CN107918027A - A kind of small size automatic chemiluminescent analyzer - Google Patents
A kind of small size automatic chemiluminescent analyzer Download PDFInfo
- Publication number
- CN107918027A CN107918027A CN201711147374.6A CN201711147374A CN107918027A CN 107918027 A CN107918027 A CN 107918027A CN 201711147374 A CN201711147374 A CN 201711147374A CN 107918027 A CN107918027 A CN 107918027A
- Authority
- CN
- China
- Prior art keywords
- small size
- size automatic
- reagent
- chemiluminescent analyzer
- module
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
Abstract
The present invention discloses a kind of small size automatic chemiluminescent analyzer, belongs to chemiluminescence immunoassay technology field.The small size automatic chemiluminescent analyzer that the present invention wants include from front to back, it is mutually independent, tiling set sample reagent frame, liquid-transfering device, magnetic bead adsorbing and extracting device and survey read apparatus, be conducive to the installation and maintenance of instrument, it is easy to use, it is easy to spread.
Description
Technical field
The present invention relates to chemiluminescence immunoassay technology field, and in particular to a kind of small size automatic chemiluminescence analysis
Instrument.
Background technology
In POCT detection techniques, the detection method of small-sized POCT projects is nearly all immunochromatographic method currently on the market,
Either fluorescent quantitation or colloidal gold, are all immunochromatographic methods for essence, are all test strips.Immunochromatographic method can not be real
Now complete quantitative, detection sensitivity is relatively low, and mainstream instrument is different platform, and testing result can not across comparison.Therefore market needs
The small-sized use separated chemical luminescence detector of particulate is wanted, which is entirely quantitative, and detection sensitivity is high, and mainstream instrument
The same platform of device, it is possible to achieve across comparison.
So in detection speed, the mainstream of domestic immune instrument test speed is 200 fast currently on the market, market competition
It is fierce.And promoted from market development and country in terms of the trend of classification diagnosis and treatment, the immune user of this large-scale immune instrument test
Object will certainly sink, and following vast primary hospitals, community clinic and community hospital will all carry out.But with advances in technology
And development, the characteristics of this portions of client object are that every usage amount is smaller, user of service's quality is relatively low, therefore market is with greater need for can be single
The small-sized full automatic equipment of item detection.
The content of the invention
Therefore, the technical problem to be solved in the present invention be to overcome lack in the prior art can single item detection it is small-sized
The defects of full automatic equipment, so as to provide a kind of small size automatic chemiluminescent analyzer.
For this reason, the present invention provides following technical solution：
A kind of small size automatic chemiluminescent analyzer, including from front to back, it is mutually independent, tiling set sample examination
Agent frame, liquid-transfering device, magnetic bead adsorbing and extracting device and survey read apparatus.
The sample reagent is provided with reagent strip grillage and is used to place reagent strip, and the reagent strip grillage is equipped with heated mould
Block, for heating reagent strip, in use, the sample reagent frame is moved to corresponding position by motor driving.
The liquid-transfering device is made of main motor, auxiliary-motor and Zhu Sai mechanisms, and the main motor is used to control Zhu Sai mechanisms
Move up and down, the auxiliary-motor control Zhu Sai mechanisms are inhaled, fluid injection body.
The magnetic bead adsorbing and extracting device includes the bar magnet and magnetic bead sheath controlled respectively by two motors, described two electricity
Machine controls bar magnet and magnetic bead sheath up and down motion respectively.
The survey read apparatus is equipped with detection probe and is used to induce the fluorescent value of detection sample and is shown in survey read apparatus
On.
The reagent strip, which is equipped with, surveys pin sensing, and magnetosheath hole, sample aperture and tip head bore, are respectively used to hold with shading work(
Survey pin sensing material, magnetosheath, sample and the tip heads of energy；Reagent wells and clean-out opening are additionally provided with the reagent strip, it is anti-to be coated with biology
The magnetic bead of body is placed in the reagent wells.
The Zhu Sai mechanisms include plunger rod and note plug cavity, for suction reagent.
