CN107137526A - A kind of Camellia nitidissima antiallergy capsule and preparation method thereof - Google Patents
A kind of Camellia nitidissima antiallergy capsule and preparation method thereof Download PDFInfo
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- 239000003814 drug Substances 0.000 claims abstract description 18
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- 241001251949 Xanthium sibiricum Species 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 12
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- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 11
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- 238000001914 filtration Methods 0.000 claims abstract description 6
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- 239000000843 powder Substances 0.000 claims description 20
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The present invention relates to tcm field, more particularly to a kind of Camellia nitidissima antiallergy capsule and preparation method thereof.The Camellia nitidissima antiallergy capsule includes following traditional Chinese medicinal components：20~30 parts of golden flower tea peels, 10~20 parts of radix bupleuri, windproof 10~15 parts, 10~15 parts of dark plum, 5~10 parts of the fruit of Chinese magnoliavine, 5~10 parts of chrysanthemum, 5~10 parts of the root of kudzu vine, 5~10 parts of the achene of Siberian cocklebur.Present invention also offers the preparation method of the Camellia nitidissima antiallergy capsule, raw material is obtained into active ingredient by extraction, filtering, concentration, the filler of doses is added, adds after lubricant and be filled in that Camellia nitidissima antiallergy capsule is made in Capsules.Active ingredient of the invention by extracting Chinese medicine composition, prepared Camellia nitidissima antiallergy capsule is set to cover the bad smell of medicine, it is easy to swallow, moreover it is possible to improve the stability and bioavilability of medicine, be conducive to the absorption of effective medicinal components, effectively treat anaphylactia.
Description
Technical field
The present invention relates to tcm field, more particularly to a kind of Camellia nitidissima antiallergy capsule and preparation method thereof.
Background technology
In recent years anaphylactia with the increment rate in year 20% in drastically ascendant trend, such as allergic asthma, mistake year by year
Quick property rhinitis, early spring pollinosis, contact dermatitis, eczema, hay fever, drug allergy etc..Turn into very noticeable society
Meeting problem, wherein climbing highest is allergic asthma and allergic rhinitis.Not only inconvenience is brought to daily life, make
Into mental suffering, reduction quality of life, and the duration is long, and what is had turns into obstinate disease, and also having causes died.
Camellia nitidissima, is all Theaceae Camellia Plants with tea, South Mountain tea, camellia, oil tea etc., Camellia nitidissima is using its petal as Huang
Color and it is famous, vegetable formal name is Camellia chrysantha (Hu) Tuyama, is Theaceae, Camellia, and evergreen shrubs is to small
Arbor.Clinical research shows that Camellia nitidissima, which has, suppresses tumour, strengthens immunity of organism, anti-aging, the various physiology work(of balanced human
Can, hypotensive strengthens blood vessel elasticity and myocardial contractive power, and enhancing liver is metabolic, and the various enzymes in human activin etc.
Effect.Wang Yong is very waited experiments prove that there is golden flower tea peels antianaphylaxis (to wait Camellia nitidissimas group to plant before Wang Yongqi, Peng Xiao, Tang
The anti-anaphylactoid screening active ingredients of IgE mediating type Is of thing, [J], Central-South pharmacy, 7 (10):721-724.).At present, on golden flower
The document that tea, especially its plant pericarp are used to treat antiallergy disease is also less, and the antiallergy research to golden flower tea peels is gone back
It is not deep enough.
Radix bupleuri is conventional diaphoretic medicine.Smoke alias, mountain dish, mushroom grass, faggot, bitter in taste, be slightly cold, Return liver, gallbladder channel.There is reconciliation
In table, the effect of soothing the liver rising Yang.
It is windproof, alias copper rue, Hui Yun, return grass, hundred, hundred kinds.It is pungent, sweet, slightly warm in nature.Expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion,
Only effect of convulsion.
Dark plum, it is sour, puckery, it is mild-natured.Return liver, spleen, lung, large intestine channel.With astringing the lung, puckery intestines promote the production of body fluid, the effect of claming ascaris.
