinically choose the anaphylactia patient 210 made a definite diagnosis, 30~75 years old age, male 80,
Women 130, is divided into three groups of experimental groups 1~3, every group 70.
2nd, experimental method：The buccal tablet prepared respectively using the embodiment of the present invention 1~3 to experimental group 1~3, three times a day,
Continuous medication one month, observes and records the recovery situation of patient.
3rd, curative effect determinate standard：Effectively：Anaphylactia clinical symptom disappearance, every sign recovers normal, in half a year not
See recurrence；It is effective：Anaphylactia clinical symptoms improve, and the performance of each sign is clearly better before patient compares medication；It is invalid：Disease
Feelings are without any improvement or aggravate.
4th, experimental data is counted：
| Classification | Case load | Effectively | It is effective | It is invalid | Adverse reaction | It is efficient |
| Embodiment 1 | 70 | 30 | 38 | 2 | 0 | 97.1 |
| Embodiment 2 | 70 | 38 | 32 | 0 | 0 | 100.0 |
| Embodiment 3 | 70 | 25 | 44 | 1 | 0 | 98.6 |
5th, experimental result：As can be seen from the above experimental data, the Camellia nitidissima antiallergy buccal tablet for preparing of the present invention for
The total effective rate of the treatment of anaphylactia is 98.6%, and 210 patients have no any adverse reaction, therefore explanation, this hair
Bright Camellia nitidissima antiallergy buccal tablet is the safe and effective medicine for treating anaphylactia, with good clinical expansion meaning.
Claims (4)
1. a kind of Camellia nitidissima antiallergy buccal tablet, it is characterised in that include the raw material of following parts by weight：Golden flower tea peels 20~30
Part, 10~15 parts of radix bupleuri, windproof 10~15 parts, 10~15 parts of dark plum, 10~15 parts of the fruit of Chinese magnoliavine, 5~10 parts of radix glycyrrhizae, periostracum cicada 10~
12 parts, balloonflower root 12~15.
2. a kind of preparation method of Camellia nitidissima antiallergy buccal tablet as claimed in claim 1, it is characterised in that including following step
Suddenly：
(1) extract
Radix bupleuri, windproof, dark plum, the fruit of Chinese magnoliavine, radix glycyrrhizae, periostracum cicada, balloonflower root composition are cleaned by the amount of raw material proportioning, crushes, obtains former
Feed powder, boils 1.5h with 20 times of decocting by raw material powder, takes juice to stay slag, then is decocted, and so decocts three times repeatedly, merges juice
Liquid, produces Chinese medicine composition juice；
Golden flower tea peels are cleaned, crushes, is put into percolator, ethanol percolation is continuously added to from top, leachate is collected, heating makes
Ethanol evaporation, obtains Camellia nitidissima Fruit peel extract；
(2) filter, concentrate
By the Chinese medicine composition juice obtained in step (1) filtering after-purification processing, the precipitation in extract solution is reduced, after purification
Extract solution concentrated again, be concentrated into clear cream shape, obtain clear cream 1；Camellia nitidissima Fruit peel extract filters dense in the same way
Contracting obtains clear cream 2；
(3) dry, sieve
By the clear cream 1 obtained in step (2) in 60 DEG C~80 DEG C vacuum drying, dry cream 1 is obtained；Clear cream 2 is low at 35 DEG C~45 DEG C
Temperature is dried, and obtains dry cream 2；Dry cream 1 is mixed with dry cream 2, crushed, 30 mesh sieves is crossed, obtains medicinal powder；Take sweetener, filler and
Lubricant sieves for subsequent use respectively；
(4) tabletting
By medicinal powder and filler and sweetener in mass ratio 40:59:1 is well mixed, and obtains buccal tablet mixed powder, lubricant is pressed into mouth
1%~2% amount of lozenge mixed powder quality is directly applied on the drift of tablet press machine, using direct power compressing method tabletting,
Produce buccal tablet.
3. the preparation method of Camellia nitidissima antiallergy buccal tablet as claimed in claim 2, it is characterised in that vacuum in step (3)
Drying temperature is 70 DEG C；The temperature of low temperature drying is 40 DEG C.
4. the preparation method of Camellia nitidissima antiallergy buccal tablet as claimed in claim 2, it is characterised in that used in step (3)
Sweetener is honey element；Filler used is protein sugar and mannitol in mass ratio 1.5:1 mixture；It is with lubricator hard
Fatty acid magnesium.
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Citations (4)
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|---|---|---|---|---|
| CN1345244A (en) * | 1999-04-01 | 2002-04-17 | 胡国讓 | Herbal compositions and uses for treatment tof allergic reactions |
| CN1476767A (en) * | 2003-06-05 | 2004-02-25 | 广西富新科技股份有限公司 | Extract liquor of camellia chrysantha |
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| CN102000172A (en) * | 2010-11-02 | 2011-04-06 | 李永胜 | Oral liquid, granules and powder for preventing and treating chronic allergic rhinitis |
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2017
- 2017-05-12 CN CN201710332837.XA patent/CN107007693A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1345244A (en) * | 1999-04-01 | 2002-04-17 | 胡国讓 | Herbal compositions and uses for treatment tof allergic reactions |
| CN1476767A (en) * | 2003-06-05 | 2004-02-25 | 广西富新科技股份有限公司 | Extract liquor of camellia chrysantha |
| CN1586583A (en) * | 2004-07-07 | 2005-03-02 | 香港养春堂中药有限公司 | Desensitization tablet |
| CN102000172A (en) * | 2010-11-02 | 2011-04-06 | 李永胜 | Oral liquid, granules and powder for preventing and treating chronic allergic rhinitis |
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| 朱玮华等: ""中西医结合治疗过敏性紫癜68例疗效观察"", 《中国医刊》 * |
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