CN107167468B - Magnetic particle chemiluminescence immunoassay analyzer - Google Patents
Magnetic particle chemiluminescence immunoassay analyzer Download PDFInfo
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- CN107167468B CN107167468B CN201610128044.1A CN201610128044A CN107167468B CN 107167468 B CN107167468 B CN 107167468B CN 201610128044 A CN201610128044 A CN 201610128044A CN 107167468 B CN107167468 B CN 107167468B
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
- G01N21/763—Bioluminescence
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
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Abstract
The invention discloses a magnetic particle chemiluminescence immunoassay analyzer, which comprises a supporting platform and reaction cup strips, wherein a cup discharging system, a sample filling system, a reagent filling system, an incubation system, a washing system, a substrate filling system, a detection system and a cup strip grabbing and transporting mechanism are arranged on the supporting platform; a sample system is arranged below the sample filling system, a reagent system is arranged below the reagent filling system, and a garbage bin is arranged below the detection system. The effect of adopting the present case is, has optimized the overall arrangement of each system to regard a plurality of magnetic particle reaction cups as detecting element, get into each system in batches through the reaction cup strip, practiced thrift detection time greatly, efficiency is higher.
Description
Technical Field
The invention relates to a medical instrument, in particular to a magnetic particle chemiluminescence immunoassay analyzer.
Background
The immunoassay is subjected to different periods of radioimmunoassay, fluorescence immunoassay, enzyme-labeled immunoassay and the like, the full-automatic chemiluminescence immunoassay is a new stage of immunoassay development, and the characteristics of environmental protection, rapidness and accuracy are generally known by people. The full-automatic chemiluminescence immunoassay analyzer is a medical inspection instrument for performing immunoassay on a human body by detecting serum of a patient, and various detections are performed on blood by using the full-automatic chemiluminescence immunoassay analyzer, so that the detection efficiency and the detection quality can be improved.
The magnetic particles are colloidal composite materials which are formed by combining magnetic nanoparticles and inorganic or organic molecules and can be uniformly dispersed in a certain base solution and have high stability. Because the magnetic particles have the characteristics of magnetic responsiveness, low cost, low energy consumption and no pollution, people can fix enzymes, antibodies, oligonucleotides and other bioactive substances on the surfaces of the magnetic particles or through functional groups on the surfaces of the magnetic particles, and can be further used in the fields of enzyme immobilization, targeted drug carriers, cell sorting, immunoassay, protein and nucleic acid separation and purification, hybridization detection and the like.
The traditional immunology detection mostly uses an enzyme label plate as a solid phase carrier, and suspended magnetic particles as the carrier have higher specific surface area, can react with a sample more fully, and have the advantages of higher sensitivity, higher detection speed, better repeatability and the like compared with the enzyme label plate due to the flexible application of an external magnetic field.
In the existing magnetic particle chemiluminescence analyzer, all systems are arranged on the same layer, and a single reaction cup is used as a transportation unit to sequentially operate in all systems, so that the detection efficiency is very low.
Disclosure of Invention
In view of solving one or more of the above-mentioned drawbacks of the prior art, the present invention provides a magnetic particle chemiluminescence immunoassay analyzer.
The technical scheme is as follows:
the utility model provides a magnetic particle chemiluminescence immunoassay appearance which the key lies in: the magnetic particle detection device comprises a supporting platform and a reaction cup strip, wherein a cup discharging system, a sample filling system, a reagent filling system, an incubation system, a washing system, a substrate filling system, a detection system and a cup strip grabbing and transporting mechanism are arranged on the supporting platform, a magnetic particle reaction cup is arranged in the cup discharging system, a reaction cup feeding mechanism is arranged between the cup discharging system and the sample filling system and used for feeding the magnetic particle reaction cup into the reaction cup strip, the reaction cup strip grabbing and transporting mechanism is used for sequentially feeding the reaction cup strip into the sample filling system, the reagent filling system, the incubation system, the washing system and the substrate filling system, a reaction cup removing mechanism is arranged between the substrate filling system and the detection system, and the reaction cup removing mechanism is used for feeding the magnetic particle reaction cup into the detection system;
a sample system is arranged below the sample filling system, a reagent system is arranged below the reagent filling system, and a garbage bin is arranged below the detection system.