The fruit of Chinese magnoliavine, with astringing the lung, nourshing kidney is promoted the production of body fluid, and sweat is received, the effect of puckery smart.
Chrysanthemum, property is sweet, be slightly cold, and has effects that dissipate wind-heat, flat liver improving eyesight, disappears and cough analgesic.
The root of kudzu vine, it is cool in nature, it is sweet, pungent.There is expelling pathogenic factors from muscles and skin to bring down a fever, promoting eruption promotes the production of body fluid to quench thirst, the work(of Shengyang Zhixie.
The achene of Siberian cocklebur, pungent, hardship is warm-natured, poisonous.Return lung is passed through.Function with the dehumidifying of scattered wind, sensible analgesic.
At present, the product using Camellia nitidissima as raw material is mostly common with drink, it is impossible to meets the demand of people, wastes golden flower
The medicine resource of tea especially golden flower tea peels, and Chinese medicine odor is poor, and mouthfeel is not good, causes many people to be unwilling to take.
The content of the invention
It is used to treat allergic asthma, anaphylaxis there is provided one kind it is an object of the invention to the defect for overcoming problem above
The Camellia nitidissima antiallergy capsule of the diseases such as rhinitis, early spring pollinosis, contact dermatitis, eczema, hay fever, drug allergy.
The purpose of the present invention can be achieved through the following technical solutions：
A kind of Camellia nitidissima antiallergy capsule, it is characterised in that include the raw material components of following parts by weight：Golden flower tea peels
20~30 parts, 10~20 parts of radix bupleuri, windproof 10~15 parts, 10~15 parts of dark plum, 5~10 parts of the fruit of Chinese magnoliavine, 5~10 parts of chrysanthemum, Pueraria lobota
5~10 parts of root, 5~10 parts of the achene of Siberian cocklebur.
A kind of preparation method of above-mentioned Camellia nitidissima antiallergy capsule, comprises the following steps：
(1) extract
Radix bupleuri, windproof, dark plum, the fruit of Chinese magnoliavine, chrysanthemum, the root of kudzu vine, achene of Siberian cocklebur composition are cleaned, crushed, by obtained raw material
Powder boils 1.5h with 20 times of decocting, takes juice to stay slag, then is decocted, and so decocts three times repeatedly, merges juice；
Golden flower tea peels are cleaned and crushed, percolator is put into, ethanol percolation is continuously added to from top, leachate is collected, plus
Heat makes ethanol evaporation, obtains extract solution；
(2) filter, concentrate
By the Chinese medicine composition juice obtained in step (1) filtering after-purification processing, the precipitation in extract solution is reduced, to net
Extract solution after change is concentrated again, is concentrated into clear cream shape, obtains clear cream 1；Camellia nitidissima Fruit peel extract mistake in the same way
Filter is concentrated to give clear cream 2；
(3) dry, sieve
The clear cream 1 obtained in step (2) is dried in vacuo, dry cream 1 is obtained；Clear cream 2 carries out low temperature drying, obtains dry cream 2；
Dry cream 1 is mixed with dry cream 2, crushed, 100 mesh sieves is crossed, obtains medicinal powder；Filler and lubricant is taken to sieve for subsequent use respectively；
(4) dispense
By medicinal powder and filler and lubricant in mass ratio 30~35:60~65:3~5 are well mixed, and are distributed into hollow glue
In capsule, capsule is produced.
Vacuum drying temperature is 80 DEG C in a kind of preparation method of above-mentioned Camellia nitidissima antiallergy capsule, step (3)；
Filler used forms sediment for pregelatinated in a kind of preparation method of above-mentioned Camellia nitidissima antiallergy capsule, step (3)
Powder, is with lubricator superfine silica gel powder.
A kind of preparation method of above-mentioned Camellia nitidissima antiallergy capsule, medicinal powder presses matter with filler and lubricant during packing
Amount compares 33.3:62.7:4 are well mixed.
