CN107167468A - Magnetic particle chemiluminescence immunoassay analyzer - Google Patents
Magnetic particle chemiluminescence immunoassay analyzer Download PDFInfo
- Publication number
- CN107167468A CN107167468A CN201610128044.1A CN201610128044A CN107167468A CN 107167468 A CN107167468 A CN 107167468A CN 201610128044 A CN201610128044 A CN 201610128044A CN 107167468 A CN107167468 A CN 107167468A
- Authority
- CN
- China
- Prior art keywords
- cup
- reaction cup
- washing
- loading system
- reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000006249 magnetic particle Substances 0.000 title claims abstract description 39
- 238000003018 immunoassay Methods 0.000 title abstract description 8
- 238000006243 chemical reaction Methods 0.000 claims abstract description 98
- 238000005406 washing Methods 0.000 claims abstract description 56
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 37
- 239000000758 substrate Substances 0.000 claims abstract description 31
- 238000001514 detection method Methods 0.000 claims abstract description 25
- 238000011534 incubation Methods 0.000 claims abstract description 20
- 239000010813 municipal solid waste Substances 0.000 claims abstract description 6
- 239000011859 microparticle Substances 0.000 claims description 17
- 238000003556 assay Methods 0.000 claims description 15
- 238000009826 distribution Methods 0.000 claims description 6
- 230000032258 transport Effects 0.000 claims 5
- 230000008450 motivation Effects 0.000 claims 1
- 238000007599 discharging Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- -1 antibody Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000002122 magnetic nanoparticle Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
- G01N21/763—Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a magnetic particle chemiluminescence immunoassay analyzer, which comprises a supporting platform and reaction cup strips, wherein a cup discharging system, a sample filling system, a reagent filling system, an incubation system, a washing system, a substrate filling system, a detection system and a cup strip grabbing and transporting mechanism are arranged on the supporting platform; a sample system is arranged below the sample filling system, a reagent system is arranged below the reagent filling system, and a garbage bin is arranged below the detection system. The effect of adopting the present case is, has optimized the overall arrangement of each system to regard a plurality of magnetic particle reaction cups as detecting element, get into each system in batches through the reaction cup strip, practiced thrift detection time greatly, efficiency is higher.
Description
Technical field
The present invention relates to a kind of medicine equipment, and in particular to a kind of magnetic microparticle chemiluminescence immune assay instrument.
Background technology
Immunoassay experienced the different times such as radioimmunoassay, fluorescence immunoassay are examined, enzyme-labeled immunity is examined, and Full-automatic chemiluminescence immunity inspection is a new stage of immunoassay development, and its environmental protection, fast and accurately feature have obtained the generally understanding of people.Full-automatic chemiluminescence immunoassay analysis meter is, by detecting patients serum so as to carry out the medical laboratory instrument of immunoassay to human body, various detections to be carried out to blood with Full-automatic chemiluminescence immunoassay analysis meter, can improve detection efficiency and detection quality.
Magnetic particle refers to that what magnetic nano-particle and inorganic or organic molecule combined to form is dispersed in the colloidal state composite in certain base fluid with high stability.Because magnetic particle has magnetic responsiveness, cost is low, less energy consumption and free of contamination feature, the bioactive substances such as enzyme, antibody, oligonucleotides are fixed on magnetic particle surface or by the functional group on magnetic particle surface by people, can be further used for isolating and purifying and the field such as hybridization check for enzyme immobilizatio, target medicine carrier, cell sorting, immune detection, albumen and nucleic acid.
Traditional immunology detection is more using ELISA Plate as solid phase carrier, suspension magnetic particle has higher specific surface area as carrier, can substantially more with example reaction, in addition the flexible Application of externally-applied magnetic field, there is higher sensitivity, faster detection speed and more preferable repeatability than ELISA Plate, be widely used in the fields such as biological and medical science detection at present.
In existing magnetic microparticle chemiluminescence analyzer, each system is arranged on same layer, and single reaction cup is operated in each system successively as delivery unit, and detection efficiency is very low.
The content of the invention
In view of said one or multiple defects in the prior art is solved, the present invention provides a kind of magnetic microparticle chemiluminescence immune assay instrument.
