CN107334897B - 用于治疗瘀血内阻所致便血的中药复方制剂及制备方法 - Google Patents
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Abstract
一种用于治疗瘀血内阻所致便血的中药复方制剂及制备方法。制剂由用量为重量比的下列药物原料制成:当归6‑15、赤芍9‑24、川芎6‑15、红花6‑15、牡丹皮6‑15、延胡索9‑24、香附6‑15、仙鹤草18‑48、侧柏叶6‑15、地榆6‑15、槐花4‑10、生甘草4‑10。本发明制剂是采用水煮提取方法来提取原料药物中的有效成分,并保持其活性,这样不仅可使药物中有效成分的溶出度提高,而且有助于药物的吸收,从而能提高其生物利用度。另外,药物为纯中药复方制剂,因而患者长期服用后不会产生毒副作用,所以安全性好。此外,本发明的制备方法工艺简单,操作方便。
Description
技术领域
本发明涉及一种中药制剂及其制备方法,特别是涉及一种以中药为原料制成的用于治疗瘀血内阻所致便血的中药复方制剂及其制备方法。
背景技术
便血又名血便、下血、泄血等。凡血自肛门而下,或先便后血,或先血后便,或血与大便相杂而下,或纯血水者,皆谓之便血。根据出血部位的不同,有远血、近血之分;按血色的鲜浊又有肠风、脏毒之别。便血一般由于湿热、虚劳和气机失调等原因造成。虽然目前临床上用于治疗便血的药物品种很多,但由于导致便血的因素有多种,而且便血也分多种类型,因此这些药物缺乏针对性,疗程相对较长,且部分药物具有一定副作用或过敏反应,所以服用后对于治疗属于瘀血内阻所致的便血这种疾病来说效果不理想。
发明内容
为了解决上述问题,本发明的目的在于提供一种用于治疗瘀血内阻所致便血的中药复方制剂及其制备方法。
为了达到上述目的,本发明提供的用于治疗瘀血内阻所致便血的中药复方制剂由用量为重量比的下列药物原料制成:
当归6-15 赤芍9-24 川芎6-15 红花6-15 牡丹皮6-15
延胡索9-24 香附6-15 仙鹤草18-48 侧柏叶6-15 地榆6-15
槐花4-10 生甘草4-10
所述的用于治疗瘀血内阻所致便血的中药复方制剂的制备方法是将上述药物原料按照配比进行称量并混合,然后加水浸泡25分钟,之后煎煮30分钟,过滤去渣即可制成所述的用于治疗瘀血内阻所致便血的中药复方制剂。
所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
本发明提供的用于治疗瘀血内阻所致便血的中药复方制剂是采用水煮提取的方法来提取原料药物中的有效成分,并保持其活性,这样不仅可使药物中有效成分的溶出度大大提高,而且有助于药物的吸收,从而能够提高其生物利用度。另外,本发明的药物为纯中药复方制剂,因而患者长期服用后不会产生毒副作用,所以安全性好。此外,本发明的制备方法工艺简单,操作方便。
具体实施方式
便血症状复杂,病程迁延,并发症较多。临床常见虚证、实证和虚实夹杂证等。此方立法于化瘀止血。方中当归甘辛温,补血,活血止痛,为君药。赤芍苦微寒,清热凉血,散瘀止痛,善清泻肝火,凉血止血;红花辛温,活血通经,祛瘀止痛;延胡索辛苦温,活血行气止痛;仙鹤草苦涩平,收敛止血,补虚;地榆苦酸涩微寒,凉血止血,解毒敛疮,以上诸药,补血活血,行气化瘀,凉血止血,共为臣药。川芎辛温,活血行气,祛风止痛;牡丹皮苦甘微寒,清热凉血,活血祛瘀;香附辛微苦微甘温,疏肝解郁,调经止痛,理气调中;侧柏叶苦涩寒,凉血止血,化痰止咳;槐花苦微寒,凉血止血,清肝泻火,以上诸药,行气活血,清热凉血,共为佐药。生甘草甘平,补脾益气,清热解毒止痛,调和诸药,以为使药。本方活血补血,行气化瘀,清热凉血止血,故适用于治疗瘀血内阻所致的便血。