The method have the advantages that：
1. the present invention has effectively been played the medicinal effects of golden flower tea peels etc., had by the reasonable compatibility of plurality of Chinese
The various anaphylactias of effect treatment；
2. the active ingredient of the invention by extracting Chinese medicine composition, makes prepared Camellia nitidissima antiallergy capsule to cover
The bad smell of lid medicine, it is easy to swallow, moreover it is possible to improve the stability and bioavilability of medicine, be conducive to effective medicinal components
Absorption, effectively treat anaphylactia.
Embodiment
Below in conjunction with specific embodiment, the present invention will be further described.
Embodiment 1
A kind of Camellia nitidissima antiallergy capsule, includes the raw material components of following parts by weight：Golden flower tea peel 25g, radix bupleuri
10g, windproof 15g, dark plum 10g, fruit of Chinese magnoliavine 5g, chrysanthemum 5g, root of kudzu vine 5g, achene of Siberian cocklebur 5g.
A kind of preparation method of above-mentioned Camellia nitidissima antiallergy capsule, comprises the following steps：
(1) extract
Radix bupleuri 10g, windproof 15g, dark plum 10g, fruit of Chinese magnoliavine 5g, chrysanthemum 5g, root of kudzu vine 5g, achene of Siberian cocklebur 5g compositions are cleaned,
Crush, obtained raw material powder is boiled into 1.5h with 20 times of decocting, takes juice to stay slag, then decocted, so decocted three times repeatedly, closed
And juice；
Golden flower tea peels 25g is cleaned and crushed, percolator is put into, ethanol percolation is continuously added to from top, leachate is collected,
Heating makes ethanol evaporation, obtains extract solution；
(2) filter, concentrate
By the Chinese medicine composition juice obtained in step (1) filtering after-purification processing, the precipitation in extract solution is reduced, to net
Extract solution after change is concentrated again, is concentrated into clear cream shape, obtains clear cream 1；Camellia nitidissima Fruit peel extract mistake in the same way
Filter is concentrated to give clear cream 2；
(3) dry, sieve
The clear cream 1 obtained in step (2) is dried in vacuo at 80 DEG C, dry cream 1 is obtained；Clear cream 2 carries out low temperature at 40 DEG C
Dry, obtain dry cream 2.Dry cream 1 is mixed with dry cream 2, crushed, 100 mesh sieves is crossed, obtains medicinal powder, auxiliary material 150.4g fillers and
9.6g lubricants also sieve respectively；
(4) dispense
Medicinal powder is well mixed with auxiliary material, is distributed into Capsules, Camellia nitidissima antiallergy capsule is produced.
Embodiment 2
A kind of Camellia nitidissima antiallergy capsule, includes the raw material components of following parts by weight：Golden flower tea peel 30g, radix bupleuri
10g, windproof 10g, dark plum 10g, fruit of Chinese magnoliavine 10g, chrysanthemum 5g, root of kudzu vine 10g, achene of Siberian cocklebur 5g.
A kind of preparation method of above-mentioned Camellia nitidissima antiallergy capsule, comprises the following steps：
(1) extract
Radix bupleuri 10g, windproof 10g, dark plum 10g, fruit of Chinese magnoliavine 10g, chrysanthemum 5g, root of kudzu vine 10g, achene of Siberian cocklebur 5g compositions are washed
Only, crush, obtained raw material powder is boiled into 1.5h with 20 times of decocting, takes juice to stay slag, then decocted, three are so decocted repeatedly
It is secondary, merge juice；
Golden flower tea peels 30g is cleaned and crushed, percolator is put into, ethanol percolation is continuously added to from top, leachate is collected,
Heating makes ethanol evaporation, obtains extract solution；
(2) filter, concentrate
By the Chinese medicine composition juice obtained in step (1) filtering after-purification processing, the precipitation in extract solution is reduced, to net
Extract solution after change is concentrated again, is concentrated into clear cream shape, obtains clear cream 1；Camellia nitidissima Fruit peel extract mistake in the same way
Filter is concentrated to give clear cream 2；
(3) dry, sieve
The clear cream 1 obtained in step (2) is dried in vacuo at 80 DEG C, dry cream 1 is obtained；Clear cream 2 carries out low temperature at 40 DEG C
Dry, obtain dry cream 2.Dry cream 1 is mixed with dry cream 2, crushed, 100 mesh sieves is crossed, obtains medicinal powder, auxiliary material 169.2g fillers and
10.8g lubricants also sieve respectively；
(4) dispense
Medicinal powder is well mixed with auxiliary material, is distributed into Capsules, Camellia nitidissima antiallergy capsule is produced.
