CN106822558B - 用于治疗肝火痰郁所致白血病的中药复方制剂及制备方法 - Google Patents
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Abstract
一种用于治疗肝火痰郁所致白血病的中药复方制剂及制备方法。制剂由用量为重量比的下列药物原料制成：龙胆4—10、炒栀子6—15、牡丹皮6—15、当归6—15、赤芍9—24、清半夏6—15、浙贝母6—15、半枝莲9—24、白花蛇舌草9—24、龙葵9—24、夏枯草18—48、柴胡4—10。本发明制剂是采用水煮提取的方法来提取原料药物中的有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度大大提高，而且有助于药物的吸收，从而能够提高其生物利用度。另外，本发明的药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。
Description
技术领域
本发明涉及一种中药制剂及其制备方法，特别是涉及一种以中药为原料制成的用于治疗肝火痰郁所致白血病的中药复方制剂及制备方法。
背景技术
白血病又称血癌，是由于正气内虚、温热毒邪乘虚而入引起的，以热毒、血瘀、痰浊互结，人体伤血为基本病机，以发热、出血、贫血及肝、脾、淋巴结肿大等为主要临床表现的一种造血系统的恶性肿瘤。虽然目前临床上用于治疗白血病的药物品种很多，但针对性不强，而且部分药物的毒副作用大，所以服用后对于治疗属于肝火痰郁所致的白血病这种疾病来说效果不明显。
发明内容
为了解决上述问题，本发明的目的在于提供一种用于治疗肝火痰郁所致白血病的中药复方制剂及制备方法。
为了达到上述目的，本发明提供的用于治疗肝火痰郁所致白血病的中药复方制剂由用量为重量比的下列药物原料制成：
龙胆4—10 炒栀子6—15 牡丹皮6—15 当归6—15 赤芍9—24
清半夏6—15 浙贝母6—15 半枝莲9—24 白花蛇舌草9—24
龙葵9—24 夏枯草18—48 柴胡4—10
所述的用于治疗肝火痰郁所致白血病的中药复方制剂的制备方法是将上述药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣即可制成所述的用于治疗肝火痰郁所致白血病的中药复方制剂。
所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
本发明提供的用于治疗肝火痰郁所致白血病的中药复方制剂是采用水煮提取的方法来提取原料药物中的有效成分，并保持其活性，这样不仅可使药物中有效成分的溶出度大大提高，而且有助于药物的吸收，从而能够提高其生物利用度。另外，本发明的药物为纯中药复方制剂，因而患者长期服用后不会产生毒副作用，所以安全性好。此外，本发明的制备方法工艺简单，操作方便。
具体实施方式
白血病症状复杂，病程迁延，并发症较多。临床常见虚证、实证和虚实夹杂证等。此方立法于清肝泻火，化痰散结。方中龙胆苦寒，清热燥湿，泻肝胆火，善清下焦湿热，为君药。炒栀子苦寒，泻火除烦，清热利湿，凉血解毒；当归甘辛温，补血，活血止痛；清半夏辛温，燥湿化痰，降逆止呕，消痞散结；半枝莲辛凉，清热解毒，利尿，消肿止痛，抗癌；龙葵苦寒，清热解毒，活血消肿，以上诸药，清热利湿，解毒消肿，共为臣药。牡丹皮苦甘微寒，清热凉血，活血祛瘀；赤芍苦微寒，清热凉血，散瘀止痛，善清泻肝火，凉血止血；浙贝母苦寒，清热化痰，散结消痈；白花蛇舌草微苦甘寒，清热解毒，利湿通淋；夏枯草辛苦寒，清热泻火，明目，散结消肿，以上诸药，清热凉血，泻火解毒，消肿散结，共为佐药。柴胡苦平微寒，疏肝解郁，升举阳气，以为使药。本方清热凉血，泻火解毒，且具有消肿、止痛、抗癌之功，故适用于肝火痰郁所致的白血病。
下面结合实施例对本发明提供的用于治疗白血病的中药复方制剂及其制备方法进行详细说明。
实施例1：
本实施例提供的用于治疗肝火痰郁所致白血病的中药复方制剂由用量为重量比的下列药物原料制成：
所述的用于治疗肝火痰郁所致白血病的中药复方制剂的制备方法是将上述药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣即可制成所述的用于治疗肝火痰郁所致白血病的中药复方制剂。
另外，所述的中药复方制剂能够与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂和膏剂。
实施例2：
本实施例提供的用于治疗肝火痰郁所致白血病的中药复方制剂由用量为重量比的下列药物原料制成：
制备方法同实施例1。
实施例3：
本实施例提供的用于治疗肝火痰郁所致白血病的中药复方制剂由用量为重量比的下列药物原料制成：
制备方法同实施例1。
本发明提供的用于治疗肝火痰郁所致白血病的中药复方制剂呈棕色至棕褐色；气淡，味微苦。为了验证该中药复方制剂的治疗效果，本发明人利用上述中药复方制剂对315例患有肝火痰郁型白血病的患者进行了系统临床观察，其中21-30岁患者83例，31-40岁121例，41-50岁111例,每次用药150ml，每日3次，120天为1个疗程。经1个疗程治疗后共治愈(血常规检查正常，骨髓象检查正常，染色体检查正常，主要症状明显改善)8例，占2.5％；有效(各项化验检查明显改善，主要症状有改善)146例，占46.3％；无效(各项化验检查无变化，主要症状无改善)161例，占51.1％；总有效率为48.9％。经2个疗程治疗后共治愈14例，占4.4％；有效215例，占66.2％；无效86例，占27.3％；总有效率为72.7％。
同时，本发明人对治疗效果与年龄、治疗效果与疗程之间的关系进行了分析，分析结果分别见表1、表2。
表1：本发明提供的中药复方制剂治疗效果与年龄关系表
将上述表1中的数据用x2检验法进行计算，结果为0.050＞P＞0.025，由此可以证明服用本发明提供的中药复方制剂来治疗肝火痰郁型白血病，对各年龄组的治疗效果不随年龄而变化。
表2：本发明提供的中药复方制剂治疗效果与疗程关系表
将上述表2中的数据用x2检验法进行计算，结果为P＜0.005，由此可以证明服用本发明提供的中药复方制剂来治疗肝火痰郁型白血病，随着治疗的深入，治愈率、有效率均明显提高。
Claims (2)
1.一种用于治疗肝火痰郁所致白血病的中药复方制剂，其特征在于：所述的中药复方制剂由用量为重量比的下列药物原料制成：
龙胆4—10 炒栀子6—15 牡丹皮6—15 当归6—15 赤芍9—24
清半夏6—15 浙贝母6—15 半枝莲9—24 白花蛇舌草9—24
龙葵9—24 夏枯草18—48 柴胡4—10；
所述的中药复方制剂为与常用的药用辅料制成颗粒剂、片剂、胶囊剂、糖浆剂、口服液、丸剂或膏剂。
2.一种用于治疗肝火痰郁所致白血病的中药复方制剂的制备方法，其特征在于：所述的制备方法是将权利要求1所述的药物原料按照配比进行称量并混合，然后加水浸泡25分钟，之后煎煮30分钟，过滤去渣即可制成所述的用于治疗肝火痰郁所致白血病的中药复方制剂。
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