下面结合实施例对本发明提供的用于治疗瘀血内阻所致便血的中药复方制剂及其制备方法进行详细说明。
实施例1:
本实施例用于治疗瘀血内阻所致便血的中药复方制剂由用量为重量比的下列药物原料制成:
当归6 赤芍9 川芎6 红花6 牡丹皮6
延胡索9 香附6 仙鹤草18 侧柏叶6 地榆6
槐花4 生甘草4
所述的用于治疗瘀血内阻所致便血的中药复方制剂的制备方法是将上述药物原料按照配比进行称量并混合,然后加水浸泡25分钟,之后煎煮30分钟,过滤去渣即可制成所述的用于治疗瘀血内阻所致便血的中药复方制剂。
另外,所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
实施例2:
本实施例用于治疗瘀血内阻所致便血的中药复方制剂由用量为重量比的下列药物原料制成:
当归15 赤芍24 川芎15 红花15 牡丹皮15
延胡索24 香附15 仙鹤草48 侧柏叶15 地榆15
槐花10 生甘草10
制备方法同实施例1。
实施例3:
本实施例用于治疗瘀血内阻所致便血的中药复方制剂由用量为重量比的下列药物原料制成:
当归9 赤芍12 川芎9 红花9 牡丹皮9
延胡索12 香附9 仙鹤草25 侧柏叶9 地榆9
槐花5 生甘草5
制备方法同实施例1。
本发明提供的用于治疗瘀血内阻所致便血的中药复方制剂呈棕色至棕褐色;气淡,味微苦。为了验证该中药复方制剂的治疗效果,本发明人利用上述中药复方制剂对285例患有瘀血内阻型便血的患者进行了系统临床观察,其中21-30岁患者68例,31-40岁105例,41-50岁112例,每次用药150ml,每日3次,120天为1个疗程。经1个疗程治疗后共治愈(出血症状基本消失)135例,占47.4%;有效(主要症状有改善)124例,占43.5%;无效(主要症状无改善)26例,占9.1%;总有效率为90.9%。经2个疗程治疗后共治愈209例,占73.3%;有效68例,占23.9%;无效8例,占2.8%;总有效率为97.2%。
同时,本发明人对治疗效果与年龄、治疗效果与疗程之间的关系进行了分析,分析结果分别见表1、表2。
表1:本发明提供的中药复方制剂治疗效果与年龄关系表
将上述表1中的数据用x2检验法进行计算,结果为0.050>P>0.025,由此可以证明服用本发明提供的中药复方制剂来治疗瘀血内阻型便血,对各年龄组的治疗效果不随年龄而变化。
表2:本发明提供的中药复方制剂治疗效果与疗程关系表
将上述表2中的数据用x2检验法进行计算,结果为P<0.005,由此可以证明服用本发明提供的中药复方制剂来治疗瘀血内阻型便血,随着治疗的深入,治愈率、有效率均明显提高。
Claims (3)
1.一种用于治疗瘀血内阻所致便血的中药复方制剂,其特征在于:所述的中药复方制剂由用量为重量比的下列药物原料制成:
当归6-15 赤芍9-24 川芎6-15 红花6-15 牡丹皮6-15
延胡索9-24 香附6-15 仙鹤草18-48 侧柏叶6-15 地榆6-15
槐花4-10 生甘草4-10。
2.一种如权利要求1所述的用于治疗瘀血内阻所致便血的中药复方制剂的制备方法,其特征在于:所述的制备方法是将上述药物原料按照配比进行称量并混合,然后加水浸泡25分钟,之后煎煮30分钟,过滤去渣即可制成所述的用于治疗瘀血内阻所致便血的中药复方制剂。
3.根据权利要求2所述的制备方法,其特征在于:所述的中药复方制剂与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂或膏剂。
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