Technical scheme is as follows：
A kind of magnetic microparticle chemiluminescence immune assay instrument, its key is：Including support platform and reaction cup bar, provided with row's cup system in the support platform, sample loading system, reagent loading system, incubation system, washing system, substrate loading system, detecting system and cup bar crawl transport establishment, magnetic particle reaction cup is provided with row cup system, reaction cup feeding mechanism is provided between row's cup system and sample loading system, magnetic particle reaction cup is sent into the reaction cup bar by the reaction cup feeding mechanism, the reaction cup bar is sequentially sent to the sample loading system by the cup bar crawl transport establishment, reagent loading system, incubation system, washing system and substrate loading system, reaction cup shift-out mechanism is provided between the substrate loading system and detecting system, the magnetic particle reaction cup is sent into the detecting system by the reaction cup shift-out mechanism；
Sample system is provided with below the sample loading system, reagent system is provided with below the reagent loading system, trash repository is provided with below the detecting system.
Remarkable result using above technical scheme is; change the layout type of traditional magnetic microparticle chemiluminescence analyzer; sample loading system is directly sampled from sample system below, and reagent loading system directly takes reagent from reagent system below, so as to reduce sampling and take the time of reagent；Meanwhile, multiple magnetic particle reaction cups constitute a detection unit by reaction cup bar, and detection efficiency is higher；Trash repository below detecting system is used to collect reaction cup after the completion of detection.
Provided with two cup bar crawl transport establishments in above-mentioned support platform, the incubation system, washing system, substrate loading system, detecting system are located between two cup bar crawl transport establishments, row's cup system, sample loading system and reagent loading system are located therein on the outside of any cup bar crawl transport establishment, and the reagent loading system is close to the incubation system.Using above technical scheme, two cup bars capture transport establishment, and the distribution relation of each system can further improve the running efficiency of reaction cup bar.
It is provided with close to above-mentioned sample loading system plus sample channel, reagent adding passage is provided with close to the reagent loading system, between the incubation system and washing system passage is mixed provided with reagent, passage is waited provided with detection between the substrate loading system and detecting system, the reaction cup shift-out mechanism is located at the detection and waited between passage and detecting system.Using above technical scheme, plus sample channel can contain reaction cup bar when filling sample, reagent adding passage can contain reaction cup bar when filling reagent, reagent, which mixes passage, can will enter the magnetic particle reaction cup mixing before incubation system, detection waits passage to be used to contain reaction cup bar to be detected, reaction cup shift-out mechanism, which is used to detect, waits the reaction cup to be detected in passage to send into detecting system, and can remove the reaction cup after system detectio after testing, loses into trash repository.
Surge flask rest area is provided with close to its edge in above-mentioned support platform, electric-control system is provided with below the incubation system, close to the sample loading system provided with tip rest areas.Using above technical scheme, surge flask rest area is used to place cleaning fluid, clear water and washing lotion, is arranged on the convenient operation in support platform edge.
At least one transfer hole is vertically offered on above-mentioned reaction cup bar and at least one reaction cup being adapted with the magnetic particle reaction cup places through hole, the bottom of the magnetic particle reaction cup passes the reaction cup and places the stopper slot that arc is equipped with through hole, the two sides of the reaction cup bar.Using above technical scheme, magnetic particle reaction cup is during transfer, it is ensured that detection is normally carried out；The bottom of magnetic particle reaction cup passes reaction cup and places through hole, convenient that magnetic particle reaction cup bottom is tapped, and magnetic particle reaction cup is shaken up.
Above-mentioned washing system includes substrate, the substrate is provided with supporting vertical plate, the supporting vertical plate is provided with vertical lifting mechanism, the vertical lifting mechanism is provided with first level sliding equipment, the first level sliding equipment is provided with washing pin, the second horizontal sliding equipment is provided with the substrate, the second horizontal sliding equipment is mutually perpendicular to the first level sliding equipment, the second horizontal sliding equipment is provided with washing dolly, the washing dolly is located at below the washing pin, provided with least two glasss of bar holding grooves on the washing dolly, the length direction of the cup bar holding groove is parallel with the glide direction of the described second horizontal sliding equipment, the two ends of the cup bar holding groove are open, the bottom opening of the cup bar holding groove, reaction cup uniform shaking mechanism is provided with the substrate below the washing dolly.Using above technical scheme, elevating mechanism and first level sliding equipment drive washing pin to do two dimensional motion, second horizontal sliding equipment drives washing cart vertical to be moved in first level sliding equipment, multiple reaction cup bars can be set on washing dolly, moved more than, washing pin can be washed to the reaction cup in multiple reaction cup bars, and efficiency is greatly improved.
