CN107137557B - 用于治疗气虚精亏所致贫血病的中药复方制剂及制备方法 - Google Patents

用于治疗气虚精亏所致贫血病的中药复方制剂及制备方法 Download PDF

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CN107137557B
CN107137557B CN201710308648.9A CN201710308648A CN107137557B CN 107137557 B CN107137557 B CN 107137557B CN 201710308648 A CN201710308648 A CN 201710308648A CN 107137557 B CN107137557 B CN 107137557B
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马力
王维蔚
齐燕松
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Tianjin Shanji Hongxing Technology Development Co ltd
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Abstract

一种用于治疗气虚精亏所致贫血病的中药复方制剂及制备方法。制剂由用量为重量比的下列药物原料制成：炙黄芪18‑48、太子参6‑15、炒白术9‑24、茯苓9‑24、山药9‑24、熟地黄12‑32、炒白芍9‑24、菟丝子9‑24、枸杞子6‑15、女贞子6‑15、墨旱莲6‑15、炙龟甲9‑24、鹿角胶6‑15、怀牛膝9‑24。本发明制剂是采用水煮提取方法来提取原料药物中有效成分，并保持其活性，这样不仅可使药物中有效成分溶出度提高，且有助于药物的吸收，从而能提高其生物利用度。另外，药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，安全性好。此外，制备方法工艺简单，操作方便。

Description

用于治疗气虚精亏所致贫血病的中药复方制剂及制备方法
技术领域
本发明涉及一种中药制剂及其制备方法，特别是涉及一种以中药为原料制成的用于治疗气虚精亏所致贫血病的中药复方制剂及制备方法。
背景技术
贫血是指外周血单位体积血液中的血红蛋白(Hb)浓度、红细胞(RBC)计数及血细胞比容(HCT)低于可比人群正常值的下限，其中以血红蛋白最为重要。贫血属于中医学“虚劳”、“黄病”、“虚黄”等范畴，多由于先天禀賦不足、饮食不节、长期失血、烦劳过度、妊娠失养和大病久病虚损等引起脾肾亏损，脾虚则运化失职，气血生化无源，肾虚则精气不足，无以生髓化血，导致气血亏虚。虽然目前临床上用于治疗贫血病的药物品种很多，但由于导致贫血病的因素有多种，因此贫血病也分多种类型，所以这些药物缺乏针对性，疗程相对较长，且部分药物具有一定副作用或过敏反应，所以服用后对于治疗属于气虚精亏所致的贫血病这种疾病来说效果不理想。
发明内容
为了解决上述问题，本发明的目的在于提供一种用于治疗气虚精亏所致贫血病的中药复方制剂及制备方法。
为了达到上述目的，本发明提供的用于治疗气虚精亏所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成：
炙黄芪18-48 太子参6-15 炒白术9-24 茯苓9-24 山药9-24
熟地黄12-32 炒白芍9-24 菟丝子9-24 枸杞子6-15 女贞子6-15
墨旱莲6-15 炙龟甲9-24 鹿角胶6-15 怀牛膝9-24
所述的用于治疗气虚精亏所致贫血病的中药复方制剂的制备方法是按照下列步骤顺序进行∶
(a)将炙龟甲按照配比进行称量，然后加水煎煮30分钟；
(b)将鹿角胶粉碎成小块或粉末，加入少许黄酒，隔水加热蒸至溶化；
(c)将上述药物原料中除炙龟甲和鹿角胶之外的其它药物原料按照配比进行称量并混合，然后加水浸泡25分钟，再将步骤(a)中的炙龟甲及其煎煮液加入混合，煎煮30分钟，过滤去渣；
(d)将步骤(b)所得鹿角胶溶液与步骤(c)所得清液混合均匀即可制成所述的用于治疗气虚精亏所致贫血病的中药复方制剂。
所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
本发明提供的用于治疗气虚精亏所致贫血病的中药复方制剂是采用水煮提取的方法来提取原料药物中的有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度大大提高，而且有助于药物的吸收，从而能够提高其生物利用度。另外，本发明的药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。
具体实施方式
贫血病症状复杂，病程迁延，并发症较多。临床常见虚证、实证和虚实夹杂证等。此方立法于益气生精。方中炙黄芪甘微温，健脾补中，升阳举陷，益卫固表，利尿，托毒生肌，为补中益气之要药，为君药。太子参甘微苦平，补气健脾，生津润肺；茯苓甘淡平，利水渗湿，健脾化痰，宁心安神；熟地黄甘微温，补血养阴，填精益髓；菟丝子辛甘平，补肾益精，养肝明目，止泻；女贞子甘苦凉，滋补肝肾，乌须明目；炙龟甲甘寒，滋阴潜阳，益肾健骨，养血补心，以上诸药，健脾益气，补肾填精，滋阴潜阳，共为臣药。炒白术甘苦温，益气健脾，燥湿利尿，为补气健脾第一要药；山药甘平，补脾养胃，为慢性久病调补脾胃之佳品；炒白芍苦酸微寒，养血敛阴，柔肝止痛，平抑肝阳；枸杞子甘平，滋补肝肾，益精明目，为平补肾精肝血之精品；墨旱莲甘酸寒，滋补肝肾，凉血止血；鹿角胶甘咸，补肝肾，益精血，止血，以上诸药，补养脾胃，滋肝补肾，填精补血，为佐药。怀牛膝苦甘酸平，活血通经，补肝肾，强筋骨，利水通淋，引火(血)下行，以为使药。本方健脾益气，补肾填精，故适用于治疗气虚精亏所致的贫血病。
下面结合实施例对本发明提供的用于治疗气虚精亏所致贫血病的中药复方制剂及其制备方法进行详细说明。
实施例1：
本实施例提供的用于治疗气虚精亏所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成：
炙黄芪18 太子参6 炒白术9 茯苓9 山药9
熟地黄12 炒白芍9 菟丝子9 枸杞子6 女贞子6
墨旱莲6 炙龟甲9 鹿角胶6 怀牛膝9
所述的用于治疗气虚精亏所致贫血病的中药复方制剂的制备方法是按照下列步骤顺序进行∶
(a)将炙龟甲按照配比进行称量，然后加水煎煮30分钟；
(b)将鹿角胶粉碎成小块或粉末，加入少许黄酒，隔水加热蒸至溶化；
(c)将上述药物原料中除炙龟甲和鹿角胶之外的其它药物原料按照配比进行称量并混合，然后加水浸泡25分钟，再将步骤(a)中的炙龟甲及其煎煮液加入混合，煎煮30分钟，过滤去渣；
(d)将步骤(b)所得鹿角胶溶液与步骤(c)所得清液混合均匀即可制成所述的用于治疗气虚精亏所致贫血病的中药复方制剂。
所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
实施例2：
本实施例提供的用于治疗气虚精亏所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成：
炙黄芪48 太子参15 炒白术24 茯苓24 山药24
熟地黄32 炒白芍24 菟丝子24 枸杞子15 女贞子15
墨旱莲15 炙龟甲24 鹿角胶15 怀牛膝24
制备方法同实施例1。
实施例3：
本实施例提供的用于治疗气虚精亏所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成：
炙黄芪32 太子参12 炒白术17 茯苓17 山药17
熟地黄22 炒白芍17 菟丝子17 枸杞子12 女贞子12
墨旱莲12 炙龟甲17 鹿角胶12 怀牛膝17
制备方法同实施例1。
本发明提供的用于治疗气虚精亏所致贫血病的中药复方制剂呈棕色至棕褐色；气淡，味微苦。为了验证该中药复方制剂的治疗效果，本发明人利用上述中药复方制剂对292例患有气虚精亏型贫血病的患者进行了系统临床观察，其中21-30岁患者83例，31-40岁104例，41-50岁105例,每次用药150ml，每日3次，120天为1个疗程。经1个疗程治疗后共治愈(血红蛋白(Hb)浓度、红细胞(RBC)计数及血细胞比容(HCT)等主要症状明显改善)144例，占49.3％；有效(各项化验检查明显改善，主要症状有改善)132例，占45.2％；无效(各项化验检查无变化，主要症状无改善)16例，占5.5％；总有效率为94.5％。经2个疗程治疗后共治愈229例，占78.4％；有效51例，占17.5％；无效12例，占4.1％；总有效率为95.9％。
同时，本发明人对治疗效果与年龄、治疗效果与疗程之间的关系进行了分析，分析结果分别见表1、表2。
表1：本发明提供的中药复方制剂治疗效果与年龄关系表
Figure BDA0001286479100000051
将上述表1中的数据用x2检验法进行计算，结果为0.050＞P＞0.025，由此可以证明服用本发明提供的中药复方制剂来治疗气虚精亏型贫血病，对各年龄组的治疗效果不随年龄而变化。
表2：本发明提供的中药复方制剂治疗效果与疗程关系表
Figure BDA0001286479100000052
Figure BDA0001286479100000061
将上述表2中的数据用x2检验法进行计算，结果为P＜0.005，由此可以证明服用本发明提供的中药复方制剂来治疗气虚精亏型贫血病，随着治疗的深入，治愈率、有效率均明显提高。