The technical scheme has the obvious effects that the layout mode of the traditional magnetic particle chemiluminescence analyzer is changed, the sample filling system directly samples from the sample system below the sample filling system, and the reagent filling system directly takes the reagent from the reagent system below the reagent filling system, so that the sampling and reagent taking time is reduced; meanwhile, a plurality of magnetic particle reaction cups form a detection unit through the reaction cup strips, so that the detection efficiency is higher; and the garbage bin below the detection system is used for collecting the reaction cups after the detection is finished.
The support platform is provided with two cup strip grabbing and transporting mechanisms, the incubation system, the washing system, the substrate filling system and the detection system are located between the two cup strip grabbing and transporting mechanisms, the cup discharging system, the sample filling system and the reagent filling system are located on the outer side of any one of the cup strip grabbing and transporting mechanisms, and the reagent filling system is close to the incubation system. By adopting the technical scheme, the two cup strip grabbing and conveying mechanisms and the distribution relation of each system can further improve the operation efficiency of the reaction cup strips.
A sample adding channel is arranged near the sample adding system, a reagent adding channel is arranged near the reagent adding system, a reagent mixing channel is arranged between the incubation system and the washing system, a detection waiting channel is arranged between the substrate adding system and the detection system, and the reaction cup moving-out mechanism is positioned between the detection waiting channel and the detection system. By adopting the technical scheme, the sample adding channel can be used for containing reaction cup strips when samples are added, the reagent adding channel can be used for containing reaction cup strips when reagents are added, the reagent mixing channel can be used for mixing magnetic particle reaction cups before entering the incubation system, the detection waiting channel is used for containing reaction cup strips to be detected, the reaction cup moving-out mechanism is used for sending the reaction cups to be detected in the detection waiting channel into the detection system, and the reaction cups detected by the detection system can be moved out and thrown into a garbage bin.
A buffer bottle placing area is arranged on the supporting platform and close to the edge of the supporting platform, an electric control system is arranged below the incubation system, and a tip head placing area is arranged close to the sample filling system. Technical scheme more than adopting, the buffer bottle is placed the district and is used for placing washing liquid, clear water and washing liquid, sets up the convenient operation in support platform edge.
The reaction cup strip is vertically provided with at least one transfer hole and at least one reaction cup placing through hole matched with the magnetic particle reaction cup, the bottom of the magnetic particle reaction cup penetrates out of the reaction cup placing through hole, and two side faces of the reaction cup strip are provided with arc-shaped limiting grooves. By adopting the technical scheme, the magnetic particle reaction cup ensures the normal operation of detection in the transferring process; the bottom of the magnetic particle reaction cup penetrates through the reaction cup placing through hole, so that the bottom of the magnetic particle reaction cup can be conveniently knocked, and the magnetic particle reaction cup is shaken uniformly.
The washing system comprises a base plate, wherein a supporting vertical plate is arranged on the base plate, a vertical lifting mechanism is arranged on the supporting vertical plate, a first horizontal sliding mechanism is arranged on the vertical lifting mechanism, a washing needle is arranged on the first horizontal sliding mechanism, a second horizontal sliding mechanism is arranged on the base plate, the second horizontal sliding mechanism is perpendicular to the first horizontal sliding mechanism, a washing trolley is arranged on the second horizontal sliding mechanism and is positioned below the washing needle, at least two cup strip receiving grooves are formed in the washing trolley, the length direction of each cup strip receiving groove is parallel to the sliding direction of the second horizontal sliding mechanism, two ends of each cup strip receiving groove are open, the bottom of each cup strip receiving groove is open, and a reaction cup shaking mechanism is arranged on the base plate below the washing trolley. Technical scheme more than adopting, elevating system and first horizontal sliding mechanism drive the washing needle and do two-dimensional motion, and second horizontal sliding mechanism drives the motion of the first horizontal sliding mechanism of washing dolly perpendicular to, can set up a plurality of reaction cup strips on the washing dolly, through above motion, the washing needle can wash the reaction cup in a plurality of reaction cup strips, and efficiency improves greatly.
The first horizontal sliding mechanism is provided with a washing head, at least 2 groups of washing needles are arranged on the washing head, and the washing heads are distributed along the length direction of the cup strip receiving groove. By adopting the technical scheme, a plurality of groups of washing needles are arranged to wash a plurality of magnetic particle reaction cups simultaneously, so that the time is greatly saved.
The washing head is provided with a trolley positioning rod which is used for extending into the transfer hole, a plurality of magnets are distributed on two inner groove walls of the cup strip bearing groove, and the magnets are distributed along the length direction of the cup strip bearing groove in a staggered manner. After the technical scheme is adopted, the trolley positioning rod and the washing needle descend to enter the transfer hole, the reaction cup strips are positioned, the second horizontal sliding mechanism drives the washing trolley to move, and the magnetic particle reaction cups in the reaction cup strips sequentially pass through the magnets distributed in a staggered mode, so that the magnetic particles in the magnetic particle reaction cups reciprocate.