Washing head is provided with above-mentioned first level sliding equipment, provided with pin is at least washed described in 2 groups on the washing head, length direction of the washing head along the cup bar holding groove is distributed.Using above technical scheme, set multigroup washing pin to be washed simultaneously to multiple magnetic particle reaction cups, greatly save the time.
Dolly locating rod is provided with above-mentioned washing head, the dolly locating rod is used to stretch into the transfer hole, multiple magnet is distributed with two internal groove side walls of the cup bar holding groove, the magnet is interspersed along the cup bar holding groove length direction.Using above technical scheme, dolly locating rod and washing pin are lowered into behind transfer hole, and reaction cup bar is positioned, and the second horizontal sliding equipment drives washing moving of car, magnetic particle reaction cup in reaction cup bar sequentially passes through the magnet being interspersed, and moves back and forth the magnetic particle in magnetic particle reaction cup.
Above-mentioned reaction cup uniform shaking mechanism include it is fixed on the substrate shake up motor, the output shaft for shaking up motor is connected with after protruding upward and shakes up disk, shaken up at this provided with eccentric thimble on disk, it is described when shaking up disc spins, drive eccentric thimble to tap the magnetic particle reaction cup bottom.Using above technical scheme, shake up motor belt motor and shake even disk, make the continuous drumming reaction cup bottom in eccentric top, mix magnetic particle reaction cup.
Beneficial effect：Using the magnetic microparticle chemiluminescence immune assay instrument of the present invention, the layout of each system is optimized, and regard multiple magnetic particle reaction cups as detection unit; each system is entered by reaction cup bar batch, detection time is greatlyd save, it is more efficient; reaction cup bar can be recycled, and save cost.
Brief description of the drawings
Fig. 1 is structural representation of the invention；
Fig. 2 is the distribution schematic diagram of each system in support platform 1；
Fig. 3 is the distribution schematic diagram of each system in the lower section of support platform 1；
The structural representation that Fig. 4 is washing system f in Fig. 2；
Fig. 5 is washing dolly f8 and reaction cup uniform shaking mechanism f10 corresponding relation figure；
Fig. 6 is distribution maps of the magnet f12 along cup bar holding groove f9 length directions；
Fig. 7 is reaction cup bar a structural representation；
Fig. 8 is magnetic particle reaction cup j and reaction cup bar a installation graph.
Embodiment
With reference to embodiment and accompanying drawing, the invention will be further described.
As shown in Fig. 1 to Fig. 8, a kind of magnetic microparticle chemiluminescence immune assay instrument, including support platform 1 and reaction cup bar a, provided with row's cup system b in the support platform 1, sample loading system c, reagent loading system d, incubation system e, washing system f, substrate loading system g, detecting system h and cup bar crawl transport establishment i, magnetic particle reaction cup j is provided with row cup system b, reaction cup feeding mechanism k is provided between row's cup system b and sample loading system c, magnetic particle reaction cup j is sent into the reaction cup bar a by the reaction cup feeding mechanism k, the reaction cup bar a is sequentially sent to the sample loading system c by the cup bar crawl transport establishment i, reagent loading system d, incubation system e, washing system f and substrate loading system g, reaction cup shift-out mechanism u is provided between the substrate loading system g and detecting system h, the magnetic particle reaction cup j is sent into the detecting system h by the reaction cup shift-out mechanism u；
Sample system m is provided with below the sample loading system c, reagent system n is provided with below the reagent loading system d, trash repository p is provided with below the detecting system h.
Provided with two cup bar crawl transport establishment i in the support platform 1, the incubation system e, washing system f, substrate loading system g, detecting system h are located between two cup bar crawl transport establishment i, row's cup system b, sample loading system c and reagent loading system d are located therein on the outside of any cup bar crawl transport establishment i, and the reagent loading system d is close to the incubation system e.
