CN106943485B - 用于治疗血热出血所致贫血病的中药复方制剂及制备方法 - Google Patents
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Abstract
一种用于治疗血热出血所致贫血病的中药复方制剂及制备方法。制剂由用量为重量比的下列药物原料制成：生地黄12‑32、当归6‑15、赤芍9‑24、牡丹皮6‑15、紫草6‑15、仙鹤草18‑48、茜草6‑15、黄柏6‑15、地榆6‑15、侧柏炭6‑15、荆芥炭6‑15、生甘草4‑10。本发明制剂是采用水煮提取的方法来提取原料药物中有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度大大提高，且有助于药物的吸收，从而能提高其生物利用度。另外，药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。
Description
技术领域
本发明涉及一种中药制剂及其制备方法，特别是涉及一种以中药为原料制成的用于治疗血热出血所致贫血病的中药复方制剂及制备方法。
背景技术
贫血是指外周血单位体积血液中的血红蛋白(Hb)浓度、红细胞(RBC)计数及血细胞比容(HCT)低于可比人群正常值的下限，其中以血红蛋白最为重要。贫血属于中医学“虚劳”、“黄病”、“虚黄”等范畴，多由于先天禀賦不足、饮食不节、长期失血、烦劳过度、妊娠失养和大病久病虚损等引起脾肾亏损，脾虚则运化失职，气血生化无源，肾虚则精气不足，无以生髓化血，导致气血亏虚。虽然目前临床上用于治疗贫血病的药物品种很多，但由于导致贫血病的因素有多种，因此贫血病也分多种类型，所以这些药物缺乏针对性，疗程相对较长，且部分药物具有一定副作用或过敏反应，所以服用后对于治疗属于血热出血所致的贫血病这种疾病来说效果不理想。
发明内容
为了解决上述问题，本发明的目的在于提供一种用于治疗血热出血所致贫血病的中药复方制剂及制备方法。
为了达到上述目的，本发明提供的用于治疗血热出血所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成：
生地黄12-32当归6-15赤芍9-24牡丹皮6-15紫草6-15
仙鹤草18-48茜草6-15黄柏6-15地榆6-15侧柏炭6-15
荆芥炭6-15生甘草4-10
所述的用于治疗血热出血所致贫血病的中药复方制剂的制备方法是将上述药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣即可制成所述的用于治疗血热出血所致贫血病的中药复方制剂。
所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
本发明提供的用于治疗血热出血所致贫血病的中药复方制剂是采用水煮提取的方法来提取原料药物中的有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度大大提高，而且有助于药物的吸收，从而能够提高其生物利用度。另外，本发明的药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。
具体实施方式
贫血病症状复杂，病程迁延，并发症较多。临床常见虚证、实证和虚实夹杂证等。此方立法于凉血止血。方中生地黄甘苦寒，清热凉血，养阴生津，是清热凉血止血之要药，故为君药。当归甘辛温，补血，活血止痛；牡丹皮苦甘微寒，清热凉血，活血祛瘀；仙鹤草苦涩平，收敛止血，补虚；黄柏苦寒，清热燥湿，泻火除蒸，解毒疗疮；侧柏炭苦涩寒，凉血止血，化痰止咳，以上诸药，凉血止血，活血补血，共为臣药。赤芍苦微寒，清热凉血，散瘀止痛，善清泻肝火，凉血止血；紫草甘咸寒，清热凉血，活血，解毒透疹；茜草苦寒，凉血化瘀止血，通经；地榆苦酸涩微寒，凉血止血，解毒敛疮；荆芥炭辛微温，祛风解表，透疹消疮，止血，以上诸药，清热凉血解毒，活血通经化瘀，为佐药。生甘草甘平，补脾益气，清热解毒止痛，调和诸药，以为使药。本方清热凉血，化瘀止血，同时具有养阴生血之功，故适用于治疗血热出血所致的贫血病。
下面结合实施例对本发明提供的用于治疗血热出血所致贫血病的中药复方制剂及制备方法进行详细说明。
实施例1：
本实施例提供的用于治疗血热出血所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成：
生地黄12当归6赤芍9牡丹皮6紫草6
仙鹤草18茜草6黄柏6地榆6侧柏炭6
荆芥炭6生甘草4
所述的用于治疗血热出血所致贫血病的中药复方制剂的制备方法是将上述药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣即可制成所述的用于治疗血热出血所致贫血病的中药复方制剂。
另外，所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
实施例2：
本实施例提供的用于治疗血热出血所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成：
生地黄32当归15赤芍24牡丹皮15紫草15
仙鹤草48茜草15黄柏15地榆15侧柏炭15
荆芥炭15生甘草10
制备方法同实施例1。
实施例3：
本实施例提供的用于治疗血热出血所致贫血病的中药复方制剂由用量为重量比的下列药物原料制成：
生地黄22当归12赤芍17牡丹皮12紫草12
仙鹤草32茜草12黄柏12地榆12侧柏炭12
荆芥炭12生甘草8
制备方法同实施例1。
本发明提供的用于治疗血热出血所致贫血病的中药复方制剂呈棕色至棕褐色；气淡，味微苦。为了验证该中药复方制剂的治疗效果，本发明人利用上述中药复方制剂对415例患有血热出血型贫血病的患者进行了系统临床观察，其中21-30岁患者107例，31-40岁145例，41-50岁163例,每次用药150ml，每日3次，120天为1个疗程。经1个疗程治疗后共治愈(血红蛋白(Hb)浓度、红细胞(RBC)计数及血细胞比容(HCT)等主要症状明显改善)172例，占41.4％；有效(各项化验检查明显改善，主要症状有改善)133例，占32.0％；无效(各项化验检查无变化，主要症状无改善)110例，占26.5％；总有效率为73.5％。经2个疗程治疗后共治愈305例，占73.5％；有效86例，占20.7％；无效24例，占5.8％；总有效率为94.2％。
同时，本发明人对治疗效果与年龄、治疗效果与疗程之间的关系进行了分析，分析结果分别见表1、表2。
表1：本发明提供的中药复方制剂治疗效果与年龄关系表
将上述表1中的数据用x2检验法进行计算，结果为0.050＞P＞0.025，由此可以证明服用本发明提供的中药复方制剂来治疗血热出血型贫血病，对各年龄组的治疗效果不随年龄而变化。
表2：本发明提供的中药复方制剂治疗效果与疗程关系表
将上述表2中的数据用x2检验法进行计算，结果为P＜0.005，由此可以证明服用本发明提供的中药复方制剂来治疗血热出血型贫血病，随着治疗的深入，治愈率、有效率均明显提高。
Claims (3)
1.一种用于治疗血热出血所致贫血病的中药复方制剂，其特征在于：所述的中药复方制剂由用量为重量比的下列药物原料制成：
生地黄12-32 当归6-15 赤芍9-24 牡丹皮6-15 紫草6-15
仙鹤草18-48 茜草6-15 黄柏6-15 地榆6-15 侧柏炭6-15
荆芥炭6-15 生甘草4-10。
2.一种如权利要求1所述的用于治疗血热出血所致贫血病的中药复方制剂的制备方法，其特征在于：所述的制备方法是将上述药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣即可制成所述的用于治疗血热出血所致贫血病的中药复方制剂。
3.根据权利要求2所述的制备方法，其特征在于：所述的中药复方制剂与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂或膏剂。
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