The reaction cup shaking mechanism comprises a shaking motor fixed on the base plate, an output shaft of the shaking motor extends upwards and is connected with a shaking plate, an eccentric thimble is arranged on the shaking plate, and the eccentric thimble is driven to knock the bottom of the magnetic particle reaction cup when the shaking plate rotates. By adopting the technical scheme, the shaking-up motor drives the shaking-up disc to enable the eccentric top to continuously knock the bottom of the reaction cup, so that the magnetic particle reaction cup is uniformly mixed.
Has the advantages that: the magnetic particle chemiluminescence immunoassay analyzer optimizes the layout of each system, takes a plurality of magnetic particle reaction cups as detection units, and enters each system in batches through the reaction cup strips, thereby greatly saving the detection time, having higher efficiency, recycling the reaction cup strips and saving the cost.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic diagram of the distribution of the systems on the support platform 1;
FIG. 3 is a schematic diagram of the distribution of the systems under the support platform 1;
FIG. 4 is a schematic diagram of the washing system f of FIG. 2;
FIG. 5 is a diagram showing the correspondence between the washing cart f8 and the cuvette shaking mechanism f 10;
FIG. 6 is a view showing the distribution of the magnet f12 along the length of the cup bar receiving groove f 9;
FIG. 7 is a schematic structural view of a reaction cup strip a;
FIG. 8 is a diagram showing the mounting relationship between the magnetic particle cuvette j and the cuvette bar a.
Detailed Description
The invention is further illustrated by the following examples and figures.
As shown in fig. 1 to 8, a magnetic particle chemiluminescence immunoassay analyzer comprises a support platform 1 and a reaction cup strip a, wherein a cup discharge system b, a sample filling system c, a reagent filling system d, an incubation system e, a washing system f, a substrate filling system g, a detection system h and a cup strip grabbing and transporting mechanism i are arranged on the support platform 1, a magnetic particle reaction cup j is arranged in the cup discharge system b, a reaction cup feeding mechanism k is arranged between the cup discharge system b and the sample filling system c, the reaction cup feeding mechanism k feeds the magnetic particle reaction cup j into the reaction cup strip a, the cup strip grabbing and transporting mechanism i sequentially feeds the reaction cup strip a into the sample filling system c, the reagent system d, the incubation system e, the washing system f and the substrate filling system g, a reaction cup removing mechanism u is arranged between the substrate filling system g and the detection system h, the reaction cup moving-out mechanism u sends the magnetic particle reaction cup j into the detection system h;
a sample system m is arranged below the sample filling system c, a reagent system n is arranged below the reagent filling system d, and a garbage bin p is arranged below the detection system h.
The support platform 1 is provided with two cup strip grabbing and transporting mechanisms i, the incubation system e, the washing system f, the substrate filling system g and the detection system h are located between the two cup strip grabbing and transporting mechanisms i, the cup discharging system b, the sample filling system c and the reagent filling system d are located on the outer side of any one of the cup strip grabbing and transporting mechanisms i, and the reagent filling system d is close to the incubation system e.
The reaction cup moving mechanism is characterized in that a sample adding channel q is arranged near the sample adding system c, a reagent adding channel r is arranged near the reagent adding system d, a reagent mixing channel s is arranged between the incubation system e and the washing system f, a detection waiting channel t is arranged between the substrate adding system g and the detection system h, and the reaction cup moving mechanism u is located between the detection waiting channel t and the detection system h.
A buffer bottle placing area v is arranged on the supporting platform 1 close to the edge of the supporting platform, an electric control system w is arranged below the incubation system e, and a tip head placing area x is arranged close to the sample filling system c.
The reaction cup strip a is vertically provided with at least one transfer hole a1 and at least one reaction cup placing through hole a2 matched with the magnetic particle reaction cup j, the bottom of the magnetic particle reaction cup j penetrates through the reaction cup placing through hole a2, and two side faces of the reaction cup strip a are provided with arc-shaped limiting grooves a 3.