It is provided with close to the sample loading system c plus sample channel q, reagent adding passage r is provided with close to the reagent loading system d, between the incubation system e and washing system f passage s is mixed provided with reagent, passage t, the reaction cup shift-out mechanism u are waited between the detection waits passage t and detecting system h provided with detection between the substrate loading system g and detecting system h.
Surge flask rest area v is provided with close to its edge in the support platform 1, electric-control system w is provided with below the incubation system e, close to the sample loading system c provided with tip rest area x.
At least one transfer hole a1 is vertically offered on the reaction cup bar a and at least one reaction cup being adapted with the magnetic particle reaction cup j places through hole a2, the bottom of the magnetic particle reaction cup j passes the reaction cup and places the stopper slot a3 that arc is equipped with through hole a2, the two sides of the reaction cup bar a.
The washing system f includes substrate f1, substrate f1 is provided with supporting vertical plate f2, supporting vertical plate f2 is provided with vertical lifting mechanism f3, vertical lifting mechanism f3 is provided with first level sliding equipment f4, first level sliding equipment f4 is provided with washing pin f5, the second horizontal sliding equipment f7 is provided with the substrate f1, the second horizontal sliding equipment f7 and first level sliding equipment f4 is mutually perpendicular to, the second horizontal sliding equipment f7 is provided with washing dolly f8, washing dolly f8 is located at below the washing pin f5, provided with least two glasss of bar holding groove f9 on the washing dolly f8, the length direction of the cup bar holding groove f9 is parallel with the described second horizontal sliding equipment f7 glide direction, the two ends of the cup bar holding groove f9 are open, the bottom opening of the cup bar holding groove f9, reaction cup uniform shaking mechanism f10 is provided with the substrate f1 below the washing dolly f8.
Washing head f11 is provided with the first level sliding equipment f4, it is provided with washing head f11 and pin f5 is washed at least described in 2 groups, length direction distributions of the washing head f11 along the cup bar holding groove f9, dolly locating rod f6 is provided with the washing head f11, dolly locating rod f6 is used to stretch into the transfer hole a1, multiple magnet f12 are distributed with two internal groove side walls of the cup bar holding groove f9, the magnet f12 is interspersed along the cup bar holding groove f9 length directions.
The reaction cup uniform shaking mechanism f10 includes being fixed on the substrate f1 shaking up motor f101, the output shaft for shaking up motor f101 is connected with after protruding upward and shakes up disk f102, shaken up at this on disk f102 provided with eccentric thimble f103, it is described when shaking up disk f102 rotations, drive eccentric thimble f103 to tap the magnetic particle reaction cup j bottoms.
It is last it should be noted that; foregoing description is only the preferred embodiments of the present invention; one of ordinary skill in the art is under the enlightenment of the present invention; on the premise of without prejudice to present inventive concept and claim; expression as multiple types can be made, such conversion is each fallen within protection scope of the present invention.
Claims (9)
1. a kind of magnetic microparticle chemiluminescence immune assay instrument, it is characterised in that：Including support platform (1) and
Reaction cup bar (a), in the support platform (1) provided with row cup system (b), sample loading system (c),
Reagent loading system (d), incubation system (e), washing system (f), substrate loading system (g), detection system
Unite (h) and cup bar crawl transport establishment (i), magnetic particle reaction cup (j) be provided with row cup system (b),
Reaction cup feeding mechanism (k) is provided between row's cup system (b) and sample loading system (c), this is anti-
Answer cup feeding mechanism (k) that magnetic particle reaction cup (j) is sent into the reaction cup bar (a), the cup bar crawl
The reaction cup bar (a) is sequentially sent to the sample loading system (c), reagent and filled by transport establishment (i)
System (d), incubation system (e), washing system (f) and substrate loading system (g), the substrate filling
Reaction cup shift-out mechanism (u), the reaction cup shift-out mechanism are provided between system (g) and detecting system (h)
(u) the magnetic particle reaction cup (j) is sent into the detecting system (h)；
Sample system (m) is provided with below the sample loading system (c), in the reagent loading system (d)
Lower section is provided with reagent system (n), and trash repository (p) is provided with below the detecting system (h).