Embodiment 3
A kind of Camellia nitidissima antiallergy capsule, includes the raw material components of following parts by weight：Golden flower tea peel 25g, radix bupleuri
15g, windproof 15g, dark plum 10g, fruit of Chinese magnoliavine 5g, chrysanthemum 10g, root of kudzu vine 5g, achene of Siberian cocklebur 10g.
(1) extract
Radix bupleuri 15g, windproof 15g, dark plum 10g, fruit of Chinese magnoliavine 5g, chrysanthemum 10g, root of kudzu vine 5g, achene of Siberian cocklebur 10g compositions are washed
Only, crush, obtained raw material powder is boiled into 1.5h with 20 times of decocting, takes juice to stay slag, then decocted, three are so decocted repeatedly
It is secondary, merge juice；
Golden flower tea peels 25g is cleaned and crushed, percolator is put into, ethanol percolation is continuously added to from top, leachate is collected,
Heating makes ethanol evaporation, obtains extract solution；
(2) filter, concentrate
By the Chinese medicine composition juice obtained in step (1) filtering after-purification processing, the precipitation in extract solution is reduced, to net
Extract solution after change is concentrated again, is concentrated into clear cream shape, obtains clear cream 1；Camellia nitidissima Fruit peel extract mistake in the same way
Filter is concentrated to give clear cream 2；
(3) dry, sieve
The clear cream 1 obtained in step (2) is dried in vacuo at 80 DEG C, dry cream 1 is obtained；Clear cream 2 carries out low temperature at 40 DEG C
Dry, obtain dry cream 2.Dry cream 1 is mixed with dry cream 2, crushed, 100 mesh sieves is crossed, obtains medicinal powder, auxiliary material 159.8g fillers and
10.2g lubricants also sieve respectively；
(4) dispense
Medicinal powder is well mixed with auxiliary material, is distributed into Capsules, Camellia nitidissima antiallergy capsule is produced.
Animal toxicity test：
1st, experiment mice 90 is taken, male and female half and half, 140~180g of body weight is respectively divided into three group 1~3, every group each 30,
Every group of mouse sign is good, and the physiological performance such as body weight is without exception, with comparativity.
2nd, filled after the Camellia nitidissima antiallergy capsule dissolving prepared respectively using the embodiment of the present invention 1~3 to three groups of mouse
Stomach is administered, and three times a day, continuously takes one month, the sign situation of all mouse is observed and recorded during testing.
3rd, the sign performance of all mouse is without exception in experimentation, and experiment does not occur dead mouse situation after terminating, right
5 progress dissection inspections are randomly selected in every group of mouse, major organs are no abnormal, from experimental result, the present invention
Camellia nitidissima antiallergy capsule without overt toxicity, can safety of medication.
Conditioning for anaphylactia state improves clinical observation statistics：
1st, case is chosen：Clinically choose the anaphylactia patient 180 made a definite diagnosis, 20~80 years old age, male 80,
Women 100, is divided into three groups of experimental groups 1~3, every group 60.
2nd, experimental method：The capsule prepared respectively using the embodiment of the present invention 1~3 to experimental group 1~3, three times a day,
Continuous medication one month, observes and records the recovery situation of patient.
3rd, curative effect determinate standard：Effectively：Anaphylactia clinical symptom disappearance, every sign recovers normal, in half a year not
See recurrence；It is effective：Anaphylactia clinical symptoms improve, and the performance of each sign is clearly better before patient compares medication；It is invalid：Disease
Feelings are without any improvement or aggravate.