The washing system f comprises a base plate f1, a supporting vertical plate f2 is arranged on the base plate f1, a vertical lifting mechanism f3 is arranged on the supporting vertical plate f2, the vertical lifting mechanism f3 is provided with a first horizontal sliding mechanism f4, the first horizontal sliding mechanism f4 is provided with a washing needle f5, the base plate f1 is provided with a second horizontal sliding mechanism f7, the second horizontal sliding mechanism f7 is vertical to the first horizontal sliding mechanism f4, a washing trolley f8 is arranged on the second horizontal sliding mechanism f7, the washing trolley f8 is positioned below the washing needle f5, at least two cup strip receiving grooves f9 are arranged on the washing trolley f8, the length direction of the cup strip receiving groove f9 is parallel to the sliding direction of the second horizontal sliding mechanism f7, the two ends of the cup strip receiving groove f9 are open, the bottom of the cup strip receiving groove f9 is open, a reaction cup shaking mechanism f10 is arranged on the base plate f1 below the washing trolley f 8.
The first horizontal sliding mechanism f4 is provided with a washing head f11, the washing head f11 is provided with at least 2 groups of washing needles f5, the washing heads f11 are distributed along the length direction of the cup strip receiving groove f9, the washing head f11 is provided with a trolley positioning rod f6, the trolley positioning rod f6 is used for extending into the transfer hole a1, a plurality of magnets f12 are distributed on two inner groove walls of the cup strip receiving groove f9, and the magnets f12 are distributed along the length direction of the cup strip receiving groove f9 in a staggered mode.
The reaction cup shaking-up mechanism f10 comprises a shaking-up motor f101 fixed on the base plate f1, an output shaft of the shaking-up motor f101 extends upwards and is connected with a shaking-up disc f102, an eccentric thimble f103 is arranged on the shaking-up disc f102, and when the shaking-up disc f102 rotates, the eccentric thimble f103 is driven to knock the bottom of the magnetic particle reaction cup j.
Finally, it should be noted that the above-mentioned description is only a preferred embodiment of the present invention, and those skilled in the art can make various similar representations without departing from the spirit and scope of the present invention.
Claims (6)
1. A magnetic particle chemiluminescence immunoassay analyzer is characterized in that: comprises a supporting platform (1) and a reaction cup strip (a), wherein a cup discharging system (b), a sample filling system (c), a reagent filling system (d), an incubation system (e), a washing system (f), a substrate filling system (g), a detection system (h) and a cup strip grabbing and conveying mechanism (i) are arranged on the supporting platform (1), a magnetic particle reaction cup (j) is arranged in the cup discharging system (b), a reaction cup feeding mechanism (k) is arranged between the cup discharging system (b) and the sample filling system (c), the reaction cup feeding mechanism (k) feeds the magnetic particle reaction cup (j) into the reaction cup strip (a), and the cup strip grabbing and conveying mechanism (i) sequentially feeds the reaction cup strip (a) into the sample filling system (c), the reagent filling system (d), the incubation system (e), the washing system (f) and the substrate filling system (g), a reaction cup removing mechanism (u) is arranged between the substrate filling system (g) and the detection system (h), and the reaction cup removing mechanism (u) sends the magnetic particle reaction cup (j) to the detection system (h);
a sample system (m) is arranged below the sample filling system (c), a reagent system (n) is arranged below the reagent filling system (d), and a garbage bin (p) is arranged below the detection system (h);
two cup strip grabbing and transporting mechanisms (i) are arranged on the supporting platform (1), the incubation system (e), the washing system (f), the substrate filling system (g) and the detection system (h) are positioned between the two cup strip grabbing and transporting mechanisms (i), the cup discharging system (b), the sample filling system (c) and the reagent filling system (d) are positioned on the outer side of any one of the cup strip grabbing and transporting mechanisms (i), and the reagent filling system (d) is close to the incubation system (e);
the washing system (f) comprises a base plate (f1), a supporting vertical plate (f2) is arranged on the base plate (f1), a vertical lifting mechanism (f3) is arranged on the supporting vertical plate (f2), a first horizontal sliding mechanism (f4) is arranged on the vertical lifting mechanism (f3), a washing needle (f5) is arranged on the first horizontal sliding mechanism (f4), a second horizontal sliding mechanism (f7) is arranged on the base plate (f1), the second horizontal sliding mechanism (f7) is perpendicular to the first horizontal sliding mechanism (f4), a washing trolley (f8) is arranged on the second horizontal sliding mechanism (f7), the washing trolley (f8) is located below the washing needle (f5), at least two cup strip receiving grooves (f9) are arranged on the washing trolley (f8), the length direction of the cup strip receiving grooves (f9) is parallel to the sliding direction of the second horizontal sliding mechanism (f7), both ends of the cup strip receiving groove (f9) are open, the bottom of the cup strip receiving groove (f9) is open, and a reaction cup shaking-up mechanism (f10) is arranged on a base plate (f1) below the washing trolley (f 8);
a plurality of magnets (f12) are distributed on two inner groove walls of the cup strip bearing groove (f9), and the magnets (f12) are distributed in a staggered mode along the length direction of the cup strip bearing groove (f 9);
the reaction cup shaking-up mechanism (f10) comprises a shaking-up motor (f101) fixed on the base plate (f1), an output shaft of the shaking-up motor (f101) extends upwards and then is connected with a shaking-up disc (f102), an eccentric thimble (f103) is arranged on the shaking-up disc (f102), and when the shaking-up disc (f102) rotates, the eccentric thimble (f103) is driven to knock the bottom of the magnetic particle reaction cup (j).