2. magnetic microparticle chemiluminescence immune assay instrument according to claim 1, it is characterised in that：Institute
Support platform (1) is stated provided with two cup bars crawl transport establishments (i), the incubation system (e),
Washing system (f), substrate loading system (g), detecting system (h) are located at two cup bar crawl transports
Between mechanism (i), row's cup system (b), sample loading system (c) and reagent loading system (d)
It is located therein on the outside of any cup bar crawl transport establishment (i), the reagent loading system (d) is close to institute
State incubation system (e).
3. magnetic microparticle chemiluminescence immune assay instrument according to claim 1, it is characterised in that：It is close
The sample loading system (c) sets provided with sample channel (q) is added close to the reagent loading system (d)
There is reagent adding passage (r), passage is mixed provided with reagent between the incubation system (e) and washing system (f)
(s) passage (t), institute, are waited provided with detection between the substrate loading system (g) and detecting system (h)
Reaction cup shift-out mechanism (u) is stated to be located between the detection wait passage (t) and detecting system (h).
4. the magnetic microparticle chemiluminescence immune assay instrument according to claim 1,2,3, it is characterised in that：
Surge flask rest area (v) is provided with close to its edge in the support platform (1), in the incubation system (e)
Lower section is provided with electric-control system (w), close to the sample loading system (c) provided with tip rest areas (x).
5. the magnetic microparticle chemiluminescence immune assay instrument according to claim 1,2,3, it is characterised in that：
Vertically offered on the reaction cup bar (a) at least one transfer hole (a1) and at least one with it is described
The reaction cup that magnetic particle reaction cup (j) is adapted places through hole (a2), the magnetic particle reaction cup (j)
Bottom passes and is equipped with arc on reaction cup placement through hole (a2), the two sides of the reaction cup bar (a)
Stopper slot (a3).
6. magnetic microparticle chemiluminescence immune assay instrument according to claim 5, it is characterised in that：It is described
Washing system (f) includes substrate (f1), and the substrate (f1) is provided with supporting vertical plate (f2), the supporting vertical plate
(f2) vertical lifting mechanism (f3) is provided with, the vertical lifting mechanism (f3) is slided provided with first level
Mechanism (f4), the first level sliding equipment (f4) is provided with washing pin (f5), at the substrate (f1)
The second horizontal sliding equipment (f7) is provided with, the second horizontal sliding equipment (f7) slides with the first level
Motivation structure (f4) is mutually perpendicular to, and the second horizontal sliding equipment (f7), should provided with washing dolly (f8)
Wash dolly (f8) to be located at below the washing pin (f5), provided with least on the washing dolly (f8)
Two cup bar holding grooves (f9), length direction and second level of the cup bar holding groove (f9) are slided
The glide direction of mechanism (f7) is parallel, and the two ends of the cup bar holding groove (f9) are open, and the cup bar is held
The bottom opening of access slot (f9), reaction cup is provided with the substrate (f1) below the washing dolly (f8)
Uniform shaking mechanism (f10).
7. magnetic microparticle chemiluminescence immune assay instrument according to claim 6, it is characterised in that：Institute
First level sliding equipment (f4) is stated provided with washing head (f11), provided with extremely on the washing head (f11)
Washing pin (f5), length side of the washing head (f11) along the cup bar holding groove (f9) described in few 2 groups
To distribution.
8. magnetic microparticle chemiluminescence immune assay instrument according to claim 7, it is characterised in that：Institute
Washing head (f11) is stated provided with dolly locating rod (f6), the dolly locating rod (f6) is used to stretch into the shifting
Hole (a1) is sent, multiple magnet (f12) are distributed with two internal groove side walls of the cup bar holding groove (f9),
The magnet (f12) is interspersed along cup bar holding groove (f9) length direction.