The reagent strip grillage is 8, and the Zhu Sai mechanisms are 8 sets；The magnetic bead adsorbing and extracting device is 8 sets, with reality
Detected while existing 8 identical or different projects.
Circuitry module is further included, the circuitry module is described whole by the way of driving is added in single master control
The main control part of login module is by the way of optocoupler is isolated with circuit system.
The circuitry module, including incubate module and be used to control temperature；
Response Code scan module, and be responsible for communicating and dispatch with the master control of setting；
Liquid crystal screen module, for technical grade liquid crystal display and assembles WINCE systems, dominant frequency 1GHz, supports Visual Studio to open
Hair；
Totally 3 tunnels incubate module to the circuitry module, per the independent sets target temperature in road；The Response Code scan module
Scan process Quick Response Code is responsible for using high-performance dedicated scan head.
Technical solution of the present invention, has the following advantages that：
1. the general frame technical solution of small size automatic chemiluminescent analyzer provided by the invention is using the knot of tiling
Structure, is sample reagent frame, liquid-transfering device, magnetic bead adsorbing and extracting device, survey read apparatus respectively from front to back, and structure is separate,
Be conducive to the installation and maintenance of instrument, it is easy to use, it is easy to spread.
2. small size automatic chemiluminescent analyzer provided by the invention can place 8 reagent strips, in each reagent strip
Lower panel rack position, is all correspondingly arranged on heating module, can ensure the uniformity of 8 reagent strip heating-up temperatures.
3. the note of small size automatic chemiluminescent analyzer provided by the invention is plugged with 8 sets, its entirety is controlled by main motor
Move up and down, auxiliary-motor control note plug is inhaled, fluid injection body.8 sets of note plugs move at the same time, it is possible to achieve synchronous suction liquid, can guarantee that 8
A note plug is inhaled, the uniformity of fluid injection body, and position accurately controls, and failure rate is low.
4. small size automatic chemiluminescent analyzer magnetic bead adsorbing and extracting device provided by the invention is by two motors point
Not Kong Zhi bar magnet and magnetic bead sheath up and down motion.It can realize magnetic bead absorption, vibration, separation function, can realize at the same time
The the picking and placeing of magnetosheath, the stirring of magnetic bead and absorption, pick and place function.
5. small size automatic chemiluminescent analyzer provided by the invention, during use, reagent strip removes and reagent is housed
Outside, magnetosheath and tip heads are also placed with, as long as the sample of required test is put into sample aperture, it is enterprising just can be directly placed on machine
Row experiment, finishes the magnetosheath discarded after test and tip are all put back in reagent strip, it is only necessary to reagent strip is taken out, it is possible to again
Do next group of experiment.Avoid and periodic cleaning and cleaning are carried out to discarded object and liquid.Surveying pin sensing material requirements has shade function,
So individually it is positioned over as a part in reagent strip.After experiment discard magnetosheath and tip all put back to corresponding recovery holes
Position, it is only necessary to reagent strip is taken out, with regard to next group of experiment can be done.
6. if the integrated circuit of the circuitry module of small size automatic chemiluminescent analyzer provided by the invention is divided into
Dry module, using the communication mode of CAN bus, make each module can with control software Direct Communication, so integrated circuit
Reliable and stable, autgmentability is extremely strong.
It is operated alone 7. every maintenance and operation of small size automatic chemiluminescent analyzer provided by the invention is moved by a motor, it is whole
For body by the way of driving is added in single master control, cost-effective control is flexible；Main control part is isolated using optocoupler with circuit system
Mode, avoid interference of the system noise to control unit.
6. totally 3 tunnels incubate mould to the circuitry module complete machine of small size automatic chemiluminescent analyzer provided by the invention
Block, per road can independent sets target temperature, avoid the heating that edge effect is brought inconsistent, experiment arrangement is more flexible；Quick Response Code
Scan module is responsible for scan process Quick Response Code using high-performance dedicated scan head, and configures a master control for it and be responsible for communicating and adjust
Degree, independent collaborative work, disposal ability again greatly improve mutually for the two；Liquid crystal screen module is assembled using technical grade liquid crystal display
The dominant frequency of WINCE systems, up to 1GHz, supports Visual Studio exploitations, complete machine interface and control program development are rapid, simultaneous
Capacitive higher.
Brief description of the drawings
, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution of the prior art
Embodiment or attached drawing needed to be used in the description of the prior art are briefly described, it should be apparent that, in describing below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
Put, other attached drawings can also be obtained according to these attached drawings.
Fig. 1 is the small size automatic chemiluminescent analyzer schematic diagram of the present invention；
Fig. 2 is sample reagent frame schematic diagram of the present invention；
Fig. 3 is liquid-transfering device schematic diagram of the present invention；
Fig. 4 is magnetic bead adsorbing and extracting schematic device of the present invention；
Fig. 5 is reagent strip schematic diagram of the present invention；
Fig. 6 fills in structural scheme of mechanism for present invention note；
Description of reference numerals：
1- sample reagent framves；2- liquid-transfering devices；3- magnetic bead adsorbing and extracting devices；4- surveys read apparatus；5- reagent strips；6- note plugs
Mechanism；7- bar magnets；8- magnetic bead sheaths；9- surveys pin sensing；10- magnetosheaths hole；11- sample apertures；12-tip head bore；13- reagent wells；14-
Plunger rod；15- note plug cavitys；16- incubates module；17- liquid crystal screen modules；18- clean-out openings.
Embodiment
Technical scheme is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
Personnel's all other embodiments obtained without making creative work, belong to the scope of protection of the invention.
As long as in addition, technical characteristic involved in invention described below different embodiments non-structure each other
It can be combined with each other into conflict.
The principle explanation of instrument of the present invention：
The dilution and be coated with the magnetic bead of biological reagent with matching somebody with somebody that liquid-transfering device is drawn in reagent strip according to being actually needed
Solution processed simultaneously completes adsorption reaction, and then magnetic bead adsorbing and extracting device installs magnetosheath, and adsorbs vibration magnetic bead and fully react, it
The magnetic bead fully reacted is cleaned afterwards, is preparing corresponding detection solution, the detection probe for surveying read apparatus detects that fluorescent value reacts
Read to detect so as to complete test on display screen to surveying.
Embodiment 1
The present embodiment provides a kind of small size automatic chemiluminescent analyzer, including from front to back, it is mutually independent, tiling
Sample reagent frame 1, liquid-transfering device 2, magnetic bead adsorbing and extracting device 3 and the survey read apparatus 4 of setting.
The sample reagent frame 1 is equipped with reagent strip grillage and is used to place reagent strip 5, and the reagent strip grillage is equipped with heating
Module, for heating reagent strip 5, in use, the sample reagent frame is moved to corresponding position by motor driving.
The liquid-transfering device 2 is made of main motor, auxiliary-motor and Zhu Sai mechanisms 6, and the main motor is used to control note plug machine
Structure 6 moves up and down, and the auxiliary-motor control Zhu Sai mechanisms 6 are inhaled, fluid injection body.
The magnetic bead adsorbing and extracting device 3 includes the bar magnet 7 and magnetic bead sheath 8 that are controlled respectively by two motors, and described two
A motor controls bar magnet 7 and magnetic bead sheath 8 up and down motion respectively.
The read apparatus 4 of surveying is equipped with detection probe for inducing the fluorescent value of detection sample and being shown in survey read apparatus
On 4.
The reagent strip, which is equipped with, surveys pin sensing 9, and magnetosheath hole 10, sample aperture 11 and tip head bore 12, being respectively used to hold has
Survey pin sensing material, magnetosheath, sample and the tip heads of shade function；Reagent wells 13 and clean-out opening 18 are additionally provided with the reagent strip, are wrapped
The magnetic bead for being had biological antibody is placed in the reagent wells 13.
The Zhu Sai mechanisms 6 include plunger rod 14 and note plug cavity 15, for suction reagent.
The reagent strip grillage is 8, and the Zhu Sai mechanisms 6 are 8 sets；The magnetic bead adsorbing and extracting device 3 is 8 sets, with
Detected while realizing 8 identical or different projects.
Circuitry module is further included, the circuitry module is described whole by the way of driving is added in single master control
The main control part of login module is by the way of optocoupler is isolated with circuit system.
The circuitry module, including incubate module 16 and be used to control temperature；
Response Code scan module, and be responsible for communicating and dispatch with the master control of setting；
Liquid crystal screen module 17, for technical grade liquid crystal display and assembles WINCE systems, dominant frequency 1GHz, supports Visual Studio
Exploitation；
Totally 3 tunnels incubate module 16 to the circuitry module, per the independent sets target temperature in road；The two-dimensional code scanning mould
Block is responsible for scan process Quick Response Code using high-performance dedicated scan head.
The comparison of 1 product of the present invention of table and the common similar products of the prior art
The key technical indexes of 2 product of the present invention of table
Obviously, the above embodiments are merely examples for clarifying the description, and the restriction not to embodiment.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of change or
Change.There is no necessity and possibility to exhaust all the enbodiments.And the obvious change thus extended out or
Among changing still in the protection domain of the invention.
Claims (10)
- A kind of 1. small size automatic chemiluminescent analyzer, it is characterised in that including from front to back, it is mutually independent, tiling set Sample reagent frame, liquid-transfering device, magnetic bead adsorbing and extracting device and the survey read apparatus put.
- 2. small size automatic chemiluminescent analyzer according to claim 1, it is characterised in that the sample reagent is provided with Reagent strip grillage is used to place reagent strip, and the reagent strip grillage is equipped with heating module, for heating reagent strip, in use, The sample reagent frame is moved to corresponding position by motor driving.
- 3. small size automatic chemiluminescent analyzer according to claim 2, it is characterised in that the liquid-transfering device is by main electricity Machine, auxiliary-motor and Zhu Sai mechanisms composition, the main motor are used to control Zhu Sai mechanisms to move up and down, the auxiliary-motor control note plug Mechanism is inhaled, fluid injection body.
- 4. small size automatic chemiluminescent analyzer according to claim 3, it is characterised in that the magnetic bead adsorbing and extracting dress Put bar magnet and magnetic bead sheath including being controlled respectively by two motors, described two motors control bar magnet respectively and magnetic bead sheath Up and down motion.
- 5. small size automatic chemiluminescent analyzer according to claim 4, it is characterised in that the survey read apparatus is equipped with Detection probe is used to induce the fluorescent value of detection sample and be shown in survey read apparatus.
- 6. small size automatic chemiluminescent analyzer according to claim 5, it is characterised in that the reagent strip, which is equipped with, to be surveyed Pin sensing, magnetosheath hole, sample aperture and tip head bore, be respectively used to hold the survey pin sensing material with shade function, magnetosheath, sample and Tip heads；Reagent wells and clean-out opening are additionally provided with the reagent strip, the magnetic bead for being coated with biological antibody is placed in the reagent wells.
- 7. small size automatic chemiluminescent analyzer according to claim 6, it is characterised in that the Zhu Sai mechanisms include column Stopper rod and note plug cavity, for suction reagent.
- 8. small size automatic chemiluminescent analyzer according to claim 7, it is characterised in that the reagent strip grillage is 8 A, the Zhu Sai mechanisms are 8 sets；The magnetic bead adsorbing and extracting device is 8 sets, while to realize 8 identical or different projects Detection.
- 9. small size automatic chemiluminescent analyzer according to claim 8, it is characterised in that further include circuitry mould Block, by the way of driving is added in single master control, the main control part of the circuitry module uses the circuitry module The mode that optocoupler is isolated with circuit system.
- 10. small size automatic chemiluminescent analyzer according to claim 9, it is characterised in that the circuitry module, It is used to control temperature including incubating module；Response Code scan module, and be responsible for communicating and dispatch with the master control of setting；Liquid crystal screen module, for technical grade liquid crystal display and assembles WINCE systems, dominant frequency 1GHz, supports Visual Studio exploitations；Totally 3 tunnels incubate module to the circuitry module, per the independent sets target temperature in road；The Response Code scan module uses High-performance dedicated scan head is responsible for scan process Quick Response Code.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711147374.6A CN107918027A (en) | 2017-11-17 | 2017-11-17 | A kind of small size automatic chemiluminescent analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711147374.6A CN107918027A (en) | 2017-11-17 | 2017-11-17 | A kind of small size automatic chemiluminescent analyzer |
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| Publication Number | Publication Date |
|---|---|
| CN107918027A true CN107918027A (en) | 2018-04-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711147374.6A Pending CN107918027A (en) | 2017-11-17 | 2017-11-17 | A kind of small size automatic chemiluminescent analyzer |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108776217A (en) * | 2018-09-03 | 2018-11-09 | 深圳加美生物有限公司 | A kind of full instrument of immune colloid gold |
| CN109142708A (en) * | 2018-09-02 | 2019-01-04 | 广州源起健康科技有限公司 | A kind of Full-automatic magnetic beads time-resolved fluorescence immunoassay instrument |
| CN109406804A (en) * | 2018-10-30 | 2019-03-01 | 深圳泰乐德医疗有限公司 | Full-automatic chemiluminescence analyzer |
| CN110749742A (en) * | 2019-11-15 | 2020-02-04 | 成都宜乐芯生物科技有限公司 | POCT full-automatic chemiluminescence device based on active magnetic separation technology |
| CN111913000A (en) * | 2020-06-22 | 2020-11-10 | 深圳天深医疗器械有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN113820195A (en) * | 2021-11-25 | 2021-12-21 | 成都宜乐芯生物科技有限公司 | Multichannel parallel pretreatment device |
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| CN107167584A (en) * | 2017-05-27 | 2017-09-15 | 北京热景生物技术股份有限公司 | Chemical illumination immunity analysis instrument |
| CN206583802U (en) * | 2017-02-14 | 2017-10-24 | 北京源诚科仪生物技术有限公司 | Miniature full-automatic chemical luminescence detector |
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| US20040157224A1 (en) * | 2003-01-29 | 2004-08-12 | Roh Hee Joun | Kit for separating and purifying nucleic acids or various biological materials, and system for automatically performing separation or purification of biological materials using the same |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109142708A (en) * | 2018-09-02 | 2019-01-04 | 广州源起健康科技有限公司 | A kind of Full-automatic magnetic beads time-resolved fluorescence immunoassay instrument |
| CN109142708B (en) * | 2018-09-02 | 2023-01-24 | 广州源起健康科技有限公司 | Full-automatic magnetic bead time-resolved fluorescence immunoassay appearance |
| CN108776217A (en) * | 2018-09-03 | 2018-11-09 | 深圳加美生物有限公司 | A kind of full instrument of immune colloid gold |
| CN108776217B (en) * | 2018-09-03 | 2023-12-22 | 深圳加美生物有限公司 | Immune colloidal gold full quantitative detector |
| CN109406804A (en) * | 2018-10-30 | 2019-03-01 | 深圳泰乐德医疗有限公司 | Full-automatic chemiluminescence analyzer |
| CN110749742A (en) * | 2019-11-15 | 2020-02-04 | 成都宜乐芯生物科技有限公司 | POCT full-automatic chemiluminescence device based on active magnetic separation technology |
| CN111913000A (en) * | 2020-06-22 | 2020-11-10 | 深圳天深医疗器械有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN113820195A (en) * | 2021-11-25 | 2021-12-21 | 成都宜乐芯生物科技有限公司 | Multichannel parallel pretreatment device |
| CN113820195B (en) * | 2021-11-25 | 2022-03-08 | 成都宜乐芯生物科技有限公司 | Multichannel parallel pretreatment device |
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Application publication date: 20180417 |