2. The magnetic particle chemiluminescence immunoassay analyzer of claim 1, wherein: be close to sample filling system (c) is equipped with sample passageway (q), is close to reagent filling system (d) is equipped with reagent passageway (r), it is equipped with reagent mixing passageway(s) to incubate between system (e) and the washing system (f), be equipped with between substrate filling system (g) and detecting system (h) and detect and wait passageway (t), reaction cup shift-out mechanism (u) is located between detection and wait passageway (t) and detecting system (h).
3. The magnetic particle chemiluminescence immunoassay analyzer of claim 1 or 2, wherein: a buffer bottle placing area (v) is arranged on the supporting platform (1) close to the edge of the supporting platform, an electric control system (w) is arranged below the incubation system (e), and a tip head placing area (x) is arranged close to the sample filling system (c).
4. The magnetic particle chemiluminescence immunoassay analyzer of claim 1 or 2, wherein: the reaction cup strip (a) is vertically provided with at least one transfer hole (a1) and at least one reaction cup placing through hole (a2) matched with the magnetic particle reaction cup (j), the bottom of the magnetic particle reaction cup (j) penetrates through the reaction cup placing through hole (a2), and two side faces of the reaction cup strip (a) are provided with arc-shaped limiting grooves (a 3).
5. The magnetic particle chemiluminescence immunoassay analyzer of claim 4, wherein: the first horizontal sliding mechanism (f4) is provided with a washing head (f11), the washing head (f11) is provided with at least 2 groups of washing needles (f5), and the washing heads (f11) are distributed along the length direction of the cup strip receiving groove (f 9).
6. The magnetic particle chemiluminescence immunoassay analyzer of claim 5, wherein: a trolley positioning rod (f6) is arranged on the washing head (f11), and the trolley positioning rod (f6) is used for extending into the transfer hole (a 1).
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| CN201610128044.1A CN107167468B (en) | 2016-03-07 | 2016-03-07 | Magnetic particle chemiluminescence immunoassay analyzer |
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| CN201610128044.1A CN107167468B (en) | 2016-03-07 | 2016-03-07 | Magnetic particle chemiluminescence immunoassay analyzer |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107831325B (en) * | 2017-10-20 | 2021-02-26 | 厦门市波生生物技术有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN107918027A (en) * | 2017-11-17 | 2018-04-17 | 南通伊仕生物技术股份有限公司 | A kind of small size automatic chemiluminescent analyzer |
| CN110082291B (en) * | 2018-01-25 | 2022-08-05 | 深圳市新产业生物医学工程股份有限公司 | Adsorption mechanism, cleaning device, chemiluminescence detector and cleaning method |
| CN108872078B (en) * | 2018-06-29 | 2020-11-24 | 广州市进德生物科技有限公司 | Full-automatic chemiluminescence analyzer |
| CN108732164B (en) * | 2018-08-07 | 2023-09-29 | 广州万孚生物技术股份有限公司 | Full-automatic chemiluminescence immunoassay instrument |
| CN109799336B (en) * | 2019-02-20 | 2023-11-03 | 重庆科斯迈生物科技有限公司 | Dark box detection system of magnetic particle chemiluminescence immunoassay analyzer |
| WO2020168870A1 (en) * | 2019-02-20 | 2020-08-27 | 重庆科斯迈生物科技有限公司 | Chemiluminescence immunoassay instrument washing system with uniformly-mixing function |
| CN114833141B (en) * | 2022-04-28 | 2024-01-30 | 科来思(深圳)科技有限公司 | Full-automatic chemiluminescence immunoassay analyzer washing module |
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