9. magnetic microparticle chemiluminescence immune assay instrument according to claim 1, it is characterised in that：It is described
Reaction cup uniform shaking mechanism (f10) includes being fixed on the substrate (f1) shaking up motor (f101), and this shakes
The output shaft of even motor (f101) is connected with after protruding upward and shakes up disk (f102), and disk (f102) is shaken up at this
It is described when shaking up disk (f102) rotation provided with eccentric thimble (f103), drive eccentric thimble (f103)
Tap magnetic particle reaction cup (j) bottom.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610128044.1A CN107167468B (en) | 2016-03-07 | 2016-03-07 | Magnetic particle chemiluminescence immunoassay analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610128044.1A CN107167468B (en) | 2016-03-07 | 2016-03-07 | Magnetic particle chemiluminescence immunoassay analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107167468A true CN107167468A (en) | 2017-09-15 |
| CN107167468B CN107167468B (en) | 2020-01-14 |
Family
ID=59849885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610128044.1A Active CN107167468B (en) | 2016-03-07 | 2016-03-07 | Magnetic particle chemiluminescence immunoassay analyzer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107167468B (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107831325A (en) * | 2017-10-20 | 2018-03-23 | 厦门市波生生物技术有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN107918027A (en) * | 2017-11-17 | 2018-04-17 | 南通伊仕生物技术股份有限公司 | A kind of small size automatic chemiluminescent analyzer |
| CN108732164A (en) * | 2018-08-07 | 2018-11-02 | 广州万孚生物技术股份有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN108872078A (en) * | 2018-06-29 | 2018-11-23 | 广州市进德生物科技有限公司 | A kind of Full-automatic chemiluminescence analyzer |
| CN109675889A (en) * | 2019-02-20 | 2019-04-26 | 重庆科斯迈生物科技有限公司 | Washing system with uniform mixing function for chemiluminescence immunoassay analyzer |
| CN109799336A (en) * | 2019-02-20 | 2019-05-24 | 重庆科斯迈生物科技有限公司 | Dark box detection system of magnetic particle chemiluminescence immunoassay analyzer |
| CN110082291A (en) * | 2018-01-25 | 2019-08-02 | 深圳市新产业生物医学工程股份有限公司 | Adsorbing mechanism, cleaning device, chemiluminescence detector and cleaning method |
| CN114833141A (en) * | 2022-04-28 | 2022-08-02 | 科来思(深圳)科技有限公司 | Washing module of full-automatic chemiluminescence immunoassay analyzer |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4678752A (en) * | 1985-11-18 | 1987-07-07 | Becton, Dickinson And Company | Automatic random access analyzer |
| CN201926657U (en) * | 2011-02-14 | 2011-08-10 | 四川迈克生物科技股份有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN103399161A (en) * | 2013-07-17 | 2013-11-20 | 深圳市新产业生物医学工程股份有限公司 | Portable full-automatic chemiluminescence immune assay system and assay method thereof |
| CN103884856A (en) * | 2014-04-01 | 2014-06-25 | 重庆科斯迈生物科技有限公司 | Cup strip conveying system of chemiluminescence immunoassay analyzer |
| CN104714042A (en) * | 2013-12-16 | 2015-06-17 | 深圳市亚辉龙生物科技有限公司 | Full-automatic chemiluminescence immune analyzer and use method thereof |
-
2016
- 2016-03-07 CN CN201610128044.1A patent/CN107167468B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4678752A (en) * | 1985-11-18 | 1987-07-07 | Becton, Dickinson And Company | Automatic random access analyzer |
| CN201926657U (en) * | 2011-02-14 | 2011-08-10 | 四川迈克生物科技股份有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN103399161A (en) * | 2013-07-17 | 2013-11-20 | 深圳市新产业生物医学工程股份有限公司 | Portable full-automatic chemiluminescence immune assay system and assay method thereof |
| CN104714042A (en) * | 2013-12-16 | 2015-06-17 | 深圳市亚辉龙生物科技有限公司 | Full-automatic chemiluminescence immune analyzer and use method thereof |
| CN103884856A (en) * | 2014-04-01 | 2014-06-25 | 重庆科斯迈生物科技有限公司 | Cup strip conveying system of chemiluminescence immunoassay analyzer |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107831325A (en) * | 2017-10-20 | 2018-03-23 | 厦门市波生生物技术有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN107918027A (en) * | 2017-11-17 | 2018-04-17 | 南通伊仕生物技术股份有限公司 | A kind of small size automatic chemiluminescent analyzer |