Claims (3)

1.一种用于治疗气虚精亏所致贫血病的中药复方制剂，其特征在于：所述的用于治疗气虚精亏所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成：
炙黄芪18-48 太子参6-15 炒白术9-24 茯苓9-24 山药9-24
熟地黄12-32 炒白芍9-24 菟丝子9-24 枸杞子6-15 女贞子6-15
墨旱莲6-15 炙龟甲9-24 鹿角胶6-15 怀牛膝9-24。
2.一种如权利要求1所述的用于治疗气虚精亏所致贫血病的中药复方制剂的制备方法，其特征在于：所述的制备方法是按照下列步骤顺序进行∶
（a）将炙龟甲按照配比进行称量，然后加水煎煮30分钟；
（b）将鹿角胶粉碎成小块或粉末，加入少许黄酒，隔水加热蒸至溶化；
（c）将上述药物原料中除炙龟甲和鹿角胶之外的其它药物原料按照配比进行称量并混合，然后加水浸泡25分钟，再将步骤（a）中的炙龟甲及其煎煮液加入混合，煎煮30分钟，过滤去渣；
（d）将步骤（b）所得鹿角胶溶液与步骤（c）所得滤液混合均匀即可制成所述的用于治疗气虚精亏所致贫血病的中药复方制剂。
3.根据权利要求2所述的制备方法，其特征在于：所述的中药复方制剂与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂或膏剂。
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