4th, experimental data is counted：
| Classification | Case load | Effectively | It is effective | It is invalid | Adverse reaction | It is efficient |
| Embodiment 1 | 60 | 22 | 38 | 0 | 0 | 100.0 |
| Embodiment 2 | 60 | 30 | 29 | 1 | 0 | 98.3 |
| Embodiment 3 | 60 | 25 | 35 | 0 | 0 | 100.0 |
5th, experimental result：As can be seen from the above experimental data, the Camellia nitidissima antiallergy capsule for preparing of the present invention for
The total effective rate of the treatment of anaphylactia is 99.4%, and 180 patients have no any adverse reaction, therefore explanation, this hair
Bright Camellia nitidissima antiallergy capsule is the safe and effective medicine for treating anaphylactia, with good clinical expansion meaning.
Claims (5)
1. a kind of Camellia nitidissima antiallergy capsule, it is characterised in that include the raw material components of following parts by weight：Golden flower tea peels 20
~30 parts, 10~20 parts of radix bupleuri, windproof 10~15 parts, 10~15 parts of dark plum, 5~10 parts of the fruit of Chinese magnoliavine, 5~10 parts of chrysanthemum, the root of kudzu vine 5
~10 parts, 5~10 parts of the achene of Siberian cocklebur.
2. a kind of preparation method of Camellia nitidissima antiallergy capsule as claimed in claim 1, it is characterised in that including following step
Suddenly：
(1) extract
Radix bupleuri, windproof, dark plum, the fruit of Chinese magnoliavine, chrysanthemum, the root of kudzu vine, achene of Siberian cocklebur composition are cleaned, crushed, obtained raw material powder is used
1.5h is boiled in 20 times of decocting, takes juice to stay slag, then is decocted, and is so decocted three times repeatedly, merges juice；
Golden flower tea peels are cleaned and crushed, percolator is put into, ethanol percolation is continuously added to from top, leachate is collected, heating makes
Ethanol evaporation, obtains extract solution；
(2) filter, concentrate
By the Chinese medicine composition juice obtained in step (1) filtering after-purification processing, the precipitation in extract solution is reduced, after purification
Extract solution concentrated again, be concentrated into clear cream shape, obtain clear cream 1；Camellia nitidissima Fruit peel extract filters dense in the same way
Contracting obtains clear cream 2；
(3) dry, sieve
The clear cream 1 obtained in step (2) is dried in vacuo, dry cream 1 is obtained；Clear cream 2 carries out low temperature drying, obtains dry cream 2；Will be dry
Cream 1 is mixed with dry cream 2, is crushed, and is crossed 100 mesh sieves, is obtained medicinal powder；Filler and lubricant is taken to sieve for subsequent use respectively；
(4) dispense
By medicinal powder and filler and lubricant in mass ratio 30~35:60~65:3~5 are well mixed, and are distributed into Capsules
In, produce capsule.
3. a kind of preparation method of Camellia nitidissima antiallergy capsule as claimed in claim 2, it is characterised in that in step (3)
Vacuum drying temperature is 80 DEG C.
4. a kind of preparation method of Camellia nitidissima antiallergy capsule as claimed in claim 2, it is characterised in that in step (3)
Filler used is pregelatinized starch, is with lubricator superfine silica gel powder.
5. the preparation method of Camellia nitidissima antiallergy capsule as claimed in claim 2, it is characterised in that medicinal powder is with filling out during packing
Fill agent and lubricant in mass ratio 33.3:62.7:4 are well mixed.
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| CN1586583A (en) * | 2004-07-07 | 2005-03-02 | 香港养春堂中药有限公司 | Desensitization tablet |
| CN102000172A (en) * | 2010-11-02 | 2011-04-06 | 李永胜 | Oral liquid, granules and powder for preventing and treating chronic allergic rhinitis |
| CN103007096A (en) * | 2012-12-25 | 2013-04-03 | 臧金文 | Preparation raw materials of dropping liquid for treating rhinitis and tympanitis and production process thereof |
| CN106344701A (en) * | 2016-10-01 | 2017-01-25 | 四川兴聚焦医药科技有限责任公司 | Powder medicine for treating allergic dermatitis and preparation method thereof |
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Application publication date: 20170908 |