| CN110082291A (en) * | 2018-01-25 | 2019-08-02 | 深圳市新产业生物医学工程股份有限公司 | Adsorbing mechanism, cleaning device, chemiluminescence detector and cleaning method |
| CN110082291B (en) * | 2018-01-25 | 2022-08-05 | 深圳市新产业生物医学工程股份有限公司 | Adsorption mechanism, cleaning device, chemiluminescence detector and cleaning method |
| CN108872078A (en) * | 2018-06-29 | 2018-11-23 | 广州市进德生物科技有限公司 | A kind of Full-automatic chemiluminescence analyzer |
| CN108872078B (en) * | 2018-06-29 | 2020-11-24 | 广州市进德生物科技有限公司 | Full-automatic chemiluminescence analyzer |
| CN108732164A (en) * | 2018-08-07 | 2018-11-02 | 广州万孚生物技术股份有限公司 | Full-automatic chemiluminescence immunoassay analysis meter |
| CN108732164B (en) * | 2018-08-07 | 2023-09-29 | 广州万孚生物技术股份有限公司 | Full-automatic chemiluminescence immunoassay instrument |
| CN109799336A (en) * | 2019-02-20 | 2019-05-24 | 重庆科斯迈生物科技有限公司 | Dark box detection system of magnetic particle chemiluminescence immunoassay analyzer |
| CN109675889A (en) * | 2019-02-20 | 2019-04-26 | 重庆科斯迈生物科技有限公司 | Washing system with uniform mixing function for chemiluminescence immunoassay analyzer |
| WO2020168870A1 (en) * | 2019-02-20 | 2020-08-27 | 重庆科斯迈生物科技有限公司 | Chemiluminescence immunoassay instrument washing system with uniformly-mixing function |
| CN109799336B (en) * | 2019-02-20 | 2023-11-03 | 重庆科斯迈生物科技有限公司 | Dark box detection system of magnetic particle chemiluminescence immunoassay analyzer |
| CN114833141A (en) * | 2022-04-28 | 2022-08-02 | 科来思(深圳)科技有限公司 | Washing module of full-automatic chemiluminescence immunoassay analyzer |
| CN114833141B (en) * | 2022-04-28 | 2024-01-30 | 科来思(深圳)科技有限公司 | Full-automatic chemiluminescence immunoassay analyzer washing module |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107167468B (en) | 2020-01-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107167468A (en) | Magnetic particle chemiluminescence immunoassay analyzer | |
| US20210302456A1 (en) | Sample analysis device | |
| CN207866714U (en) | Chemiluminescence detector | |
| JP5759411B2 (en) | Device for transferring samples | |
| WO2018126774A1 (en) | Automatic analysis device and sample analysis method | |
| WO2018126772A1 (en) | Reaction incubation device, immunity analyzer and reaction incubation method | |
| CN106706942A (en) | Automatic analysis device and sample analysis method | |
| EP2835178A1 (en) | Centrifuge and method for centrifuging a reaction vessel unit | |
| US10613106B2 (en) | Reaction vessel handling apparatus, testing apparatus, and methods using same | |
| JP2003522322A (en) | Structures and methods for automatic analysis of samples | |
| CN102066934A (en) | Analyzer using magnetic particles | |
| CN116840499A (en) | Automatic analysis device and sample analysis method thereof | |
| WO2021147187A1 (en) | Sample analysis method and sample analysis device | |
| CN107167621B (en) | Multi-channel detection method for magnetic particle chemiluminescence immunoassay analyzer | |
| CN114019178A (en) | Full-automatic immune biochemical integrated analyzer and use method thereof | |
| CN109541198A (en) | A kind of pipeline system automatic chemiluminescence immunoassay device | |
| CN206146952U (en) | Sample system of magnetic particle chemiluminescence immunoassay analyzer | |
| WO2021147183A1 (en) | Analysis apparatus | |
| CN108362901A (en) | A kind of chemiluminescence immune assay device and its analysis method | |
| EP0572640A1 (en) | Systems for conducting multiple analytical procedures using a central processing hub | |
| CN103884856A (en) | Cup strip conveying system of chemiluminescence immunoassay analyzer | |
| WO2021147186A1 (en) | Dilution method and dilution apparatus | |
| WO2021147184A1 (en) | Analysis device | |
| WO2021147185A1 (en) | Analysis apparatus | |
| CN114167071A (en) | Multifunctional sample analysis system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |